Kinesin molecular motor Eg5 functions during polypeptide synthesis

Molecular Biology of the Cell

Volumn 22, Issue 18, 2011, Pages 3420-3430

  Bartoli, Kristen M ^a,b   Jakovljevic, Jelena ^c   Woolford Jr , John L ^c   Saunders, William S ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KINESIN 5; MOLECULAR MOTOR;

ARTICLE; HUMAN; HUMAN CELL; INTERPHASE; MICROTUBULE; POLYSOME; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RIBOSOME; RNA TRANSLATION;

ANIMALS; CELL LINE; CENTRIFUGATION, DENSITY GRADIENT; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOPRECIPITATION; INTERPHASE; KINESIN; MICE; MICROTUBULES; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PYRIMIDINES; RIBOSOMES; RNA INTERFERENCE; THIONES;

EID: 80052836438     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-03-0211     Document Type: Article

References (61)

1. Ashe MP, De Long SK, Sachs AB (2000). Glucose depletion rapidly inhibits translation initiation in yeast. Mol Biol Cell 11, 833-848. (Pubitemid 30159305)
2. Bergnes G, Brejc K, Belmont L (2005). Mitotic kinesins: prospects for antimitotic drug discovery. Curr Top Med Chem 5, 127-145. (Pubitemid 40514510)
3. Bernstam VA, Gray RH, Bernstein IA (1980). Effect of microtubule- disrupting drugs on protein and RNA synthesis in Physarum polycephalum amoebae. Arch Microbiol 128, 34-40. (Pubitemid 11164954)
4. Bisbal M, Wojnacki J, Peretti D, Ropolo A, Sesma J, Jausoro I, Caceres A (2009). KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons. J Biol Chem 284, 9489-9497.
5. Bradford CT, Sullivan DT (1981). Isolation of polysomes from larval and adult Drosophila melanogaster. Anal Biochem 112, 176-181.
6. Burris HA 3rd, Jones SF, Williams DD, Kathman SJ, Hodge JP, Pandite L, Ho PT, Boerner SA, Lorusso P (2011). A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors. Invest New Drugs 29, 467-472.
7. Cahu J, Olichon A, Hentrich C, Schek H, Drinjakovic J, Zhang C, Doherty-Kirby A, Lajoie G, Surrey T (2008). Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles. PLoS One 3, e3936.
8. Chin GM, Herbst R (2006). Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint. Mol Cancer Ther 5, 2580-2591. (Pubitemid 44650923)
9. Cole DG, Saxton WM, Sheehan KB, Scholey JM (1994). A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos. J Biol Chem 269, 22913-22916.
10. Dang Y, Kedersha N, Low WK, Romo D, Gorospe M, Kaufman R, Anderson P, Liu JO (2006). Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem 281, 32870-32878. (Pubitemid 46036842)
11. DeBonis S, Skoufias DA, Lebeau L, Lopez R, Robin G, Margolis RL, Wade RH, Kozielski F (2004). In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Mol Cancer Ther 3, 1079-1090.
12. Duhl DM, Renhowe PA (2005). Inhibitors of kinesin motor proteins-research and clinical progress. Curr Opin Drug Discov Dev 8, 431-436. (Pubitemid 40917404)
13. Fan H, Penman S (1970). Regulation of protein synthesis in mammalian cells. II. Inhibition of protein synthesis at the level of initiation during mitosis. J Mol Biol 50, 655-670.
14. Ferhat L, Cook C, Chauviere M, Harper M, Kress M, Lyons GE, Baas PW (1998). Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development. J Neurosci 18, 7822-7835. (Pubitemid 28441022)
15. Fulton AB, Wan KM, Penman S (1980). The spatial distribution of polyribosomes in 3T3 cells and the associated assembly of proteins into the skeletal framework. Cell 20, 849-857. (Pubitemid 10078564)
16. Gartner M, Sunder-Plassmann N, Seiler J, Utz M, Vernos I, Surrey T, Giannis A (2005). Development and biological evaluation of potent and specific inhibitors of mitotic kinesin Eg5. Chembiochem 6, 1173-1177. (Pubitemid 40978175)
17. Hamill D, Davis J, Drawbridge J, Suprenant KA (1994). Polyribosome targeting to microtubules: enrichment of specific mRNAs in a reconstituted microtubule preparation from sea urchin embryos. J Cell Biol 127, 973-984. (Pubitemid 24355986)
18. Han Y, Yu J, Guo F, Watkins SC (2006). Polysomes are associated with microtubules in fertilized eggs of Chinese pine (Pinus tabulaeformis). Protoplasma 227, 223-227. (Pubitemid 43807453)
19. Haque SA, Hasaka TP, Brooks AD, Lobanov PV, Baas PW (2004). Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons. Cell Motil Cytoskeleton 58, 10-16. (Pubitemid 38569169)
20. Hesketh JE, Pryme IF (1988). Evidence that insulin increases the proportion of polysomes that are bound to the cytoskeleton in 3T3 fibroblasts. FEBS Lett 231, 62-66.
21. Huszar D, Theoclitou ME, Skolnik J, Herbst R (2009). Kinesin motor proteins as targets for cancer therapy. Cancer Metastasis Rev 28, 197-208.
22. Jansen RP (1999). RNA-cytoskeletal associations. FASEB J 13, 455-466.
23. Kapitein LC, Peterman EJ, Kwok BH, Kim JH, Kapoor TM, Schmidt CF (2005). The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435, 114-118. (Pubitemid 40655918)
24. Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ (2000). Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J Cell Biol 150, 975-988.
25. Kashina AS, Baskin RJ, Cole DG, Wedaman KP, Saxton WM, Scholey JM (1996). A bipolar kinesin. Nature 379, 270-272. (Pubitemid 26025214)
26. Kashina AS, Rogers GC, Scholey JM (1997). The bimC family of kinesins: essential bipolar mitotic motors driving centrosome separation. Biochim Biophys Acta 1357, 257-271. (Pubitemid 27303747)
27. Lad L, Luo L, Carson JD, Wood KW, Hartman JJ, Copeland RA, Sakowicz R (2008). Mechanism of inhibition of human KSP by ispinesib. Biochemistry 47, 3576-3585. (Pubitemid 351399246)
28. Lenk R, Ransom L, Kaufmann Y, Penman S (1977). A cytoskeletal structure with associated polyribosomes obtained from HeLa cells. Cell 10, 67-78. (Pubitemid 8046477)
29. Lerner RS, Seiser RM, Zheng T, Lager PJ, Reedy MC, Keene JD, Nicchitta CV (2003). Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes. RNA 9, 1123-1137. (Pubitemid 37093621)
30. Levesque AA, Compton DA (2001). The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J Cell Biol 154, 1135-1146. (Pubitemid 34286192)
31. Loschi M, Leishman CC, Berardone N, Boccaccio GL (2009). Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci 122, 3973-3982.
32. Macgregor HC, Stebbings H (1970). A massive system of microtubules associated with cytoplasmic movement in telotrophic ovarioles. J Cell Sci 6, 431-449.
33. Maliga Z, Kapoor TM, Mitchison TJ (2002). Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol 9, 989-996. (Pubitemid 35273719)
34. Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ (1999). Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-974.
35. Miyamoto DT, Perlman ZE, Burbank KS, Groen AC, Mitchison TJ (2004). The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol 167, 813-818. (Pubitemid 39628104)
36. Moon RT, Nicosia RF, Olsen C, Hille MB, Jeffery WR (1983). The cytoskeletal framework of sea urchin eggs and embryos: developmental changes in the association of messenger RNA. Dev Biol 95, 447-458. (Pubitemid 13163953)
37. Moyer ML, Gilbert SP, Johnson KA (1996). Purification and characterization of two monomeric kinesin constructs. Biochemistry 35, 6321-6329. (Pubitemid 26164064)
38. Myers KA, Baas PW (2007). Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array. J Cell Biol 178, 1081-1091. (Pubitemid 47443328)
39. Nadar VC, Ketschek A, Myers KA, Gallo G, Baas PW (2008). Kinesin-5 is essential for growth-cone turning. Curr Biol 18, 1972-1977.
40. Nakai R et al. (2009). K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res 69, 3901-3909.
41. Nie M, Htun H (2006). Different modes and potencies of translational repression by sequence-specific RNA-protein interaction at the 5′-UTR. Nucleic Acids Res 34, 5528-5540. (Pubitemid 44742441)
42. Peterman EJ, Scholey JM (2009). Mitotic microtubule crosslinkers: insights from mechanistic studies. Curr Biol 19, R1089-R1094.
43. Ramaekers FC, Benedetti EL, Dunia I, Vorstenbosch P, Bloemendal H (1983). Polyribosomes associated with microfilaments in cultured lens cells. Biochim Biophys Acta 740, 441-448. (Pubitemid 13012497)
44. Rapley J, Nicolas M, Groen A, Regue L, Bertran MT, Caelles C, Avruch J, Roig J (2008). The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci 121, 3912-3921.
45. Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, Dor Y, Zisman P, Meyuhas O (2005). Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 19, 2199-2211. (Pubitemid 41330321)
46. Saini P, Eyler DE, Green R, Dever TE (2009). Hypusine-containing protein eIF5A promotes translation elongation. Nature 459, 118-121.
47. Sakowicz R et al. (2004). Antitumor activity of a kinesin inhibitor. Cancer Res 64, 3276-3280. (Pubitemid 38581433)
48. Sarli V, Giannis A (2008). Targeting the kinesin spindle protein: basic principles and clinical implications. Clin Cancer Res 14, 7583-7587.
49. Sawin KE, LeGuellec K, Philippe M, Mitchison TJ (1992). Mitotic spindle organization by a plus-end-directed microtubule motor. Nature 359, 540-543.
50. Sharp DJ, McDonald KL, Brown HM, Matthies HJ, Walczak C, Vale RD, Mitchison TJ, Scholey JM (1999). The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol 144, 125-138. (Pubitemid 29047016)
51. Shin BS, Kim JR, Acker MG, Maher KN, Lorsch JR, Dever TE (2009). rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit. Mol Cell Biol 29, 808-821.
52. Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ (2004). Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Curr Biol 14, 1941-1945. (Pubitemid 39464818)
53. Sivan G, Kedersha N, Elroy-Stein O (2007). Ribosomal slowdown mediates translational arrest during cellular division. Mol Cell Biol 27, 6639-6646. (Pubitemid 47483618)
54. Sotelo-Silveira JR, Calliari A, Cardenas M, Koenig E, Sotelo JR (2004). Myosin Va and kinesin II motor proteins are concentrated in ribosomal domains (periaxoplasmic ribosomal plaques) of myelinated axons. J Neurobiol 60, 187-196. (Pubitemid 39006992)
55. Suprenant KA (1993). Microtubules, ribosomes, and RNA: evidence for cytoplasmic localization and translational regulation. Cell Motil Cytoskeleton 25, 1-9.
56. Suprenant KA, Tempero LB, Hammer LE (1989). Association of ribosomes with in vitro assembled microtubules. Cell Motil Cytoskeleton 14, 401-415. (Pubitemid 20001958)
57. Tanenbaum ME, Medema RH (2010). Mechanisms of centrosome separation and bipolar spindle assembly. Dev Cell 19, 797-806.
58. van den Wildenberg SM, Tao L, Kapitein LC, Schmidt CF, Scholey JM, Peterman EJ (2008). The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations. Curr Biol 18, 1860-1864.
59. Verhey KJ, Kaul N, Soppina V (2011). Kinesin assembly and movement in cells. Annu Rev Biophys 40, 267-288.
60. Wang H, Dictenberg JB, Ku L, Li W, Bassell GJ, Feng Y (2008). Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes. Mol Biol Cell 19, 105-114. (Pubitemid 351186137)
61. Zhang Y, Xu W (2008). Progress on kinesin spindle protein inhibitors as anti-cancer agents. Anticancer Agents Med Chem 8, 698-704.