Advancements in burn therapy: Promise of nanomedicine

Burns: Prevention, Causes and Treatment

Volumn , Issue , 2012, Pages 40-63

  Hurler, Julia ^a   Škalko Basnet, Nataša ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84892076995     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (103)

1. Acar, A., Uygur, F., Diktas, H., Evinç, R. ülkür, E., öncül, O. and Görenek, L. (2011) Comparison of silver-coated dressing (Acticoat®), chlorhexidine acetate 0.5% (Bactigrass®) and nystatin for topical antifungal effect in Candida albicans-contaminated, full-skin-thickness rat burn wounds. Burns, doi:10.1016/j.burns.2011.01.024
2. Alemdaroglu, C., Degim, Z., Çelebi, N., Zor, F., öztürk, S. and Erdogan, D. (2006) An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns 32:319-327.
3. Alsarra, I.A. (2009) Chitosan topical gel formulation in the management of burn wounds. International Journal of Biological Macromolecules 45: 16-21.
4. Atiyeh, B.S., Costagliola, M., Hayek, S.N. and Dibo, S.A. (2007) Effect of silver on burn wound infection control and healing: Review of the literature. Burns 33:139-148.
5. Bhattacharyya, J., Mondal, G., Madhusudana, K., Agawane, S.B., Ramakrishna, S., Gangireddy, S.R., Madhavi, R.D., Reddy, P.K., Konda, V.R., Rao, S.R., Udaykumar, P. and Chaudhuri, A. (2009) Single subcutaneous administration of RGDK-lipopeptide: rhPDGF-B gene complex helas wounds in streptozotocin-induced diabetic rats. Molecular Pharmaceutics 6: 918-927.
6. Boateng, J.S., Matthews, K.H., Stevens, H.N. and Eccleston, G.N. (2008) Wound healing dressings and drug delivery systems: a review. Journal of Pharmaceutical Sciences 97: 2892-2923.
7. Boucard, N., Viton, C., Agay, D., Mari, E., Roger, T., Chancerelle, Y. and Domard, A. (2007) The use of physical hydrogels of chitosan for skin regeneration following third-degree burns. Biomaterials 28: 3478-3488.
8. Branski, L. K., Gauglitz, G.G., Herndon, D.N. and Jeschke, M.G. (2009) A review of gene and stem cell therapy in cutaneous wound healing. Burns 35: 171-180.
9. Brigham, P.A. and McLoughlin, E. (1996) Burn incidence and medical care use in the United States: estimates, trends, and data sources. Journal of Burn Care and Rehabilitation 17: 95-107.
10. Broughton II, G., Janis, J.E. and Attinger, E. (2006) A brief history of wound care. Plastic Reconstructive Surgery 117: 6-11S.
11. Burd, A., Ahmed, K., Lam, S., Ayyappan, T. and Huang, L. (2007) Stem cell strategies in burns care. Burns 33: 282-291.
12. Burger, C., Hsiao, B.S. and Chu, B. (2006) Nanofibrous materials and their applications. Annual Reviews in Material Research 36: 333-368.
13. Caldorera-Moore, M. and Peppas, N.A. (2009) Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems. Advanced Drug Delivery Reviews 61: 1391-1401.
14. Chen, R., Huang, C., Ke, Q., He, C., Wang, H. and Mo, X. (2010) Preparation and characterization of coaxial electrospun thermoplastic polyurethane/collagen compound nanofibers for tissue engineering applications. Colloids and Surfaces B: Interfaces 79: 315-325.
15. Chi, C.C., Wang, S.H. and Kuo, T.T. (2006) Localized cutaneous polyvinilypyrrolidone storage disease mimicking cheilitis granulomatosa. Journal of Cutaneous Pathology 33: 454-457.
16. Coolen, N.A., Vlig, M., van der Bogaerdt, A.J., Middelkoop, e. AND Ulrich, M.M.W. (2008) Development of an in vitro burn wound model. Wound Repair and Regeneration 16: 559-567.
17. Cortivo, R., Vindigni, V., Iacobellis, L., Abatangelo, G., Pinton, P. and Zavan, B. (2010) Nanoscale particle therapies for wounds and ulcers. Future medicine 5: 641-656.
18. Davidson, J.M., Whitsitt, J.S., Pennington, Ballas, C.B., Eming, S.A. and Benn, S.I. (1999) Gene therapy of wounds with growth factors. Current Topics in Dermatology, Desmouliere A and Tuchweber, B. (Eds), Springer-Verlag Berlin Heidelberg, Vol 93 111-121.
19. Davidson, J.M., Krieg, T. and Eming, S.A. (2000) Particle-mediated gene therapy of wounds. Wound Repair and Regeneration 8: 452-459.
20. Davidson, J.M., Eming, S.A. and Dasgupta, J. (2003) Particle-mediated gene therapy of wounds. Methods in Molecular Medicine 78: 433-452.
21. Dileo, J., Miller Jr, T.E, Chesnoy, S. and Huang, L. (2003) Gene transfer to subdermal tissues via a new gene gun design. Human Gene Therapy 14: 79-87.
22. Demling, R.H. (2008) Burns: what are the pharmacological treatment options? Expert Opinion in Pharmacotherapy 9: 1895-1908.
23. Eisenbud D., Huang, N.F. Luke, S. and Silberklang, M. (2004) Skin substitutes and wound healing: Current status and challenges. Wounds 16: 2-17.
24. Emanuelsson, P. and Kratz, G. (1997) Characterization of a new in vitro burn wound model. Burns 23: 32-36.
25. Eming, S.A., Whitsitt, J.S., He, L., Krieg, T., Morgan, J.R. and Davidson, J.M. (1999) Particle-mediated gene transfer of PDGF isoforms promotes wound repair. Journal of Investigative Dermatology 112: 297-302.
26. Eriksson, E., Yao, F., Svensjö, T., Winkler, T., Slama, J., Macklin, M.D., Andree, C., McGregor, M., Hinshaw, V. and Swain, F. (1998) In vivo gene transfer to skin and wound by microseeding. Journal of Surgical Research 78: 85-91.
27. Felgner, P.L., Tsai, Y.L. and Sukhu, L. (1995) Improved cationic lipid formulation for in vivo gene therapy. Annals of New York Academy of Science 772: 126-139.
28. Fergusson, E.L., Alshame, A.M.J. and Thomas, D.W. (2010) Evaluation of hyaluronic acid-protein conjugates for polymer masked-unmasked protein therapy. International Journal of Pharmaceutics 402: 95-102.
29. Giannini, G.T., Boothby, J.T. and Sabelman, E.E. (2010) Infected wound model development of an in vitro biomaterial-protected wound infection model to study microbial activity and antimicrobial treatment trough microdialysis. Advances in Skin and Wound Care 23: 358-364.
30. Galvan-Garcia, P., Keefer, E.W., Yang, F., Zhang, M., Fang, S., Zakhidov, A.A., Baughman, R.H. and Romero, M.I. (2007) Robust cell migration and neuronal growth on pristine carbon nanotube sheets and yarns. Journal of Biomaterials Science, Polymer Edition 18: 1245-1261.
31. Geckil, H., Xu, F., Zhang, X., Moon, SJ. and Demirici, U. (2010) Engineering hydrogels as extracellular matrix mimics. Nanomedicine (Lond) 5: 469-484.
32. Greenhalgh, K. and Turos, E. (2009) In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications. Nanomedicine, Nanotechnology, Biology and Medicine 5: 46-54.
33. Guo, R., Xu, S., Ma, L., Huang, A. and Gao, C. (2011) The healing of full thickness burns treated by plasmid DNA encoding VEGF-165 activated collagen-chitosan dermal equivalents. Biomaterials 32: 1019-1031.
34. Gurung, S. and Skalko-Basnet, N. (2009) Wound healing properties of Carica papaya latex: in vivo evaluation in mice burn model. Journal of Ethnopharmacology 121: 338-341.
35. Harding K., Gray D., Timmons J. and Hurd T. (2007) Evolution or revolution? Adapting to complexity in wound management. International Wound Journal Suppl 2: 1-12.
36. Hardwicke J., Ferguson, E.L., Moseley, R., Stephens, P., Thomas, D.W. and Duncan, R. (2008) Dextrin-rhEGF conjugates as bioresponsive nanomedicine for wound repair. Journal of Controlled Release 130: 275-283.
37. Hardwicke J., Moseley, R., Stephens, P., Harding, K., Duncan, R. and Thomas, D.W. (2010) Bioresponsive dextrin-rhEGF conjugates: In vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7: 699-707.
38. Hayashi, M., Matsuzaki, Y. and Shimonaka, M. (2009) Impact of plasminogenon an in vitro wound healing model based on a perfusion cell culture system. Molecular and Cellular Biochemistry 322: 1-13.
39. Hemmila, M.R., Mattar, A., Taddonio, M.A., Arabi, S., Hamouda, T., Ward, P.A., Wang, S.C. and Baker Jr J.R. (2010) Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury. Surgery 148:499-509.
40. Hengge, U.R., Chan, E.F., Foster, R.A., Walker, P.S. and Vogel, J.C. (1995) Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nature Genetics 10: 161-166.
41. Herman, I.M. and Leung, A. (2009) Creation of human skin equivalents for the in vitro study of angiogenesis in wound healing, in Methods in Molecular Biology, 467 Angiogenesis Protocols 2nd Ed. Totowa, USA, pp. 241-248.
42. Hetrick, E.M., Shin, J.H., Paul, H.S. and Schoenfisch, M.H. (2009) Anti-biofilm efficiency of nitric oxide-releasing silica nanoparticles. Biomaterials 30: 2782-2789.
43. Hill, K.E., Malic, S., McKee, R., Rennison, T., Harding, K.G., Williams, D.W. and Thomas, D.W. (2010) An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. Journal of Antimicrobial Chemotherapy 65: 1195-1206.
44. Hosseini, S.N., Karimian, A., Mousavinasab, S:N:, Rahmanpour, H.; Yamini, M. and Zahmatkesh, S.H. (2009) Xenoderm versus 1% silver sulfadiazine in partial-thickness burns. Asian Journal of Surgery 33: 234-239.
45. Hromadka, M., Collins, J.B., Reed, C., Han, L., Kolappa, K.K., Cairns, B.A., Andrady, T. and van Aalst, J.A. (2008) Nnaofiber applications for burn care. Journal of Burn Care and Research 29: 695-703.
46. Huang, L., Dai, T., Xuan, Y., Tegos, G.P. and Hamblin, M.R. (2011) Synergistic combination of chitosan acetate with nanoparticulate silve as a topical antimicrobial: efficacy against bacterial burn infections. Antimicrobial Agents and Chemotherapy 2011 0:AAC.01803-10.
47. Hurler, J., Berg O.A., Skar M., Conradi A.H., Johnson P.J. and Skalko-Basnet N. (2011) Liposomal mupirocin: on the way to improved wound and burns therapy, Pharmaceutical Sciences for the Future of Medicines, June 2011, Prague, Czech Republic, abstract.
48. Jeschke, M.G., Barrow, R.E., Hawkins, H.K., Tao, Z., Perez-Polo, J.R. and Herndon, D.N. (2000) Bioditribution and feasibility of non-viral IGF-I gene transfers in thermally injured skin. Laboratory Investigation 80: 151-158.
49. Jeschke, M.G., Herndon, D.N., Baer, W., Barrow, R.E. and Jauch, K.W. (2001) Possibilities of non-viral gene transfer to improve cutaneous wound healing. Current Gene Therapy 1: 267-278.
50. Jeschke, M.G., Richter, G., Höfstädter, F., Herndon, D.N.,Perez-Polo, J-R. and Jauch, K.W. (2002) Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer. Gene Therapy 9:1065-1074.
51. Khavari, P.A., Rollman, O. and Vahlquist, A. (2002) Cutaneous gene transfer for skin and systemic diseases. Journal of Internal Medicine 252: 1-10.
52. Khil, M-S., Cha, D-I., Kim, H-Y.; Kim, I-S.; Bhattarai, N. (2003) Electrospun nanofibrous polyurethane membrane as wound dressing. Journal of Biomedical Materials Research, Part B: Applied Biomaterials 67B: 675-679.
53. Khundkar, R., Malic, C. and Burge, T. (2010) Use of ActicoatTM dressings in burns: What is the evidence? Burns 36:751-758.
54. Kratz, G. (1998) Modeling of wound healing processes in human skin using tissue culture. Microscopy Research and Techniques 42: 345-350.
55. Lazic, T. and Falanga, V. (2010) Bioengineered skin constructs and their use in wound healing. Plastic and Reconstructive Surgery 127: 75S-90S.
56. Lebonvallet, N., Jeanmaire, C., Danoux, L., Sibille, P., Pauly and G., Misery, L. (2010) The evolution and use of skin explants: potential and limitations for dermatological research. European Journal of Dermatology 20: 671-684.
57. Lee, P.Y., Chesnoy, S. and Huang, L. (2004) Electroporatic delivery of TGF-beta1 gene works synergistically with electric therapy to enhance diabetic wound healing in db/db mice. Journal of Investigative Dermatology 123: 791-798.
58. Lee, W., Debasitis, J.C., Lee, V.K., Lee, J.H., Fiescher, K., Edminister, K., Park, J.K. and Yoo, S.S. (2009) Multi-layered culture of human skin fibriblasts and keratinocytes through three-dimensional freeform fabrication. Biomaterials 30: 1587-1595.
59. Li, J., Chen, J. and Kirsner, R. (2007) Pathophysiology of acute wound healing. Clinics in Dermatology 25: 9-18.
60. Li, Z., Ning, W., Wang, J., Choi, A., Lee, P-Y., Tyagi, P. and Hunag L. (2003) Controlled gene delivery system based on thermosensitive biodegradable hydrogel. Pharmaceutical Research 20: 884-888.
61. Lipp, C., Kirker, K., Agostinho, A., James, G. and Stewart, P. (2010) Testing wound dressings using an in vitro wound model. Journal of Wound Care 19: 220-226.
62. Lu, S., Gao, W. and Gu H.Y. (2008) Construction, application and biosafety of silver nanocrystalline chitosan wound dressing. Burns 34:623-628.
63. Marti, G., Ferguson, M., Wang, J., Byrnes, C., Dieb, R., Qaiser, R., Bonde, P., Duncan, M.D. and Harmon, J.W. (2004) Electroporative transfection with KGF-1 DNA improves wound healing in a diabetic mouse model. Gene Therapy 11: 1780-1785.
64. Megeed, Z., Cappello, J. and Ghandehari, H. (2002a) Controlled release of plasmid DNA from a genetically engineered silk-elastinlike hydrogel. Pharmaceutical Research 19: 954-959.
65. Megeed, Z., Cappello, J. and Ghandehari, H. (2002b) Genetically engineered silk-elastinlike protein polymers for controlled drug delivery. Advanced Drug Delivery Reviews 54: 1075-1091.
66. Min, B-M., Lee, S.W., Lim, J.N., You, Y., Lee, T.S., Kang, P.H. and Park, W.H. (2004) Chitin and chitosan nanofibers: electrospinning of chitin and deacetylation of chitin nanofibers. Polymer 45: 7137-7142.
67. Mou, D., Chen, H., Du, D., Mao, C., Wan, J., Xu, H. and Yang, X. (2008) Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. International Journal of Pharmaceutics 353:270-276.
68. Murday, J.S., Siegel, R.W., Stein, J. and Wright, J.F. (2009) Translational nanomedicine: status assessment and opportunities. Nanomedicine, Nanotechnology, Biology, and Medicine 5: 251-273.
69. Muzzarelli, R.A.A., Morganti, P., Morganti, G., Palombo, P., Palombo, M., Biagini, G., Mattioli Belmonte, M., Giantomassi, F., Orlandi, F. and Muzzarelli, C. (2007) Chitin nanofibrils/chitosan glycolate compisutes as wound medicaments. Carbohydrate Polymers 70: 274-284.
70. Nanney, L.B., Paulsen, S., Davidson, M.K.M Cardwell, N.L., Whitsitt, J.S. and Davidson, J.M. (2000) Boosting epidermal growth factor receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Repair and Regeneration 8: 117-127.
71. Oberringer, M., Meins, C., Bubel, M. and Pohlemann, T. (2007) A new in vitro wound model based on the co-culture of human dermal microvascular and endothelial cells and human dermal fibroblasts. Biology of the Cell 99: 197-207.
72. Park, K. (2008) Bioresponsive drug delivery for regenerative medicine. Journal of Controlled Release 130: 201.
73. Pavelic, Z., Skalko-Basnet, N. and Schubert R. (2001) Liposomal gels for vaginal delivery. International Journal of Pharmaceutics 219: 139-149.
74. Peng, C-C. Yang, M-H., Chiu, W-T., Chiu, C-H., Yang, C-S., Chen, Y-W., Chen, K-C. and Peng, R.Y. (2008) Composite nano-titanium oxide-chitosan artificial skin exhibits strong wound-healing effect-an approach with anti-inflammatory and bactericidal kinetics. Macromolecular Bioscience 8: 316-327.
75. Peschka-Suss, R. and Skalko-Basnet, N. (2000) The association of plain and ligand-bearing neutral and pH-sensitive liposomes with various cells. Journal of Liposome Research 10: 43-59.
76. Petros, R.A. and DeSimone, J.M. (2010) Strategies in the design of nanoparticles for therapeutic applications. Nature Reviews, Drug Discovery 9: 615-627.
77. Rasulov, M.F., Vasil'chenkov, A. V., Onishchenko, N.A., Krasheninnikov, M.E., Kravchenko, V.I., Gorshenin, T.L., Pidtsan, E. E., and Potapov, I.V. (2005) First experience of the use bone marrow mesenchymal stem cells for the treatment of patients with deep skin burns. Cell Technologies in Biology and Medicine 1: 141-144.
78. Rho, K.S., Jeong, L., Lee, G., Seo, B-M., Park, Y.J., Hong, S-D., Roh, S., Cho, J.J., Park, W.H. and Min, B-M. (2006) Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials 27: 1452-61.
79. Riehemann, K., Schneider, S.W., Luger, T.A., Godin, B., Ferrari, M. and Fuchs, H. (2009) Nanomedicine-Challenge and perspectives. Angewandte Chemie 48: 872-897.
80. Rizzi, S.C., Upton, Z., Bott, K. and Dargaville, T. R. (2010) Recent advances in dermal wound healing: biomedical device approaches. Experts Reviews 7: 143-154.
81. Schneider, A.; Wang, X.Y., Kaplan, D.L., Garlick, J.A. and Egles, C. (2009) Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomaterialia 5: 2570-2578.
82. Sezer, A.D., Cevher, E., Hatipoglu, F., Ogurtan, Z., Bas, A.L. and Akbuga, J. (2008) Preparation of fuciodan-chitosan hydrogel and its application ac burn healing accelerator on rabbits. Biological and Pharmaceutical Bulletin 31: 2326-2333.
83. Shukla, A., Fleming, K.E., Chuang, H.F., Chau, T.M., Loose, C.R., Stephanopoulos, N. and Hammond, P.T. (2010) Controlling the release of peptide antimicrobial agents from surfaces. Biomaterials 31: 2348-2357.
84. Singh, A.V., A.S, A., Gade, W.N., Vats, T., Lenardi, C. and Milani, P. (2010) Nanomaterials: New generation therapeutics in wound healing and tissue repair. Current Nanoscience 6: 577-586.
85. Steffansen, B. and Herping S.P.K. (2008) Novel wound models for characterizing ibuprofen release from foam dressings. International Journal of Pharmaceutics 364: 150-155.
86. Steed, D.L. (2006) Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plastic Reconstructive Surgery 117: 143S-149S.
87. Steinstraesser, L., Sorkin, M., Niederbichler, A.D., Becerikli, M., Stupka, J., Daigeler, A., Kesting, M.R., Stricker, I., Jacobsen, F. and Schulte, M. (2010) A novel human skin chamber model to study wound infection ex vivo. Archives of Dermatological Research 302: 357-365.
88. Sun, L., Xu, L., Chang, H., Henry, F.A., Miller, R.M., Harmon, J.M. and Nielsen, T.B. (1997) Transfection with aFGF cDNA improves wound healing. Journal of Investigative Dermatology 108:313-318.
89. Tanaka, A., Nagate, T. and Matsuda, H. (2005) Acceleration of wound healing by gelatin film dressings with epidermal growth factor. Journal of Veterinary Medical Sciences 67: 909-913.
90. Tian, J., Wong, K.K., Ho, C.M., Lok, C-N, Yu, W-Y., Che, C-M., Chiu, J-F AND Tam, P.K.H. (2007) ChemMedChem 2: 129-136.
91. Tokudome, Y., Uchida, R., Yokote, T., Todo, H., Hada, N., Kon, T., Yasuda, J., Hayashi, H., Hashimoto, F. and Sugibayashi K. (2010) Effect of topically applied sphingomyelin-based liposomes on the ceramide level in a three-dimensional cultured human skin model. Journal of Liposome Research 20: 49-54.
92. Ulijn, R.V., Bibi N., Jayawarna, V., Thornton, P.D., Todd, S.J., Mart, R.J., Smith, A.M. and Gough, J. E. (2007) Bioresponsive hydrogels. Materials Today 10(4): 40-48.
93. Uygur, F., Oncul, O., Evinc, R., Diktas, H., Acar, A. and Ulkur, E. (2009) Effects of three different topical antibacterial dressings on Acinetobacter baumannii-contaminated full-thickness burns in rats. Burns 35: 270-273.
94. Vicent, M., Dieudonné, L., Carbajo, R.J. and Pineda-Lucena, A. (2008) Polymer conjugates as therapeutics: future trends, challenges and opportunities. Expert Opinion in Drug Delivery 5: 593-614.
95. Vogel, J.C. (2000) Nonviral skin gene therapy. Human Gene Therapy 11: 2253-2259.
96. Vogt, P.M., Reimer, K., Hauser, J., Roßbach, O., Steinau, H.U., Bosse, B., Muller, S., Schmidt, T. and Fleischer, W. (2006) PVP-iodine in hydrosomes and hydrogel-A novel concept in wound therapy leads to enhanced epithelialisation and reduced loss of skin grafts. Burns 32: 698-705.
97. Wiegand, C., Heinze, T. and Hipler, U.C. (2009) Comparative in vitro study on cytotoxicity, antimicrobial activity, and binding capacity for pathophysiological factors in chronic wounds of alginate and silver-containing alginate. Wound Repair and Regeneration 17: 511-521.
98. Witthayaprapakorn, C., Molloy, R., Nalampang, K. and Tighe, B.J. (2008) Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing. Advanced Materials Research 55-57: 681-684.
99. Wolf, N.B., Kuechler, S., Radowski, M.R.; Blaschke, T., Kramer, K.D., Weindl, G., Kleuser, B., Haag, R. and Schaefer-Korting, M. (2009) Influences of opioids and nanoparticles on in vitro wound healing models. European Journal of Pharmaceutics and Biopharmaceutics 73: 34-42.
100. Yeo, I-S., Oh, J-E., Jeong, L., Lee, T. S., Lee, Seung, J., Park, W.H. and Min, B-M. (2008) Collagen-based biomimetic nanofibrous scaffolds: Preparation and characterization of collagen/silk fibroin bicomponent nanofibrous structures. Biomacromolecules 9: 1106-1116.
101. You, J-O., Almeda, D., Ye, G.J.C. and Auguste, D.T. (2010) Bioresponsive matrices in drug delivery. Journal of Biological Engineering 4: 15.
102. Zajicek, R., Matouskova, E., Broz, L., Kubok, R., waldauf, P. and Königova, R. (2011) New biological temporary skin cover Xe-Derma® in the treatment of superficial scald burns in children. Burns 37: 333-337.
103. Zhou, H.; Yue, Y., Liu, M., Li, Y., Zhang, J., Gong, Q., Yan, Z. and Duan, M. (2010) Preparation and characterization of a lecithin nanoemulsion as a topical delivery system. Nanoscale Research Letters 5:224-230.