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Volumn 23, Issue 5, 2013, Pages 649-663

BACE2 as a new diabetes target: A patent review (2010-2012)

Author keywords

BACE1; BACE2; Diabetes; IC50s; Inhibitors; TMEM27

Indexed keywords

1,3 OXAZINE DERIVATIVE; AMIDE; ANTIDIABETIC AGENT; ASPARTIC PROTEINASE INHIBITOR; BETA SECRETASE 1; BETA SECRETASE 2; BETA SECRETASE 2 INHIBITOR; HETEROCYCLIC COMPOUND; PYRIMIDINE DERIVATIVE; SULFONE DERIVATIVE; THIAZEPINE DERIVATIVE; THIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84876545164     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2013.780032     Document Type: Review
Times cited : (17)

References (56)
  • 2
    • 80054084051 scopus 로고    scopus 로고
    • Pharmacological management of type 2 diabetes mellitus: An update
    • El-Kaissi S, Sherbeeni S. Pharmacological management of type 2 diabetes mellitus: an update. Curr Diabetes Rev 2011;7:392-405
    • (2011) Curr Diabetes Rev , vol.7 , pp. 392-405
    • El-Kaissi, S.1    Sherbeeni, S.2
  • 3
    • 80052723784 scopus 로고    scopus 로고
    • Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass
    • Esterhazy D, Stutzer I, Wang H, et al. Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab 2011;14:365-77
    • (2011) Cell Metab , vol.14 , pp. 365-377
    • Esterhazy, D.1    Stutzer, I.2    Wang, H.3
  • 4
    • 33644875891 scopus 로고    scopus 로고
    • Tmem27: A cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation
    • Akpinar P, Kuwajima S, Krutzfeldt J, Stoffel M. Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab 2005;2:385-97
    • (2005) Cell Metab , vol.2 , pp. 385-397
    • Akpinar, P.1    Kuwajima, S.2    Krutzfeldt, J.3    Stoffel, M.4
  • 5
    • 61449134171 scopus 로고    scopus 로고
    • BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells
    • Finzi G, Franzi F, Placidi C, et al. BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells. Ultrastruct Pathol 2008;32:246-51
    • (2008) Ultrastruct Pathol , vol.32 , pp. 246-251
    • Finzi, G.1    Franzi, F.2    Placidi, C.3
  • 7
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar R, Bennett B, Babu-Khan S, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (New York, N.Y.) 1999;286:735-41
    • (1999) Science (New York, N.Y) , vol.286 , pp. 735-741
    • Vassar, R.1    Bennett, B.2    Babu-Khan, S.3
  • 8
    • 0033518264 scopus 로고    scopus 로고
    • Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
    • Yan R, Bienkowski M, Shuck M, et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 1999;402:533-7
    • (1999) Nature , vol.402 , pp. 533-537
    • Yan, R.1    Bienkowski, M.2    Shuck, M.3
  • 9
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein beta-secretase from human brain
    • Sinha S, Anderson J, Barbour R, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 1999;402:537-40
    • (1999) Nature , vol.402 , pp. 537-540
    • Sinha, S.1    Anderson, J.2    Barbour, R.3
  • 12
    • 0033970139 scopus 로고    scopus 로고
    • The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region
    • DOI 10.1016/S0014-5793(00)01192-3, PII S0014579300011923
    • Acquati F, Accarino M, Nucci C, et al. The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region. FEBS Lett 2000;468:59-64 (Pubitemid 30101682)
    • (2000) FEBS Letters , vol.468 , Issue.1 , pp. 59-64
    • Acquati, F.1    Accarino, M.2    Nucci, C.3    Fumagalli, P.4    Jovine, L.5    Ottolenghi, S.6    Taramelli, R.7
  • 16
    • 84655162702 scopus 로고    scopus 로고
    • Developing beta-secretase inhibitors for treatment of Alzheimer's disease
    • Ghosh AK, Brindisi M, Tang J. Developing beta-secretase inhibitors for treatment of Alzheimer's disease. J Neurochem 2012;120(Suppl):71-83
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. , pp. 71-83
    • Ghosh, A.K.1    Brindisi, M.2    Tang, J.3
  • 17
    • 84861512510 scopus 로고    scopus 로고
    • Small-molecule BACE1 inhibitors: A patent literature review 2006-2011
    • Probst G, Xu YZ. Small-molecule BACE1 inhibitors: a patent literature review (2006-2011). Expert Opin Ther Pat 2012;22:511-40
    • (2012) Expert Opin Ther Pat , vol.22 , pp. 511-540
    • Probst, G.1    Xu, Y.Z.2
  • 19
    • 84876536086 scopus 로고    scopus 로고
    • EPO-Espacenet Available from [Acessed January 2013]
    • EPO-Espacenet. Available from: http://worldwide.espacenet.com/ advancedSearch? locale=en-EP [Acessed January 2013]
  • 20
    • 84876559583 scopus 로고    scopus 로고
    • Available from [Acessed January 2013]
    • WIPO PATENTSCOPE. Available from: http://patentscope.wipo.int/search/en/ search.jsf [Acessed January 2013]
    • WIPO Patentscope
  • 21
    • 84876527014 scopus 로고    scopus 로고
    • Available from [Acessed January 2013]
    • FPO IP Research & Communities. Available from: http://www. freepatentsonline.com/[Acessed January 2013]
    • FPO IP Research & Communities
  • 22
    • 84876553834 scopus 로고    scopus 로고
    • Available from [Acessed January 2013]
    • Europe PubMed Central. Available from: http://europepmc.org/[Acessed January 2013]
    • Europe Pub Med Central
  • 23
    • 84876555593 scopus 로고    scopus 로고
    • Available from [Acessed January 2013]
    • SureChemOpen. Available from: https://open.surechem.com/en/[Acessed January 2013]
    • Sure Chem Open
  • 24
    • 84876530579 scopus 로고    scopus 로고
    • InChI in the wild: An Assessment of InChIKey searching in Google
    • Southan C. InChI in the wild: an Assessment of InChIKey searching in Google. J Cheminform 2013;5:10
    • (2013) J Cheminform , vol.5 , pp. 10
    • Southan, C.1
  • 25
    • 84872265994 scopus 로고    scopus 로고
    • Available from [Acessed January 2013]
    • The PubChem Project. Available from: http://pubchem.ncbi.nlm.nih.gov/ [Acessed January 2013]
    • The Pub Chem Project
  • 26
    • 84876523261 scopus 로고    scopus 로고
    • Available from [Acessed January 2013]
    • ChEMBLdb. Available from: https://www.ebi.ac.uk/chembldb/index.php [Acessed January 2013]
    • ChEMBLdb
  • 47
    • 84861388554 scopus 로고    scopus 로고
    • Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2
    • Esterhazy D, Akpinar P, Stoffel M. Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2. Biol Chem 2012;393:473-84
    • (2012) Biol Chem , vol.393 , pp. 473-484
    • Esterhazy, D.1    Akpinar, P.2    Stoffel, M.3
  • 48
    • 78649637990 scopus 로고    scopus 로고
    • BACE2 plays a role in the insulin receptor trafficking in pancreatic beta-cells
    • Casas S, Casini P, Piquer S, et al. BACE2 plays a role in the insulin receptor trafficking in pancreatic beta-cells. Am J Physiol Endocrinol Metab 2010;299:E1087-95
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Casas, S.1    Casini, P.2    Piquer, S.3
  • 49
    • 84055223593 scopus 로고    scopus 로고
    • Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
    • Meakin PJ, Harper AJ, Hamilton DL, et al. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. Biochem J 2012;441:285-96
    • (2012) Biochem J , vol.441 , pp. 285-296
    • Meakin, P.J.1    Harper, A.J.2    Hamilton, D.L.3
  • 51
    • 84887031752 scopus 로고    scopus 로고
    • Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
    • Accepted Article
    • Van Bebber F, Hruscha A, Willem M, et al. Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. J Neurochem 2013; Accepted Article
    • (2013) J Neurochem
    • Van Bebber, F.1    Hruscha, A.2    Willem, M.3
  • 52
    • 84856541277 scopus 로고    scopus 로고
    • Rare variants in APP PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families
    • Cruchaga C, Haller G, Chakraverty S, et al. Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. PLoS One 2012;7(5):10
    • (2012) PLoS One , vol.7 , Issue.5 , pp. 10
    • Cruchaga, C.1    Haller, G.2    Chakraverty, S.3
  • 53
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • Jonsson T, Atwal JK, Steinberg S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012;488:96-9
    • (2012) Nature , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3
  • 54
    • 79959444149 scopus 로고    scopus 로고
    • Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds
    • Southan C, Boppana K, Jagarlapudi SAA, Muresan S. Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: ranking 1654 human protein targets by assayed compounds and molecular scaffolds. J Cheminform 2011;3:14
    • (2011) J Cheminform , vol.3 , pp. 14
    • Southan, C.1    Boppana, K.2    Saa, J.3    Muresan, S.4
  • 55
    • 84867583311 scopus 로고    scopus 로고
    • Identification of BACE2 as an avid beta-amyloid-degrading protease
    • Abdul-Hay SO, Sahara T, McBride M, et al. Identification of BACE2 as an avid beta-amyloid-degrading protease. Mol Neurodegener 2012;7:46
    • (2012) Mol Neurodegener , vol.7 , pp. 46
    • Abdul-Hay, S.O.1    Sahara, T.2    McBride, M.3
  • 56
    • 84862999162 scopus 로고    scopus 로고
    • Type 2 diabetes and cognitive impairment: Linking mechanisms
    • Luchsinger JA. Type 2 diabetes and cognitive impairment: linking mechanisms. J Alzheimer's Dis 2012;30(Suppl):2
    • (2012) J Alzheimer's Dis , vol.30 , Issue.SUPPL. , pp. 2
    • Luchsinger, J.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.