Induction of apoptosis by isoegomaketone from Perilla frutescens L. in B16 melanoma cells is mediated through ROS generation and mitochondrial-dependent, -independent pathway

Food and Chemical Toxicology

Volumn 65, Issue , 2014, Pages 97-104

  Kwon, Soon Jae ^a   Lee, Ju Hye ^b   Moon, Kwang Deog ^a   Jeong, Il Yun ^c   Ahn, Dong UK ^d   Lee, Mi Kyung ^b   Seo, Kwon Il ^b  

^a Kyungpook National University   (South Korea)

^b Sunchon National University   (South Korea)

^c Korea Atomic Energy Research Institute   (South Korea)

^d IOWA STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Apoptosis inducing factor; B16 melanoma cells; Isoegomaketone; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE; CYTOCHROME C; ESSENTIAL OIL; ISOEGOMAKETONE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL SURVIVAL; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG DOSE COMPARISON; MALE; MELANOMA B16; MELANOMA CELL; MITOCHONDRION; MOUSE; NONHUMAN; PERILLA FRUTESCENS; UPREGULATION; ANTINEOPLASTIC ACTIVITY; CELL COUNT; CELL PROLIFERATION; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; GROWTH INHIBITION; MELANOMA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; TUMOR VOLUME;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; B16 MELANOMA CELLS; ISOEGOMAKETONE; REACTIVE OXYGEN SPECIES;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; ENZYME ACTIVATION; FURANS; KETONES; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; PERILLA FRUTESCENS; REACTIVE OXYGEN SPECIES;

PERILLA FRUTESCENS;

EID: 84892183922     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.12.031     Document Type: Article

References (40)

1. Candé C., Cohen I., Daugas E., Ravagnan L., Larochette N., Zamzami N., Kroemer G. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie 2002, 84:215-222.
2. Chen C.Y., Liu T.Z., Liu Y.W., Tseng W.C., Liu R.H., Lu F.J., Lin Y.S., Kuo S.H., Chen C.H. 6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism. J. Agric. Food Chem. 2007, 55:948-954. 10.1021/jf0624594.
3. Cho B.O., Jin C.H., Park Y.D., Ryu H.W., Byun M.W., Seo K.I., Jeong I.Y. Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells. Biosci. Biotechnol. Biochem. 2011, 75:1306-1311.
4. Chu Z.L., Pio F., Xie Z., Welsh K., Krajewska M., Krajewski S., Godzik A., Reed J.C. A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J. Biol. Chem. 2001, 276:9239-9245. 10.1074/jbc.M006309200.
5. Donohoe M. Causes and health consequences of environmental degradation and social injustice. Soc. Sci. Med. 2003, 56:573-587.
6. Du C., Fang M., Li Y., Li L., Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000, 102:33-42.
7. Fouad M., Agha A., Merzabani M.A., Shouman S. Resveratrol inhibits proliferation, angiogenesis and induces apoptosis in colon cancer cells Calorie restriction is the force to the cytotoxicity. Hum. Exp. Toxicol. 2013, 32:1067-1080. doi: 10.1177/0960327113475679.
8. Green D.R. Means to an End: Apoptosis and Other Cell Death Mechanisms 2011, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
9. Jerant A.F., Johnson J.T., Sheridan C.D., Caffrey T.J. Early detection and treatment of skin cancer. Am. Fam. Physician 2000, 62. 357-68, 375-6, 381-2.
10. Jin C.H., Lee H.J., Park Y.D., Choi D.S., Kim D.S., Kang S.Y., Seo K.I., Jeong I.Y. Isoegomaketone inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages through the heme oxygenase-1 induction and inhibition of the interferon-beta-STAT-1 pathway. J. Agric. Food Chem. 2010, 58:860-867. 10.1021/jf9033333; 10.1021/jf9033333.
11. Kim J.Y., Park K.W., Moon K.D., Lee M.K., Choi J., Yee S.T., Shim K.H., Seo K.I. Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix. Food Chem. Toxicol. 2008, 46:3753-3758. 10.1016/j.fct.2008.09.067; 10.1016/j.fct.2008.09.067.
12. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat. Med. 2000, 6:513-519.
13. Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007, 87:99-163.
14. Kuo P.L., Hsu Y.L., Chang C.H., Lin C.C. The mechanism of ellipticine-induced apoptosis and cell cycle arrest in human breast MCF-7 cancer cells. Cancer Lett. 2005, 223:293-301. 10.1016/j.canlet.2004.09.046.
15. Lee J.H., Kishikawa M., Kumazoe M., Yamada K., Tachibana H. Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor. PLoS One 2010, 5:e11051. 10.1371/journal.pone.0011051; 10.1371/journal.pone.0011051.
16. Lee J.H., Won Y.S., Park K.H., Lee M.K., Tachibana H., Yamada K., Seo K.I. Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling. Apoptosis 2012, 17:1275-1286. 10.1007/s10495-012-0767-5; 10.1007/s10495-012-0767-5.
17. Looi C.Y., Arya A., Cheah F.K., Muharram B., Leong K.H., Mohamad K., Wong W.F., Rai N., Mustafa M.R. Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PLoS One 2013, 8:e56643. 10.1371/journal.pone.0056643; 10.1371/journal.pone.0056643.
18. Lucas, R., McMichael, T., Smith, W., Armstrong, B., 2006. Environmental Burden of Disease Series 13.
19. Massaoka M.H., Matsuo A.L., Figueiredo C.R., Farias C.F., Girola N., Arruda D.C., Scutti J.A., Romoff P., Favero O.A., Ferreira M.J., Lago J.H., Travassos L.R. Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo. PLoS One 2012, 7:e38698. 10.1371/journal.pone.0038698; 10.1371/journal.pone.0038698.
20. Oh H.A., Park C.S., Ahn H.J., Park Y.S., Kim H.M. Effect of Perilla frutescens var. acuta Kudo and rosmarinic acid on allergic inflammatory reactions. Exp. Biol. Med. (Maywood) 2011, 236:99-106. 10.1258/ebm.2010.010252; 10.1258/ebm.2010.010252.
21. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993, 74:609-619.
22. Park S.Y., Cho S.J., Kwon H.C., Lee K.R., Rhee D.K., Pyo S. Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett. 2005, 224:123-132. 10.1016/j.canlet.2004.10.009.
23. Park Y.D., Jin C.H., Choi D.S., Byun M.W., Jeong I.Y. Biological evaluation of isoegomaketone isolated from Perilla frutescens and its synthetic derivatives as anti-inflammatory agents. Arch. Pharm. Res. 2011, 34:1277-1282. 10.1007/s12272-011-0806-8; 10.1007/s12272-011-0806-8.
24. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA Cancer. J. Clin. 2005, 55:74-108.
25. Perdomo J., Cabrera J., Estevez F., Loro J., Reiter R.J., Quintana J. Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells. J. Pineal Res. 2013, 55:195-206. 10.1111/jpi.12062; 10.1111/jpi.12062.
26. Qiao Y., Xiang Q., Yuan L., Xu L., Liu Z., Liu X. Herbacetin induces apoptosis in HepG2 cells: involvements of ROS and PI3K/Akt pathway. Food Chem. Toxicol. 2013, 51:426-433. 10.1016/j.fct.2012.09.036; 10.1016/j.fct.2012.09.036.
27. Ravindran J., Gupta N., Agrawal M., Bala Bhaskar A.S., Lakshmana Rao P.V. Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. Apoptosis 2011, 16:145-161. 10.1007/s10495-010-0554-0; 10.1007/s10495-010-0554-0.
28. Ricote M., Garcia-Tunon I., Fraile B., Fernandez C., Aller P., Paniagua R., Royuela M. P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells. Apoptosis 2006, 11:1969-1975. 10.1007/s10495-006-0086-9.
29. Seo W.H., Baek H.H. Characteristic aroma-active compounds of Korean perilla (Perilla frutescens Britton) leaf. J. Agric. Food Chem. 2009, 57:11537-11542. 10.1021/jf902669d; 10.1021/jf902669d.
30. Simon H.U., Haj-Yehia A., Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000, 5:415-418.
31. Skehan P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Warren J.T., Bokesch H., Kenney S., Boyd M.R. New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 1990, 82:1107-1112.
32. Tan S., Sagara Y., Liu Y., Maher P., Schubert D. The regulation of reactive oxygen species production during programmed cell death. J. Cell Biol. 1998, 141:1423-1432.
33. Taylor R.C., Cullen S.P., Martin S.J. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 2008, 9:231-241.
34. Tian J., Duan Y.X., Bei C.Y., Chen J. Calycosin induces apoptosis by upregulation of RASD1 in human breast cancer cells MCF-7. Horm. Metab. Res. 2013, 45:593-598. 10.1055/s-0033-1341510; 10.1055/s-0033-1341510.
35. Tsujimoto Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?. Genes Cells 1998, 3:697-707.
36. Wan C.K., Wang C., Cheung H.Y., Yang M., Fong W.F. Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells. Cancer Lett. 2006, 241:31-41. 10.1016/j.canlet.2005.10.001.
37. Wang C.Z., Zhang Z., Huang W.H., Du G.J., Wen X.D., Calway T., Yu C., Nass R., Zhao J., Du W., Li S.P., Yuan C.S. Identification of potential anticancer compounds from Oplopanax horridus. Phytomedicine 2013, 20:999-1006. 10.1016/j.phymed.2013.04.013; 10.1016/j.phymed.2013.04.013.
38. Whited J.D., Grichnik J.M. Does this patient have a mole or a melanoma. JAMA 1998, 279:696-701.
39. Yang E.J., Ku S.K., Lee W., Lee S., Lee T., Song K.S., Bae J.S. Barrier protective effects of rosmarinic acid on HMGB1-induced inflammatory responses in vitro and in vivo. J. Cell. Physiol. 2013, 228:975-982. 10.1002/jcp.24243; 10.1002/jcp.24243.
40. Zhao D., Lin F., Wu X., Zhao Q., Zhao B., Lin P., Zhang Y., Yu X. Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells. Toxicol. In Vitro 2012, 26:595-602. 10.1016/j.tiv.2012.02.004; 10.1016/j.tiv.2012.02.004.