Antibiotic production by actinomycetes: The Janus faces of regulation

Journal of Industrial Microbiology and Biotechnology

Volumn 33, Issue 7, 2006, Pages 500-506

  Cundliffe, Eric ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Actinomycetes; Antibiotic production; Gamma butyrolactones; Pathway specific regulation; Pleiotropic regulation; SARPs

Indexed keywords

ANTIBIOTIC AGENT; BUTYROLACTONE; STREPTOMYCIN; TYLOSIN; VIRGINIAMYCIN;

ACTINOBACTERIA; AUTOREGULATION; BIOSYNTHESIS; CONFERENCE PAPER; DRUG MANUFACTURE; GENE CLUSTER; GENE CONTROL; GENE SEQUENCE; GENETIC TRANSCRIPTION; MOLECULAR WEIGHT; NONHUMAN; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ACTINOBACTERIA; ANTI-BACTERIAL AGENTS; GENE EXPRESSION REGULATION, BACTERIAL;

ACTINOBACTERIA (CLASS);

EID: 33745038222     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-006-0083-6     Document Type: Conference Paper

References (35)

1. Arias P, Fernández-Moreno MA, Malpartida F (1999) Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. J Bacteriol 181:6958-6968
2. Arisawa A, Kawamura N, Tsunekawa H, Okamura K, Tone H, Okamoto R (1993) Cloning and nucleotide sequences of two genes involved in the 4″-O-acylation of macrolide antibiotics from Streptomyces thermotolerans. Biosci Biotech Biochem 57:2020-2025
3. Bate N, Butler AR, Gandecha AR, Cundliffe E (1999) Multiple regulatory genes in the tylosin-biosynthetic cluster of Streptomyces fradiae. Chem Biol 6:617-624
4. Bate N, Stratigopoulos G, Cundliffe E (2002) Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. Molec Microbiol 43:449-458
5. Bibb M (1996) The regulation of antibiotic production in Streptomyces coelicolor A3(2). Microbiol 142:1335-1344
6. Bibb MJ (2005) Regulation of secondary metabolism in streptomycetes. Curr Op Microbiol 8:208-215
7. Butler AR, Gandecha AR, Cundliffe E (2001) Influence of ancillary genes, encoding aspects of methionine metabolism, on tylosin biosynthesis in Streptomyces fradiae. J Antibiot 54:642-649
8. Challis GL, Hopwood DA (2003) Synergy and contingency as driving forces for the evolution of secondary metabolite production by Streptomyces species. Proc Natl Acad Sci USA 100:14555-14561
9. Cundliffe E (1989) How antibiotic-producing organisms avoid suicide. Annu Rev Microbiol 43:207-233
10. Dobbs BJT (1991) The Janus Faces of Genius: the role of alchemy in Newton's thought. Cambridge University Press, Cambridge
11. Fernández-Moreno MA, Caballero JL, Hopwood DA, Malpartida F (1991) The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. Cell 66:769-780
12. Folcher M, Gaillard H, Nguyen LT, Nguyen KT, Lacroix P, Bamas-Jacques N, Rinkel M, Thompson CJ (2001) Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase. J Biol Chem 276:44297-44306
13. Kawachi R, Wangchaisoonthorn U, Nihira T, Yamada Y (2000) Identification by gene deletion analysis of a regulator, VmsR, that controls virginiamycin biosynthesis in Streptomyces virginiae. J Bacteriol 182:6259-6263
14. Kinoshita H, Ipposhi H, Okamoto S, Nakano H, Nihira T, Yamada Y (1997) Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae. J Bacteriol 179:6986-6993
15. Kinoshita H, Tsuji T, Ipposhi H, Nihira T, Yamada Y (1999) Characterization of binding sequences for butyrolactone autoregulator receptors in streptomycetes. J Bacteriol 181:5075-5080
16. Kitani S, Kinoshita H, Nihira T, Yamada Y (1999) In vitro analysis of the butyrolactone autoregulator receptor protein (FarA) of Streptomyces lavendulae FRI-5 reveals that FarA acts as a DNA-binding transcriptional regulator that controls its own synthesis. J Bacteriol 181:5081-5084
17. 1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius. J Bacteriol 177:1208-1215
18. Martin JF, Demain AL (1980) Control of antibiotic biosynthesis. Microbiol Rev 44:230-251
19. Matsuno K, Yamada Y, Lee C-K, Nihira T (2004) Identification by gene deletion analysis of barB as a negative regulator controlling an early process of virginiamycin biosynthesis in Streptomyces virginiae. Arch Microbiol 181:52-59
20. Nakano H, Takehara E, Nihira T, Yamada Y (1998) Gene replacement analysis of the Streptomyces virginiae barA gene encoding the butyrolactone autoregulator receptor reveals that BarA acts as a repressor in virginiamycin biosynthesis. J Bacteriol 180:3317-3322
21. Ohnishi Y, Kameyama S, Onaka H, Horinouchi S (1999) The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Molec Microbiol 34:102-111
22. Retzlaff L, Distler J (1995) The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites. Molec Microbiol 18:151-162
23. Santamarta I, Rodríguez-García A, Pérez-Redondo R, Martín JF, Liras P (2002) CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus. J Bacteriol 184: 3106-3113
24. Stratigopoulos G, Bate N, Cundliffe E (2004) Positive control of tylosin biosynthesis: pivotal role of TylR. Molec Microbiol 54:1326-1334
25. Stratigopoulos G, Cundliffe E (2002a) Expression analysis of the tylosin-biosynthetic gene cluster: pivotal regulatory role of the tylQ product. Chem Biol 9:71-78
26. Stratigopoulos G, Cundliffe E (2002b) Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer. J Ind Microbiol Biotechnol 28:219-224
27. Stratigopoulos G, Gandecha AR, Cundliffe E (2002) Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced γ-butyrolactone receptor. Molec Microbiol 45:735-744
28. Tahlan K, Anders C, Jensen SE (2004) The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. J Bacteriol 186: 6286-6297
29. Takano E, Chakraburtty R, Nihira T, Yamada Y, Bibb MJ (2001) Complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2). Molec Microbiol 41:1015-1028
30. Takano E, Kinoshita H, Mersinias V, Bucca G, Hotchkiss G, Nihira T, Smith CP, Bibb M, Wohlleben W, Chater K (2005) A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type 1 polyketide biosynthetic gene cluster of Streptomyces coelicolor. Molec Microbiol 56:465-479
31. Tang L, Grimm A, Zhang Y-X, Hutchinson CR (1996) Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius. Molec Microbiol 22:801-813
32. Tomono A, Tsai Y, Yamazaki H, Ohnishi Y, Horinouchi S (2005) Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus. J Bacteriol 187:5595-5604
33. Wietzorrek A, Bibb M (1997) A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Molec Microbiol 25:1177-1184
34. Yamada Y (1999) Autoregulatory factors and regulation of antibiotic production in Streptomyces. In: England RR, Hobbs G, Bainton NJ, Roberts DMcL (eds) Microbial signalling and communication. Cambridge University Press, Cambridge, pp 177-196
35. Yamazaki H, Tomono A, Ohnishi Y, Horinouchi S (2004) DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus. Molec Microbiol 53:555-572