Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5

Acta Pharmacologica Sinica

Volumn 32, Issue 12, 2011, Pages 1543-1548

  Sun, Xiao Dong ^a   Shi, Xing Juan ^a   Sun, Xiao Ou ^a   Luo, You Guang ^a   Wu, Xiao Jing ^a   Yao, Chang Fu ^a   Yu, Hai Yang ^a   Li, Deng Wen ^a   Liu, Min ^b   Zhou, Jun ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

cell invasion; cell migration; cell proliferation; dimethylenastron; Eg5; kinesin; molecular modeling; pancreatic cancer

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOSINE DIPHOSPHATE; ANTINEOPLASTIC AGENT; DIMETHYLENASTRON; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; PANCREAS CANCER; PROTEIN SECRETION; WOUND HEALING;

ALLOSTERIC REGULATION; CELL LINE, TUMOR; CELL MOVEMENT; HUMANS; KINESIN; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; QUINAZOLINES; THIONES;

EID: 82955225066     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.130     Document Type: Article

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