Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: Relevance to pathogenesis of pulmonary hypertension and vascular remodeling

American Journal of Respiratory Cell and Molecular Biology

Volumn 25, Issue 1, 2001, Pages 104-110

  Wort, S J ^a   Woods, M ^a   Warner, T D ^a   Evans, T W ^a   Mitchell, J A ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034914829     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.25.1.4331     Document Type: Article

References (39)

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3. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon sensitive metalloprotease with acidic pH optimum
4. Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells
5. Endothelin-1 and angiotensin II act as progression but not competence growth factors in vascular smooth muscle cells
6. Endothelin-1: A mediator of pulmonary hypertension?
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8. Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: A novel autocrine function
9. Secretion of endothelin-1 and endothelin-3 by human cultured vascular smooth muscle cells
10. Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: Evidence for intracellular endothelin-converting enzyme
11. Thrombin induces endothelin expression in arterial smooth cells
12. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
13. Pulmonary and cardiac expression of preproendothelin-1 mRNA are increased in heart failure after myocardial infarction in rats: Localisation of preproendothelin-1 mRNA and the endothelin peptide
14. Expression of endothelin-1 in rats developing hypobaric hypoxia-induced pulmonary hypertension
15. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
16. Overexpression of endothelin-1 and enhanced growth of pulmonary artery smooth muscle cells from fawn-hooded rats
17. Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop
18. Autocrine effect of endothelin on DNA synthesis in human vascular endothelial cells
19. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes
20. Endothelin releasing activity in calf serum and porcine follicular fluid
21. Human serum, plasma, and platelets stimulate prostacyclin and endothelin-1 synthesis in human vascular endothelial cells
22. Secretory mechanisms of immunoreactive endothelin in cultured bovine endothelial cells
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27. High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells
28. Secretory pathways in endothelin synthesis
29. Endothelin converting enzyme is located on α-actin filaments in smooth muscle cells
30. BQ123, an ET-A receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells
31. Endothelin and PDGF enhance arachidonic acid release and DNA synthesis in vascular smooth muscle cells
32. Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells
33. Endothelin-1 stimulates proliferation of normal airway epithelial cells
34. Effect of novel mixed ET-A/ET-B antagonists on responses to ET-1 in human small muscular pulmonary arteries
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37. Continuous infusion of epoprostenol improves the net balance between pulmonary endothelin-1 clearance and release in primary pulmonary hypertension
38. The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodelling in Sprague-Dawley rats
39. Endothelins and endothelin receptor antagonists