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Volumn 171, Issue 3, 2014, Pages 567-579

Pulmonary arterial hypertension: Basis of sex differences in incidence and treatment response

Author keywords

oestrogen; pulmonary arterial hypertension; serotonin; sex hormones; testosterone; vascular remodelling

Indexed keywords

ANASTROZOLE; ANTICOAGULANT AGENT; AROMATASE; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CALCIUM CHANNEL BLOCKING AGENT; CATECHOL METHYLTRANSFERASE; CYTOCHROME P450; DEXFENFLURAMINE; DIGOXIN; DILTIAZEM; DIURETIC AGENT; ESTRADIOL; ESTRIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTRONE; ILOPROST; NIFEDIPINE; OXYGEN; PROSTACYCLIN; PROTEIN S100B; SEX HORMONE; SILDENAFIL; TADALAFIL; TREPROSTINIL;

EID: 84892420254     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12281     Document Type: Review
Times cited : (89)

References (123)
  • 1
    • 77956326235 scopus 로고    scopus 로고
    • Cardiac and metabolic effects of anabolic-androgenic steroid abuse on lipids, blood pressure, left ventricular dimensions, and rhythm
    • Achar S, Rostamian A, Narayan SM, (2010). Cardiac and metabolic effects of anabolic-androgenic steroid abuse on lipids, blood pressure, left ventricular dimensions, and rhythm. Am J Cardiol 106: 893-901.
    • (2010) Am J Cardiol , vol.106 , pp. 893-901
    • Achar, S.1    Rostamian, A.2    Narayan, S.M.3
  • 2
    • 0346964663 scopus 로고    scopus 로고
    • Estrogen and enalapril attenuate the development of right ventricular hypertrophy induced by monocrotaline in ovariectomized rats
    • Ahn BH, Park HK, Cho HG, Lee HA, Lee YM, Yang EK, et al. (2003). Estrogen and enalapril attenuate the development of right ventricular hypertrophy induced by monocrotaline in ovariectomized rats. J Korean Med Sci 18: 641-648.
    • (2003) J Korean Med Sci , vol.18 , pp. 641-648
    • Ahn, B.H.1    Park, H.K.2    Cho, H.G.3    Lee, H.A.4    Lee, Y.M.5    Yang, E.K.6
  • 3
    • 71049187330 scopus 로고    scopus 로고
    • Alterations in oestrogen metabolism: Implications for higher penetrance of familial pulmonary arterial hypertension in females
    • Austin ED, Cogan JD, West JD, Hedges LK, Hamid R, Dawson EP, et al. (2009). Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females. Eur Respir 34: 1093-1099.
    • (2009) Eur Respir , vol.34 , pp. 1093-1099
    • Austin, E.D.1    Cogan, J.D.2    West, J.D.3    Hedges, L.K.4    Hamid, R.5    Dawson, E.P.6
  • 5
    • 0034800442 scopus 로고    scopus 로고
    • Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol
    • Badawi AF, Cavalieri EL, Rogan EG, (2001). Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol. Metabolism 50: 1001-1003.
    • (2001) Metabolism , vol.50 , pp. 1001-1003
    • Badawi, A.F.1    Cavalieri, E.L.2    Rogan, E.G.3
  • 6
  • 7
    • 0029555279 scopus 로고
    • The epidemiology of DHEAS and cardiovascular disease
    • Barrett-Connor E, Goodman-Gruen D, (1995). The epidemiology of DHEAS and cardiovascular disease. Ann N Y Acad Sci 774: 259-270.
    • (1995) Ann N y Acad Sci , vol.774 , pp. 259-270
    • Barrett-Connor, E.1    Goodman-Gruen, D.2
  • 8
    • 0022921501 scopus 로고
    • A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease
    • Barrett-Connor E, Khaw KT, Yen SS, (1986). A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med 315: 1519-1524.
    • (1986) N Engl J Med , vol.315 , pp. 1519-1524
    • Barrett-Connor, E.1    Khaw, K.T.2    Yen, S.S.3
  • 9
    • 0037203482 scopus 로고    scopus 로고
    • Androgens and aging men
    • Baulieu EE, (2002). Androgens and aging men. Mol Cell Endocrinol 198: 41-49.
    • (2002) Mol Cell Endocrinol , vol.198 , pp. 41-49
    • Baulieu, E.E.1
  • 10
    • 77954759389 scopus 로고    scopus 로고
    • Predicting survival in pulmonary arterial hypertension: Insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)
    • Benza RL, Miller DP, Gomberg-Maitland M, Frantz RP, Foreman AJ, Coffey CS, et al. (2010). Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 122: 164-172.
    • (2010) Circulation , vol.122 , pp. 164-172
    • Benza, R.L.1    Miller, D.P.2    Gomberg-Maitland, M.3    Frantz, R.P.4    Foreman, A.J.5    Coffey, C.S.6
  • 11
    • 84863519076 scopus 로고    scopus 로고
    • An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry
    • Benza RL, Miller DP, Barst RJ, Badesch DB, Frost AE, McGoon MD, (2012). An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest 142: 448-456.
    • (2012) Chest , vol.142 , pp. 448-456
    • Benza, R.L.1    Miller, D.P.2    Barst, R.J.3    Badesch, D.B.4    Frost, A.E.5    McGoon, M.D.6
  • 13
    • 70349664184 scopus 로고    scopus 로고
    • Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis
    • Bonnet S, Paulin R, Sutendra G, Dromparis P, Roy M, Watson KO, et al. (2009). Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis. Circulation 120: 1231-1240.
    • (2009) Circulation , vol.120 , pp. 1231-1240
    • Bonnet, S.1    Paulin, R.2    Sutendra, G.3    Dromparis, P.4    Roy, M.5    Watson, K.O.6
  • 16
    • 2442519516 scopus 로고    scopus 로고
    • Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension
    • Chaouat A, Coulet F, Favre C, Simonneau G, Weitzenblum E, Soubrier F, et al. (2004). Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension. Thorax 59: 446-448.
    • (2004) Thorax , vol.59 , pp. 446-448
    • Chaouat, A.1    Coulet, F.2    Favre, C.3    Simonneau, G.4    Weitzenblum, E.5    Soubrier, F.6
  • 17
    • 70449650331 scopus 로고    scopus 로고
    • Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications: A systematic review and economic evaluation
    • Chen YF, Jowett S, Barton P, Malottki K, Hyde C, Gibbs JS, et al. (2009). Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications: a systematic review and economic evaluation. Health Technol Assess 13: 1-320.
    • (2009) Health Technol Assess , vol.13 , pp. 1-320
    • Chen, Y.F.1    Jowett, S.2    Barton, P.3    Malottki, K.4    Hyde, C.5    Gibbs, J.S.6
  • 19
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman BW, McPherson CD, Newman JH, King GA, Bernard GR, Groves BM, et al. (1992). An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 327: 70-75.
    • (1992) N Engl J Med , vol.327 , pp. 70-75
    • Christman, B.W.1    McPherson, C.D.2    Newman, J.H.3    King, G.A.4    Bernard, G.R.5    Groves, B.M.6
  • 20
    • 0038219969 scopus 로고    scopus 로고
    • Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo
    • Ciolino H, MacDonald C, Memon O, Dankwah M, Yeh GC, (2003). Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo. Int J Cancer 105: 321-325.
    • (2003) Int J Cancer , vol.105 , pp. 321-325
    • Ciolino, H.1    Macdonald, C.2    Memon, O.3    Dankwah, M.4    Yeh, G.C.5
  • 22
    • 84871985829 scopus 로고    scopus 로고
    • Imatinib Attenuates Hypoxia-induced Pulmonary Arterial Hypertension Pathology via Reduction in 5-Hydroxytryptamine through Inhibition of Tryptophan Hydroxylase 1 Expression
    • Ciuclan L, Hussey MJ, Burton V, Good R, Duggan N, Beach S, et al. (2013). Imatinib Attenuates Hypoxia-induced Pulmonary Arterial Hypertension Pathology via Reduction in 5-Hydroxytryptamine through Inhibition of Tryptophan Hydroxylase 1 Expression. Am J Respir Crit Care Med 187: 78-89.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 78-89
    • Ciuclan, L.1    Hussey, M.J.2    Burton, V.3    Good, R.4    Duggan, N.5    Beach, S.6
  • 23
    • 0032777126 scopus 로고    scopus 로고
    • Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth
    • Cool CD, Stewart JS, Werahera P, Miller GJ, Williams RL, Voelkel NF, et al. (1999). Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth. Am J Pathol 155: 411-419.
    • (1999) Am J Pathol , vol.155 , pp. 411-419
    • Cool, C.D.1    Stewart, J.S.2    Werahera, P.3    Miller, G.J.4    Williams, R.L.5    Voelkel, N.F.6
  • 24
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension. Results from a national prospective registry
    • D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. (1991). Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 115: 343-349.
    • (1991) Ann Intern Med , vol.115 , pp. 343-349
    • D'Alonzo, G.E.1    Barst, R.J.2    Ayres, S.M.3    Bergofsky, E.H.4    Brundage, B.H.5    Detre, K.M.6
  • 25
  • 27
    • 83655181464 scopus 로고    scopus 로고
    • Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females
    • Dempsie Y, Nilsen M, White K, Mair KM, Loughlin L, Ambartsumian N, et al. (2011). Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respir Res 12: 159.
    • (2011) Respir Res , vol.12 , pp. 159
    • Dempsie, Y.1    Nilsen, M.2    White, K.3    Mair, K.M.4    Loughlin, L.5    Ambartsumian, N.6
  • 28
    • 0033838125 scopus 로고    scopus 로고
    • Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
    • Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, et al. (2000). Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet 67: 737-744.
    • (2000) Am J Hum Genet , vol.67 , pp. 737-744
    • Deng, Z.1    Morse, J.H.2    Slager, S.L.3    Cuervo, N.4    Moore, K.J.5    Venetos, G.6
  • 29
    • 40849102385 scopus 로고    scopus 로고
    • DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: Potential role in the treatment of pulmonary arterial hypertension
    • Dessouroux A, Akwa Y, Baulieu EE, (2008). DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension. J Steroid Biochem Mol Biol 109: 81-89.
    • (2008) J Steroid Biochem Mol Biol , vol.109 , pp. 81-89
    • Dessouroux, A.1    Akwa, Y.2    Baulieu, E.E.3
  • 31
    • 77951092239 scopus 로고    scopus 로고
    • Dehydroepiandrosterone: A new treatment for vascular remodeling diseases including pulmonary arterial hypertension
    • Dumas de la Roque E, Savineau JP, Bonnet S, (2010). Dehydroepiandrosterone: a new treatment for vascular remodeling diseases including pulmonary arterial hypertension. Pharmacol Ther 126: 186-199.
    • (2010) Pharmacol Ther , vol.126 , pp. 186-199
    • Dumas De La Roque, E.1    Savineau, J.P.2    Bonnet, S.3
  • 32
    • 78650649961 scopus 로고    scopus 로고
    • Bosentan for the treatment of adult pulmonary hypertension
    • Dwyer N, Kilpatrick D, (2011). Bosentan for the treatment of adult pulmonary hypertension. Future Cardiol 7: 19-37.
    • (2011) Future Cardiol , vol.7 , pp. 19-37
    • Dwyer, N.1    Kilpatrick, D.2
  • 33
    • 0035216166 scopus 로고    scopus 로고
    • Gender differences in the vasomotor effects of different steroid hormones in rat pulmonary and coronary arteries
    • English KM, Jones RD, Jones TH, Morice AH, Channer KS, (2001). Gender differences in the vasomotor effects of different steroid hormones in rat pulmonary and coronary arteries. Horm Metab Res 33: 645-652.
    • (2001) Horm Metab Res , vol.33 , pp. 645-652
    • English, K.M.1    Jones, R.D.2    Jones, T.H.3    Morice, A.H.4    Channer, K.S.5
  • 34
    • 0027165908 scopus 로고
    • Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats
    • Farhat MY, Chen MF, Bhatti T, Iqbal A, Cathapermal S, Ramwell PW, (1993). Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats. Br J Pharmacol 110: 719-723.
    • (1993) Br J Pharmacol , vol.110 , pp. 719-723
    • Farhat, M.Y.1    Chen, M.F.2    Bhatti, T.3    Iqbal, A.4    Cathapermal, S.5    Ramwell, P.W.6
  • 35
    • 0031951708 scopus 로고    scopus 로고
    • Effect of dehydroepiandrosterone on hypoxic pulmonary vasoconstriction: A Ca(2+)-activated K(+)-channel opener
    • Farrukh IS, Peng W, Orlinska U, Hoidal JR, (1998). Effect of dehydroepiandrosterone on hypoxic pulmonary vasoconstriction: a Ca(2+)-activated K(+)-channel opener. Am J Physiol 274: L186-L195.
    • (1998) Am J Physiol , vol.274
    • Farrukh, I.S.1    Peng, W.2    Orlinska, U.3    Hoidal, J.R.4
  • 36
    • 0033780783 scopus 로고    scopus 로고
    • Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    • Filardo EJ, Quinn JA, Bland KI, Frackelton AR Jr, (2000). Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol 14: 1649-1660.
    • (2000) Mol Endocrinol , vol.14 , pp. 1649-1660
    • Filardo, E.J.1    Quinn, J.A.2    Bland, K.I.3    Frackelton, Jr.A.R.4
  • 37
    • 78651415646 scopus 로고    scopus 로고
    • The changing picture of patients with pulmonary arterial hypertension in the United States: How REVEAL differs from historic and non-US Contemporary Registries
    • Frost AE, Badesch DB, Barst RJ, Benza RL, Elliott CG, Farber HW, et al. (2011). The changing picture of patients with pulmonary arterial hypertension in the United States: how REVEAL differs from historic and non-US Contemporary Registries. Chest 139: 128-137.
    • (2011) Chest , vol.139 , pp. 128-137
    • Frost, A.E.1    Badesch, D.B.2    Barst, R.J.3    Benza, R.L.4    Elliott, C.G.5    Farber, H.W.6
  • 38
    • 84855440266 scopus 로고    scopus 로고
    • Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension
    • Gabler NB, French B, Strom BL, Liu Z, Palevsky HI, Taichman DB, et al. (2012). Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. Chest 141: 20-26.
    • (2012) Chest , vol.141 , pp. 20-26
    • Gabler, N.B.1    French, B.2    Strom, B.L.3    Liu, Z.4    Palevsky, H.I.5    Taichman, D.B.6
  • 40
    • 70049112901 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
    • Galie N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA, et al. (2009b). Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J 30: 2493-2537.
    • (2009) Eur Heart J , vol.30 , pp. 2493-2537
    • Galie, N.1    Hoeper, M.M.2    Humbert, M.3    Torbicki, A.4    Vachiery, J.L.5    Barbera, J.A.6
  • 41
    • 70049108513 scopus 로고    scopus 로고
    • The use of combination therapy in pulmonary arterial hypertension: New developments
    • Galie N, Negro L, Simonneau G, (2009c). The use of combination therapy in pulmonary arterial hypertension: new developments. Eur Respir Rev 18: 148-153.
    • (2009) Eur Respir Rev , vol.18 , pp. 148-153
    • Galie, N.1    Negro, L.2    Simonneau, G.3
  • 42
    • 0029055964 scopus 로고
    • Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
    • Giaid A, Saleh D, (1995). Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 333: 214-221.
    • (1995) N Engl J Med , vol.333 , pp. 214-221
    • Giaid, A.1    Saleh, D.2
  • 43
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A, Yanagisawa M, Langleben D, Michel RP, Levy R, Shennib H, et al. (1993). Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 328: 1732-1739.
    • (1993) N Engl J Med , vol.328 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3    Michel, R.P.4    Levy, R.5    Shennib, H.6
  • 45
    • 0036196176 scopus 로고    scopus 로고
    • Inhibitors of pentose phosphate pathway cause vasodilation: Involvement of voltage-gated potassium channels
    • Gupte SA, Li KX, Okada T, Sato K, Oka M, (2002). Inhibitors of pentose phosphate pathway cause vasodilation: involvement of voltage-gated potassium channels. J Pharmacol Exp Ther 301: 299-305.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 299-305
    • Gupte, S.A.1    Li, K.X.2    Okada, T.3    Sato, K.4    Oka, M.5
  • 46
    • 33646820004 scopus 로고    scopus 로고
    • Selective inhibition of L-type Ca2+ channels in A7r5 cells by physiological levels of testosterone
    • Hall J, Jones RD, Jones TH, Channer KS, Peers C, (2006). Selective inhibition of L-type Ca2+ channels in A7r5 cells by physiological levels of testosterone. Endocrinology 147: 2675-2680.
    • (2006) Endocrinology , vol.147 , pp. 2675-2680
    • Hall, J.1    Jones, R.D.2    Jones, T.H.3    Channer, K.S.4    Peers, C.5
  • 47
    • 0038056185 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats
    • Hampl V, Bibova J, Povysilova V, Herget J, (2003). Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats. Eur Respir J 21: 862-865.
    • (2003) Eur Respir J , vol.21 , pp. 862-865
    • Hampl, V.1    Bibova, J.2    Povysilova, V.3    Herget, J.4
  • 48
    • 0035962326 scopus 로고    scopus 로고
    • Effect of sex hormones on cardiac mass
    • Hayward CS, Webb CM, Collins P, (2001). Effect of sex hormones on cardiac mass. Lancet 357: 1354-1356.
    • (2001) Lancet , vol.357 , pp. 1354-1356
    • Hayward, C.S.1    Webb, C.M.2    Collins, P.3
  • 49
    • 84879332558 scopus 로고    scopus 로고
    • Testosterone negatively regulates right ventricular load stress responses in mice
    • Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J, et al. (2012). Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ 2: 352-358.
    • (2012) Pulm Circ , vol.2 , pp. 352-358
    • Hemnes, A.R.1    Maynard, K.B.2    Champion, H.C.3    Gleaves, L.4    Penner, N.5    West, J.6
  • 50
    • 37349071022 scopus 로고    scopus 로고
    • Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation
    • Homma N, Nagaoka T, Morio Y, Ota H, Gebb SA, Karoor V, et al. (2007). Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J Cardiovasc Pharmacol 50: 697-702.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 697-702
    • Homma, N.1    Nagaoka, T.2    Morio, Y.3    Ota, H.4    Gebb, S.A.5    Karoor, V.6
  • 52
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, et al. (2010a). Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 122: 156-163.
    • (2010) Circulation , vol.122 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3    Bertocchi, M.4    Habib, G.5    Gressin, V.6
  • 53
    • 77955953602 scopus 로고    scopus 로고
    • Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension
    • Humbert M, Sitbon O, Yaici A, Montani D, O'Callaghan DS, Jais X, et al. (2010b). Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension. Eur Respir J 36: 549-555.
    • (2010) Eur Respir J , vol.36 , pp. 549-555
    • Humbert, M.1    Sitbon, O.2    Yaici, A.3    Montani, D.4    O'Callaghan, D.S.5    Jais, X.6
  • 56
    • 58149234707 scopus 로고    scopus 로고
    • Exogenous estrogen rapidly attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction
    • Lahm T, Crisostomo PR, Markel TA, Wang M, Wang Y, Weil B, et al. (2008). Exogenous estrogen rapidly attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction. Shock 30: 660-667.
    • (2008) Shock , vol.30 , pp. 660-667
    • Lahm, T.1    Crisostomo, P.R.2    Markel, T.A.3    Wang, M.4    Wang, Y.5    Weil, B.6
  • 57
    • 84860634134 scopus 로고    scopus 로고
    • 17beta-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects
    • Lahm T, Albrecht M, Fisher AJ, Selej M, Patel NG, Brown JA, et al. (2012). 17beta-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med 185: 965-980.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 965-980
    • Lahm, T.1    Albrecht, M.2    Fisher, A.J.3    Selej, M.4    Patel, N.G.5    Brown, J.A.6
  • 58
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
    • Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA 3rd, Loyd JE, et al. (2000). Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet 26: 81-84.
    • (2000) Nat Genet , vol.26 , pp. 81-84
    • Lane, K.B.1    Machado, R.D.2    Pauciulo, M.W.3    Thomson, J.R.4    Phillips III, J.A.5    Loyd, J.E.6
  • 59
    • 0042315387 scopus 로고    scopus 로고
    • Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms
    • Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT, (2003). Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology 144: 3382-3398.
    • (2003) Endocrinology , vol.144 , pp. 3382-3398
    • Lee, A.J.1    Cai, M.X.2    Thomas, P.E.3    Conney, A.H.4    Zhu, B.T.5
  • 60
    • 84867599718 scopus 로고    scopus 로고
    • Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: Results from the pulmonary hypertension registry of the United Kingdom and Ireland
    • Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JS, et al. (2012). Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland. Am J Respir Crit Care Med 186: 790-796.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 790-796
    • Ling, Y.1    Johnson, M.K.2    Kiely, D.G.3    Condliffe, R.4    Elliot, C.A.5    Gibbs, J.S.6
  • 62
    • 60549110421 scopus 로고    scopus 로고
    • Expression, distribution and regulation of sex steroid hormone receptors in mouse heart
    • Lizotte E, Grandy SA, Tremblay A, Allen BG, Fiset C, (2009). Expression, distribution and regulation of sex steroid hormone receptors in mouse heart. Cell Physiol Biochem 23: 75-86.
    • (2009) Cell Physiol Biochem , vol.23 , pp. 75-86
    • Lizotte, E.1    Grandy, S.A.2    Tremblay, A.3    Allen, B.G.4    Fiset, C.5
  • 63
    • 77951227152 scopus 로고    scopus 로고
    • The serotonin hypothesis of pulmonary hypertension revisited
    • Maclean MR, Dempsie Y, (2010). The serotonin hypothesis of pulmonary hypertension revisited. Adv Exp Med Biol 661: 309-322.
    • (2010) Adv Exp Med Biol , vol.661 , pp. 309-322
    • Maclean, M.R.1    Dempsie, Y.2
  • 64
    • 0017280690 scopus 로고
    • Editorial: Pulmonary hypertension and oral contraceptive usage
    • Masi AT, (1976). Editorial: pulmonary hypertension and oral contraceptive usage. Chest 69: 451-453.
    • (1976) Chest , vol.69 , pp. 451-453
    • Masi, A.T.1
  • 65
    • 84864287179 scopus 로고    scopus 로고
    • Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats
    • Matori H, Umar S, Nadadur RD, Sharma S, Partow-Navid R, Afkhami M, et al. (2012). Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats. Hypertension 60: 425-430.
    • (2012) Hypertension , vol.60 , pp. 425-430
    • Matori, H.1    Umar, S.2    Nadadur, R.D.3    Sharma, S.4    Partow-Navid, R.5    Afkhami, M.6
  • 66
    • 58249107821 scopus 로고    scopus 로고
    • Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities
    • McGoon MD, Frost AE, Oudiz RJ, Badesch DB, Galie N, Olschewski H, et al. (2009). Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. Chest 135: 122-129.
    • (2009) Chest , vol.135 , pp. 122-129
    • McGoon, M.D.1    Frost, A.E.2    Oudiz, R.J.3    Badesch, D.B.4    Galie, N.5    Olschewski, H.6
  • 68
    • 53049097296 scopus 로고    scopus 로고
    • Thiomethylstilbenes as inhibitors of CYP1A1, CYP1A2 and CYP1B1 activities
    • Mikstacka R, Baer-Dubowska W, Wieczorek M, Sobiak S, (2008). Thiomethylstilbenes as inhibitors of CYP1A1, CYP1A2 and CYP1B1 activities. Mol Nutr Food Res 52 (Suppl. 1): S77-S83.
    • (2008) Mol Nutr Food Res , vol.52 , Issue.SUPPL. 1
    • Mikstacka, R.1    Baer-Dubowska, W.2    Wieczorek, M.3    Sobiak, S.4
  • 69
    • 0026545224 scopus 로고
    • Age- and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjects
    • Miyauchi T, Yanagisawa M, Iida K, Ajisaka R, Suzuki N, Fujino M, et al. (1992). Age- and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjects. Am Heart J 123: 1092-1093.
    • (1992) Am Heart J , vol.123 , pp. 1092-1093
    • Miyauchi, T.1    Yanagisawa, M.2    Iida, K.3    Ajisaka, R.4    Suzuki, N.5    Fujino, M.6
  • 70
    • 33646473361 scopus 로고    scopus 로고
    • Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice
    • Morani A, Barros RP, Imamov O, Hultenby K, Arner A, Warner M, et al. (2006). Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice. Proc Natl Acad Sci U S A 103: 7165-7169.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7165-7169
    • Morani, A.1    Barros, R.P.2    Imamov, O.3    Hultenby, K.4    Arner, A.5    Warner, M.6
  • 71
    • 79960903772 scopus 로고    scopus 로고
    • Role of phosphodiesterases in adult-onset pulmonary arterial hypertension
    • Murray F, Maclean MR, Insel PA, (2011). Role of phosphodiesterases in adult-onset pulmonary arterial hypertension. Handb Exp Pharmacol 204: 279-305.
    • (2011) Handb Exp Pharmacol , vol.204 , pp. 279-305
    • Murray, F.1    Maclean, M.R.2    Insel, P.A.3
  • 72
    • 84863318702 scopus 로고    scopus 로고
    • Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension
    • Nadadur RD, Umar S, Wong G, Eghbali M, Iorga A, Matori H, et al. (2012). Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension. J Appl Physiol 113: 149-158.
    • (2012) J Appl Physiol , vol.113 , pp. 149-158
    • Nadadur, R.D.1    Umar, S.2    Wong, G.3    Eghbali, M.4    Iorga, A.5    Matori, H.6
  • 73
    • 0035797529 scopus 로고    scopus 로고
    • Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
    • Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA 3rd, et al. (2001). Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 345: 319-324.
    • (2001) N Engl J Med , vol.345 , pp. 319-324
    • Newman, J.H.1    Wheeler, L.2    Lane, K.B.3    Loyd, E.4    Gaddipati, R.5    Phillips III, J.A.6
  • 74
    • 34247851038 scopus 로고    scopus 로고
    • Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension
    • Oka M, Karoor V, Homma N, Nagaoka T, Sakao E, Golembeski SM, et al. (2007). Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension. Cardiovasc Res 74: 377-387.
    • (2007) Cardiovasc Res , vol.74 , pp. 377-387
    • Oka, M.1    Karoor, V.2    Homma, N.3    Nagaoka, T.4    Sakao, E.5    Golembeski, S.M.6
  • 75
    • 61649096423 scopus 로고    scopus 로고
    • Inhaled iloprost for the treatment of pulmonary hypertension
    • Olschewski H, (2009). Inhaled iloprost for the treatment of pulmonary hypertension. Eur Respir Rev 18: 29-34.
    • (2009) Eur Respir Rev , vol.18 , pp. 29-34
    • Olschewski, H.1
  • 77
    • 0344172843 scopus 로고    scopus 로고
    • Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging
    • Parker CR Jr, (1999). Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids 64: 640-647.
    • (1999) Steroids , vol.64 , pp. 640-647
    • Parker, Jr.C.R.1
  • 80
    • 46749142123 scopus 로고    scopus 로고
    • Molecular pathogenesis of pulmonary arterial hypertension
    • Rabinovitch M, (2008). Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 118: 2372-2379.
    • (2008) J Clin Invest , vol.118 , pp. 2372-2379
    • Rabinovitch, M.1
  • 81
    • 0019482038 scopus 로고
    • Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery
    • Rabinovitch M, Gamble WJ, Miettinen OS, Reid L, (1981). Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery. Am J Physiol 240: H62-H72.
    • (1981) Am J Physiol , vol.240
    • Rabinovitch, M.1    Gamble, W.J.2    Miettinen, O.S.3    Reid, L.4
  • 82
    • 77949729370 scopus 로고    scopus 로고
    • Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
    • Rajkumar R, Konishi K, Richards TJ, Ishizawar DC, Wiechert AC, Kaminski N, et al. (2010). Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension. Am J Physiol Heart Circ Physiol 298: H1235-H1248.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Rajkumar, R.1    Konishi, K.2    Richards, T.J.3    Ishizawar, D.C.4    Wiechert, A.C.5    Kaminski, N.6
  • 83
    • 0035015033 scopus 로고    scopus 로고
    • Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression
    • Resta TC, Kanagy NL, Walker BR, (2001). Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression. Am J Physiol Lung Cell Mol Physiol 280: L88-L97.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280
    • Resta, T.C.1    Kanagy, N.L.2    Walker, B.R.3
  • 86
    • 74949133887 scopus 로고    scopus 로고
    • Testosterone acts as an efficacious vasodilator in isolated human pulmonary arteries and veins: Evidence for a biphasic effect at physiological and supra-physiological concentrations
    • Rowell KO, Hall J, Pugh PJ, Jones TH, Channer KS, Jones RD, (2009). Testosterone acts as an efficacious vasodilator in isolated human pulmonary arteries and veins: evidence for a biphasic effect at physiological and supra-physiological concentrations. J Endocrinol Invest 32: 718-723.
    • (2009) J Endocrinol Invest , vol.32 , pp. 718-723
    • Rowell, K.O.1    Hall, J.2    Pugh, P.J.3    Jones, T.H.4    Channer, K.S.5    Jones, R.D.6
  • 87
    • 84867578454 scopus 로고    scopus 로고
    • Endothelin receptor antagonists for the treatment of pulmonary artery hypertension
    • Rubin LJ, (2012). Endothelin receptor antagonists for the treatment of pulmonary artery hypertension. Life Sci 91: 517-521.
    • (2012) Life Sci , vol.91 , pp. 517-521
    • Rubin, L.J.1
  • 89
    • 84872381980 scopus 로고    scopus 로고
    • Pulmonary hypertension in systemic lupus erythematosus: Prevalence, predictors and diagnostic strategy
    • Ruiz-Irastorza G, Garmendia M, Villar I, Egurbide M-V, Aguirre C, (2012). Pulmonary hypertension in systemic lupus erythematosus: prevalence, predictors and diagnostic strategy. Autoimmun Rev 12: 410-415.
    • (2012) Autoimmun Rev , vol.12 , pp. 410-415
    • Ruiz-Irastorza, G.1    Garmendia, M.2    Villar, I.3    Egurbide, M.-V.4    Aguirre, C.5
  • 91
    • 84856762337 scopus 로고    scopus 로고
    • Sex differences in the diagnosis, treatment, and outcome of patients with pulmonary arterial hypertension enrolled in the registry to evaluate early and long-term pulmonary arterial hypertension disease management
    • Shapiro S, Traiger GL, Turner M, McGoon MD, Wason P, Barst RJ, (2012). Sex differences in the diagnosis, treatment, and outcome of patients with pulmonary arterial hypertension enrolled in the registry to evaluate early and long-term pulmonary arterial hypertension disease management. Chest 141: 363-373.
    • (2012) Chest , vol.141 , pp. 363-373
    • Shapiro, S.1    Traiger, G.L.2    Turner, M.3    McGoon, M.D.4    Wason, P.5    Barst, R.J.6
  • 95
    • 70350122864 scopus 로고    scopus 로고
    • Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension
    • Sweeney L, Voelkel NF, (2009). Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension. Eur J Med Res 14: 433-442.
    • (2009) Eur J Med Res , vol.14 , pp. 433-442
    • Sweeney, L.1    Voelkel, N.F.2
  • 96
    • 84866515810 scopus 로고    scopus 로고
    • Oral Treprostinil for the Treatment of Pulmonary Arterial Hypertension in Patients on Background Endothelin Receptor Antagonist and/or Phosphodiesterase Type 5 Inhibitor Therapy (The FREEDOM-C Study): A Randomized Controlled Trial
    • Tapson VF, Torres F, Kermeen F, Keogh AM, Allen RP, Frantz RP, et al. (2012). Oral Treprostinil for the Treatment of Pulmonary Arterial Hypertension in Patients on Background Endothelin Receptor Antagonist and/or Phosphodiesterase Type 5 Inhibitor Therapy (The FREEDOM-C Study): a Randomized Controlled Trial. Chest 142: 1383-1390.
    • (2012) Chest , vol.142 , pp. 1383-1390
    • Tapson, V.F.1    Torres, F.2    Kermeen, F.3    Keogh, A.M.4    Allen, R.P.5    Frantz, R.P.6
  • 97
    • 0033624868 scopus 로고    scopus 로고
    • Differential effects of 17beta-estradiol and testosterone on the contractile responses of porcine coronary arteries
    • Teoh H, Quan A, Leung SW, Man RY, (2000). Differential effects of 17beta-estradiol and testosterone on the contractile responses of porcine coronary arteries. Br J Pharmacol 129: 1301-1308.
    • (2000) Br J Pharmacol , vol.129 , pp. 1301-1308
    • Teoh, H.1    Quan, A.2    Leung, S.W.3    Man, R.Y.4
  • 98
    • 0036177557 scopus 로고    scopus 로고
    • Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels
    • Tep-areenan P, Kendall DA, Randall MD, (2002). Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels. Br J Pharmacol 135: 735-740.
    • (2002) Br J Pharmacol , vol.135 , pp. 735-740
    • Tep-Areenan, P.1    Kendall, D.A.2    Randall, M.D.3
  • 99
    • 0033623296 scopus 로고    scopus 로고
    • Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family
    • Thomson JR, Machado RD, Pauciulo MW, Morgan NV, Humbert M, Elliott GC, et al. (2000). Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family. J Med Genet 37: 741-745.
    • (2000) J Med Genet , vol.37 , pp. 741-745
    • Thomson, J.R.1    Machado, R.D.2    Pauciulo, M.W.3    Morgan, N.V.4    Humbert, M.5    Elliott, G.C.6
  • 101
    • 0036793580 scopus 로고    scopus 로고
    • Testosterone, cytochrome P450, and cardiac hypertrophy
    • Thum T, Borlak J, (2002). Testosterone, cytochrome P450, and cardiac hypertrophy. FASEB J 16: 1537-1549.
    • (2002) FASEB J , vol.16 , pp. 1537-1549
    • Thum, T.1    Borlak, J.2
  • 102
    • 84878810447 scopus 로고    scopus 로고
    • Estrogens exacerbate development of occlusive pulmonary arterial hypertension and formation of plexiform lesions
    • Tofovic SP, Rafikova O, Champion H, Schneider F, (2012). Estrogens exacerbate development of occlusive pulmonary arterial hypertension and formation of plexiform lesions. Am J Respir Crit Care Med 185: A6803.
    • (2012) Am J Respir Crit Care Med , vol.185
    • Tofovic, S.P.1    Rafikova, O.2    Champion, H.3    Schneider, F.4
  • 103
    • 43449122441 scopus 로고    scopus 로고
    • 2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling
    • Tofovic SP, Zhang X, Zhu H, Jackson EK, Rafikova O, Petrusevska G, (2008). 2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling. Vascul Pharmacol 48: 174-183.
    • (2008) Vascul Pharmacol , vol.48 , pp. 174-183
    • Tofovic, S.P.1    Zhang, X.2    Zhu, H.3    Jackson, E.K.4    Rafikova, O.5    Petrusevska, G.6
  • 104
    • 0035797556 scopus 로고    scopus 로고
    • Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
    • Trembath RC, Thomson JR, Machado RD, Morgan NV, Atkinson C, Winship I, et al. (2001). Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. N Engl J Med 345: 325-334.
    • (2001) N Engl J Med , vol.345 , pp. 325-334
    • Trembath, R.C.1    Thomson, J.R.2    Machado, R.D.3    Morgan, N.V.4    Atkinson, C.5    Winship, I.6
  • 105
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
    • Tuder RM, Cool CD, Geraci MW, Wang J, Abman SH, Wright L, et al. (1999). Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 159: 1925-1932.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1925-1932
    • Tuder, R.M.1    Cool, C.D.2    Geraci, M.W.3    Wang, J.4    Abman, S.H.5    Wright, L.6
  • 107
    • 84863971673 scopus 로고    scopus 로고
    • Estrogen paradox in pulmonary hypertension: Current controversies and future perspectives
    • Umar S, Rabinovitch M, Eghbali M, (2012). Estrogen paradox in pulmonary hypertension: current controversies and future perspectives. Am J Respir Crit Care Med 186: 125-131.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 125-131
    • Umar, S.1    Rabinovitch, M.2    Eghbali, M.3
  • 108
    • 0017798882 scopus 로고
    • Effects of high altitude on plasma concentrations of testosterone and pituitary gonadotropins in man
    • Vander AJ, Moore LG, Brewer G, Menon KM, England BG, (1978). Effects of high altitude on plasma concentrations of testosterone and pituitary gonadotropins in man. Aviat Space Environ Med 49: 356-357.
    • (1978) Aviat Space Environ Med , vol.49 , pp. 356-357
    • Vander, A.J.1    Moore, L.G.2    Brewer, G.3    Menon, K.M.4    England, B.G.5
  • 109
    • 79952209415 scopus 로고    scopus 로고
    • Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle study
    • Ventetuolo CE, Ouyang P, Bluemke DA, Tandri H, Barr RG, Bagiella E, et al. (2011). Sex hormones are associated with right ventricular structure and function: the MESA-right ventricle study. Am J Respir Crit Care Med 183: 659-667.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 659-667
    • Ventetuolo, C.E.1    Ouyang, P.2    Bluemke, D.A.3    Tandri, H.4    Barr, R.G.5    Bagiella, E.6
  • 110
    • 33747155391 scopus 로고    scopus 로고
    • Temporal trends and drug exposures in pulmonary hypertension: An American experience
    • Walker AM, Langleben D, Korelitz JJ, Rich S, Rubin LJ, Strom BL, et al. (2006). Temporal trends and drug exposures in pulmonary hypertension: an American experience. Am Heart J 152: 521-526.
    • (2006) Am Heart J , vol.152 , pp. 521-526
    • Walker, A.M.1    Langleben, D.2    Korelitz, J.J.3    Rich, S.4    Rubin, L.J.5    Strom, B.L.6
  • 111
    • 0031747446 scopus 로고    scopus 로고
    • Outcome of pulmonary vascular disease in pregnancy: A systematic overview from 1978 through 1996
    • Weiss BM, Zemp L, Seifert B, Hess OM, (1998). Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996. J Am Coll Cardiol 31: 1650-1657.
    • (1998) J Am Coll Cardiol , vol.31 , pp. 1650-1657
    • Weiss, B.M.1    Zemp, L.2    Seifert, B.3    Hess, O.M.4
  • 112
    • 79955369537 scopus 로고    scopus 로고
    • The serotonin transporter, gender, and 17beta oestradiol in the development of pulmonary arterial hypertension
    • White K, Dempsie Y, Nilsen M, Wright AF, Loughlin L, MacLean MR, (2011a). The serotonin transporter, gender, and 17beta oestradiol in the development of pulmonary arterial hypertension. Cardiovasc Res 90: 373-382.
    • (2011) Cardiovasc Res , vol.90 , pp. 373-382
    • White, K.1    Dempsie, Y.2    Nilsen, M.3    Wright, A.F.4    Loughlin, L.5    Maclean, M.R.6
  • 113
    • 79955764346 scopus 로고    scopus 로고
    • Serotonin transporter, sex, and hypoxia: Microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH
    • White K, Loughlin L, Maqbool Z, Nilsen M, McClure J, Dempsie Y, et al. (2011b). Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiol Genomics 43: 417-437.
    • (2011) Physiol Genomics , vol.43 , pp. 417-437
    • White, K.1    Loughlin, L.2    Maqbool, Z.3    Nilsen, M.4    McClure, J.5    Dempsie, Y.6
  • 114
    • 84865446457 scopus 로고    scopus 로고
    • Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension
    • White K, Johansen AK, Nilsen M, Ciuclan L, Wallace E, Paton L, et al. (2012). Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension. Circulation 126: 1087-1098.
    • (2012) Circulation , vol.126 , pp. 1087-1098
    • White, K.1    Johansen, A.K.2    Nilsen, M.3    Ciuclan, L.4    Wallace, E.5    Paton, L.6
  • 115
    • 0034036174 scopus 로고    scopus 로고
    • The effects of dehydroepiandrosterone on carcinogenesis, obesity, the immune system, and aging
    • Williams JR, (2000). The effects of dehydroepiandrosterone on carcinogenesis, obesity, the immune system, and aging. Lipids 35: 325-331.
    • (2000) Lipids , vol.35 , pp. 325-331
    • Williams, J.R.1
  • 116
    • 18244385519 scopus 로고    scopus 로고
    • Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs
    • Williams MR, Ling S, Dawood T, Hashimura K, Dai A, Li H, et al. (2002). Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs. J Clin Endocrinol Metab 87: 176-181.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 176-181
    • Williams, M.R.1    Ling, S.2    Dawood, T.3    Hashimura, K.4    Dai, A.5    Li, H.6
  • 117
    • 4544302443 scopus 로고    scopus 로고
    • Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors
    • Williams MR, Dawood T, Ling S, Dai A, Lew R, Myles K, et al. (2004). Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors. J Clin Endocrinol Metab 89: 4708-4715.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4708-4715
    • Williams, M.R.1    Dawood, T.2    Ling, S.3    Dai, A.4    Lew, R.5    Myles, K.6
  • 118
    • 0034914829 scopus 로고    scopus 로고
    • Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: Relevance to pathogenesis of pulmonary hypertension and vascular remodeling
    • Wort SJ, Woods M, Warner TD, Evans TW, Mitchell JA, (2001). Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: relevance to pathogenesis of pulmonary hypertension and vascular remodeling. Am J Respir Cell Mol Biol 25: 104-110.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 104-110
    • Wort, S.J.1    Woods, M.2    Warner, T.D.3    Evans, T.W.4    Mitchell, J.A.5
  • 119
    • 78650483925 scopus 로고    scopus 로고
    • Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats
    • Xu DQ, Luo Y, Liu Y, Wang J, Zhang B, Xu M, et al. (2010). Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats. Respir Res 11: 182.
    • (2010) Respir Res , vol.11 , pp. 182
    • Xu, D.Q.1    Luo, Y.2    Liu, Y.3    Wang, J.4    Zhang, B.5    Xu, M.6
  • 120
    • 84877088786 scopus 로고    scopus 로고
    • Oestradiol ameliorates monocrotaline pulmonary hypertension via NO, PGI2 and ET-1 pathways
    • Yuan P, Wu WH, Gao L, Zheng ZQ, Liu D, Mei HY, et al. (2012). Oestradiol ameliorates monocrotaline pulmonary hypertension via NO, PGI2 and ET-1 pathways. Eur Respir J 41: 1116-1125.
    • (2012) Eur Respir J , vol.41 , pp. 1116-1125
    • Yuan, P.1    Wu, W.H.2    Gao, L.3    Zheng, Z.Q.4    Liu, D.5    Mei, H.Y.6
  • 122
    • 33747778425 scopus 로고    scopus 로고
    • Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype binding
    • Zhu BT, Han GZ, Shim JY, Wen Y, Jiang XR, (2006). Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: insights into the structural determinants favoring a differential subtype binding. Endocrinology 147: 4132-4150.
    • (2006) Endocrinology , vol.147 , pp. 4132-4150
    • Zhu, B.T.1    Han, G.Z.2    Shim, J.Y.3    Wen, Y.4    Jiang, X.R.5
  • 123
    • 84860716076 scopus 로고    scopus 로고
    • Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension
    • Zhu D, Ran Y, (2006). Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension. J Physiol Sci 62: 163-172.
    • (2006) J Physiol Sci , vol.62 , pp. 163-172
    • Zhu, D.1    Ran, Y.2


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