Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats

Hypertension

Volumn 60, Issue 2, 2012, Pages 425-430

  Matori, Humann ^a   Umar, Soban ^a   Nadadur, Rangarajan D ^a   Sharma, Salil ^a   Partow Navid, Rod ^a   Afkhami, Michelle ^b   Amjedi, Marjan ^a   Eghbali, Mansoureh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

angiogenesis; estrogen receptor ; genistein; pulmonary hypertension; right heart failure

Indexed keywords

GENISTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE THERAPY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; ENDOTHELIUM CELL; HEART PROTECTION; HEART RIGHT VENTRICLE EJECTION FRACTION; HEART RIGHT VENTRICLE FAILURE; HEART RIGHT VENTRICLE PRESSURE; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; SURVIVAL;

ANIMALS; CAPILLARIES; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ESTROGEN RECEPTOR BETA; GENISTEIN; HEART FAILURE; HUMANS; HYPERTENSION, PULMONARY; MALE; PHYTOESTROGENS; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SOYBEANS; TREATMENT OUTCOME;

EID: 84864287179     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.191445     Document Type: Article

References (24)

1. Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med. 2004;351:1425-1436.
2. Farhat MY, Chen MF, Bhatti T, Iqbal A, Cathapermal S, Ramwell PW. Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats. Br J Pharmacol. 1993;110:719-723. (Pubitemid 23279284)
3. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999;340:1801-1811. (Pubitemid 29266405)
4. Moolman JA. Unravelling the cardioprotective mechanism of action of estrogens. Cardiovasc Res. 2006;69:777-780. (Pubitemid 43227974)
5. Umar S, Iorga A, Matori H, Nadadur RD, Li J, Maltese F, van der LA, Eghbali M. Estrogen rescues preexisting severe pulmonary hypertension in rats. Am J Respir Crit Care Med. 2011;184:715-723.
6. Lupulescu A. Estrogen use and cancer incidence: A review. Cancer Invest. 1995;13:287-295.
7. Deodato B, Altavilla D, Squadrito G, Campo GM, Arlotta M, Minutoli L, Saitta A, Cucinotta D, Calapai G, Caputi AP, Miano M, Squadrito F. Cardioprotection by the phytoestrogen genistein in experimental myocardial ischaemia-reperfusion injury. Br J Pharmacol. 1999;128:1683-1690. (Pubitemid 30011881)
8. Tissier R, Waintraub X, Couvreur N, Gervais M, Bruneval P, Mandet C, Zini R, Enriquez B, Berdeaux A, Ghaleh B. Pharmacological postconditioning with the phytoestrogen genistein. J Mol Cell Cardiol. 2007;42:79-87. (Pubitemid 44958633)
9. Homma N, Morio Y, Takahashi H, Yamamoto A, Suzuki T, Sato K, Muramatsu M, Fukuchi Y. Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension. Respiration. 2006;73:105-112.
10. Umar S, van der Valk E, Schalij MJ, van der Wall EE, Atsma DE, van der Laarse A. Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent. Mol Cell Biochem. 2009;320:75-84.
11. Bogaard HJ, Natarajan R, Henderson SC, Long CS, Kraskauskas D, Smithson L, Ockaili R, McCord JM, Voelkel NF. Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation. 2009;120:1951-1960.
12. Partovian C, Adnot S, Eddahibi S, Teiger E, Levame M, Dreyfus P, Raffestin B, Frelin C. Heart and lung VEGF mRNA expression in rats with monocrotaline-or hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 1998;275:H1948-H1956.
13. Ghofrani HA, Wiedemann R, Rose F, Schermuly RT, Olschewski H, Weissmann N, Gunther A, Walmrath D, Seeger W, Grimminger F. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: A randomised controlled trial. Lancet. 2002;360:895-900. (Pubitemid 35283832)
14. Gomez A, Bialostozky D, Zajarias A, Santos E, Palomar A, Martinez ML, Sandoval J. Right ventricular ischemia in patients with primary pulmonary hypertension. J Am Coll Cardiol. 2001;38:1137-1142. (Pubitemid 32912723)
15. Umar S, Nadadur RD, Li J, Maltese F, Partownavid P, van der Laarse A, Eghbali M. Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats. Hypertension. 2011;58:512-518.
16. Guzman MJ, Crisostomo PR, Wang M, Markel TA, Wang Y, Meldrum DR. Vascular endothelial growth factor improves myocardial functional recovery following ischemia/reperfusion injury. J Surg Res. 2008;150:286-292.
17. Tofovic SP, Salah EM, Mady HH, Jackson EK, Melhem MF. Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats. J Cardiovasc Pharmacol. 2005;46:430-437. (Pubitemid 41407569)
18. Morani A, Barros RP, Imamov O, Hultenby K, Arner A, Warner M, Gustafsson JA. Lung dysfunction causes systemic hypoxia in estrogen receptor - knockout (ER-/-) mice. Proc Natl Acad Sci USA. 2006;103:7165-7169.
19. Babiker FA, Lips D, Meyer R, Delvaux E, Zandberg P, Janssen B, van EG, Grohe C, Doevendans PA. Estrogen receptor - protects the murine heart against left ventricular hypertrophy. Arterioscler Thromb Vasc Biol. 2006;26:1524-1530. (Pubitemid 44288978)
20. Abe K, Toba M, Alzoubi A, Koubsky K, Ito M, Ota H, Gairhe S, Gerthoffer WT, Fagan KA, McMurtry IF, Oka M. Tyrosine kinase inhibitors are potent acute pulmonary vasodilators in rats. Am J Respir Cell Mol Biol. 2011;45:804-808.
21. Ghofrani HA, Morrell NW, Hoeper MM, Olschewski H, Peacock AJ, Barst RJ, Shapiro S, Golpon H, Toshner M, Grimminger F, Pascoe S. Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy. Am J Respir Crit Care Med. 2010;182:1171-1177.
22. Karamsetty MR, Klinger JR, Hill NS. Phytoestrogens restore nitric oxidemediated relaxation in isolated pulmonary arteries from chronically hypoxic rats. J Pharmacol Exp Ther. 2001;297:968-974. (Pubitemid 32472493)
23. Abe K, Toba M, Alzoubi A, Ito M, Fagan KA, Cool CD, Voelkel NF, McMurtry IF, Oka M. Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation. 2010;121:2747-2754.
24. Csiszar A, Labinskyy N, Olson S, Pinto JT, Gupte S, Wu JM, Hu F, Ballabh P, Podlutsky A, Losonczy G, de CR, Mathew R, Wolin MS, Ungvari Z. Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension. 2009;54:668-675.