Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury

Surgery

Volumn 148, Issue 3, 2010, Pages 499-509

  Hemmila, Mark R ^a,d   Mattar, Aladdein ^a   Taddonio, Michael A ^a   Arbabi, Saman ^c   Hamouda, Tarek ^b   Ward, Peter A ^a   Wang, Stewart C ^a   Baker Jr , James R ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NanoBio Corporation   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; EMULSIFYING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAFENIDE; MAFENIDE ACETATE; MYELOPEROXIDASE; NB 201; PLACEBO; RINGER LACTATE SOLUTION; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; BURN; COLONY FORMING UNIT; DISEASE MODEL; DRUG POTENCY; ENZYME ASSAY; GROWTH INHIBITION; HAIR CELL; HISTOPATHOLOGY; IMMUNOMODULATION; MALE; NANOEMULSION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OCCLUSIVE DRESSING; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; QUANTITATIVE STUDY; RAT; SCALD; SIGNAL TRANSDUCTION; SKIN INFLAMMATION; THERMAL INJURY; TISSUE HOMOGENATE; TREATMENT OUTCOME; WOUND INFECTION;

ANIMALS; APOPTOSIS; BACTERIAL INFECTIONS; BIOLOGICAL MARKERS; BURNS; EMULSIONS; HOT TEMPERATURE; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; PEROXIDASE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; WOUND INFECTION;

EID: 77955922782     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2010.01.001     Document Type: Article

References (28)

1. P.Q. Bessey Wound care D.N. Herndon, Total burn care 3rd ed. 2007 Elsevier Philadelphia 127 135
2. L. Steinstraesser, B.F. Tack, A.J. Waring, T. Hong, L.M. Boo, and M.H. Fan Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns Antimicrob Agents Chemother 46 2002 1837 1844
3. R.G. Barton, J.R. Saffle, S.E. Morris, M. Mone, B. Davis, and J. Shelby Resuscitation of thermally injured patients with oxygen transport criteria as goals of therapy J Burn Care Rehabil 18 1 Pt 1 1997 1 9
4. T. Hamouda, M.M. Hayes, Z. Cao, R. Tonda, K. Johnson, and D.C. Wright A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species J Infect Dis 180 1999 1939 1949
5. T. Hamouda, A. Myc, B. Donovan, A.Y. Shih, J.D. Reuter, and J.R. Baker Jr. A novel surfactant nanoemulsion with a unique non-irritant topical antimicrobial activity against bacteria, enveloped viruses and fungi Microbiol Res 1561 2001 1 7
6. T. Hamouda, and J.R. Baker Jr. Antimicrobial mechanism of action of surfactant lipid preparations in enteric Gram-negative bacilli J Appl Microbiol 89 2000 397 403
7. A. Myc, T. Vanhecke, J.J. Landers, T. Hamouda, and J.R. Baker Jr. The fungicidal activity of novel nanoemulsion (X8W60PC) against clinically important yeast and filamentous fungi Mycopathologia 155 2001 195 201
8. Michigan Nanotechnology Institute for Medicine and Biological Sciences [NIMBS Web site]. Antimicrobial nanoemulsions. Available at: http://nano.med.umich.edu/Platforms/Antimicrobial-Nanoemulsion.html. Accessed October 21, 2009.
9. G.D. Neal, G.R. Lindholm, M.J. Lee, J.A. Marvin, and D.M. Heimbach Burn wound histologic culture-a new technique for predicting burn wound sepsis J Burn Care Rehabil 2 1981 35 39
10. T.E. Taddonio, P.D. Thomson, M.J. Tait, J.K. Prasad, and I. Feller Rapid quantification of bacterial and fungal growth in burn wounds: biopsy homogenate Gram stain versus microbial culture results Burns Incl Therm Inj 14 1988 180 184
11. S.K. Uppal, S. Ram, B. Kwatra, S. Garg, and R. Gupta Comparative evaluation of surface swab and quantitative full thickness wound biopsy culture in burn patients Burns 33 2007 460 463
12. L. Steinstraesser, M. Föhn, R.D. Klein, A. Aminlari, D.G. Remick, and G.L. Su Feasibility of biolistic gene therapy in burns Shock 15 2001 272 277
13. K. Ipaktchi, A. Mattar, A.D. Niederbichler, L.M. Hoesel, M.R. Hemmila, and G.L. Su Topical p38MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn wounds Shock 26 2006 201 209
14. A. Lyons, A. Goebel, J.A. Mannick, and J.A. Lederer Protective effects of early interleukin 10 antagonism in injury-induced immune dysfunction Arch Surg 134 1999 1317 1323
15. M. Varedi, M.G. Jeschke, E.W. Englander, D.N. Herndon, and R.E. Barrow Serum TGF-beta in thermally injured rats Shock 16 2001 380 382
16. Z. Huang, C. Pereira, T. Toliver-Kinsky, E.D. Murphey, T.K. Varma, and C.Y. Lin Effect of transforming growth factor-beta neutralization on survival and bacterial clearance in a murine model of Pseudomonas aeruginosa burn wound infection J Burn Care Res 27 2006 682 687
17. L. Steinstraesser, R.D. Klein, A. Aminlari, M.H. Fan, V. Khilanani, and D.G. Remick Protegrin-1 enhances bacterial killing in thermally injured skin Crit Care Med 29 2001 1431 1437
18. J.F. Hansbrough, T. Wikstrom, M. Braide, M. Tenenhaus, O.H. Rennekampff, and V. Kiessig Neutrophil activation and tissue neutrophil sequestration in a rat model of thermal injury J Surg Res 61 1996 17 22
19. M.T. Piccolo, Y. Wang, S. Verbrugge, R.L. Warner, P. Sannomiya, and N.S. Piccolo Role of chemotactic factors in neutrophil activation after thermal injury in rats Inflammation 23 1999 371 385
20. G.O. Till, K.J. Johnson, R. Kunkel, and P.A. Ward Intravascular activation of complement and acute lung injury: dependency on neutrophils and toxic oxygen metabolites J Clin Invest 69 1982 1126 1135
21. K. Ipaktchi, A. Mattar, A.D. Niederbichler, L.M. Hoesel, S. Vollmannshauser, and M.R. Hemmila Topical p38 MAPK inhibition reduces bacterial growth in an in vivo burn wound model Surgery 142 2007 86 93
22. K. Ipaktchi, A. Mattar, A.D. Niederbichler, L.M. Hoesel, S. Vollmannshauser, and M.R. Hemmila Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury J Immunol 177 2006 8065 8071
23. K. Ipaktchi, A. Mattar, A.D. Niederbichler, J. Kim, L.M. Hoesel, and M.R. Hemmila Attenuating burn wound inflammation improves pulmonary function and survival in a burn-pneumonia model Crit Care Med 35 2007 2139 2144
24. L.M. Hoesel, A. Mattar, S. Arbabi, A.D. Niederbichler, K. Ipaktchi, and G.L. Su Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction Surgery 146 2009 775 785
25. Jones T, Ijzerman MM, Flack MR, Baker JR Jr. Subject-assessed time to healing in a randomized double-blind, vehicle-controlled trial of a novel topical antiviral nanoemulsion (NB-001) for recurrent Herpes labialis. In Programs and abstracts of the 48th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy; October 25-28, 2008; Washington, DC. Abstract V-3771.
26. NanoBio Corporation successfully completes Phase 2b study in Herpes labialis. NanoBio Corporation home page on the Internet. Available at: http://nanobio.com/News/NB-00X-Herpes2b.html. Accessed October 21, 2009.
27. Jarrat M, Ijzerman MM, Flack MR, Baker JR Jr. Safety, tolerability and pharmacokinetics of NB-001 in a phase 2 dose ranging trial in subjects with recurrent Herpes labialis. In Programs and abstracts of the 48th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy; October 25-28, 2008; Washington, DC. Abstract V-3539.
28. Ciotti S, Eisma R, Ma L, Baker JR Jr. Novel nanoemulsion NB-001 permeates skin by the follicular route. In Programs and abstracts of the 48th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy; October 25-28, 2008; Washington, DC. Abstract A-1898.