SPA0355, a thiourea analogue, inhibits inflammatory responses and joint destruction in fibroblast-like synoviocytes and mice with collagen-induced arthritis

British Journal of Pharmacology

Volumn 164, Issue 2 B, 2011, Pages 794-806

  Lee, Y R ^a   Hwang, J K ^a   Lee, H S ^a   Cheon, Y J ^b   Ryu, J H ^b   Lee, S I ^c   Kwak, H B ^d   Lee, S M ^a   Kim, J S ^a   Park, J W ^a   Jeon, R ^b   Park, B H ^a  

^a Chonbuk National University   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c Gyeongsang National University School of Medicine   (South Korea)

^d Wonkwang University   (South Korea)

Author keywords

CIA; inflammation; NF B; RA; synoviocytes; thiourea; TNF

Indexed keywords

CHEMOKINE; COLLAGEN; COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; SPA 0355; THIOUREA DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARTHRITIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; FIBROBLAST; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; JOINT DESTRUCTION; MALE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SYNOVIOCYTE; SYNOVITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; BENZOXAZINES; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINES; CYTOKINES; EDEMA; FIBROBLASTS; HUMANS; JOINTS; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED DBA; MICE, INBRED ICR; NF-KAPPA B; OSTEOCLASTS; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; THIOUREA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052230565     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01441.x     Document Type: Article

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