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Volumn 4, Issue 12, 2013, Pages 2302-2316

Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5

Author keywords

Angiogenesis; Eg5 kinesin; Ispinesib; Mklp2 kinesin; VEGF

Indexed keywords

KINESIN; PROTEIN EG5; PROTEIN KIF11; PROTEIN KIF20A; PROTEIN MKLP2; UNCLASSIFIED DRUG; VASCULOTROPIN A;

EID: 84891943309     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1490     Document Type: Article
Times cited : (57)

References (49)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D and Weinberg RA. The hallmarks of cancer. Cell. 2000; 100(1):57-70.
    • (2000) Cell. , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G, Cohen T, Gengrinovitch S and Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. Faseb J. 1999; 13(1):9-22.
    • (1999) Faseb J. , vol.13 , Issue.1 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 3
    • 84857179053 scopus 로고    scopus 로고
    • FDA cancels approval for bevacizumab in advanced breast cancer
    • Tanne JH. FDA cancels approval for bevacizumab in advanced breast cancer. BMJ. 2011; 343:d7684.
    • (2011) BMJ. , vol.343
    • Tanne, J.H.1
  • 4
    • 0026782208 scopus 로고
    • The effects of growth factors on the day 13 chorioallantoic membrane (CAM): a study of VEGF165 and PDGF-BB
    • Wilting J, Christ B and Weich HA. The effects of growth factors on the day 13 chorioallantoic membrane (CAM): a study of VEGF165 and PDGF-BB. Anatomy and embryology. 1992; 186(3):251-257.
    • (1992) Anatomy and embryology. , vol.186 , Issue.3 , pp. 251-257
    • Wilting, J.1    Christ, B.2    Weich, H.A.3
  • 5
    • 33646481056 scopus 로고    scopus 로고
    • Inhibitors of mitotic kinesins: next-generation antimitotics
    • Sarli V and Giannis A. Inhibitors of mitotic kinesins: next-generation antimitotics. ChemMedChem. 2006; 1(3):293-298.
    • (2006) ChemMedChem. , vol.1 , Issue.3 , pp. 293-298
    • Sarli, V.1    Giannis, A.2
  • 7
    • 34247487308 scopus 로고    scopus 로고
    • The kinesin related motor protein, Eg5, is essential for maintenance of pre-implantation embryogenesis
    • Castillo A and Justice MJ. The kinesin related motor protein, Eg5, is essential for maintenance of pre-implantation embryogenesis. Biochemical and biophysical research communications. 2007; 357(3):694-699.
    • (2007) Biochemical and biophysical research communications. , vol.357 , Issue.3 , pp. 694-699
    • Castillo, A.1    Justice, M.J.2
  • 8
    • 45449097416 scopus 로고    scopus 로고
    • Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality
    • Chauviere M, Kress C and Kress M. Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality. Biochemical and biophysical research communications. 2008; 372(4):513-519.
    • (2008) Biochemical and biophysical research communications. , vol.372 , Issue.4 , pp. 513-519
    • Chauviere, M.1    Kress, C.2    Kress, M.3
  • 9
    • 0034331310 scopus 로고    scopus 로고
    • The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis
    • Hill E, Clarke M and Barr FA. The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO J. 2000; 19(21):5711-5719.
    • (2000) EMBO J. , vol.19 , Issue.21 , pp. 5711-5719
    • Hill, E.1    Clarke, M.2    Barr, F.A.3
  • 12
    • 84864333830 scopus 로고    scopus 로고
    • Kinesins and cancer
    • Rath O and Kozielski F. Kinesins and cancer. Nat Rev Cancer. 2012; 12(8):527-539.
    • (2012) Nat Rev Cancer. , vol.12 , Issue.8 , pp. 527-539
    • Rath, O.1    Kozielski, F.2
  • 13
    • 0345688612 scopus 로고    scopus 로고
    • Mechanisms of Taxol resistance related to microtubules
    • Orr GA, Verdier-Pinard P, McDaid H and Horwitz SB. Mechanisms of Taxol resistance related to microtubules. Oncogene. 2003; 22(47):7280-7295.
    • (2003) Oncogene. , vol.22 , Issue.47 , pp. 7280-7295
    • Orr, G.A.1    Verdier-Pinard, P.2    McDaid, H.3    Horwitz, S.B.4
  • 14
    • 79955490607 scopus 로고    scopus 로고
    • Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration
    • Falnikar A, Tole S and Baas PW. Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration. Molecular biology of the cell. 2011.
    • (2011) Molecular biology of the cell
    • Falnikar, A.1    Tole, S.2    Baas, P.W.3
  • 15
    • 82955225066 scopus 로고    scopus 로고
    • Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5
    • Sun XD, Shi XJ, Sun XO, Luo YG, Wu XJ, Yao CF, Yu HY, Li DW, Liu M and Zhou J. Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. Acta pharmacologica Sinica. 2011; 32(12):1543-1548.
    • (2011) Acta pharmacologica Sinica. , vol.32 , Issue.12 , pp. 1543-1548
    • Sun, X.D.1    Shi, X.J.2    Sun, X.O.3    Luo, Y.G.4    Wu, X.J.5    Yao, C.F.6    Yu, H.Y.7    Li, D.W.8    Liu, M.9    Zhou, J.10
  • 17
    • 33646019197 scopus 로고    scopus 로고
    • KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity
    • Midorikawa R, Takei Y and Hirokawa N. KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity. Cell. 2006; 125(2):371-383.
    • (2006) Cell. , vol.125 , Issue.2 , pp. 371-383
    • Midorikawa, R.1    Takei, Y.2    Hirokawa, N.3
  • 18
    • 2142753111 scopus 로고    scopus 로고
    • VEGF coordinates interaction of pericytes and endothelial cells during vasculogenesis and experimental angiogenesis
    • Hagedorn M, Balke M, Schmidt A, Bloch W, Kurz H, Javerzat S, Rousseau B, Wilting J and Bikfalvi A. VEGF coordinates interaction of pericytes and endothelial cells during vasculogenesis and experimental angiogenesis. Dev Dyn. 2004; 230(1):23-33.
    • (2004) Dev Dyn. , vol.230 , Issue.1 , pp. 23-33
    • Hagedorn, M.1    Balke, M.2    Schmidt, A.3    Bloch, W.4    Kurz, H.5    Javerzat, S.6    Rousseau, B.7    Wilting, J.8    Bikfalvi, A.9
  • 21
    • 78249232298 scopus 로고    scopus 로고
    • Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor
    • Tcherniuk S, Skoufias DA, Labriere C, Rath O, Gueritte F, Guillou C and Kozielski F. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl. 2010; 49(44):8228-8231.
    • (2010) Angew Chem Int Ed Engl. , vol.49 , Issue.44 , pp. 8228-8231
    • Tcherniuk, S.1    Skoufias, D.A.2    Labriere, C.3    Rath, O.4    Gueritte, F.5    Guillou, C.6    Kozielski, F.7
  • 25
    • 42949106096 scopus 로고    scopus 로고
    • A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes
    • Herbert JM, Stekel D, Sanderson S, Heath VL and Bicknell R. A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes. BMC Genomics. 2008; 9:153.
    • (2008) BMC Genomics. , vol.9 , pp. 153
    • Herbert, J.M.1    Stekel, D.2    Sanderson, S.3    Heath, V.L.4    Bicknell, R.5
  • 34
    • 33646358250 scopus 로고    scopus 로고
    • Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol
    • Maliga Z and Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC chemical biology. 2006; 6:2.
    • (2006) BMC chemical biology. , vol.6 , pp. 2
    • Maliga, Z.1    Mitchison, T.J.2
  • 35
    • 77955386873 scopus 로고    scopus 로고
    • Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol
    • Kaan HY, Ulaganathan V, Rath O, Prokopcova H, Dallinger D, Kappe CO and Kozielski F. Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. J Med Chem. 2010; 53(15):5676-5683.
    • (2010) J Med Chem. , vol.53 , Issue.15 , pp. 5676-5683
    • Kaan, H.Y.1    Ulaganathan, V.2    Rath, O.3    Prokopcova, H.4    Dallinger, D.5    Kappe, C.O.6    Kozielski, F.7
  • 42
    • 84880618527 scopus 로고    scopus 로고
    • The expression of Eg5 predicts a poor outcome for patients with renal cell carcinoma
    • Sun D, Lu J, Ding K, Bi D, Niu Z, Cao Q, Zhang J and Ding S. The expression of Eg5 predicts a poor outcome for patients with renal cell carcinoma. Med Oncol. 2013; 30(1):476.
    • (2013) Med Oncol. , vol.30 , Issue.1 , pp. 476
    • Sun, D.1    Lu, J.2    Ding, K.3    Bi, D.4    Niu, Z.5    Cao, Q.6    Zhang, J.7    Ding, S.8
  • 43
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis LM and Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer. 2008; 8(8):579-591.
    • (2008) Nat Rev Cancer. , vol.8 , Issue.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 45
    • 79960134214 scopus 로고    scopus 로고
    • Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents
    • Zhang Q, Bindokas V, Shen J, Fan H, Hoffman RM and Xing HR. Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents. Molecular cancer therapeutics. 2011; 10(7):1173-1184.
    • (2011) Molecular cancer therapeutics. , vol.10 , Issue.7 , pp. 1173-1184
    • Zhang, Q.1    Bindokas, V.2    Shen, J.3    Fan, H.4    Hoffman, R.M.5    Xing, H.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.