Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle study

American Journal of Respiratory and Critical Care Medicine

Volumn 183, Issue 5, 2011, Pages 659-667

  Ventetuolo, Corey E ^a   Ouyang, Pamela ^b   Bluemke, David A ^c   Tandri, Harikrishna ^b   Barr, R Graham ^a,d   Bagiella, Emilia ^d   Cappola, Anne R ^e   Bristow, Michael R ^f   Johnson, Craig ^g   Kronmal, Richard A ^g   Kizer, Jorge R ^h   Lima, Joao A C ^b   Kawut, Steven M ^c,e  

^a Columbia University ^*  (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d University of Pennsylvania School of Medicine ^*  (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF WASHINGTON   (United States)

^h WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Right ventricle; Sex; Sex hormones

Indexed keywords

ESTRADIOL; PRASTERONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; ESTRADIOL BLOOD LEVEL; FEMALE; HEART RIGHT VENTRICLE EJECTION FRACTION; HEART RIGHT VENTRICLE ENDDIASTOLIC VOLUME; HEART RIGHT VENTRICLE ENDSYSTOLIC VOLUME; HEART RIGHT VENTRICLE FUNCTION; HEART STROKE VOLUME; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTMENOPAUSE; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ANDROGENS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; ESTRADIOL; FEMALE; GONADAL STEROID HORMONES; HEART VENTRICLES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGAN SIZE; PROSPECTIVE STUDIES; RADIOIMMUNOASSAY; STROKE VOLUME; TESTOSTERONE; VENTRICULAR FUNCTION, RIGHT;

EID: 79952209415     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201007-1027OC     Document Type: Article

References (49)

1. He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med 2001;161:996-1002. (Pubitemid 32295654)
2. Resta TC, Kanagy NL, Walker BR. Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression. Am J Physiol Lung Cell Mol Physiol 2001;280:L88-L97.
3. Giuberti K, Pereira RB, Bianchi PR, Paigel AS, Vassallo DV, Stefanon I. Influence of ovariectomy in the right ventricular contractility in heart failure rats. Arch Med Res 2007;38:170-175. (Pubitemid 46080547)
4. Lahm T, Patel KM, Crisostomo PR, Markel TA, Wang M, Herring C, Meldrum DR. Endogenous estrogen attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction: the effects of sex and menstrual cycle. Am J Physiol Endocrinol Metab 2007;293:E865-E871. (Pubitemid 47359001)
5. Rowell KO, Hall J, Pugh PJ, Jones TH, Channer KS, Jones RD. Testosterone acts as an efficacious vasodilator in isolated human pulmonary arteries and veins: evidence for a biphasic effect at physiological and supra-physiological concentrations. J Endocrinol Invest 2009;32:718-723.
6. Liu J, Wu S, Wei H, Zhou K, Ruan Y, Lai W. Effects of sex hormones and their balance on the proliferation of rat vascular endothelial cells. Horm Res Paediatr 2002;58:16-20. (Pubitemid 34914041)
7. Bonnet S, Dumas-de-La-Roque E, Begueret H, Marthan R, Fayon M, Dos Santos P, Savineau JP, Baulieu EE. Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension. Proc Natl Acad Sci USA 2003;100:9488-9493. (Pubitemid 37033955)
8. Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Am J Physiol Lung Cell Mol Physiol 2008;295:L71-L78.
9. Becchis M, Sullivan PM, Ordronneau P, Petrusz P, Joseph DR. Distribution of immunoreactive androgen-binding protein/sex hormone-binding globulin in tissues of the fetal rat. Steroids 1996;61:392-400. (Pubitemid 26250651)
10. Schock HW, Herbert Z, Sigusch H, Figulla HR, Jirikowski GF, Lotze U. Expression of androgen-binding protein (ABP) in human cardiac myocytes. Horm Metab Res 2006;38:225-229. (Pubitemid 43845213)
11. Badesch DB, Raskob GE, Elliott CG, Krichman AM, Farber HW, Frost AE, Barst RJ, Benza RL, Liou TG, Turner M, et al. Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest 2010;137:376-387.
12. Kawut SM, Al-Naamani N, Agerstrand C, Berman Rosenzweig E, Rowan C, Barst RJ, Bergmann S, Horn EM. Determinants of right ventricular ejection fraction in pulmonary arterial hypertension. Chest 2009;135:752-759.
13. Benza RL, Miller DP, Gomberg-Maitland M, Frantz RP, Foreman AJ, Coffey CS, Frost A, Barst RJ, Badesch DB, Elliott CG, et al. Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 2010;122:164-172.
14. Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaici A, Weitzenblum E, Cordier JF, Chabot F, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 2010;122:156-163.
15. Arnlov J, Pencina MJ, Amin S, Nam BH, Benjamin EJ, Murabito JM, Wang TJ, Knapp PE, D'Agostino RB Sr, Bhasin S, et al. Endogenous sex hormones and cardiovascular disease incidence in men. Ann Intern Med 2006;145:176-184. (Pubitemid 46780562)
16. Tivesten A, Mellstrom D, Jutberger H, Fagerberg B, Lernfelt B, Orwoll E, Karlsson MK, Ljunggren O, Ohlsson C. Low serum testosterone and high serum estradiol associate with lower extremity peripheral arterial disease in elderly men: the MROS Study in Sweden. J Am Coll Cardiol 2007;50:1070-1076. (Pubitemid 47364717)
17. Ventetuolo C, Ouyang P, Bluemke D, Tandri H, Barr R, Bagiella E, Bristow M, Johnson C, Kizer J, Lima J, et al. Sex hormones and the right ventricle: the MESA-Right Ventricle Study [abstract]. Am J Respir Crit Care Med 2009;179:A4150.
18. Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, Greenland P, Jacobs DR, Kronmal R, Liu K, et al. Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol 2002;156:871-881. (Pubitemid 35215769)
19. Natori S, Lai S, Finn JP, Gomes AS, Hundley WG, Jerosch-Herold M, Pearson G, Sinha S, Arai A, Lima JAC, et al. Cardiovascular function in Multi-Ethnic Study of Atherosclerosis: normal values by age, sex, and ethnicity. AJR Am J Roentgenol 2006;186:S357-S365. (Pubitemid 46105405)
20. Chahal H, Johnson C, Tandri H, Jain A, Hundley WG, Barr RG, Kawut SM, Lima JA, Bluemke DA. Relation of cardiovascular risk factors to right ventricular structure and function as determined by magnetic resonance imaging (results from the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol 2010;106:110-116.
21. Vogel-Claussen J, Finn JP, Gomes AS, Hundley GW, Jerosch-Herold MP, Pearson G, Sinha SP, Lima JAC, Bluemke DA. Left ventricular papillary muscle mass: relationship to left ventricular mass and volumes by magnetic resonance imaging. J Comput Assist Tomogr 2006;30:426-432. (Pubitemid 43922260)
22. Cushman M, Cornell E, Howard P, Bovill E, Tracy R. Laboratory methods and quality assurance in the Cardiovascular Health Study. Clin Chem 1995;41:264-270.
23. Södergård R, Bäckström T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature. J Steroid Biochem 1982;16:801-810. (Pubitemid 13228095)
24. Golden SH, Dobs AS, Vaidya D, Szklo M, Gapstur S, Kopp P, Liu K, Ouyang P. Endogenous sex hormones and glucose tolerance status in postmenopausal women. J Clin Endocrinol Metab 2007;92:1289-1295. (Pubitemid 46556400)
25. Psaty B, Lee M, Savage PJ, Rutan GH, German PS, Lyles M; Cardiovascular Health Study Collaborative Research Group. Assessing the use of medication in the elderly: methods and initial experience in the Cardiovascular Health Study. J Clin Epidemiol 1992;45:683-692.
26. Barr RG, Bluemke DA, Ahmed FS, Carr JJ, Enright PL, Hoffman EA, Jiang R, Kawut SM, Kronmal RA, Lima JAC, et al. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med 2010;362:217-227.
27. Rodriguez J, Jiang R, Johnson WC, MacKenzie BA, Smith LJ, Barr RG. The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction. Ann Intern Med 2010;152:201-210.
28. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990;1:43-46. (Pubitemid 20255621)
29. Heckbert SR, Post W, Pearson GDN, Arnett DK, Gomes AS, Jerosch-Herold M, Hundley WG, Lima JA, Bluemke DA. Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multi-Ethnic Study of Atherosclerosis. J Am Coll Cardiol 2006;48:2285-2292. (Pubitemid 44855426)
30. Roeleveld RJ, Vonk-Noordegraaf A, Marcus JT, Bronzwaer JGF, Marques KMJ, Postmus PE, Boonstra A. Effects of epoprostenol on right ventricular hypertrophy and dilatation in pulmonary hypertension. Chest 2004;125:572-579. (Pubitemid 38223638)
31. Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH, et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med 1996;334:296-301. (Pubitemid 26033085)
32. Iwakura A, Shastry S, Luedemann C, Hamada H, Kawamoto A, Kishore R, Zhu Y, Qin G, Silver M, Thorne T, et al. Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 2006;113:1605-1614. (Pubitemid 43739420)
33. Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science 2005;308:1583-1587. (Pubitemid 40807497)
34. Handoko ML, de Man FS, Happe CM, Schalij I, Musters RJP, Westerhof N, Postmus PE, Paulus WJ, van der Laarse WJ, Vonk-Noordegraaf A. Opposite effects of training in rats with stable and progressive pulmonary hypertension. Circulation 2009;120:42-49.
35. Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, et al. Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. Circ Res 2009;104:265-275.
36. Matthews KA, Kuller LH, Wing RR, Meilahn EN, Plantinga P. Before use of estrogen replacement therapy, are users healthier than nonusers? Am J Epidemiol 1996;143:971-978.
37. Nahrendorf M, Frantz S, Hu K, von zur Muhlen C, Tomaszewski M, Scheuermann H, Kaiser R, Jazbutyte V, Beer S, Bauer W, et al. Effect of testosterone on post-myocardial infarction remodeling and function. Cardiovasc Res 2003;57:370-378.
38. Kłapcińska B, Jagsz S, Sadowska-Krȩpa E, Górski J, Kempa K, Langfort L. Effects of castration and testosterone replacement on the antioxidant defense system in rat left ventricle. J Physiol Sci 2008;58:173-177. (Pubitemid 351846446)
39. Khaw K, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) prospective population study. Circulation 2007;116:2694-2701. (Pubitemid 350291241)
40. Malkin CJ, Pugh PJ, West JN, van Beek EJR, Jones TH, Channer KS. Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J 2006;27:57-64. (Pubitemid 41785933)
41. Aaron C, Tandri H, Barr R, Johnson C, Bagiella E, Chahal H, Jain A, Kizer J, Lima J, Bluemke D, et al. Physical activity and right ventricular structure and function: the MESA-Right Ventricle Study. Am J Respir Crit Care Med 2011;183:396-404.
42. Bonnet S, Paulin R, Sutendra G, Dromparis P, Roy M, Watson KO, Nagendran J, Haromy A, Dyck JRB, Michelakis ED. Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the AKT/GSK3-b/NFAT axis. Circulation 2009;120:1231-1240.
43. Ponikowska B, Jankowska EA, Maj J, Wegrzynowska-Teodorczyk K, Biel B, Reczuch K, Borodulin-Nadzieja L, Banasiak W, Ponikowski P. Gonadal and adrenal androgen deficiencies as independent predictors of increased cardiovascular mortality in men with type II diabetes mellitus and stable coronary artery disease. Int J Cardiol 2009;21:21.
44. Formoso G, Chen H, Kim JA, Montagnani M, Consoli A, Quon MJ. Dehydroepiandroesterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent pathways in vascular endothelium. Mol Endocrinol 2006;20:1153-1163.
45. Cappola AR, O'Meara ES, Guo W, Bartz TM, Fried LP, Newman AB. Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci 2009;64A:1268-1274.
46. Guder G, Frantz S, Bauersachs J, Allolio B, Ertl G, Angermann CE, Stork S. Low circulating androgens and mortality risk in heart failure. Heart 2010;96:504-509.
47. Ouyang P, Vaidya D, Dobs A, Golden SH, Szklo M, Heckbert SR, Kopp P, Gapstur SM. Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2009;204:255-261.
48. Grothues F, Moon JC, Bellenger NG, Smith GS, Klein HU, Pennell DJ. Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance. Am Heart J 2004;147:218-223. (Pubitemid 38176819)
49. Hankinson SE, Manson JE, Spiegelman D, Willett WC, Longcope C, Speizer FE. Reproducibility of plasma hormone levels in postmenopausal women over a 2-3 year period. Cancer Epidemiol Biomarkers Prev 1995;4:649-654.