The efficacy of SPA0355 in protecting β cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes

Experimental and Molecular Medicine

Volumn 45, Issue 11, 2013, Pages

  Bae, Ui Jin ^a   Song, Mi Young ^a   Jang, Hyun Young ^a   Gim, Hyo Jin ^b   Ryu, Jae Ha ^b   Lee, Sang Myeong ^c   Jeon, Raok ^b   Park, Byung Hyun ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

Cytokine; NF kB; SPA0355; STAT; Type 1 diabetes; cell

Indexed keywords

1 METHYL 3 [4 (2 PHENOXAZIN 10 YLETHOXY)PHENYL]THIOUREA; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE; SPA 0355; UNCLASSIFIED DRUG; BENZOXAZINE DERIVATIVE; SPA0355; THIOUREA; DRUG DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; GENETIC TRANSCRIPTION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS;

ANIMALS; APOPTOSIS; BENZOXAZINES; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; INSULIN-SECRETING CELLS; JANUS KINASES; MICE; MICE, INBRED NOD; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RATS; THIOUREA;

EID: 84892157409     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2013.109     Document Type: Article

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