Antiplatelet drugs and outcome in mixed admissions to an intensive care unit

Critical Care Medicine

Volumn 38, Issue 1, 2010, Pages 32-37

  Winning, Johannes ^a   Neumann, Jens ^b   Kohl, Matthias ^c   Claus, Ralf A ^a   Reinhart, Konrad ^a   Bauer, Michael ^a   Lösche, Wolfgang ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b Central Hospital Meinigen   (Germany)

^c UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Antiplatelet drugs; Critical illness; Fatal outcome; Multiple organ failure; Sepsis

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL;

ADULT; AGED; ANTICOAGULANT THERAPY; APACHE; ARTERY DISEASE; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BRAIN HEMORRHAGE; CEREBROVASCULAR DISEASE; CHEMOPROPHYLAXIS; COHORT ANALYSIS; DRUG EFFECT; FEMALE; HOSPITAL ADMISSION; HOSPITAL BED CAPACITY; HOSPITAL PATIENT; HUMAN; INJURY SEVERITY; INTENSIVE CARE UNIT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RISK FACTOR; SECONDARY PREVENTION; TERTIARY HEALTH CARE; TREATMENT OUTCOME; VASCULAR DISEASE; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CRITICAL ILLNESS; DRUG UTILIZATION; INTENSIVE CARE; METHODOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PERIPHERAL VASCULAR DISEASE; PROBABILITY; RISK; STATISTICAL MODEL; STATISTICS; STROKE; SURVIVAL; THROMBOSIS;

ADULT; AGED; APACHE; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; COHORT STUDIES; CONFIDENCE INTERVALS; CRITICAL ILLNESS; DRUG UTILIZATION; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PATIENT ADMISSION; PERIPHERAL VASCULAR DISEASES; PLATELET AGGREGATION INHIBITORS; PROBABILITY; RETROSPECTIVE STUDIES; RISK ASSESSMENT; STATISTICS, NONPARAMETRIC; STROKE; SURVIVAL ANALYSIS; THROMBOSIS;

EID: 74049125172     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181b4275c     Document Type: Article

References (27)

1. Vincent JL, Yagushi A, Pradier O: Platelet function in sepsis. Crit Care Med 2002; 30(Suppl):S313-S317
2. Levi M: Platelets in sepsis. Hematology 2005; 10(Suppl 1):129-131
3. Russwurm S, Vickers J, Meier-Hellmann A, et al: Platelet and leukocyte activation correlate with the severity of septic organ dysfunction. Shock 2002; 17:263-268
4. Akca S, Haji-Michael P, de Mendonca A, et al: Time course of platelet counts in critically ill patients. Crit Care Med 2002; 30:753-756
5. Gear AR, Camerini D: Platelet chemokines and chemokine receptors: Linking hemosta-sis, inflammation, and host defense. Microcirculation 2003; 10:335-350
6. Weyrich AS, Zimmerman GA: Platelets: Signaling cells in the immune continuum. Trends Immunol 2004; 25:489-495
7. Bockmeyer CL, Claus RA, Budde U, et al: Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor. Haematologica 2008; 93: 137-140
8. Steinhubl SR: Platelets as mediators of inflammation. Hematol Oncol Clin North Am 2007; 21:115-121
9. Taylor FB, Coller BS, Chang AC, et al: 7E3 F(ab')2, a monoclonal antibody to the platelet GPIIb/IIIa receptor, protects against microangiopathic hemolytic anemia and microvascular thrombotic renal failure in baboons treated with C4b binding protein and a sublethal infusion of Escherichia coli. Blood 1997; 89:4078-4084
10. Pu Q, Wiel E, Corseaux D, et al: Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endotox-in-induced shock. Crit Care Med 2001; 29: 1181-1188
11. Chaer RA, Graham JA, Mureebe L: Platelet function and pharmacologic inhibition. Vasc Endovasc Surg 2006; 40:261-267
12. Storey RF: Biology and pharmacology of the platelet P2Y12 receptor. Curr Pharm Des 2006; 12:1255-1259
13. Lipcsey M, Larsson A, Olovsson M, et al: Early endotoxin-mediated haemostatic and inflammatory responses in the clopidogrel-treated pig. Platelets 2005; 16:408-414
14. Evangelista V, Manarini S, Dell'Elba G, et al: Clopidogrel inhibits platelet-leukocyte adhesion and platelet-dependent leukocyte activation. Thromb Haemost 2005; 94:568-577
15. Evangelista V, dell'Elba G, Martelli N, et al: Anti-inflammatory effects of clopidogrel in the mouse. J Thromb Haemost 2007; 5(Suppl 2):P-M-283
16. Ferguson JJ: The role of oral antiplatelet agents in atherothrombotic disease. Am J Cardiovasc Drugs 2006; 6:149-157
17. Vane JR, Botting RM: The mechanism of action of aspirin. Thromb Res 2003; 110: 255-258
18. Ridker PM, Cushman M, Stampfer MJ, et al: Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336:973-979
19. Ikonomidis I, Andreotti F, Economou E, et al: Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin. Circulation 1999; 100: 793-798
20. Cyrus T, Sung S, Zhao L, et al: Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 2002; 106:1282-1287
21. von Kugelgen I: Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 2006; 110:415-432
22. Fitzpatrick FA: Cyclooxygenase enzymes: Regulation and function. Curr Pharm Des 2004; 10:577-588
23. Weyrich AS, Denis MM, Kuhlmann-Eyre JR, et al: Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates. Circulation 2005; 111:633-642
24. Setzer F, Oberle V, Blaess M, et al: Platelet-derived microvesicles induce differential gene expression in monocytic cells: A DNA microarray study. Platelets 2006; 17:571-576
25. Winning J, Reichel J, Eisenhut Y, et al: Anti-platelet drugs and outcome in severe infection: Clinical impact and underlying mechanisms. Platelets 2009; 20:50-57
26. Samama CM, Bastien O, Forestier F, et al: Antiplatelet agents in the perioperative period: Expert recommendations of the French Society of Anesthesiology and Intensive Care (SFAR) 2001\-Summary statement. Can J Anaesth 2002; 49:S26-S35
27. Chassot PG, Delabays A, Spahn DR: Periop-erative use of anti-platelet drugs. Best Pract Res Clin Anaesthesiol 2007; 21:241-256