Alterations of energy metabolism in cutaneous aging

Textbook of Aging Skin

Volumn , Issue , 2010, Pages 295-312

  Blatt, Thomas ^a   Wenck, Horst ^a   Wittern, Klaus Peter ^a  

^a BEIERSDORF AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84892131063     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-540-89656-2_29     Document Type: Chapter

References (123)

1. Birch-Machin MA. The role of mitochondria in ageing and carcinogenesis. Clin Exp Dermatol. 2006;31:548-552.
2. Jendrach M, Pohl S, Voth M, et al. Morpho-dynamic changes of mitochondria during ageing of human endothelial cells. Mech Ageing Dev. 2005;126:813-821.
3. Hansford RG. Bioenergetics in aging. Biochim Biophys Acta. 1983;726:41-80.
4. Goldstein S, Moerman EJ, Porter K. High-voltage electron microscopy of human diploid fibroblasts during ageing in vitro. Morphometric analysis of mitochondria. Exp Cell Res. 1984;154:101-111.
5. Brantova O, Tesarova M, Hansikova H, et al. Ultrastructural changes of mitochondria in the cultivated skin fibroblasts of patients with point mutations in mitochondrial DNA. Ultrastruct Pathol. 2006;30:239-245.
6. Feldman D, Bryce GF, Shapiro SS. Mitochondrial inclusions in keratinocytes of hairless mouse skin exposed to UVB radiation. J Cutan Pathol. 1990;17:96-100.
7. Guillery O, Malka F, Frachon P, et al. Modulation of mitochondrial morphology by bioenergetics defects in primary human fibroblasts. Neuromuscul Disord. 2008;18:319-330.
8. Lazarou M, McKenzie M, Ohtake A, Thorburn DR, Ryan MT Analysis of the assembly profiles for mitochondrial-and nuclear-DNA-encoded subunits into complex I. Mol Cell Biol. 2007;27:4228-4237.
9. Papa S. Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications. Biochim Biophys Acta. 1996;1276:87-105.
10. Zwerschke W, Mazurek S, Stockl P, et al. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J. 2003;376:403-411.
11. Sugrue MM, Tatton WG. Mitochondrial membrane potential in aging cells. Biol Signals Recept. 2001;10:176-188.
12. Rottenberg H, Wu S. Mitochondrial dysfunction in lymphocytes from old mice: Enhanced activation of the permeability transition. Biochem Biophys Res Commun. 1997;240:68-74.
13. Yen TC, Chen YS, King KL, Yeh SH, Wei YH. Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun. 1989;165:944-1003.
14. Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: Possible factor in ageing. Lancet. 1989;1:637-639.
15. Mammone T, Gan D, Foyouzi-Youssefi R. Apoptotic cell death increases with senescence in normal human dermal fibroblast cultures. Cell Biol Int. 2006;30:903-909.
16. Greco M, Villani G, Mazzucchelli F, et al. Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts. Faseb J. 2003;17:1706-1708.
17. Lenz H, Schmidt M, Welge V, et al. The creatine kinase system in human skin: Protective effects of creatine against oxidative and UV damage in vitro and in vivo. J Invest Dermatol. 2005;124:443-452.
18. Paz ML, Gonzalez Maglio DH, Weill FS, Bustamante J, Leoni J. Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes. Photodermatol Photoimmunol Photomed. 2008;24:115-122.
19. Jongkind JF, Verkerk A, Poot M. Glucose flux through the hexose monophosphate shunt and NADP(H) levels during in vitro ageing of human skin fibroblasts. Gerontology. 1987;33:281-286.
20. Stucker M, Struk A, Altmeyer P, et al. The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis and epidermis. J Physiol. 2002;538:985-994.
21. Ronquist G, Andersson A, Bendsoe N, Falck B. Human epidermal energy metabolism is functionally anaerobic. Exp Dermatol. 2003;12:572-579.
22. Hornig-Do HT, von Kleist-Retzow JC, Lanz K, et al. Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment. J Invest Dermatol. 2007;127:1084-1093.
23. Dzeja PP, Terzic A. Phosphotransfer networks and cellular energetics. J Exp Biol. 2003;206:2039-2047.
24. Bessman SP, Carpenter CL. The creatine-creatine phosphate energy shuttle. Annu Rev Biochem. 1985;54:831-862.
25. Blatt T, Lenz H, Koop U, et al. Stimulation of skin's energy metabolism provides multiple benefits for mature human skin. Biofactors. 2005;25:179-185.
26. Wilken B, Ramirez JM, Probst I, Richter DW, Hanefeld F. Creatine protects the central respiratory network of mammals under anoxic conditions. Pediatr Res. 1998;43:8-14.
27. Bessman SP. The creatine phosphate energy shuttle-the molecular asymmetry of a "pool". Anal Biochem. 1987;161:519-523.
28. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasis. Biochem J. 1992;281(Pt 1):21-40.
29. Wyss M, Smeitink J, Wevers RA, Wallimann T. Mitochondrial creatine kinase: A key enzyme of aerobic energy metabolism. Biochim Biophys Acta. 1992;1102:119-166.
30. Schlattner U, Mockli N, Speer O, Werner S, Wallimann T. Creatine kinase and creatine transporter in normal, wounded, and diseased skin. J Invest Dermatol. 2002;118:416-423.
31. Zemtsov A. Skin phosphocreatine. Skin Res Technol. 2007;13: 115-118.
32. Snow RJ, Murphy RM. Creatine and the creatine transporter: A review. Mol Cell Biochem. 2001;224:169-181.
33. Speer O, Neukomm LJ, Murphy RM, et al. Creatine transporters: A reappraisal. Mol Cell Biochem. 2004;256-257:407-424.
34. McCully KK, Forciea MA, Hack LM, et al. Muscle metabolism in older subjects using 31P magnetic resonance spectroscopy. Can J Physiol Pharmacol. 1991;69:576-580.
35. Steinhagen-Thiessen E, Hilz H. The age-dependent decrease in creatine kinase and aldolase activities in human striated muscle is not caused by an accumulation of faulty proteins. Mech Ageing Dev. 1976;5:447-457.
36. Verzar F, Ermini M. Decrease of creatine-phosphate restitution of muscle in old age and the influence of glucose. Gerontologia. 1970;16:223-230.
37. Bogatskaia LN, Shegera VA. Creatine kinase activity and isoenzymic spectrum of myocardium creatine kinase in rats of different age. Ukr Biokhim Zh. 1981;53:71-74.
38. Ponticos M, Lu QL, Morgan JE, et al. Dual regulation of the AMPactivated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J. 1998;17:1688-1699.
39. Stachowiak O, Schlattner U, Dolder M, Wallimann T. Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: Implications for cellular function and mitochondrial structure. Mol Cell Biochem. 1998;184:141-151.
40. Chung JH, Eun HC. Angiogenesis in skin aging and photoaging. J Dermatol. 2007;34:593-600.
41. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA. 1993;90: 7915-7922.
42. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483-495.
43. Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA. 1994;91: 10771-10778.
44. Wei YH, Lu CY, Wei CY, Ma YS, Lee HC. Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system. Chin J Physiol. 2001;44:1-11.
45. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev. 1979;59:527-605.
46. Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000;29:222-230.
47. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47-95.
48. Stadtman ER. Protein oxidation and aging. Science. 1992;257: 1220-1224.
49. Huber LA, Xu QB, Jurgens G, et al. Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged. Eur J Immunol. 1991;21:2761-2765.
50. Nelson KK, Melendez JA. Mitochondrial redox control of matrix metalloproteinases. Free Radic Biol Med. 2004;37:768-784.
51. Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300.
52. Sohal RS. Hydrogen peroxide production by mitochondria may be a biomarker of aging. Mech Ageing Dev. 1991;60:189-198.
53. Mori A, Utsumi K, Liu J, Hosokawa M. Oxidative damage in the senescence-accelerated mouse. Ann N Y Acad Sci. 1998; 854:239-250.
54. Chiba Y, Yamashita Y, Ueno M, et al. Cultured murine dermal fibroblast-like cells from senescence-accelerated mice as in vitro models for higher oxidative stress due to mitochondrial alterations. J Gerontol A Biol Sci Med Sci. 2005;60:1087-1098.
55. Trifunovic A, Wredenberg A, Falkenberg M, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004;429:417-423.
56. Hayakawa M, Torii K, Sugiyama S, Tanaka M, Ozawa T. Ageassociated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm. Biochem Biophys Res Commun. 1991;179:1023-1029.
57. Mecocci P, MacGarvey U, Kaufman AE, et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol. 1993;34:609-616.
58. Ames BN, Shigenaga MK, Gold LS. DNA lesions, inducible DNA repair, and cell division: Three key factors in mutagenesis and carcinogenesis. Environ Health Perspect. 1993;5(Suppl 101):35-44.
59. Sohal RS, Dubey A. Mitochondrial oxidative damage, hydrogen peroxide release, and aging. Free Radic Biol Med. 1994;16:621-626.
60. Laganiere S, Yu BP. Modulation of membrane phospholipid fatty acid composition by age and food restriction. Gerontology. 1993;39:7-18.
61. Dumas M, Maftah A, Bonte F, et al. Flow cytometric analysis of human epidermal cell ageing using two fluorescent mitochondrial probes. C R Acad Sci III. 1995;318:191-197.
62. Paradies G, Ruggiero FM. Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria. Biochim Biophys Acta. 1990;1016:207-212.
63. Paradies G, Ruggiero FM. Effect of aging on the activity of the phosphate carrier and on the lipid composition in rat liver mitochondria. Arch Biochem Biophys. 1991;284:332-337.
64. Ruggiero FM, Cafagna F, Petruzzella V, Gadaleta MN, Quagliariello E. Lipid composition in synaptic and nonsynaptic mitochondria from rat brains and effect of aging. J Neurochem. 1992;59:487-491.
65. Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: Implications for cell death. Annu Rev Pharmacol Toxicol. 2007;47:143-183.
66. Ha MK, Chung KY, Bang D, Park YK, Lee KH. Proteomic analysis of the proteins expressed by hydrogen peroxide treated cultured human dermal microvascular endothelial cells. Proteomics. 2005; 5:1507-1519.
67. Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, et al. UVinduced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem. 1997;378:1247-1257.
68. Suzuki YJ, Forman HJ, Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med. 1997;22:269-285.
69. Davies KJ. The broad spectrum of responses to oxidants in proliferating cells: A new paradigm for oxidative stress. IUBMB Life. 1999;48:41-47.
70. Bladier C, Wolvetang EJ, Hutchinson P, De Haan JB, Kola I. Response of a primary human fibroblast cell line to H2O2: Senescence-like growth arrest or apoptosis? Cell Growth Differ. 1997;8:589-598.
71. Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA. 1994;91:4130-4134.
72. Campisi J. The role of cellular senescence in skin aging. J Invest Dermatol Symp Proc. 1998;3:1-5.
73. Wallace DC. Mitochondrial genetics: A paradigm for aging and degenerative diseases? Science. 1992;256:628-632.
74. Pang CY, Lee HC, Yang JH, Wei YH. Human skin mitochondrial DNA deletions associated with light exposure. Arch Biochem Biophys. 1994;312:534-538.
75. Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet. 1989;1:642-645.
76. Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol. 1995;27:647-653.
77. Piko L, Hougham AJ, Bulpitt KJ. Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging. Mech Ageing Dev. 1988;43:279-293.
78. Cortopassi GA, Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 1990;18:6927-6933.
79. Eshaghian A, Vleugels RA, Canter JA, et al. Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers. J Invest Dermatol. 2006;126:336-344.
80. Porteous WK, James AM, Sheard PW, et al. Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion. Eur J Biochem. 1998;257:192-201.
81. Shoffner JM, Lott MT, Voljavec AS, et al. Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slip-replication model and metabolic therapy. Proc Natl Acad Sci USA. 1989;86:7952-7956.
82. Schroeder P, Gremmel T, Berneburg M, Krutmann J. Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin. J Invest Dermatol. 2008;128:2297-2303.
83. Berneburg M, Plettenberg H, Medve-Konig K, et al. Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin. J Invest Dermatol. 2004;122:1277-1283.
84. Yang JH, Lee HC, Wei YH. Photoageing-associated mitochondrial DNA length mutations in human skin. Arch Dermatol Res. 1995;287:641-648.
85. Birket MJ, Passos JF, von Zglinicki T, Birch-Machin MA. The relationship between the aging-and photo-dependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts. J Invest Dermatol. 2009;129(6):1361-1366.
86. Bandy B, Davison AJ. Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging? Free Radic Biol Med. 1990;8:523-539.
87. Wei YH, Lee CF, Lee HC, et al. Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4, 977 BP-deleted mitochondrial DNA. Ann N Y Acad Sci. 2001;928:97-112.
88. Lu CY, Lee HC, Fahn HJ, Wei YH. Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mutat Res. 1999;423:11-21.
89. Berneburg M, Grether-Beck S, Kurten V, et al. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem. 1999;274:15345-15349.
90. Kueper T, Grune T, Prahl S, et al. Vimentin is the specific target in skin glycation. Structural prerequisites, functional consequences, and role in skin aging. J Biol Chem. 2007;282:23427-23436.
91. Hipkiss AR. Does chronic glycolysis accelerate aging? Could this explain how dietary restriction works? Ann N Y Acad Sci. 2006; 1067:361-368.
92. Alikhani Z, Alikhani M, Boyd CM, et al. Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways. J Biol Chem. 2005;280:12087-12095.
93. Kasper M, Funk RH. Age-related changes in cells and tissues due to advanced glycation end products (AGEs). Arch Gerontol Geriatr. 2001;32:233-243.
94. Rugolo M, Lenaz G. Monitoring of the mitochondrial and plasma membrane potentials in human fibroblasts by tetraphenylphosphonium ion distribution. J Bioenerg Biomembr. 1987;19: 705-718.
95. Scaduto RC Jr., Grotyohann LW. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys J. 1999;76:469-477.
96. Koopman WJ, Visch HJ, Smeitink JA, Willems PH. Simultaneous quantitative measurement and automated analysis of mitochondrial morphology, mass, potential, and motility in living human skin fibroblasts. Cytometry A. 2006;69:1-12.
97. Plasek J, Vojtiskova A, Houstek J. Flow-cytometric monitoring of mitochondrial depolarisation: From fluorescence intensities to millivolts. J Photochem Photobiol B. 2005;78:99-108.
98. Distelmaier F, Koopman WJ, Testa ER, et al. Life cell quantification of mitochondrial membrane potential at the single organelle level. Cytometry A. 2008;73:129-138.
99. Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C. A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5, 5', 6, 6'-tetrachloro-1, 1', 3, 3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun. 1993;197: 40-45.
100. Hagens R, Khabiri F, Schreiner V, et al. Non-invasive monitoring of oxidative skin stress by ultraweak photon emission measurement. II: Biological validation on ultraviolet A-stressed skin. Skin Res Technol. 2008;14:112-120.
101. Khabiri F, Hagens R, Smuda C, et al. Non-invasive monitoring of oxidative skin stress by ultraweak photon emission (UPE)-measurement. I: Mechanisms of UPE of biological materials. Skin Res Technol. 2008;14:103-111.
102. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1997;83:2055-2063.
103. Daly MM, Seifter S. Uptake of creatine by cultured cells. Arch Biochem Biophys. 1980;203:317-324.
104. Meyer LE, Machado LB, Santiago AP, et al. Mitochondrial creatine kinase activity prevents reactive oxygen species generation: Antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity. J Biol Chem. 2006;281:37361-37371.
105. Lenz H, Schmidt M, Welge V, et al. Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT-and HeLaS3-cells affects cell viability and mitochondrial morphology. Mol Cell Biochem. 2007;306:153-162.
106. O'Gorman E, Beutner G, Dolder M, et al. The role of creatine kinase in inhibition of mitochondrial permeability transition. FEBS Lett. 1997;414:253-257.
107. Brdiczka D, Beutner G, Ruck A, Dolder M, Wallimann T. The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition. Biofactors. 1998;8:235-242.
108. Dolder M, Walzel B, Speer O, Schlattner U, Wallimann T. Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation. J Biol Chem. 2003;278:17760-17766.
109. Dolder M, Wendt S, Wallimann T. Mitochondrial creatine kinase in contact sites: Interaction with porin and adenine nucleotide translocase, role in permeability transition and sensitivity to oxidative damage. Biol Signals Recept. 2001;10:93-111.
110. Berneburg M, Gremmel T, Kurten V, et al. Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences. J Invest Dermatol. 2005;125:213-220.
111. Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001;20:591-598.
112. McLennan HR, Degli Esposti M. The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species. J Bioenerg Biomembr. 2000;32:153-162.
113. Lopez-Lluch G, Barroso MP, Martin SF, et al. Role of plasma membrane coenzyme Q on the regulation of apoptosis. Biofactors. 1999;9:171-177.
114. Mellors A, Tappel AL. The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem. 1966; 241:4353-4356.
115. Frei B, Kim MC, Ames BN. Ubiquinol-10 is an effective lipidsoluble antioxidant at physiological concentrations. Proc Natl Acad Sci USA. 1990;87:4879-4883.
116. Lass A, Kwong L, Sohal RS. Mitochondrial coenzyme Q content and aging. Biofactors. 1999;9:199-205.
117. Hoppe U, Bergemann J, Diembeck W, et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9:371-378.
118. Podda M, Traber MG, Weber C, Yan LJ, Packer L. UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin. Free Radic Biol Med.1998;24:55-65.
119. Kim DW, Hwang IK, Yoo KY, et al. Coenzyme Q-{10} effects on manganese superoxide dismutase and glutathione peroxidase in the hairless mouse skin induced by ultraviolet B irradiation. Biofactors. 2007;30:139-147.
120. Stab F, Wolber R, Blatt T, Keyhani R, Sauermann G. Topically applied antioxidants in skin protection. Methods Enzymol. 2000;319:465-478.
121. Hadshiew IM, Treder-Conrad C, v Bulow R, et al. Polymorphous light eruption (PLE) and a new potent antioxidant and UVAprotective formulation as prophylaxis. Photodermatol Photoimmunol Photomed. 2004;20:200-204.
122. Rippke F, Wendt G, Bohnsack K, et al. Results of photoprovocation and field studies on the efficacy of a novel topically applied antioxidant in polymorphous light eruption. J Dermatolog Treat. 2001;12:3-8.
123. Wolber R, Stab F, Max H, et al. Alpha-glucosylrutin, a highly effective flavonoid for protection against oxidative stress. J Dtsch Dermatol Ges. 2004;2:580-587.