메뉴 건너뛰기




Volumn 18, Issue 111, 2009, Pages 29-34

Inhaled iloprost for the treatment of pulmonary hypertension

Author keywords

Clinical trials; Iloprost; Inhalation; Pulmonary hypertension; Review

Indexed keywords

BOSENTAN; ILOPROST; PROSTACYCLIN;

EID: 61649096423     PISSN: 09059180     EISSN: None     Source Type: Journal    
DOI: 10.1183/09059180.00011111     Document Type: Article
Times cited : (37)

References (28)
  • 1
    • 42949166212 scopus 로고    scopus 로고
    • Prostacyclin therapies for the treatment of pulmonary arterial hypertension
    • Gomberg-Maitland M, Olschewski H. Prostacyclin therapies for the treatment of pulmonary arterial hypertension. Eur Respir J 2008; 31: 891-901.
    • (2008) Eur Respir J , vol.31 , pp. 891-901
    • Gomberg-Maitland, M.1    Olschewski, H.2
  • 2
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
    • Tuder RM, Cool CD, Geraci MW, et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 1999; 159: 1925-1932.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1925-1932
    • Tuder, R.M.1    Cool, C.D.2    Geraci, M.W.3
  • 3
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman BW, McPherson CD, Newman JH, et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 1992; 327: 70-75.
    • (1992) N Engl J Med , vol.327 , pp. 70-75
    • Christman, B.W.1    McPherson, C.D.2    Newman, J.H.3
  • 4
    • 2942522878 scopus 로고    scopus 로고
    • Clinical classification of pulmonary hypertension
    • Simonneau G, Galie N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 2004; 43:Suppl. 12, 5S-12S.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.SUPPL. 12
    • Simonneau, G.1    Galie, N.2    Rubin, L.J.3
  • 5
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group
    • Barst RJ, Rubin LJ, Long WA, et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N Engl J Med 1996; 334: 296-302.
    • (1996) N Engl J Med , vol.334 , pp. 296-302
    • Barst, R.J.1    Rubin, L.J.2    Long, W.A.3
  • 6
    • 0037151645 scopus 로고    scopus 로고
    • Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: Prognostic factors and survival
    • Sitbon O, Humbert M, Nunes H, et al. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J Am Coll Cardiol 2002; 40: 780-788.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 780-788
    • Sitbon, O.1    Humbert, M.2    Nunes, H.3
  • 7
    • 45949097539 scopus 로고    scopus 로고
    • Inhaled prostanoids in the therapy of pulmonary hypertension
    • Gessler T, Seeger W, Schmehl T. Inhaled prostanoids in the therapy of pulmonary hypertension. J Aerosol Med 2008; 21:1-12.
    • (2008) J Aerosol Med , vol.21 , pp. 1-12
    • Gessler, T.1    Seeger, W.2    Schmehl, T.3
  • 8
    • 4644290657 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension
    • Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004; 351:1425-1436.
    • (2004) N Engl J Med , vol.351 , pp. 1425-1436
    • Humbert, M.1    Sitbon, O.2    Simonneau, G.3
  • 9
    • 0037086133 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: A double-blind, randomized, placebo-controlled trial
    • Simonneau G, Barst RJ, Galie N, et al. Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 2002; 165: 800-804.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 800-804
    • Simonneau, G.1    Barst, R.J.2    Galie, N.3
  • 10
    • 0036569119 scopus 로고    scopus 로고
    • Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double- blind, placebo-controlled trial
    • Galie N, Humbert M, Vachiery JL, et al. Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double- blind, placebo-controlled trial. J Am Coll Cardiol 2002; 39:1496-1502.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1496-1502
    • Galie, N.1    Humbert, M.2    Vachiery, J.L.3
  • 11
    • 0027366628 scopus 로고
    • Aerosolised prostacyclin in adult respiratory distress syndrome
    • Walmrath D, Schneider T, Pilch J, Grimminger F, Seeger W. Aerosolised prostacyclin in adult respiratory distress syndrome. Lancet 1993; 342: 961-962.
    • (1993) Lancet , vol.342 , pp. 961-962
    • Walmrath, D.1    Schneider, T.2    Pilch, J.3    Grimminger, F.4    Seeger, W.5
  • 14
    • 0034696634 scopus 로고    scopus 로고
    • Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group
    • Olschewski H, Ghofrani HA, Schmehl T, et al. Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group. Ann Intern Med 2000; 132: 435-443.
    • (2000) Ann Intern Med , vol.132 , pp. 435-443
    • Olschewski, H.1    Ghofrani, H.A.2    Schmehl, T.3
  • 15
    • 0033584039 scopus 로고    scopus 로고
    • Sustained improvement of performance and haemody- namics with long-term aerosolised prostacyclin therapy in severe pulmonary hypertension
    • Stricker H, Domenighetti G, Fiori G, Mombelli G. Sustained improvement of performance and haemody- namics with long-term aerosolised prostacyclin therapy in severe pulmonary hypertension. Schweiz Med Wochenschr 1999; 129: 923-927.
    • (1999) Schweiz Med Wochenschr , vol.129 , pp. 923-927
    • Stricker, H.1    Domenighetti, G.2    Fiori, G.3    Mombelli, G.4
  • 16
    • 0034702248 scopus 로고    scopus 로고
    • Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue
    • Hoeper MM, Schwarze M, Ehlerding S, et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 2000; 342: 1866-1870.
    • (2000) N Engl J Med , vol.342 , pp. 1866-1870
    • Hoeper, M.M.1    Schwarze, M.2    Ehlerding, S.3
  • 18
    • 0032810972 scopus 로고    scopus 로고
    • Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis
    • Olschewski H, Ghofrani HA, Walmrath D, et al. Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis. Am J Respir Crit Care Med 1999; 160: 600-607.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 600-607
    • Olschewski, H.1    Ghofrani, H.A.2    Walmrath, D.3
  • 19
    • 60249087242 scopus 로고    scopus 로고
    • Iloprost improves gas exchange in COPD patients with pulmonary arterial hypertension
    • Dernaika TA, Beavin ML, Kinasewitz GT. Iloprost improves gas exchange in COPD patients with pulmonary arterial hypertension. Am J Respir Crit Care Med 2008; 177: A443.
    • (2008) Am J Respir Crit Care Med , vol.177
    • Dernaika, T.A.1    Beavin, M.L.2    Kinasewitz, G.T.3
  • 20
    • 62549090739 scopus 로고    scopus 로고
    • Krowka MJ, Ahmad S, de Andrade JA, et al. A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of iloprost inhalation in adults with abnormal pulmonary arterial pressure and exercise limitation associated with idiopathic pulmonary fibrosis. Chest 2007; 132: Suppl., 633S.
    • Krowka MJ, Ahmad S, de Andrade JA, et al. A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of iloprost inhalation in adults with abnormal pulmonary arterial pressure and exercise limitation associated with idiopathic pulmonary fibrosis. Chest 2007; 132: Suppl., 633S.
  • 21
    • 0036682273 scopus 로고    scopus 로고
    • Inhaled iloprost for severe pulmonary hypertension
    • Olschewski H, Simonneau G, Galie N, et al. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 2002; 347: 322-329.
    • (2002) N Engl J Med , vol.347 , pp. 322-329
    • Olschewski, H.1    Simonneau, G.2    Galie, N.3
  • 22
    • 33845526777 scopus 로고    scopus 로고
    • Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension
    • McLaughlin VV, Oudiz RJ, Frost A, et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am J Respir Crit Care Med 2006; 174: 1257-1263.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1257-1263
    • McLaughlin, V.V.1    Oudiz, R.J.2    Frost, A.3
  • 23
    • 33847368988 scopus 로고    scopus 로고
    • Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
    • Hoeper MM, Leuchte H, Halank M, et al. Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. EurRespirJ2006; 28: 691-694.
    • (2006) EurRespirJ , vol.28 , pp. 691-694
    • Hoeper, M.M.1    Leuchte, H.2    Halank, M.3
  • 24
    • 21544449424 scopus 로고    scopus 로고
    • Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension
    • Opitz CF, Wensel R, Winkler J, et al. Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension. Eur Heart J 2005; 26: 1895-1902.
    • (2005) Eur Heart J , vol.26 , pp. 1895-1902
    • Opitz, C.F.1    Wensel, R.2    Winkler, J.3
  • 25
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension. Results from a national prospective registry
    • D'Alonzo GE, Barst RJ, Ayres SM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 1991; 115:343-349.
    • (1991) Ann Intern Med , vol.115 , pp. 343-349
    • D'Alonzo, G.E.1    Barst, R.J.2    Ayres, S.M.3
  • 26
    • 62549108807 scopus 로고    scopus 로고
    • Bayer Schering Pharma AG. Open-label, uncontrolled, long- term surveillance study of iloprost aerosol inhalation therapy in the treatment of patients with primary or secondary pulmonary hypertension. www. clinicalstudyresults.org/ drugdetails /?company-id=73&indication-id= 854&sort=c. company-name&page=1&drug-id=2423 Date last updated: May 2007. Date last accessed: December 16, 2008.
    • Bayer Schering Pharma AG. Open-label, uncontrolled, long- term surveillance study of iloprost aerosol inhalation therapy in the treatment of patients with primary or secondary pulmonary hypertension. www. clinicalstudyresults.org/ drugdetails /?company-id=73&indication-id= 854&sort=c. company-name&page=1&drug-id=2423 Date last updated: May 2007. Date last accessed: December 16, 2008.
  • 27
    • 17444422003 scopus 로고    scopus 로고
    • Long-term survival in patients with pulmonary hypertension inhaling iloprost
    • abstract 2567
    • Olschewski H, Nikkho S, Behr J, et al. Long-term survival in patients with pulmonary hypertension inhaling iloprost. Eur Heart J 2003; 24: 482 (abstract 2567).
    • (2003) Eur Heart J , vol.24 , pp. 482
    • Olschewski, H.1    Nikkho, S.2    Behr, J.3
  • 28
    • 62549144567 scopus 로고    scopus 로고
    • Frost AE, the STEP investigators. STEP-open label extension: long-term benefits of inhaled iloprost (ILO) addition to bosentan for treatment of pulmonary arterial hypertension (PAH). Am J Respir Crit Care Med 2007; 175: Suppl., A1001.
    • Frost AE, the STEP investigators. STEP-open label extension: long-term benefits of inhaled iloprost (ILO) addition to bosentan for treatment of pulmonary arterial hypertension (PAH). Am J Respir Crit Care Med 2007; 175: Suppl., A1001.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.