Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

Biochemical Journal

Volumn 457, Issue 3, 2014, Pages 369-377

  Murphy, James M ^a,b   Lucet, Isabelle S ^c   Hildebrand, Joanne M ^a,b   Tanzer, Maria C ^a,b   Young, Samuel N ^a   Sharma, Pooja ^a,b   Lessene, Guillaume ^a,b   Alexander, Warren S ^a,b   Babon, Jeffrey J ^a,b   Silke, John ^a,b   Czabotar, Peter E ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

ATP binding; Mixed lineage kinase domain like (MLKL); Necroptosis; Pseudoenzyme; Pseudokinase; Receptor interacting protein kinase 3 (RIPK3)

Indexed keywords

MIXED LINEAGE KINASE DOMAIN LIKE PROTEIN; MUTANT PROTEIN; NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; MOLECULAR EVOLUTION; MUTAGENESIS; NUCLEOTIDE BINDING SITE; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; WILD TYPE; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; EVOLUTION, MOLECULAR; HUMANS; LYSINE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN ENGINEERING; PROTEIN KINASES; PROTEIN STABILITY; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; SEQUENCE ALIGNMENT;

EID: 84892185626     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131270     Document Type: Article

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