Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity

American Journal of Respiratory and Critical Care Medicine

Volumn 179, Issue 6, 2009, Pages 467-473

  Freishtat, Robert J ^a,b,c,f   Natale, Joanne ^d,e   S benton, Angela ^b   Cohen, Joanna ^a,c   Sharron, Matthew ^f   Wiles, Andrew A ^b   Ngor, Wai Man ^b   Mojgani, Bahar ^b   Bradbury, Margaret ^b   Degnan, Andrew ^c   Sachdeva, Reecha ^c   Debiase, Lindsay M ^b   Ghimbovschi, Svetlana ^b   Chow, Matthew ^g   Bunag, Clarice ^g   Kristosturyan, Ervand ^h   Hoffman, Eric P ^b,c  

^a Division of Emergency Medicine   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Apoptosis; Blood platelets; Granzyme B; Sepsis

Indexed keywords

GRANZYME B; MESSENGER RNA; GRANZYME; GZMA PROTEIN, HUMAN; GZMB PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; EX VIVO STUDY; GENE EXPRESSION PROFILING; INFLAMMATION; LYMPHOCYTOTOXICITY; LYMPHOID CELL; MEGAKARYOCYTE; MORTALITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEPSIS; SPLEEN CELL; THROMBOCYTE; UNINDEXED SEQUENCE; ADOLESCENT; ANIMAL; CHILD; FEMALE; GENETICS; HOSPITALIZATION; HUMAN; INFANT; MALE; METABOLISM; PATHOLOGY; PRESCHOOL CHILD; SPLEEN;

ADOLESCENT; ANIMALS; APOPTOSIS; BLOOD PLATELETS; CHILD; CHILD, PRESCHOOL; FEMALE; GRANZYMES; HUMANS; INFANT; MALE; MEGAKARYOCYTES; MICE; RNA, MESSENGER; SEPSIS; SEVERITY OF ILLNESS INDEX; SPLEEN;

EID: 63249101191     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200807-1085OC     Document Type: Article

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