Evaluation of hyaluronic acid-protein conjugates for polymer masked-unmasked protein therapy

International Journal of Pharmaceutics

Volumn 402, Issue 1-2, 2010, Pages 95-102

  Ferguson, Elaine L ^a   Alshame, Alshame M J ^a   Thomas, David W ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Bioresponsive; Hyaluronic acid; Nanomedicines; Polymer therapeutics; PUMPT

Indexed keywords

DEXTRIN; ELASTASE; EPIDERMAL GROWTH FACTOR; HYALURONIC ACID; POLYMER; TRYPSIN;

ARTICLE; CELL PROLIFERATION; CONJUGATION; IMMUNOGENICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; TISSUE REPAIR; WOUND HEALING IMPAIRMENT;

ANIMALS; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHICKENS; COMB AND WATTLES; EPIDERMAL GROWTH FACTOR; HUMANS; HYALURONIC ACID; HYALURONOGLUCOSAMINIDASE; MALE; PANCREATIC ELASTASE; POLYMERS; PROTEIN STABILITY; SHEEP; TIME FACTORS; TRYPSIN;

EID: 78349304634     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.09.029     Document Type: Article

References (34)

1. Almond A. Hyaluronan. Cell. Mol. Life Sci. 2007, 64:1591-1596.
2. Aronson N.J., Davidson E. Lysosomal hyaluronidase from rat liver: II. Properties. J. Biol. Chem. 1967, 242:441-444.
3. Bendele A., Seely J., Richey C., Sennello G., Shopp G. Short communication: renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins. Toxicol. Sci. 1998, 42:152-157.
4. Brecht M., Mayer U., Schlosser E., Prehm P. Increased hyaluronate synthesis is required for fibroblast detachment and mitosis. Biochem. J. 1986, 239:445-450.
5. Chen W.Y., Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999, 7:79-89.
6. Chi C.C., Wang S.H., Kuo T.T. Localized cutaneous polyvinylpyrrolidone storage disease mimicking cheilitis granulomatosa. J. Cutan. Pathol. 2006, 33:454-457.
7. David-Raoudi M., Tranchepain F., Deschrevel B., Vincent J.C., Bogdanowicz P., Boumediene K., Pujol J.P. Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing. Wound Repair Regen. 2008, 16:274-287.
8. Duncan R. The dawning era of polymer therapeutics. Nat. Rev. Drug Discov. 2003, 2:347-360.
9. Duncan R. Polymer conjugates as anticancer nanomedicines. Nat. Rev. Cancer 2006, 6:688-701.
10. Duncan R., Gilbert H.R.P., Carbajo R.J., Vicent M.J. Polymer masked-unmasked protein therapy (PUMPT) 1. Bioresponsive dextrin-trypsin and -MSH conjugates designed for α-amylase activation. Biomacromolecules 2008, 9:1146-1154.
11. Ellis I.R., Schor S.L. Differential effects of TGF-beta1 on hyaluronan synthesis by fetal and adult skin fibroblasts: implications for cell migration and wound healing. Exp. Cell Res. 1996, 228:326-333.
12. 2: synthesis and evaluation as a novel bioresponsive anticancer conjugate. Biomacromolecules 2009, 10:1358-1364.
13. Franzmann E.J., Schroeder G.L., Goodwin W.J., Weed D.T., Fisher P., Lokeshwar V.B. Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. Int. J. Cancer 2003, 106:438-445.
14. Gaffney J., Matou-Nasri S., Grau-Olivares M., Slevin M. Therapeutic applications of hyaluronan. Mol. Biosyst. 2010, 6:437-443.
15. Gao F., Liu Y., He Y., Yang C., Wang Y., Shi X., Wei G. Hyaluronan oligosaccharides promote excisional wound healing through enhanced angiogenesis. Matrix Biol. 2010, 29:107-116.
16. Gilbert H.R.P., Duncan R. Polymer-protein conjugates for triggered activation: hyaluronic acid-trypsin as a model. Proc. Ann. Meet. Control. Release Soc. 2006, 33:661. Vienna, Austria.
17. Gilbert, H.R.P., 2007. Bioresponsive Polymer-Protein Conjugates as a Unimolecular Drug Delivery System. PhD, Cardiff University, Cardiff, UK.
18. Hardwicke J., Ferguson E.L., Moseley R., Stephens P., Thomas D., Duncan R. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. J. Control. Release 2008, 130:275-283.
19. Huang L., Gu H., Burd A. A reappraisal of the biological effects of hyaluronan on human dermal fibroblast. J. Biomed. Mater. Res. A 2009, 90:1177-1185.
20. Hynes W.L., Walton S.L. Hyaluronidases of Gram-positive bacteria. FEMS Microbiol. Lett. 2000, 183:201-207.
21. Johnson K.D., Clark A., Marshall S. A functional comparison of ovine and porcine trypsins. Comp. Biochem. Phys. B 2002, 131:423-431.
22. Kogan G., Soltes L., Stern R., Gemeiner P. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol. Lett. 2007, 29:17-25.
23. Kreil G. Hyaluronidases-a group of neglected enzymes. Protein Sci. 1995, 4:1666-1669.
24. Leach J.B., Schmidt C.E. Hyaluronan. Encyclopedia of Biomaterials and Biomedical Engineering 2004, 779-789. Marcel Dekker, Inc., New York. G.L. Bowlin, G. Wnek (Eds.).
25. Lu H.S., Chai J.J., Li M., Huang B.R., He C.H., Bi R.C. Crystal structure of human epidermal growth factor and its dimerization. J. Biol. Chem. 2001, 276:34913-34917.
26. Ludowieg J., Vennesland B., Dorfman A. The mechanism of action of hyaluronidases. J. Biol. Chem. 1961, 236:333-339.
27. Miyasaki K. Experimental polymer storage disease in rabbits. An approach to the histogenesis of sphingolipidoses. Virchows Arch. A: Pathol. Anat. Histol. 1975, 365:351-365.
28. Oh E.J., Park K., Choi J.S., Joo C.K., Hahn S.K. Synthesis, characterization, and preliminary assessment of anti-Flt1 peptide-hyaluronate conjugate for the treatment of corneal neovascularization. Biomaterials 2009, 30:6026-6034.
29. Parent, E.G., Larsen, N.E., 2006. Hydrophilic biopolymer-drug conjugates, their preparation and use. US Patent 7,034,127 B2.
30. Price R.D., Berry M.G., Navsaria H.A. Hyaluronic acid: the scientific and clinical evidence. J. Plast. Reconstr. Aesthetic Surg. 2007, 60:1110-1119.
31. Sakurai K., Miyazaki K., Kodera Y., Nishimura H., Shingu M., Inada Y. Anti-inflammatory activity of superoxide dismutase conjugated with sodium hyaluronate. Glycoconj. J. 1997, 14:723-728.
32. Stern R., Kogan G., Jedrzejas M.J., Soltes L. The many ways to cleave hyaluronan. Biotechnol. Adv. 2007, 25:537-557.
33. Treetharnmathurot B., Ovartlarnporn C., Wungsintaweekul J., Duncan R., Wiwattanapatapee R. Effect of PEG molecular weight and linking chemistry on the biological activity and thermal stability of PEGylated trypsin. Int. J. Pharm. 2008, 357:252-259.
34. Treetharnmathurot B., Dieudonne L., Ferguson E.L., Schmaljohann D., Duncan R., Wiwattanapatapee R. Dextrin-trypsin and ST-HPMA-trypsin conjugates: enzyme activity, autolysis and thermal stability. Int. J. Pharm. 2009, 373:68-76.