Sulfuretin protects against cytokine-induced β-cell damage and prevents streptozotocin-induced diabetes

Experimental and Molecular Medicine

Volumn 42, Issue 9, 2010, Pages 628-638

  Song, Mi Young ^a   Jeong, Gil Saeng ^b   Kwon, Kang Beom ^c   Ka, Sun O ^a   Jang, Hyun Young ^a   Park, Jin Woo ^a   Kim, Youn Chul ^b   Park, Byung Hyun ^a  

^a Chonbuk National University   (South Korea)

^b Wonkwang University   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

Cytokines; Diabetes mellitus; Experimental; NF B; Rhus verniciflua; Streptozotocin; Sulfuretin

Indexed keywords

3',4,6' TRIHYDROXYAURONE; FLAVONOID; GAMMA INTERFERON; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1BETA; NITRIC OXIDE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DIABETES MELLITUS; DRUG STRUCTURE; GENE ACTIVATION; HYPERGLYCEMIA; HYPOINSULINEMIA; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; INHIBITION KINETICS; INSULIN RELEASE; INSULINOMA; MEDICINAL PLANT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; RHUS VERNICIFLUA; SIGNAL TRANSDUCTION;

MUS; RATTUS; RHUS; TOXICODENDRON VERNICIFLUUM;

EID: 77957738989     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2010.42.9.062     Document Type: Article

References (54)

1. Adcock IM, Brown CR, Kwon O, Barnes PJ. Oxidative stress induces NFkB DNA binding and inducible NOS mRNA in human epithelial cells. Biochem Biophys Res Commun 1994; 199:1518-24
2. Arnush M, Heitmeier MR, Scarim AL, Marino MH, Manning PT, Corbett JA. IL-1 produced and released endogenously within human islets inhibits p cell function. J Clin Invest 1998; 102:516-26
3. Bedoya FJ, Flodstrom M, Eizirik DL. Pyrrolidine dithio-carbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells. Biochem Biophys Res Commun 1995; 210:816-22
4. Chang I, Kim S, Kim JY, Cho N, Kim YH, Kim HS, Lee MK, Kim KW, Lee MS. Nuclear factor kB protects pancreatic P-cells from tumor necrosis factor-a-mediated apoptosis. Diabetes 2003; 52:1169-75
5. Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic p-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005; 54 Suppl 2:S97-107
6. Corbett JA, McDaniel ML. Does nitric oxide mediate autoimmune destruction of p-cells? Possible therapeutic interventions in IDDM. Diabetes 1992; 41:897-903
7. Corbett JA, McDaniel ML. Intraislet release of interleukin 1 inhibits p cell function by inducing p cell expression of inducible nitric oxide synthase. J Exp Med 1995; 181:559-68
8. Corbett JA, McDaniel ML. The use of aminoguanidine, a selective iNOS inhibitor, to evaluate the role of nitric oxide in the development of autoimmune diabetes. Methods 1996; 10: 21-30
9. Darville MI, Eizirik DL. Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-κB and C/EBP. Diabetes 2001; 50:1741-1748
10. Eizirik DL, Colli ML, Ortis F The role of inflammation in insulitis and p-cell loss in type 1 diabetes. Nat Rev Endocrinol 2009; 5:219-26
11. Eizirik DL, Flodstrom M, Karlsen AE, Welsh N. The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic pcells. Diabetologia 1996; 39:875-90
12. Eldor R, Yeffet A, Baum K, Doviner V, Amar D, Ben-Neriah Y, Christofori G, Peled A, Carel JC, Boitard C, Klein T, Serup P, Eizirik DL, Melloul D. Conditional and specific NF-κB blockade protects pancreatic p cells from diabetogenic agents. Proc Natl Acad Sci USA 2006; 103:5072-7
13. Flodstrom M, Niemann A, Bedoya FJ, Morris SM Jr, Eizirik DL. Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic p-cells: induction of argininosuccinate synthetase by cytokines. Endocrinology 1995; 136:3200-6
14. Giannoukakis N, Rudert WA, Ghivizzani SC, Gambotto A, Ricordi C, Trucco M, Robbins PD. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1 p-induced p-cell impairment and activation of islet cell apoptosis in vitro. Diabetes 1999; 48:1730-6
15. Hanafusa T, Imagawa A. Insulitis in human type 1 diabetes. Ann N Y Acad Sci 2008; 1150:297-9
16. Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL. Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents p-cell apoptosis. Diabetes 2001; 50:2219-24
17. Heitmeier MR, Scarim AL, Corbett JA. Interferon-y increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1. J Biol Chem 1997; 272:13697-704
18. Ho E, Chen G, Bray TM. a-phenyl-tert-butylnitrone (PBN) inhibits NFkB activation offering protection against chemically induced diabetes. Free Radic Biol Med 2000; 28:604-14
19. Holstad M, Sandler S. A transcriptional inhibitor of TNF-a prevents diabetes induced by multiple low-dose strepto-zotocin injections in mice. J Autoimmun 2001; 16:441-7
20. Iwakiri R, Nagafuchi S, Kounoue E, Nakamura M, Kikuchi M, Nakano S, Niho Y. Immunohistochemical study of insulitis induced by multiple low doses of streptozocin in CD-1 mice. Diabetes Res Clin Pract 1990; 9:75-82
21. Jeon WK, Lee JH, Kim HK, Lee AY, Lee SO, Kim YS, Ryu SY, Kim SY, Lee YJ, Ko BS. Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes. J Ethnopharmacol 2006; 106:62-9
22. Jung CH, Kim JH, Hong MH, Seog HM, Oh SH, Lee PJ, Kim GJ, Kim HM, Um JY, Ko SG. Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-κB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol 2007; 110: 490-7
23. Jung MJ, Chung HY, Kang SS, Choi JH, Bae KS, Choi JS. Antioxidant activity from the stem bark of Albizzia julibrissin. Arch Pharm Res 2003; 26:458-62
24. Kanitkar M, Gokhale K, Galande S, Bhonde RR. Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. Br J Pharmacol 2008; 155: 702-13
25. Karin M, Lin A. NF-κB at the crossroads of life and death. Nat Immunol 2002; 3:221-7
26. Kim EK, Kwon KB, Koo BS, Han MJ, Song MY, Song EK, Han MK, Park JW, Ryu DG, Park BH. Activation of peroxisome proliferator-activated receptor-y protects pancreatic p-cells from cytokine-induced cytotoxicity via NFkB pathway. Int J Biochem Cell Biol 2007a; 39:1260-75
27. Kim EK, Kwon KB, Song MY, Seo SW, Park SJ, Ka SO, Na L, Kim KA, Ryu DG, So HS, Park R, Park JW, Park BH. Genistein protects pancreatic p cells against cytokine-me-diated toxicity. Mol Cell Endocrinol 2007b; 278:18-28
28. Kim MJ, Ryu GR, Kang JH, Sim SS, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Jeong IK, Hong KJ, Kim MS, Jo YH. Inhibitory effects of epicatechin on interleukin-1,3-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-κB activation. Biochem Pharmacol 2004; 68:1775-85
29. Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, Kim KW, Sherwin RS, Karin M, Lee MS. NF-κB prevents p cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci USA 2007c; 104: 1913-8
30. Kwon NS, Lee SH, Choi CS, Kho T, Lee HS. Nitric oxide generation from streptozotocin. FASEB J 1994; 8:529-33
31. Lee JC, Lim KT, Jang YS. Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochim Biophys Acta 2002; 1570: 181-91
32. Lee JH, Song MY, Song EK, Kim EK, Moon WS, Han MK, Park JW, Kwon KB, Park BH. Overexpression of SIRT1 protects pancreatic p-cells against cytokine toxicity by suppressing the nuclear factor-KB signaling pathway. Diabetes 2009; 58: 344-51
33. Liuwantara D, Elliot M, Smith MW, Yam AO, Walters SN, Marino E, McShea A, Grey ST. Nuclear factor-KB regulates P-cell death: a critical role for A20 in p-cell protection. Diabetes 2006; 55:2491-501
34. Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S. Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. Diabetes 2000; 49:1123-30
35. Lv N, Song MY, Kim EK, Park JW, Kwon KB, Park BH. Guggulsterone, a plant sterol, inhibits NF-κB activation and protects pancreatic p cells from cytokine toxicity. Mol Cell Endocrinol 2008; 289:49-59
36. Lv N, Song MY, Lee YR, Choi HN, Kwon KB, Park JW, Park BH. Dihydroavenanthramide D protects pancreatic p-cells from cytokine and streptozotocin toxicity. Biochem Biophys Res Commun 2009; 387:97-102
37. Mabley JG, Hasko G, Liaudet L, Soriano F, Southan GJ, Salzman AL, Szabo C. NFkB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes. J Endocrinol 2002; 173:457-64
38. May MJ, Ghosh S. Signal transduction through NF-κB. Immunol Today 1998; 19:80-8
39. Melloul D. Role of NF-κB in p-cell death. Biochem Soc Trans 2008; 36:334-9
40. Oberley LW. Free radicals and diabetes. Free Radic Biol Med 1988; 5:113-24
41. Papaccio G. Insulitis and islet microvasculature in type 1 diabetes. Histol Histopathol 1993; 8:751-9
42. Park KY, Jung GO, Lee KT, Choi J, Choi MY, Kim GT, Jung HJ, Park HJ. Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. J Ethnopharmacol 2004; 90: 73-9
43. Pasparakis M. Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases. Nat Rev Immunol 2009; 9:778-88
44. Schmidt KN, Amstad P, Cerutti P, Baeuerle PA. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB. Chem Biol 1995; 2: 13-22
45. Song MY, Kim EK, Moon WS, Park JW, Kim HJ, So HS, Park R, Kwon KB, Park BH. Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway. Toxicol Appl Pharmacol 2009; 235:57-67
46. Sorli CH, Zhang HJ, Armstrong MB, Rajotte RV, Maclouf J, Robertson RP. Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet. Proc Natl Acad Sci USA 1998; 95:1788-93
47. Stadler J, Billiar TR, Curran RD, Stuehr DJ, Ochoa JB, Simmons RL. Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol 1991; 260:C910-6
48. Suarez-Pinzon WL, Szabo C, Rabinovitch A. Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β-cells. Diabetes 1997; 46:907-11
49. Sumoski W, Baquerizo H, Rabinovitch A. Oxygen free radical scavengers protect rat islet cells from damage by cytokines. Diabetologia 1989; 32:792-6
50. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001; 50: 537-46
51. Takasu N, Komiya I, Asawa T, Nagasawa Y, Yamada T. Streptozocin- and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation. Diabetes 1991; 40:1141-5
52. Tellez N, Montolio M, Biarnes M, Castano E, Soler J, Montanya E. Adenoviral overexpression of interleukin-1 receptor antagonist protein increases β-cell replication in rat pancreatic islets. Gene Ther 2005; 12:120-8
53. Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997; 46: 1733-42
54. Yamamoto H, Uchigata Y, Okamoto H. Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets. Nature 1981; 294:284-6