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Volumn 89, Issue 9, 2004, Pages 4708-4715

Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTRADIOL; ESTROGEN RECEPTOR; FLUTAMIDE; FULVESTRANT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOGEN ACTIVATED PROTEIN KINASE 1; PRASTERONE; TESTOSTERONE; TRIACYLGLYCEROL;

EID: 4544302443     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031560     Document Type: Article
Times cited : (119)

References (48)
  • 1
    • 0021181906 scopus 로고
    • Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood
    • Orentreich N, Brind JL, Rizer RL, Vogelman JH 1984 Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 59:551-555
    • (1984) J Clin Endocrinol Metab , vol.59 , pp. 551-555
    • Orentreich, N.1    Brind, J.L.2    Rizer, R.L.3    Vogelman, J.H.4
  • 2
    • 0029549896 scopus 로고
    • Biosynthesis of DHEAS by the human adrenal cortex and its age-related decline
    • Hornsby PJ 1995 Biosynthesis of DHEAS by the human adrenal cortex and its age-related decline. Ann NY Acad Sci 774:29-46
    • (1995) Ann NY Acad Sci , vol.774 , pp. 29-46
    • Hornsby, P.J.1
  • 3
    • 0026457655 scopus 로고
    • Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men
    • LaCroix AZ, Yano K, Reed DM 1992 Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men. Circulation 86:1529-1535
    • (1992) Circulation , vol.86 , pp. 1529-1535
    • Lacroix, A.Z.1    Yano, K.2    Reed, D.M.3
  • 5
    • 0025827651 scopus 로고
    • Metabolism of dehydroepiandrosterone sulfate (DS) in normal women and women with high DS concentrations
    • Haning Jr RV, Carlson IH, Flood CA, Hackett RJ, Longcope C 1991 Metabolism of dehydroepiandrosterone sulfate (DS) in normal women and women with high DS concentrations. J Clin Endocrinol Metab 73:1210-1215
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1210-1215
    • Haning Jr., R.V.1    Carlson, I.H.2    Flood, C.A.3    Hackett, R.J.4    Longcope, C.5
  • 6
    • 0025846997 scopus 로고
    • Metabolic clearance rate of dehydroepiandrosterone sulfate, its metabolism to testosterone, and its intrafollicular metabolism to dehydroepiandrosterone, androstenedione, testosterone, and dihydrotestosterone in vivo
    • Haning Jr RV, Flood CA, Hackett RJ, Loughlin JS, McClure N, Longcope C 1991 Metabolic clearance rate of dehydroepiandrosterone sulfate, its metabolism to testosterone, and its intrafollicular metabolism to dehydroepiandrosterone, androstenedione, testosterone, and dihydrotestosterone in vivo. J Clin Endocrinol Metab 72:1088-1095
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 1088-1095
    • Haning Jr., R.V.1    Flood, C.A.2    Hackett, R.J.3    Loughlin, J.S.4    McClure, N.5    Longcope, C.6
  • 8
    • 0030598949 scopus 로고    scopus 로고
    • The relationship of natural androgens to coronary heart disease in males: A review
    • Alexandersen P, Haarbo J, Christiansen C 1996 The relationship of natural androgens to coronary heart disease in males: a review. Atherosclerosis 125: 1-13
    • (1996) Atherosclerosis , vol.125 , pp. 1-13
    • Alexandersen, P.1    Haarbo, J.2    Christiansen, C.3
  • 9
    • 0029972836 scopus 로고    scopus 로고
    • Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men
    • Beer NA, Jakubowicz DJ, Matt DW, Beer RM, Nestler JE 1996 Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men. Am J Med Sci 311:205-210
    • (1996) Am J Med Sci , vol.311 , pp. 205-210
    • Beer, N.A.1    Jakubowicz, D.J.2    Matt, D.W.3    Beer, R.M.4    Nestler, J.E.5
  • 10
    • 0027388918 scopus 로고
    • Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation
    • Eich DM, Nestler JE, Johnson DE, Dworkin GH, Ko D, Wechsler AS, Hess ML 1993 Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation. Circulation 87:261-269
    • (1993) Circulation , vol.87 , pp. 261-269
    • Eich, D.M.1    Nestler, J.E.2    Johnson, D.E.3    Dworkin, G.H.4    Ko, D.5    Wechsler, A.S.6    Hess, M.L.7
  • 11
    • 0029552413 scopus 로고
    • DHEAS as an effective vaccine adjuvant in elderly humans. Proof-of-principle studies
    • Araneo, B, Dowell T, Woods ML, Daynes R, Judd M, Evans T 1995 DHEAS as an effective vaccine adjuvant in elderly humans. Proof-of-principle studies. Ann NY Acad Sci 774:232-248
    • (1995) Ann NY Acad Sci , vol.774 , pp. 232-248
    • Araneo, B.1    Dowell, T.2    Woods, M.L.3    Daynes, R.4    Judd, M.5    Evans, T.6
  • 12
    • 0030293905 scopus 로고    scopus 로고
    • The use of oral dehydroepiandrosterone sulfate as an adjuvant in tetanus and influenza vaccination of the elderly
    • Evans, TG, Judd ME, Dowell T, Poe S, Daynes RA, Araneo BA 1996 The use of oral dehydroepiandrosterone sulfate as an adjuvant in tetanus and influenza vaccination of the elderly. Vaccine 14:1531-1537
    • (1996) Vaccine , vol.14 , pp. 1531-1537
    • Evans, T.G.1    Judd, M.E.2    Dowell, T.3    Poe, S.4    Daynes, R.A.5    Araneo, B.A.6
  • 13
    • 0026709674 scopus 로고
    • Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone
    • Rao MS, Subbarao V, Yeldandi AV, Reddy JK 1992 Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. Cancer Lett 65:123-126
    • (1992) Cancer Lett , vol.65 , pp. 123-126
    • Rao, M.S.1    Subbarao, V.2    Yeldandi, A.V.3    Reddy, J.K.4
  • 14
    • 0026073142 scopus 로고
    • Suppressive effects of dehydroepiandrosterone and 3β-methyl-androst- 5-en-17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids
    • Young J, Corpechot C, Haug M, Gobaille S, Baulieu EE, Robel P 1991 Suppressive effects of dehydroepiandrosterone and 3β-methyl-androst-5-en- 17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids. Biochem Biophys Res Commun 174:892-897
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 892-897
    • Young, J.1    Corpechot, C.2    Haug, M.3    Gobaille, S.4    Baulieu, E.E.5    Robel, P.6
  • 15
    • 0023896577 scopus 로고
    • Dehydroepiandrosterone sulfate improves memory in aging mice
    • Flood JF, Roberts E 1988 Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res 448:178-181
    • (1988) Brain Res , vol.448 , pp. 178-181
    • Flood, J.F.1    Roberts, E.2
  • 16
    • 0028213506 scopus 로고
    • Dehydroepiandrosterone is an anxiolytic in mice on the plus maze
    • Melchior CL, Ritzmann RF 1994 Dehydroepiandrosterone is an anxiolytic in mice on the plus maze. Pharmacol Biochem Behav 47:437-441
    • (1994) Pharmacol Biochem Behav , vol.47 , pp. 437-441
    • Melchior, C.L.1    Ritzmann, R.F.2
  • 18
    • 0030831087 scopus 로고    scopus 로고
    • Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease
    • Clarkson P, Celermajer DS, Powe AJ, Donald AE, Henry RM, Deanfield JE 1997 Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease. Circulation 96:3378-3383
    • (1997) Circulation , vol.96 , pp. 3378-3383
    • Clarkson, P.1    Celermajer, D.S.2    Powe, A.J.3    Donald, A.E.4    Henry, R.M.5    Deanfield, J.E.6
  • 21
    • 0029888913 scopus 로고    scopus 로고
    • A proposed mechanism for the cardioprotective effect of oestrogen in women: Enhanced endothelial nitric oxide release decreases coronary artery reactivity
    • Wellman GC, Brayden JE, Nelson MT 1996 A proposed mechanism for the cardioprotective effect of oestrogen in women: enhanced endothelial nitric oxide release decreases coronary artery reactivity. Clin Exp Pharmacol Physiol 23:260-266
    • (1996) Clin Exp Pharmacol Physiol , vol.23 , pp. 260-266
    • Wellman, G.C.1    Brayden, J.E.2    Nelson, M.T.3
  • 22
    • 0033566952 scopus 로고    scopus 로고
    • 17β-Estradiol stimulates expression of endothelial and inducible NO synthase in rat myocardium in-vitro and in-vivo
    • Nuedling S, Kahlert S, Loebbert K, Doevendans PA, Meyer R, Vetter H, Grohe C 1999 17β-Estradiol stimulates expression of endothelial and inducible NO synthase in rat myocardium in-vitro and in-vivo. Cardiovasc Res 43: 666-674
    • (1999) Cardiovasc Res , vol.43 , pp. 666-674
    • Nuedling, S.1    Kahlert, S.2    Loebbert, K.3    Doevendans, P.A.4    Meyer, R.5    Vetter, H.6    Grohe, C.7
  • 26
    • 0031903106 scopus 로고    scopus 로고
    • Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells
    • Somjen D, Kohen F, Jaffe A, Amir-Zaltsman Y, Knoll E, Stern N 1998 Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells. Hypertension 32:39-45
    • (1998) Hypertension , vol.32 , pp. 39-45
    • Somjen, D.1    Kohen, F.2    Jaffe, A.3    Amir-Zaltsman, Y.4    Knoll, E.5    Stern, N.6
  • 28
    • 0035018327 scopus 로고    scopus 로고
    • Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells
    • de Dios ST, Hannan KM, Dilley RJ, Hill MA, Little PJ 2001 Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells. J Diabetes Complications 15:120-127
    • (2001) J Diabetes Complications , vol.15 , pp. 120-127
    • De Dios, S.T.1    Hannan, K.M.2    Dilley, R.J.3    Hill, M.A.4    Little, P.J.5
  • 29
    • 0001637870 scopus 로고
    • Permanent cell line expressing human factor VIII-related antigen established by hybridization
    • Edgell CJ, McDonald CC, Graham JB 1983 Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA 80:3734-3737
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 3734-3737
    • Edgell, C.J.1    McDonald, C.C.2    Graham, J.B.3
  • 30
  • 31
    • 0028341050 scopus 로고
    • Physiological importance of dehydroepiandrosterone
    • Ebeling P, Koivisto VA 1994 Physiological importance of dehydroepiandrosterone. Lancet 343:1479-1481
    • (1994) Lancet , vol.343 , pp. 1479-1481
    • Ebeling, P.1    Koivisto, V.A.2
  • 33
    • 0031557110 scopus 로고    scopus 로고
    • Effects of dehydroepiandrosterone on proliferation of human aortic smooth muscle cells
    • Erratum (1997) 60:2155
    • Yoneyama A, Kamiya Y, Kawaguchi M, Fujinami T 1997 Effects of dehydroepiandrosterone on proliferation of human aortic smooth muscle cells. Life Sci [Erratum (1997) 60:2155] 60:833-838
    • (1997) Life Sci , vol.60 , pp. 833-838
    • Yoneyama, A.1    Kamiya, Y.2    Kawaguchi, M.3    Fujinami, T.4
  • 34
    • 0017744317 scopus 로고
    • Inhibitory action of dehydroepiandrosterone (DHEA) on fibroblast growth
    • Saenger P, New M 1977 Inhibitory action of dehydroepiandrosterone (DHEA) on fibroblast growth. Experientia 33:966-967
    • (1977) Experientia , vol.33 , pp. 966-967
    • Saenger, P.1    New, M.2
  • 36
    • 0031849803 scopus 로고    scopus 로고
    • Dehydroepiandrosterone attenuates preadipocyte growth in primary cultures of stromal-vascular cells
    • McIntosh M, Hausman D, Martin R, Hausman G 1998 Dehydroepiandrosterone attenuates preadipocyte growth in primary cultures of stromal-vascular cells. Am J Physiol 275:E285-E293
    • (1998) Am J Physiol , vol.275
    • McIntosh, M.1    Hausman, D.2    Martin, R.3    Hausman, G.4
  • 37
    • 0033603590 scopus 로고    scopus 로고
    • Androgen stimulates mitogen-activated protein kinase in human breast cancer cells
    • Zhu X, Li H, Liu JP, Funder JW 1999 Androgen stimulates mitogen-activated protein kinase in human breast cancer cells. Mol Cell Endocrinol 152:199-206
    • (1999) Mol Cell Endocrinol , vol.152 , pp. 199-206
    • Zhu, X.1    Li, H.2    Liu, J.P.3    Funder, J.W.4
  • 38
    • 0342803689 scopus 로고    scopus 로고
    • Estrogen-induced activation of the mitogen-acrivated protein kinase cascade in the cerebral cortex of estrogen receptor-α knock-out mice
    • Singh M, Setalo Jr G, Guan X, Frail DE, Toran-Allerand CD 2000 Estrogen-induced activation of the mitogen-acrivated protein kinase cascade in the cerebral cortex of estrogen receptor-α knock-out mice. J Neurosci 20:1694-1700
    • (2000) J Neurosci , vol.20 , pp. 1694-1700
    • Singh, M.1    Setalo Jr., G.2    Guan, X.3    Frail, D.E.4    Toran-Allerand, C.D.5
  • 39
    • 0033580762 scopus 로고    scopus 로고
    • Effects of dehydroepiandrosterone on mitogen-acrivated protein kinase in human aortic smooth muscle cells
    • Yoshimata T, Yoneyama A, Jin-no Y, Tamai N, Kamiya Y 1999 Effects of dehydroepiandrosterone on mitogen-acrivated protein kinase in human aortic smooth muscle cells. Life Sci 65:431-440
    • (1999) Life Sci , vol.65 , pp. 431-440
    • Yoshimata, T.1    Yoneyama, A.2    Jin-no, Y.3    Tamai, N.4    Kamiya, Y.5
  • 41
    • 0026074118 scopus 로고
    • Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent
    • Chen YF, Meng QC 1991 Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent. Life Sci 48:85-96
    • (1991) Life Sci , vol.48 , pp. 85-96
    • Chen, Y.F.1    Meng, Q.C.2
  • 42
    • 0035140275 scopus 로고    scopus 로고
    • Evidence that parenteral testosterone therapy may improve endothelium-dependent and -independent vasodilation in postmenopausal women already receiving estrogen
    • Worboys S, Kotsopoulos D, Teede H, McGrath B, Davis S 2001 Evidence that parenteral testosterone therapy may improve endothelium-dependent and -independent vasodilation in postmenopausal women already receiving estrogen. J Clin Endocrinol Metab 86:158-161
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 158-161
    • Worboys, S.1    Kotsopoulos, D.2    Teede, H.3    McGrath, B.4    Davis, S.5
  • 43
    • 84940801620 scopus 로고
    • Differences in rat kidney morphology between males, females and testosterone-treated females
    • Oudar O, Elger M, Bankir L, Ganten D, Ganten U, Kriz W 1991 Differences in rat kidney morphology between males, females and testosterone-treated females. Ren Physiol Biochem 14:92-102
    • (1991) Ren Physiol Biochem , vol.14 , pp. 92-102
    • Oudar, O.1    Elger, M.2    Bankir, L.3    Ganten, D.4    Ganten, U.5    Kriz, W.6
  • 44
    • 0031611277 scopus 로고    scopus 로고
    • Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats
    • Reckelhoff JF, Zhang H, Granger JP 1998 Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats. Hypertension 31:435-439
    • (1998) Hypertension , vol.31 , pp. 435-439
    • Reckelhoff, J.F.1    Zhang, H.2    Granger, J.P.3
  • 45
    • 0032735745 scopus 로고    scopus 로고
    • Gender differences in hypertension in spontaneously hypertensive rats: Role of androgens and androgen receptor
    • Reckelhoff JF, Zhang H, Srivistiva K, Granger JP 1999 Gender differences in hypertension in spontaneously hypertensive rats: role of androgens and androgen receptor. Hypertension 34:920-923
    • (1999) Hypertension , vol.34 , pp. 920-923
    • Reckelhoff, J.F.1    Zhang, H.2    Srivistiva, K.3    Granger, J.P.4
  • 46
    • 0027445164 scopus 로고
    • The role of endothelium in cardiovascular homeostasis and diseases
    • Rubanyi GM 1993 The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol 22(Suppl 4):S1-S14
    • (1993) J Cardiovasc Pharmacol , vol.22 , Issue.4 SUPPL.
    • Rubanyi, G.M.1
  • 47
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • Palmer RM, Ferrige AG, Moncada S 1987 Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524-526
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 48
    • 0024300153 scopus 로고
    • L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
    • Palmer RM, Rees DD, Ashton DS, Moncada S 1988 L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 153:1251-1256
    • (1988) Biochem Biophys Res Commun , vol.153 , pp. 1251-1256
    • Palmer, R.M.1    Rees, D.D.2    Ashton, D.S.3    Moncada, S.4


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