Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

Human Molecular Genetics

Volumn 23, Issue 3, 2014, Pages 767-781

  Casadei, Nicolas ^a   Pö hler, Anne Maria ^b   Tomás Zapico, Cristina ^c   Torres Peraza, Jesús ^c   Schwedhelm, Ivo ^a   Witz, Annemarie ^a   Zamolo, Irina ^a   De Heer, Raymond ^d   Spruijt, Berry ^d,e   Noldus, Lucas P J J ^f   Klucken, Jochen ^b   Lucas, José J ^c   Kahle, Philipp J ^g   Krüger, Rejko ^g   Riess, Olaf ^a   Nuber, Silke ^a,h  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c CSIC   (Spain)

^d Delta Phenomics BV   (Netherlands)

^e UTRECHT UNIVERSITY   (Netherlands)

^f Noldus Information Technology bv   (Netherlands)

^g UNIVERSITY OF TÜBINGEN   (Germany)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BINDING PROTEIN; SYNPHILIN 1; UNCLASSIFIED DRUG;

AGED; AGGRESOME; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; AUTOPHAGY; BIOACCUMULATION; BRAIN STEM; BRAIN TISSUE; CLEARANCE; CONTROLLED STUDY; DISEASE COURSE; FIBER; GENE OVEREXPRESSION; HUMAN; MOTOR DYSFUNCTION; MOUSE; MOUSE MODEL; MUTANT; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEARANCE; PROTEIN DEGRADATION; SOLUBILITY;

AGING; ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; BRAIN; CARRIER PROTEINS; GENE EXPRESSION; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PROTEIN FOLDING; SOLUBILITY; THIAZOLES; UBIQUITIN;

EID: 84892468324     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt467     Document Type: Article

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