Nuclear factor-κB/p65 responds to changes in the notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the γ-secretase complex blocker DAPT

Journal of Neuroscience Research

Volumn 88, Issue 12, 2010, Pages 2701-2714

  Cao, Q ^a   Li, P ^b   Lu, J ^c   Dheen, S T ^a   Kaur, Charanjit ^a   Ling, E A ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b KUNMING MEDICAL UNIVERSITY   (China)

^c DSO NATIONAL LABORATORIES   (Singapore)

Author keywords

DAPT; Microglia; NF B p65; Notch 1; Proinflammatory cytokines

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; DAPT; GAMMA SECRETASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; N [N ( 3,5 DIFLUOROPHENACETYL) 1 ALANYL]PHENYLGLYCINE TERT BUTYL ESTER; NOTCH RECEPTOR; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMOEBOID MICROGLIAL CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL FUNCTION; CELL LINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA FLANKING REGION; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; IN VIVO STUDY; INJECTION; MEDIATOR; MICROGLIA; MOUSE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, NEWBORN; CELL LINE; CELL MOVEMENT; DIPEPTIDES; GLIOSIS; INFLAMMATION MEDIATORS; MICE; MICROGLIA; PROTEASE INHIBITORS; RATS; RATS, WISTAR; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 77955496321     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22429     Document Type: Article

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