Factors contributing to the lower mortality with ticagrelor compared with clopidogrel in patients undergoing coronary artery bypass surgery

Journal of the American College of Cardiology

Volumn 60, Issue 17, 2012, Pages 1623-1630

  Varenhorst, Christoph ^a   Alström, Ulrica ^a   Scirica, Benjamin M ^b   Hogue, Charles W ^c   Åsenblad, Nils ^a   Storey, Robert F ^d   Steg, Ph Gabriel ^e,f   Horrow, Jay ^g   Mahaffey, Kenneth W ^h   Becker, Richard C ^h   James, Stefan ^a   Cannon, Christopher P ^b   Brandrup Wognsen, Gunnar ⁱ   Wallentin, Lars ^a   Held, Claes ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

^e BICHAT HOSPITAL   (France)

^f INSERM   (France)

^g ASTRAZENECA   (United Kingdom)

^h DUKE CLINICAL RESEARCH INSTITUTE   (United States)

ⁱ ASTRAZENECA R AND D   (Sweden)

Author keywords

bypass; clopidogrel; myocardial infarction; surgery; ticagrelor

Indexed keywords

CLOPIDOGREL; PLACEBO; PRASUGREL; TICAGRELOR;

ADULT; AGED; ANAMNESIS; ANGINA PECTORIS; ARTICLE; BLEEDING; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CARDIOVASCULAR MORTALITY; CHRONIC KIDNEY DISEASE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; DOUBLE BLIND PROCEDURE; FEMALE; HEART ARRHYTHMIA; HEART FAILURE; HEART INFARCTION; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; RACE DIFFERENCE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; SUDDEN DEATH; TRANSIENT ISCHEMIC ATTACK;

ACUTE CORONARY SYNDROME; ADENOSINE; CORONARY ARTERY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; EUROPE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; PROSPECTIVE STUDIES; PURINERGIC P2Y RECEPTOR ANTAGONISTS; SURVIVAL RATE; TICLOPIDINE; TREATMENT OUTCOME;

EID: 84867582405     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.07.021     Document Type: Article

References (23)

1. L. Wallentin, R.C. Becker, A. Budaj Ticagrelor versus clopidogrel in patients with acute coronary syndromes N Engl J Med 361 2009 1045 1057
2. C. Held, N. Asenblad, J.P. Bassand Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial J Am Coll Cardiol 57 2011 672 684
3. D.J. Schneider Mechanisms potentially contributing to the reduction in mortality associated with ticagrelor therapy J Am Coll Cardiol 57 2011 685 687
4. S. James, A. Akerblom, C.P. Cannon Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial Am Heart J 157 2009 599 605
5. K.A. Eagle, R.A. Guyton, R. Davidoff ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery) J Am Coll Cardiol 44 2004 e213 e310
6. J. Dunning, M. Versteegh, A. Fabbri Guideline on antiplatelet and anticoagulation management in cardiac surgery Eur J Cardiothorac Surg 34 2008 73 92
7. S. Husted, H. Emanuelsson, S. Heptinstall, P.M. Sandset, M. Wickens, G. Peters Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin Eur Heart J 27 2006 1038 1047
8. P.A. Gurbel, K.P. Bliden, K. Butler Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study Circulation 120 2009 2577 2585
9. R.F. Storey, K.P. Bliden, R. Ecob Earlier recovery of platelet function after discontinuation of treatment with ticagrelor compared with clopidogrel in patients with high antiplatelet responses J Thromb Haemost 9 2011 1730 1737
10. S. Yende, R.G. Wunderink Effect of clopidogrel on bleeding after coronary artery bypass surgery Crit Care Med 29 2001 2271 2275
11. R.H. Hongo, J. Ley, S.E. Dick, R.R. Yee The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting J Am Coll Cardiol 40 2002 231 237
12. W. Kang, T.E. Theman, J.F. Reed 3rd, J. Stoltzfus, N. Weger The effect of preoperative clopidogrel on bleeding after coronary artery bypass surgery J Surg Educ 64 2007 88 92
13. J.S. Berger, C.B. Frye, Q. Harshaw, F.H. Edwards, S.R. Steinhubl, R.C. Becker Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis J Am Coll Cardiol 52 2008 1693 1701
14. V.A. Ferraris, J.R. Brown, G.J. Despotis 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines Ann Thorac Surg 91 2011 944 982
15. S.S. Nijjer, G. Watson, T. Athanasiou, I.S. Malik Safety of clopidogrel being continued until the time of coronary artery bypass grafting in patients with acute coronary syndrome: a meta-analysis of 34 studies Eur Heart J 32 2011 2970 2978
16. F.G. Kushner, M. Hand, S.C. Smith Jr. 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 gocused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 54 2009 2205 2241
17. J.A. Jakubowski, N. Matsushima, F. Asai A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans Br J Clin Pharmacol 63 2007 421 430
18. S.D. Wiviott, E. Braunwald, C.H. McCabe Prasugrel versus clopidogrel in patients with acute coronary syndromes N Engl J Med 357 2007 2001 2015
19. P.P. Brown, A.D. Kugelmass, D.J. Cohen The frequency and cost of complications associated with coronary artery bypass grafting surgery: results from the United States Medicare program Ann Thorac Surg 85 2008 1980 1986
20. J.N. Katz, K.P. Kolappa, R.C. Becker Beyond thrombosis: the versatile platelet in critical illness Chest 139 2011 658 668
21. M. Seidel, J. Winning, R.A. Claus, M. Bauer, W. Losche Beneficial effect of clopidogrel in a mouse model of polymicrobial sepsis J Thromb Haemost 7 2009 1030 1032
22. E. Blasco-Colmenares, T.M. Perl, E. Guallar Aspirin plus clopidogrel and risk of infection after coronary artery bypass surgery Arch Intern Med 169 2009 788 796
23. Z.A. Almsherqi, C.S. McLachlan, S.M. Sharef Non-bleeding side effects of clopidogrel: have large multi-center clinical trials underestimated their incidence? Int J Cardiol 117 2007 415 417