Use of antiplatelet agents in sepsis: A glimpse into the future

Thrombosis Research

Volumn 133, Issue 2, 2014, Pages 131-138

  Akinosoglou, Karolina ^a   Alexopoulos, Dimitrios ^a  

^a University General Hospital of Patras   (Greece)

Author keywords

Antiplatelet agents; GPIIb IIIa antagonists; P2Y12 inhibitors; Platelets; Sepsis

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CILOSTAZOL; CLOPIDOGREL; DIPYRIDAMOLE; FIBRINOGEN RECEPTOR ANTAGONIST; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y12 RECEPTOR ANTAGONIST; TICLOPIDINE; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ADAPTIVE IMMUNITY; BLOOD CLOTTING; CRITICALLY ILL PATIENT; DRUG INDICATION; ENDOTHELIUM CELL; HUMAN; INFLAMMATION; INTENSIVE CARE UNIT; MORTALITY; NONHUMAN; PATHOPHYSIOLOGY; PNEUMONIA; PREVALENCE; PRIORITY JOURNAL; REVIEW; SEPSIS; THROMBOCYTE FUNCTION;

15-EPI-LIPOXIN A4; A DISINTEGRIN AND METALLOPROTEINASE WITH A THROMBOSPONDIN TYPE 1 MOTIF, MEMBER 13; ACETYLSALICULIC ACID; ACUTE LUNG INJURY; ACUTE RESPIRATORY DISTRESS SYNDROME; ADAMTS-13; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADP; ALI; ANTIPLATELET AGENTS; ARDS; ASA; ATL; ATP; C-REACTIVE PROTEIN; C4B; CABG; CAP; COMMUNITY ACQUIRED PNEUMONIA; COMPLEMENT COMPONENT 4B; CORONARY ARTERY BYPASS GRAFTING; COX; CRP; CYCLOXYGENASE; DIC; DISSEMINATED INTRAVASCULAR COAGULATION; ENDOGENOUS NITRIC OXIDE SYNTHASE; ENOS; ERK1; EXTRA CELLULAR SIGNAL KINASE 1; GLYCOPROTEIN; GP; GPIIB/IIIA ANTAGONISTS; ICU; IL-#; IL-10R; INDUCIBLE NITRIC OXIDE SYNTHASE; INOS; INTENSIVE CARE UNIT; INTERLEUKINE #; INTERLEUKINE 10 RECEPTOR; LEUKOTRIENE B4 RECEPTOR; LIPOPOLYSACCCHARIDE; LPS; LTB4R; MACROPHAGE INFLAMMATORY PROTEIN-1ALPHA; MIP-1A; MOF; MULTIPLE ORGAN FAILURE; NET; NEUTROPHIL EXTRACELLULAR TRAP; NFΚB; NITROGEN OXIDE; NO; NUCLEAR FACTOR KAPPA-LIGHT-CHAIN-ENHANCER OF ACTIVATED B CELLS; P-SELECTIN GLYCOPROTEIN LIGAND-1; P2Y12 INHIBITORS; PAF; PLATELET ACTIVATING FACTOR; PLATELET INHIBITION AND CLINICAL OUTCOMES; PLATELETS; PLATO; PMN; POLYMORPHONUCLEAR CELLS; PSGL-1; RANTES; REACTIVE OXYGEN SPECIES; REGULATED ON ACTIVATION, NORMAL T CELL EXPRESSED AND SECRETED; ROS; SEPSIS; SIRS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T-CELL RECEPTOR; TCR; TF; TISSUE FACTOR; TLR; TNF ALPHA; TOLL-LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VON WILLEBRAND FACTOR; VWF;

ANIMALS; ASPIRIN; BLOOD PLATELETS; HUMANS; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2Y12; SEPSIS;

EID: 84892366147     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.07.002     Document Type: Review

References (76)

1. D.C. Angus, W.T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M.R. Pinsky Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 2001 1303 1310
2. C. Alberti, C. Brun-Buisson, S. Chevret, M. Antonelli, S.V. Goodman, and C. Martin et al. Systemic inflammatory response and progression to severe sepsis in critically ill infected patients Am J Respir Crit Care Med 171 2005 461 468
3. S. Russwurm, J. Vickers, A. Meier-Hellmann, P. Spangenberg, D. Bredle, and K. Reinhart et al. Platelet and leukocyte activation correlate with the severity of septic organ dysfunction Shock 17 2002 263 268
4. J.L. Vincent, A. Yagushi, and O. Pradier Platelet function in sepsis Crit Care Med 30 2002 S313 S317
5. J.N. Katz, K.P. Kolappa, and R.C. Becker Beyond thrombosis: the versatile platelet in critical illness Chest 139 2011 658 668
6. A.S. Weyrich, and G.A. Zimmerman Platelets: signaling cells in the immune continuum Trends Immunol 25 2004 489 495
7. S.W. Kerrigan, and D. Cox Platelet-bacterial interactions Cell Mol Life Sci 67 2010 513 523
8. E. Christaki, P. Anyfanti, and S.M. Opal Immunomodulatory therapy for sepsis: an update Expert Rev Anti Infect Ther 9 2011 1013 1033
9. M.W. Behan, D.P. Chew, and P.E. Aylward The role of antiplatelet therapy in the secondary prevention of coronary artery disease Curr Opin Cardiol 25 2010 321 328
10. J.B. Muhlestein Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients Thromb Haemost 103 2010 71 82
11. J.W. Semple, J.E. Italiano Jr., and J. Freedman Platelets and the immune continuum Nat Rev Immunol 11 2011 264 274
12. T.E. Warkentin, W.C. Aird, and J.H. Rand Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome Hematology Am Soc Hematol Educ Program 2003 497 519
13. A.J. Reininger, M.A. Korndorfer, and L.J. Wurzinger Adhesion of ADP-activated platelets to intact endothelium under stagnation point flow in vitro is mediated by the integrin alphaIIbeta3 Thromb Haemost 79 1998 998 1003
14. T. Bombeli, B.R. Schwartz, and J.M. Harlan Adhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), alphavbeta3 integrin, and GPIbalpha J Exp Med 187 1998 329 339
15. M. Czabanka, C. Peter, E. Martin, and A. Walther Microcirculatory endothelial dysfunction during endotoxemia-insights into pathophysiology, pathologic mechanisms and clinical relevance Curr Vasc Pharmacol 5 2007 266 275
16. T.G. Diacovo, S.J. Roth, J.M. Buccola, D.F. Bainton, and T.A. Springer Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18 Blood 88 1996 146 157
17. R.J. Freishtat, J. Natale, A.S. Benton, J. Cohen, M. Sharron, and A.A. Wiles et al. Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity Am J Respir Crit Care Med 179 2009 467 473
18. J. Boldt, T. Menges, M. Wollbruck, S. Sonneborn, and G. Hempelmann Platelet function in critically ill patients Chest 106 1994 899 903
19. M. Gawaz, T. Dickfeld, C. Bogner, S. Fateh-Moghadam, and F.J. Neumann Platelet function in septic multiple organ dysfunction syndrome Intensive Care Med 23 1997 379 385
20. D. Johansson, O. Shannon, and M. Rasmussen Platelet and neutrophil responses to Gram positive pathogens in patients with bacteremic infection PLoS One 6 2011 e26928
21. C. Matera, C. Falzarano, L. Berrino, and F. Rossi Effects of tetanus toxin, Salmonella typhimurium porin, and bacterial lipopolysaccharide on platelet aggregation J Med 23 1992 327 338
22. E. Isogai, H. Kitagawa, H. Isogai, T. Matsuzawa, T. Shimizu, and Y. Yanagihara et al. Effects of leptospiral lipopolysaccharide on rabbit platelets Zentralbl Bakteriol. 271 1989 186 196
23. H. Itoh, C. Cicala, G.J. Douglas, and C.P. Page Platelet accumulation induced by bacterial endotoxin in rats Thromb Res 83 1996 405 419
24. H.I. Saba, S.R. Saba, G. Morelli, and R.C. Hartmann Endotoxin-mediated inhibition of human platelet aggregation Thromb Res 34 1984 19 33
25. J.R. Sheu, G. Hsiao, C. Lee, W. Chang, L.W. Lee, and C.H. Su et al. Antiplatelet activity of Staphylococcus aureus lipoteichoic acid is mediated through a cyclic AMP pathway Thromb Res 99 2000 249 258
26. A.C. Mavrommatis, T. Theodoridis, A. Orfanidou, C. Roussos, V. Christopoulou-Kokkinou, and S. Zakynthinos Coagulation system and platelets are fully activated in uncomplicated sepsis Crit Care Med 28 2000 451 457
27. A. Yaguchi, O. Pradier, S. Lobo, and J.L. Vincent Platelet aggregation is impaired at the level of cyclooxygenase and thromboxane synthetase in severe sepsis Intensive Care Med 27 2001 S166
28. T. Morris, M. Stables, A. Hobbs, P. de Souza, P. Colville-Nash, and T. Warner et al. Effects of low-dose aspirin on acute inflammatory responses in humans J Immunol 183 2009 2089 2096
29. B. Jilma, A. Blann, T. Pernerstorfer, P. Stohlawetz, H.G. Eichler, and B. Vondrovec et al. Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin Am J Respir Crit Care Med 159 1999 857 863
30. T. Pernerstorfer, R. Schmid, C. Bieglmayer, H.G. Eichler, S. Kapiotis, and B. Jilma Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial Clin Pharmacol Ther 66 1999 51 57
31. L.B. Hinshaw, L.A. Solomon, E.G. Erdos, D.A. Reins, and B.J. Gunter Effects of acetylsalicylic acid on the canine response to endotoxin J Pharmacol Exp Ther 157 1967 665 671
32. P.V. Halushka, W.C. Wise, and J.A. Cook Protective effects of aspirin in endotoxic shock J Pharmacol Exp Ther 218 1981 464 469
33. U. Derhaschnig, I. Schweeger-Exeli, C. Marsik, F. Cardona, P. Minuz, and B. Jilma Effects of aspirin and NO-aspirin (NCX 4016) on platelet function and coagulation in human endotoxemia Platelets 21 2010 320 328
34. P. del Soldato, R. Sorrentino, and A. Pinto NO-aspirins: a class of new anti-inflammatory and antithrombotic agents Trends Pharmacol Sci 20 1999 319 323
35. C. Lechi, G. Andrioli, S. Gaino, R. Tommasoli, V. Zuliani, and R. Ortolani et al. The antiplatelet effects of a new nitroderivative of acetylsalicylic acid-an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production Thromb Haemost 76 1996 791 798
36. J. Winning, J. Neumann, M. Kohl, R.A. Claus, K. Reinhart, and M. Bauer et al. Antiplatelet drugs and outcome in mixed admissions to an intensive care unit Crit Care Med 38 2010 32 37
37. J. Winning, J. Reichel, Y. Eisenhut, J. Hamacher, M. Kohl, and H.P. Deigner et al. Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms Platelets 20 2009 50 57
38. D.P. Eisen, D. Reid, and E.S. McBryde Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis Crit Care Med 40 2012 1761 1767
39. M. Sossdorf, G.P. Otto, J. Boettel, J. Winning, and W. Losche Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients Crit Care 17 2013 402
40. G.P. Otto, M. Sossdorf, J. Boettel, B. Kabisch, H. Breuel, and J. Winning et al. Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock Platelets Sep. 20 2012 [Epub ahead of print]
41. J.M. Erlich, D.S. Talmor, R. Cartin-Ceba, O. Gajic, and D.J. Kor Prehospitalization antiplatelet therapy is associated with a reduced incidence of acute lung injury: a population-based cohort study Chest 139 2011 289 295
42. J.C. Valerio-Rojas, I.J. Jaffer, D.J. Kor, O. Gajic, and R. Cartin-Ceba Outcomes of severe sepsis and septic shock patients on chronic antiplatelet treatment: a historical cohort study Crit Care Res Pract 2013 2013 782573
43. W. Losche, J. Boettel, B. Kabisch, J. Winning, R.A. Claus, and M. Bauer Do aspirin and other antiplatelet drugs reduce the mortality in critically ill patients? Thrombosis 2012 2012 720254
44. C.D. Goff, R.S. Corbin, S.D. Theiss, H.F. Frierson Jr., G.A. Cephas, and C.G. Tribble et al. Postinjury thromboxane receptor blockade ameliorates acute lung injury Ann Thorac Surg 64 1997 826 829
45. A. Zarbock, K. Singbartl, and K. Ley Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation J Clin Invest 116 2006 3211 3219
46. M.R. Looney, J.X. Nguyen, Y. Hu, J.A. Van Ziffle, C.A. Lowell, and M.A. Matthay Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury J Clin Invest 119 2009 3450 3461
47. D.J. Kor, J. Erlich, M.N. Gong, M. Malinchoc, R.E. Carter, and O. Gajic et al. Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients Crit Care Med 39 2011 2393 2400
48. H.R. O'Neal Jr., T. Koyama, E.A. Koehler, E. Siew, B.R. Curtis, and R.D. Fremont et al. Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome Crit Care Med 39 2011 1343 1350
49. R.F. Storey Biology and pharmacology of the platelet P2Y12 receptor Curr Pharm Des 12 2006 1255 1259
50. R.T. Dorsam, and S.P. Kunapuli Central role of the P2Y12 receptor in platelet activation J Clin Invest 113 2004 340 345
51. V. Evangelista, S. Manarini, G. Dell'Elba, N. Martelli, E. Napoleone, and A. Di Santo et al. Clopidogrel inhibits platelet-leukocyte adhesion and platelet-dependent leukocyte activation Thromb Haemost 94 2005 568 577
52. J. Winning, J. Baranyai, R. Claus, I. Eisenhut, J. Hamacher, and K. Reinhart et al. Beneficial effects of antiplatelet drugs in patients with community-acquired pneumonia and in endotoxin shock in mice Crit Care 11 2007 P27
53. V. Evangelista, G. dell'Elba, N. Martelli, C. Amore, R. Pecce, and A. Piccoli et al. Anti-inflammatory effects of clopidogrel in the mouse J Thromb Haemost 5 2007 [P-M-283]
54. R. Aslam, E.R. Speck, M. Kim, A.R. Crow, K.W. Bang, and F.P. Nestel et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo Blood 107 2006 637 641
55. F. Setzer, V. Oberle, M. Blass, E. Moller, S. Russwurm, and H.P. Deigner et al. Platelet-derived microvesicles induce differential gene expression in monocytic cells: a DNA microarray study Platelets 17 2006 571 576
56. A.L. Frelinger III, J.A. Jakubowski, Y. Li, M.R. Barnard, M.L. Fox, and M.D. Linden et al. The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin Thromb Haemost 98 2007 192 200
57. L. Totani, G. Dell'Elba, N. Martelli, A. Di Santo, A. Piccoli, and C. Amore et al. Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse Thromb Haemost 107 2012 1130 1140
58. A.K. Gross, S.P. Dunn, D.J. Feola, C.A. Martin, R. Charnigo, and Z. Li et al. Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness J Thromb Thrombolysis 35 2013 147 154
59. C. Varenhorst, U. Alstrom, B.M. Scirica, C.W. Hogue, N. Asenblad, and R.F. Storey et al. Factors contributing to the lower mortality with ticagrelor compared with clopidogrel in patients undergoing coronary artery bypass surgery J Am Coll Cardiol 60 2012 1623 1630
60. R. Storey, P. Steg, S. James, S. Husted, C. Cannon, and R. Becker et al. Reduction in pulmonary adverse events and associated sepsis and mortality in acute coronary syndrome patients treated with ticagrelor compared to clopidogrel: a post hoc analysis of the plato study J Am Coll Cardiol 59 2012 E482
61. O. Braun, M. Rahman, D. Gustafsson, and H. Thorlacius Ticagrelor Reduces Neutrophil Recruitment and Lung Damage in Abdominal Sepsis J Am Coll Cardiol 61 2013 10S
62. V.L. Serebruany Mortality benefit in PLATO cannot be explained by antiplatelet properties of ticagrelor Cardiology 117 2010 231 233
63. B.S. Coller Blockade of platelet GPIIb/IIIa receptors as an antithrombotic strategy Circulation 92 1995 2373 2380
64. Q. Pu, E. Wiel, D. Corseaux, R. Bordet, M.A. Azrin, and M.D. Ezekowitz et al. Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endotoxin-induced shock Crit Care Med 29 2001 1181 1188
65. F.B. Taylor, B.S. Coller, A.C. Chang, G. Peer, R. Jordan, and W. Engellener et al. 7E3 F(ab')2, a monoclonal antibody to the platelet GPIIb/IIIa receptor, protects against microangiopathic hemolytic anemia and microvascular thrombotic renal failure in baboons treated with C4b binding protein and a sublethal infusion of Escherichia coli Blood 89 1997 4078 4084
66. A. Walther, M. Czabanka, M.M. Gebhard, and E. Martin Glycoprotein IIB/IIIA-inhibition and microcirculatory alterations during experimental endotoxemia-an intravital microscopic study in the rat Microcirculation 11 2004 79 88
67. M. Sharron, C.E. Hoptay, A.A. Wiles, L.M. Garvin, M. Geha, and A.S. Benton et al. Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade PLoS One 7 2012 e41549
68. U. Derhaschnig, C. Pachinger, I. Schweeger-Exeli, C. Marsik, and B. Jilma Blockade of GPIIb/IIIa by eptifibatide and tirofiban does not alter tissue factor induced thrombin generation in human endotoxemia Thromb Haemost 90 2003 1054 1060
69. C. Gonano, C. Sitzwohl, E. Meitner, C. Weinstabl, and S.C. Kettner Four-day antithrombin therapy does not seem to attenuate hypercoagulability in patients suffering from sepsis Crit Care 10 2006 R160
70. G. Luckner, V.D. Mayr, D.R. Fries, P. Innerhofer, S. Jochberger, and W.R. Hasibeder et al. Uncovering hypercoagulability in sepsis using ROTEMthromboelastometry: a case series Open Crit Care Med 1 2008 1 6
71. M. Seidel, J. Winning, R.A. Claus, M. Bauer, and W. Losche Beneficial effect of clopidogrel in a mouse model of polymicrobial sepsis J Thromb Haemost 7 2009 1030 1032
72. M. Reinhofer, M. Brauer, U. Franke, D. Barz, G. Marx, and W. Losche The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass Blood Coagul Fibrinolysis 19 2008 212 219
73. A.O. Spiel, U. Derhaschnig, M. Schwameis, J. Bartko, J.M. Siller-Matula, and B. Jilma Effects of prasugrel on platelet inhibition during systemic endotoxaemia: a randomized controlled trial Clin Sci (Lond) 123 2012 591 600
74. E. Blasco-Colmenares, T.M. Perl, E. Guallar, W.A. Baumgartner, J.V. Conte, and D. Alejo et al. Aspirin plus clopidogrel and risk of infection after coronary artery bypass surgery Arch Intern Med 169 2009 788 796
75. Z.A. Almsherqi, C.S. McLachlan, and S.M. Sharef Non-bleeding side effects of clopidogrel: have large multi-center clinical trials underestimated their incidence? Int J Cardiol 117 2007 415 417
76. R. Cartin-Ceba, J. Valerio-Rojas, J. Cabello-Garza, D. Kelm, and O. Gajic Antiplatelet Therapy And Disseminated Intravascular Coagulation In Septic Shock Patients: Propensity Score Analysis Am J Respir Crit Care Med 183 2011 A4698