Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the γ-butyrolactone autoregulator in Streptomyces virginiae

Microbiology

Volumn 156, Issue 1, 2010, Pages 206-210

  Lee, Yong Jik ^a   Kitani, Shigeru ^a   Nihira, Takuya ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; GAMMA BUTYROLACTONE; PROTEIN BARX; UNCLASSIFIED DRUG; VIRGINIAE BUTANOLIDE;

ARTICLE; AUTOREGULATION; BACTERIAL GENE; BIOSYNTHESIS; CONTROLLED STUDY; GENE FUNCTION; GENE MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES VIRGINIAE;

4-BUTYROLACTONE; BACTERIAL PROTEINS; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; MUTATION; RNA, BACTERIAL; STREPTOMYCES; VIRGINIAMYCIN;

STREPTOMYCES GRISEUS; STREPTOMYCES VIRGINIAE; STREPTOMYCINEAE;

EID: 76849116002     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.032003-0     Document Type: Article

References (12)

1. Horinouchi, S. (2007). Mining and polishing of the treasure trove in the bacterial genus Streptomyces. Biosci Biotechnol Biochem 71, 283-299.
2. Hsiao, N. H., Soding, J., Linke, D., Lange, C., Hertweck, C., Wohlleben, W. & Takano, E. (2007). ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize γbutyrolactones. Microbiology 153, 1394-1404.
3. Kato, J. Y., Funa, N., Watanabe, H., Ohnishi, Y. & Horinouchi, S. (2007). Biosynthesis of γ-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces. Proc Natl Acad Sci U S A 104, 2378-2383.
4. 1 resistance. Mol Microbiol 36, 302-313.
5. Lee, Y. J., Kitani, S., Kinoshita, H. & Nihira, T. (2008). Identification by gene deletion analysis of barS2, a gene involved in the biosynthesis of γ-butyrolactone autoregulator in Streptomyces virginiae. Arch Microbiol 189, 367-374.
6. Nihira, T., Shimizu, Y., Kim, H. S. & Yamada, Y. (1988). Structure-activity relationships of virginiae butanolide C, an inducer of virginiamycin production in Streptomyces virginiae. J Antibiot (Tokyo) 41, 1828-1837.
7. Pulsawat, N., Kitani, S., Fukushima, E. & Nihira, T. (2009). Hierarchical control of virginiamycin production in Streptomyces virginiae by three pathway-specific regulators: VmsS, VmsT and VmsR. Microbiology 155, 1250-1259.
8. Sakuda, S., Higashi, A., Tanaka, S., Nihira, T. & Yamada, Y. (1992). Biosynthesis of virginiae butanolide A, a butyrolactone autoregulator from Streptomyces. J Am Chem Soc 114, 663-668.
9. Sakuda, S., Tanaka, S., Mizuno, K., Sukcharoen, O., Nihira, T. & Yamada, Y. (1993). Biosynthetic studies on virginiae butanolide A, a butyrolactone autoregulator from Streptomyces. Part 2. Preparation of possible biosynthetic intermediates and conversion experiments in a cell-free system. J Chem Soc Perkin Trans 1, 2309-2315.
10. Shikura, N., Yamamura, J. & Nihira, T. (2002). barS1, a gene for biosynthesis of a γ-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species. J Bacteriol 184, 5151-5157.
11. Takano, E. (2006). γ-Butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation. Curr Opin Microbiol 9, 287-294.
12. Yamada, Y., Sugamura, K., Kondo, K., Yanagimoto, M. & Okada, H. (1987). The structure of inducing factors for virginiamycin production in Streptomyces virginiae. J Antibiot (Tokyo) 40, 496-504.