-
2
-
-
80054084051
-
Pharmacological management of type 2 diabetes mellitus: An update
-
El-Kaissi S, Sherbeeni S. Pharmacological management of type 2 diabetes mellitus: an update. Curr Diabetes Rev 2011;7:392-405
-
(2011)
Curr Diabetes Rev
, vol.7
, pp. 392-405
-
-
El-Kaissi, S.1
Sherbeeni, S.2
-
3
-
-
80052723784
-
Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass
-
Esterhazy D, Stutzer I, Wang H, et al. Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab 2011;14:365-77
-
(2011)
Cell Metab
, vol.14
, pp. 365-377
-
-
Esterhazy, D.1
Stutzer, I.2
Wang, H.3
-
4
-
-
33644875891
-
Tmem27: A cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation
-
Akpinar P, Kuwajima S, Krutzfeldt J, Stoffel M. Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab 2005;2:385-97
-
(2005)
Cell Metab
, vol.2
, pp. 385-397
-
-
Akpinar, P.1
Kuwajima, S.2
Krutzfeldt, J.3
Stoffel, M.4
-
5
-
-
61449134171
-
BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells
-
Finzi G, Franzi F, Placidi C, et al. BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells. Ultrastruct Pathol 2008;32:246-51
-
(2008)
Ultrastruct Pathol
, vol.32
, pp. 246-251
-
-
Finzi, G.1
Franzi, F.2
Placidi, C.3
-
6
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as β-secretase
-
DOI 10.1006/mcne.1999.0811
-
Hussain I, Powell D, Howlett DR, et al. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 1999;14:419-27 (Pubitemid 30026585)
-
(1999)
Molecular and Cellular Neurosciences
, vol.14
, Issue.6
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
Smith, T.S.11
Simmons, D.L.12
Walsh, F.S.13
Dingwall, C.14
Christie, G.15
-
7
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett B, Babu-Khan S, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (New York, N.Y.) 1999;286:735-41
-
(1999)
Science (New York, N.Y)
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.2
Babu-Khan, S.3
-
8
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski M, Shuck M, et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 1999;402:533-7
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.2
Shuck, M.3
-
9
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson J, Barbour R, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 1999;402:537-40
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.2
Barbour, R.3
-
10
-
-
0034533808
-
Asp1 (BACE2) cleaves the amyloid precursor protein at the β-secretase site
-
DOI 10.1006/mcne.2000.0884
-
Hussain I, Powell DJ, Howlett DR, et al. ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol Cell Neurosci 2000;16:609-19 (Pubitemid 32001309)
-
(2000)
Molecular and Cellular Neuroscience
, vol.16
, Issue.5
, pp. 609-619
-
-
Hussain, I.1
Powell, D.J.2
Howlett, D.R.3
Chapman, G.A.4
Gilmour, L.5
Murdock, P.R.6
Tew, D.G.7
Meek, T.D.8
Chapman, C.9
Schneider, K.10
Ratcliffe, S.J.11
Tattersall, D.12
Testa, T.T.13
Southan, C.14
Ryan, D.M.15
Simmons, D.L.16
Walsh, F.S.17
Dingwall, C.18
Christie, G.19
-
11
-
-
0034652309
-
Human aspartic protease memapsin 2 cleaves the β-secretase site of β- amyloid precursor protein
-
DOI 10.1073/pnas.97.4.1456
-
Lin X, Koelsch G, Wu S, et al. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Nat Acad Sci USA 2000;97:1456-60 (Pubitemid 30118462)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.4
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
Tang, J.6
-
12
-
-
0033970139
-
The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region
-
DOI 10.1016/S0014-5793(00)01192-3, PII S0014579300011923
-
Acquati F, Accarino M, Nucci C, et al. The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region. FEBS Lett 2000;468:59-64 (Pubitemid 30101682)
-
(2000)
FEBS Letters
, vol.468
, Issue.1
, pp. 59-64
-
-
Acquati, F.1
Accarino, M.2
Nucci, C.3
Fumagalli, P.4
Jovine, L.5
Ottolenghi, S.6
Taramelli, R.7
-
13
-
-
0034662929
-
BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein
-
Farzan M, Schnitzler C, Vasilieva N, et al. BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc Nat Acad Sci USA 2000;97:9712-17 (Pubitemid 30650841)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.17
, pp. 9712-9717
-
-
Farzan, M.1
Schnitzler, C.E.2
Vasilieva, N.3
Leung, D.4
Choe, H.5
-
16
-
-
84655162702
-
Developing beta-secretase inhibitors for treatment of Alzheimer's disease
-
Ghosh AK, Brindisi M, Tang J. Developing beta-secretase inhibitors for treatment of Alzheimer's disease. J Neurochem 2012;120(Suppl):71-83
-
(2012)
J Neurochem
, vol.120
, Issue.SUPPL.
, pp. 71-83
-
-
Ghosh, A.K.1
Brindisi, M.2
Tang, J.3
-
17
-
-
84861512510
-
Small-molecule BACE1 inhibitors: A patent literature review 2006-2011
-
Probst G, Xu YZ. Small-molecule BACE1 inhibitors: a patent literature review (2006-2011). Expert Opin Ther Pat 2012;22:511-40
-
(2012)
Expert Opin Ther Pat
, vol.22
, pp. 511-540
-
-
Probst, G.1
Xu, Y.Z.2
-
18
-
-
84857736151
-
BACE1 dependent neuregulin proteolysis
-
Fleck D, Garratt A, Haass C, Willem M. BACE1 dependent neuregulin proteolysis. Curr Alzheimer Res 2012;9(2):178-83
-
(2012)
Curr Alzheimer Res
, vol.9
, Issue.2
, pp. 178-183
-
-
Fleck, D.1
Garratt, A.2
Haass, C.3
Willem, M.4
-
19
-
-
84876536086
-
-
EPO-Espacenet Available from [Acessed January 2013]
-
EPO-Espacenet. Available from: http://worldwide.espacenet.com/ advancedSearch? locale=en-EP [Acessed January 2013]
-
-
-
-
20
-
-
84876559583
-
-
Available from [Acessed January 2013]
-
WIPO PATENTSCOPE. Available from: http://patentscope.wipo.int/search/en/ search.jsf [Acessed January 2013]
-
WIPO Patentscope
-
-
-
21
-
-
84876527014
-
-
Available from [Acessed January 2013]
-
FPO IP Research & Communities. Available from: http://www. freepatentsonline.com/[Acessed January 2013]
-
FPO IP Research & Communities
-
-
-
22
-
-
84876553834
-
-
Available from [Acessed January 2013]
-
Europe PubMed Central. Available from: http://europepmc.org/[Acessed January 2013]
-
Europe Pub Med Central
-
-
-
23
-
-
84876555593
-
-
Available from [Acessed January 2013]
-
SureChemOpen. Available from: https://open.surechem.com/en/[Acessed January 2013]
-
Sure Chem Open
-
-
-
24
-
-
84876530579
-
InChI in the wild: An Assessment of InChIKey searching in Google
-
Southan C. InChI in the wild: an Assessment of InChIKey searching in Google. J Cheminform 2013;5:10
-
(2013)
J Cheminform
, vol.5
, pp. 10
-
-
Southan, C.1
-
25
-
-
84872265994
-
-
Available from [Acessed January 2013]
-
The PubChem Project. Available from: http://pubchem.ncbi.nlm.nih.gov/ [Acessed January 2013]
-
The Pub Chem Project
-
-
-
26
-
-
84876523261
-
-
Available from [Acessed January 2013]
-
ChEMBLdb. Available from: https://www.ebi.ac.uk/chembldb/index.php [Acessed January 2013]
-
ChEMBLdb
-
-
-
27
-
-
28844509722
-
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor
-
DOI 10.1016/j.jmb.2005.10.027, PII S002228360501260X
-
Ostermann N, Eder J, Eidhoff U, et al. Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J Mol Biol 2006;355:249-61 (Pubitemid 41774129)
-
(2006)
Journal of Molecular Biology
, vol.355
, Issue.2
, pp. 249-261
-
-
Ostermann, N.1
Eder, J.2
Eidhoff, U.3
Zink, F.4
Hassiepen, U.5
Worpenberg, S.6
Maibaum, J.7
Simic, O.8
Hommel, U.9
Gerhartz, B.10
-
31
-
-
29544449814
-
Conformationally biased P3 amide replacements of β-secretase inhibitors
-
DOI 10.1016/j.bmcl.2005.10.032, PII S0960894X0501317X
-
Stachel SJ, Coburn CA, Steele TG, et al. Conformationally biased P3 amide replacements of beta-secretase inhibitors. Bioorg Med Chem Lett 2006;16:641-4 (Pubitemid 43014850)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.3
, pp. 641-644
-
-
Stachel, S.J.1
Coburn, C.A.2
Steele, T.G.3
Crouthamel, M.-C.4
Pietrak, B.L.5
Lai, M.-T.6
Holloway, M.K.7
Munshi, S.K.8
Graham, S.L.9
Vacca, J.P.10
-
47
-
-
84861388554
-
Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2
-
Esterhazy D, Akpinar P, Stoffel M. Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2. Biol Chem 2012;393:473-84
-
(2012)
Biol Chem
, vol.393
, pp. 473-484
-
-
Esterhazy, D.1
Akpinar, P.2
Stoffel, M.3
-
48
-
-
78649637990
-
BACE2 plays a role in the insulin receptor trafficking in pancreatic beta-cells
-
Casas S, Casini P, Piquer S, et al. BACE2 plays a role in the insulin receptor trafficking in pancreatic beta-cells. Am J Physiol Endocrinol Metab 2010;299:E1087-95
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
-
-
Casas, S.1
Casini, P.2
Piquer, S.3
-
49
-
-
84055223593
-
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
-
Meakin PJ, Harper AJ, Hamilton DL, et al. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. Biochem J 2012;441:285-96
-
(2012)
Biochem J
, vol.441
, pp. 285-296
-
-
Meakin, P.J.1
Harper, A.J.2
Hamilton, D.L.3
-
50
-
-
24744449320
-
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice
-
DOI 10.1074/jbc.M505249200
-
Dominguez D, Tournoy J, Hartmann D, et al. Phenotypic and biochemical analyses of BACE1-and BACE2-deficient mice. J Biol Chem 2005;280:30797-806 (Pubitemid 41291810)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.35
, pp. 30797-30806
-
-
Dominguez, D.1
Tournoy, J.2
Hartmann, D.3
Huth, T.4
Cryns, K.5
Deforce, S.6
Serneels, L.7
Camacho, I.E.8
Marjaux, E.9
Craessaerts, K.10
Roebroek, A.J.M.11
Schwake, M.12
D'Hooge, R.13
Bach, P.14
Kalinke, U.15
Moechars, D.16
Alzheimer, C.17
Reiss, K.18
Saftig, P.19
De Strooper, B.20
more..
-
51
-
-
84887031752
-
Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
-
Accepted Article
-
Van Bebber F, Hruscha A, Willem M, et al. Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. J Neurochem 2013; Accepted Article
-
(2013)
J Neurochem
-
-
Van Bebber, F.1
Hruscha, A.2
Willem, M.3
-
52
-
-
84856541277
-
Rare variants in APP PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families
-
Cruchaga C, Haller G, Chakraverty S, et al. Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. PLoS One 2012;7(5):10
-
(2012)
PLoS One
, vol.7
, Issue.5
, pp. 10
-
-
Cruchaga, C.1
Haller, G.2
Chakraverty, S.3
-
53
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson T, Atwal JK, Steinberg S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012;488:96-9
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
-
54
-
-
79959444149
-
Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds
-
Southan C, Boppana K, Jagarlapudi SAA, Muresan S. Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: ranking 1654 human protein targets by assayed compounds and molecular scaffolds. J Cheminform 2011;3:14
-
(2011)
J Cheminform
, vol.3
, pp. 14
-
-
Southan, C.1
Boppana, K.2
Saa, J.3
Muresan, S.4
-
55
-
-
84867583311
-
Identification of BACE2 as an avid beta-amyloid-degrading protease
-
Abdul-Hay SO, Sahara T, McBride M, et al. Identification of BACE2 as an avid beta-amyloid-degrading protease. Mol Neurodegener 2012;7:46
-
(2012)
Mol Neurodegener
, vol.7
, pp. 46
-
-
Abdul-Hay, S.O.1
Sahara, T.2
McBride, M.3
-
56
-
-
84862999162
-
Type 2 diabetes and cognitive impairment: Linking mechanisms
-
Luchsinger JA. Type 2 diabetes and cognitive impairment: linking mechanisms. J Alzheimer's Dis 2012;30(Suppl):2
-
(2012)
J Alzheimer's Dis
, vol.30
, Issue.SUPPL.
, pp. 2
-
-
Luchsinger, J.A.1
|