Characterization of the vasodilatory action of testosterone in the human pulmonary circulation

Vascular Health and Risk Management

Volumn 4, Issue 6, 2008, Pages 1459-1466

  Smith, Alyson M ^a   Bennett, Robert T ^b   Jones, T Hugh ^a   Cowen, Mike E ^b   Channer, Kevin S ^c   Jones, Richard D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b CASTLE HILL HOSPITAL   (United Kingdom)

^c ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Human; Pulmonary circulation; Pulmonary hypertension; Sex hormone; Testosterone; Vasodilation

Indexed keywords

ALCOHOL; TESTOSTERONE;

ADULT; AGED; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN TISSUE; LUNG CIRCULATION; LUNG PARENCHYMA; LUNG PERFUSION; MALE; MYOGRAPHY; OUTCOME ASSESSMENT; PULMONARY ARTERY; PULMONARY ARTERY OCCLUSION; PULMONARY HYPERTENSION; SEX DIFFERENCE; STEROID THERAPY; VASODILATATION;

AGED; ENGLAND; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; PERFUSION; PULMONARY ARTERY; PULMONARY CIRCULATION; SEX FACTORS; TESTOSTERONE; VASODILATION;

EID: 60249096250     PISSN: 11766344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Bennett RT, Jones RD, Morice AH, et al. 2004. Vasoconstrictive effects of endothelin-1, endothelin-3, and urotensin II in isolated perfused human lungs and isolated human pulmonary arteries. Thorax, 59:401-7.
2. Bjornsson J, Edwards WD. 1985. Primary Pulmonary-Hypertension - a Histopathologic Study of 80 Cases. Mayo Clin Proc, 60:16-725.
3. Bray K, Quast, U. 1991. Differences in K+ channels opened by cromokalin, acetylcholine and Substance P in rat aorta and porcine coronary artery. Br J Pharmacol, 102:585-94.
4. Dalonzo GE, Barst RJ, Ayres SM, et al. 1991. Survival in patints with primary pulmonary-hypertension - Results from a National Prospective Registry. Ann Intern Med, 115:343-9.
5. English KM, Steeds RP, Jones TH, et al. 2000a. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina - A randomized, double-blind, placebo-controlled study. Circulation, 102:1906-11.
6. English KM, Jones RD, Jones TH, et al. 2000b. Aging reduces the responsiveness of coronary arteries from male Wistar rats to the vasodilatory action of testosterone. Clin Sci, 99:77-82.
7. English KM, Jones RD, Jones TH, et al. 2001. Gender differences in the vasomotor effects of different steroid hormones in rat pulmonary and coronary arteries. Horm Metab Res, 33:645-52.
8. Gibbs JSR, Higenbottam TW, Black C, et al. 2001. Recommendations on the management of pulmonary hypertension in clinical practice. Heart, 86:11-113.
9. Gonzales RJ, Walker BR, Kanagy NL. 2001. 17 beta-Estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta. Am J Physiol Lung Cell Mol Physiol, 280:L555-4.
10. Hall J, Jones RD, Vaughan R, et al. 2004. Mechanisms of agonist-induced vasoconstriction in isolated human pulmonary arteries. British Pharmacological Society, 2:034.
11. 2+ channels in A7r5 cells by physiological levels of testosterone. Endocrinology, 147:2675-80.
12. Jones RD, English KM, Pugh PJ, et al. 2002. Pulmonary vasodilatory action of testosterone: Evidence of a calcium antagonistic action. J Cardiovasc Pharmacol, 39:814-23.
13. Jones RD, English KM, Jones TH, et al. 2004. Testosterone-induced coronary vasodilatation occurs via a non-genomic mechanism: evidence of a direct calcium antagonism action. Clin Sci, 107:149-58.
14. Li HF, Zheng TZ, Li W, et al. 2001. Effect of progesterone on the contractile response of isolated pulmonary artery in rabbits. Can J Physiol Pharmacol, 79:545-50.
15. Malkin CJ, Jones TH, Channer KS. 2009. Testosterone in chronic heart failure. Front Horm Res, 37:183-96.
16. Pietra GG, Edwards WD, Kay JM, et al. 1989. Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry. Circulation, 80:1198-206.
17. Porto CS, Lazari MFM, Abreu LC, et al. 1995. Receptors for androgen binding proteins: Internalisation and intracellular signalling. J Steroid Biochem Mol Biol, 53:561-5.
18. Pugh PJ, Jones RD, West JN, et al. 2004. Testosterone treatment for men with chronic heart failure. Heart, 90:446-7.
19. Rich S, Kaufmann E, Levy PS. 1992. The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med, 327:76-81.
20. Rowell KO, Jones RD, Pugh PJ, et al. 2003. Testosterone is an efficacious vasodilator in isolated human pulmonary and mesenteric arteries and veins. Heart, 89:A30.
21. Rubin LJ, Nicod P, Hillis LD, et al. 1983. Treatment of primary pulmonary hypertension with nifedipine. A hemodynamic and scintigraphic evaluation. Ann Intern Med, 99:433-8.
22. Runo JR, Loyd JE. 2003. Primary pulmonary hypertension. Lancet, 361:1533-44.
23. 2+ channels. Biochem Biophys Res Commun, 318:503-6.
24. Thomas P, Dixon MS, Winterton SJ, et al. 1990. Acute haemodynamic effects of cromakalin in patients with angina pectoris. Br J Clin Pharmacol, 29:325-31.
25. Wagenvoort CA. 1980. Lung biopsy specimens in the evaluation of pulmonary vascular disease. Chest, 77:614-25.
26. Woodmansey PA, Otoole L, Channer KS, et al. 1996. Acute pulmonary vasodilatory properties of amlodipine in humans with pulmonary hypertension. Heart, 75:171-3.