Dystonia as a network disorder: What is the role of the cerebellum?

Neuroscience

Volumn 260, Issue , 2014, Pages 23-35

  Prudente, C N ^a   Hess, E J ^a   Jinnah, H A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebellum; Dystonia; Network model

Indexed keywords

ATAXIA; BASAL GANGLION; BIOACCUMULATION; BRAIN FUNCTION; BRAIN NERVE CELL; BRAIN REGION; CEREBELLUM; CEREBELLUM INJURY; CLINICAL FEATURE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DYSTONIA; EXPERIMENTAL DESIGN; HUMAN; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NERVE CELL NETWORK; NONHUMAN; OUTCOME ASSESSMENT; PRIMATE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

CEREBELLUM; DYSTONIA; NETWORK MODEL; PET; POSITRON EMISSION TOMOGRAPHY; SCAS; SPINOCEREBELLAR ATAXIAS;

ANIMALS; BASAL GANGLIA DISEASES; CEREBELLAR DISEASES; DYSTONIA; HUMANS; NERVE NET;

EID: 84891936582     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.11.062     Document Type: Review

References (132)

1. Alarcon F., Tolosa E., Munoz E. Focal limb dystonia in a patient with a cerebellar mass. Arch Neurol 2001, 58:1125-1127.
2. Albanese A., Bhatia K., Bressman S.B., DeLong M.R., Fahn S., Fung V.S.C., Hallett M., Jankovic J., Jinnah H.A., Klein C., Lang A.E., Mink J.W., Teller J.K. Phenomenology and classification of dystonia: A consensus update. Mov Disord 2013, 28:863-873.
3. Alvarez-Fischer D., Grundmann M., Lu L., Samans B., Fritsch B., Moller J.C., Schaefer M.K., Hartmann A., Oertel W.H., Bandmann O. Prolonged generalized dystonia after chronic cerebellar application of kainic acid. Brain Res 2012, 1464:82-88.
4. Argyelan M., Carbon M., Niethammer M., Ulug A.M., Voss H.U., Bressman S.B., Dhawan V., Eidelberg D. Cerebellothalamocortical connectivity regulates penetrance in dystonia. J Neurosci 2009, 29:9740-9747.
5. Avanzino L., Abbruzzese G. How does the cerebellum contribute to the pathophysiology of dystonia. Basal Ganglia 2012, 2:231-235.
6. Balcioglu A., Kim M.O., Sharma N., Cha J.H., Breakefield X.O., Standaert D.G. Dopamine release is impaired in a mouse model of DYT1 dystonia. J Neurochem 2007, 102:783-788.
7. Berardelli A., Rothwell J.C., Hallett M., Thompson P.D., Manfredi M., Marsden C.D. The pathophysiology of primary dystonia. Brain 1998, 121:1195-1212.
8. Bhatia K.P., Marsden C.D. The behavioral and motor consequences of focal lesions of the basal ganglia in man. Brain 1994, 117:859-876.
9. Bostan A.C., Strick P.L. The cerebellum and basal ganglia are interconnected. Neuropsychol Rev 2010, 20:261-270.
10. Bostan A.C., Dum R.P., Strick P.L. The basal ganglia communicate with the cerebellum. Proc Natl Acad Sci U S A 2010, 107:8452-8456.
11. Bradnam, Ridding, McDonnell Non-invasive cerebellar stimulation for treatment of focal dystonia 2013, Second International Congress on Treatment of Dystonia, Hannover, Germany.
12. Bragg D.C., Armata I.A., Nery F.C., Breakefield X.O., Sharma N. Molecular pathways in dystonia. Neurobiol Dis 2011, 42:136-147.
13. Breakefield X.O., Blood A.J., Li Y., Hallett M., Hanson P.I., Standaert D.G. The pathophysiological basis of dystonias. Nat Rev Neurosci 2008, 9:222-234.
14. Brighina F., Romano M., Giglia G., Saia V., Puma A., Giglia F., Fierro B. Effects of cerebellar TMS on motor cortex of patients with focal dystonia: a preliminary report. Exp Brain Res 2009, 192:651-656.
15. Calderon D.P., Fremont R., Kraenzlin F., Khodakhah K. The neural substrates of rapid-onset dystonia-parkinsonism. Nat Neurosci 2011, 14:357-365.
16. Campbell D.B., Hess E.J. Cerebellar circuitry is activated during convulsive episodes in the tottering (tg/tg) mutant mouse. Neurosci 1998, 85:773-783.
17. Campbell D.B., North J.B., Hess E.J. Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background. Exp Neurol 1999, 160:268-278.
18. Carbon M., Eidelberg D. Abnormal structure-function relationships in hereditary dystonia. Neuroscience 2009, 164:220-229.
19. Carbon M., Su S., Dhawan V., Raymond D., Bressman S., Eidelberg D. Regional metabolism in primary torsion dystonia: effects of penetrance and genotype. Neurology 2004, 62:1384-1390.
20. Centonze D., Grande C., Saulle E., Martin A.B., Gubellini P., Pavon N., Pisani A., Bernardi G., Moratalla R., Calabresi P. Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity. J Neurosci 2003, 23:8506-8512.
21. Chen G., Popa L.S., Wang X., Gao W., Barnes J., Hendrix C.M., Hess E.J., Ebner T.J. Low-frequency oscillations in the cerebellar cortex of the tottering mouse. J Neurophysiol 2009, 101:234-245.
22. Dang M.T., Yokoi F., Cheetham C.C., Lu J., Vo V., Lovinger D.M., Li Y. An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 DeltaGAG knock-in mice. Behav Brain Res 2012, 226:465-472.
23. Davis R. Cerebellar stimulation for cerebral palsy spasticity, function, and seizures. Arch Med Res 2000, 31:290-299.
24. Defazio G., Berardelli A., Hallett M. Do primary adult-onset focal dystonias share aetiological factors?. Brain 2007, 130:1183-1193.
25. Delmaire C., Vidailhet M., Elbaz A., Bourdain F., Bleton J.P., Sangla S., Meunier S., Terrier A., Lehericy S. Structural abnormalities in the cerebellum and sensorimotor circuit in writer's cramp. Neurology 2007, 69:376-380.
26. Elble R.J. Defining dystonic tremor. Curr Neuropharmacol 2013, 11:48-52.
27. Fan X., Hughes K.E., Jinnah H.A., Hess E.J. Selective and sustained AMPA receptor activation in cerebellum induces dystonia in mice. J Pharmacol Exp Ther 2012, 340:733-741.
28. Filip P., Lungu O.V., Bares M. Dystonia and the cerebellum: a new field of interest in movement disorders?. Clin Neurophysiol 2013, 124:1269-1274.
29. Foltz E.L., Knopp L.M., Ward A.A. Experimental spasmodic torticollis. J Neurosurg 1959, 16:55-67.
30. Fukaya C., Katayama Y., Kano T., Nagaoka T., Kobayashi K., Oshima H., Yamamoto T. Thalamic deep brain stimulation for writer's cramp. J Neurosurg 2007, 107:977-982.
31. Fung V.S., Jinnah H.A., Bhatia K., Vidailhet M. Assessment of the patient with dystonia: an update on dystonia syndromes. Mov Disord 2013, 28:889-898.
32. Fureman B.E., Hess E.J. Noradrenergic blockade prevents attacks in a model of episodic dysfunction caused by a channelopathy. Neurobiol Dis 2005, 20:227-232.
33. Fureman B.E., Jinnah H.A., Hess E.J. Triggers of paroxysmal dyskinesias in the calcium channel mouse mutant tottering. Pharmacol Biochem Behav 2002, 73:631-637.
34. Gasser T., Asmus F. Dystonia-plus syndromes. Eur J Neurol 2010, 17(Suppl 1):37-45.
35. Gerwig M., Kolb F.P., Timmann D. The involvement of the human cerebellum in eyeblink conditioning. Cerebellum 2007, 6:38-57.
36. Ghika J., Bogousslavsky J., Henderson J., Maeder P., Regli F. The "jerky dystonic unsteady hand": a delayed motor syndrome in posterior thalamic infarctions. J Neurol 1994, 241:537-542.
37. Glickstein M., Voogd J. Lodewijk Bolk and the comparative anatomy of the cerebellum. Trends Neurosci 1995, 18:206-210.
38. Gonzalez-Alegre P., Bode N., Davidson B.L., Paulson H.L. Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia. J Neurosci 2005, 25:10502-10509.
39. Goto S., Shimazu H., Matsuzaki K., Tamura T., Murase N., Nagahiro S., Kaji R. Thalamic Vo-complex vs pallidal deep brain stimulation for focal hand dystonia. Neurology 2008, 70:1500-1501.
40. Granata A., Schiavo G., Warner T.T. TorsinA and dystonia: from nuclear envelope to synapse. J Neurochem 2009, 109:1596-1609.
41. Gross R. What happened to posteroventral pallidotomy for Parkinson's disease and dystonia?. NeuroRx 2008, 5:281-293.
42. Grundmann M., Reischmann B., Vanhoutte G., Hubener J., Teismann P., Hauser T.K., Bonin M., Wilbertz J., Horn S., Nguyen H.P., Kuhn M., Chanarat S., Wolburg H., Van der Linden A., Riess O. Overexpression of human wildtype torsinA and human deltaGAG torsinA in a transgenic mouse model causes phenotypic abnormalities. Neurobiol Dis 2007, 27:190-206.
43. Grundmann K., Glockle N., Martella G., Sciamanna G., Hauser T.K., Yu L., Castaneda S., Pichler B., Fehrenbacher B., Schaller M., Nuscher B., Haass C., Hettich J., Yue Z., Nguyen H.P., Pisani A., Riess O., Ott T. Generation of a novel rodent model for DYT1 dystonia. Neurobiol Dis 2012, 47:61-74.
44. Guehl D., Cuny E., Ghorayeb I., Michelet T., Bioulac B., Burbaud P. Primate models of dystonia. Prog Neurobiol 2009, 87:118-131.
45. Hallett M. Pathophysiology of dystonia. J Neural Transm Suppl 2006, 70:485-488.
46. He F., Zhang S., Qian G., Zhang C. Delayed dystonia with striatal CT lucencies induced by a mycotoxin (3-nitropropionic acid). Neurology 1995, 45:2178-2183.
47. Hedera P., Phibbs F.T., Fang J.Y., Cooper M.K., Charles P.D., Davis T.L. Clustering of dystonia in some pedigrees with autosomal dominant essential tremor suggests the existence of a distinct subtype of essential tremor. BMC Neurol 2010, 10:66.
48. Hedera P., Phibbs F.T., Dolhun R., Charles P.D., Konrad P.E., Neimat J.S., Davis T.L. Surgical targets for dystonic tremor: Considerations between the globus pallidus and ventral intermediate thalamic nucleus. Parkinsonism Relat Disord 2013, 19:684-686.
49. Hedreen JC, Zweig RM, DeLong MR, Whitehouse PJ, Price DL (1988) Primary dystonias: a review of the pathology and suggestions for new directions of study (Fahn, S, et al., eds). Adv Neurol 50:123-132.
50. Herz E. Dystonias, part 3: pathology and conclusions. Arch Neurol Psychiatr 1944, 52:20.
51. Hewett J.W., Zeng J., Niland B.P., Bragg D.C., Breakefield X.O. Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics. Neurobiol Dis 2006, 22:98-111.
52. Hewett J., Johanson P., Sharma N., Standaert D., Balcioglu A. Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo. J Neurochem 2010, 113:228-235.
53. Hitchcock E. Dentate lesions for involuntary movement. Proc R Soc Med 1973, 66:877-879.
54. Hoffland B.S., Kassavetis P., Bologna M., Teo J.T., Bhatia K.P., Rothwell J.C., Edwards M.J., van de Warrenburg B.P. Cerebellum-dependent associative learning deficits in primary dystonia are normalized by rTMS and practice. Eur J Neurosci 2013, 38:2166-2177.
55. Hopp J.J., Fuchs A.F. The characteristics and neuronal substrate of saccadic eye movement plasticity. Prog Neurobiol 2004, 72:27-53.
56. Hoshi E., Tremblay L., Feger J., Carras P.L., Strick P.L. The cerebellum communicates with the basal ganglia. Nat Neurosci 2005, 8:1491-1493.
57. Hubsch C., Vidailhet M., Rivaud-Pechoux S., Pouget P., Brochard V., Degos B., Pelisson D., Golmard J.L., Gaymard B., Roze E. Impaired saccadic adaptation in DYT11 dystonia. J Neurol Neurosurg Psychiatry 2011, 82:1103-1106.
58. Hutchinson M., Nakamura T., Moeller J.R., Antonini A., Belakhlef A., Dhawan V., Eidelberg D. The metabolic topography of esential blepharospasm. Neurology 2000, 55:673-677.
59. Jinnah H.A., Hess E.J. A new twist on the anatomy of dystonia: the basal ganglia and the cerebellum. Neurology 2006, 67:1740-1741.
60. Jinnah H.A., Hess E.J. Experimental therapeutics for dystonia. Neurotherapeutics 2008, 5:198-209.
61. Jinnah H.A., Langlais P.J., Friedmann T. Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome. J Pharmacol Exp Ther 1992, 263:596-607.
62. Jinnah H.A., Wojcik B.E., Hunt M.A., Narang N., Lee K.Y., Goldstein M., Wamsley J.K., Langlais P.J., Friedmann T. Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J Neurosci 1994, 14:1164-1175.
63. Jinnah H.A., Hess E.J., LeDoux M.S., Sharma N., Baxter M.G., DeLong M.R. Rodent models for dystonia research: characteristics, evaluation, and utility. Mov Disord 2005, 20:283-292.
64. Jinnah H.A., Richter A., Mink J.W., Caldwell G.A., Caldwell K.A., Gonzalez-Alegre P., Cookson M.R., Breakefield X.O., Delong M.R., Hess E.J. Animal models for drug discovery in dystonia. Expert Opin Drug Discovery 2008, 3:83-97.
65. Jinnah H.A., Berardelli A., Comella C., Defazio G., DeLong M., Factor S., Hallett M., Galpern W., Ludlow C.L., Perlmutter J.S., Rosen A. The focal dystonias: current views and challenges for future research. Mov Disord 2013, 7:926-943.
66. Kemberling S.R., Baird H.W., Spiegel E.A. Experimental torticollis of rhombencephalic origin. J Neuropathol Exp Neurol 1952, 11:184-191.
67. Khooshnoodi M.A., Factor S.A., Jinnah H.A. Secondary blepharospasm associated with structural lesions of the brain. J Neurol Sci 2013, 331:98-101.
68. Kim J.S. Delayed onset mixed involuntary movements after thalamic stroke. Brain 2001, 124:299-309.
69. Klier E.M., Wang H., Constantin A.G., Crawford J.D. Midbrain control of three-dimensional head orientation. Science 2002, 295:1314-1316.
70. Krauss J.K., Seeger W., Jankovic J. Cervical dystonia associated with tumors of the posterior fossa. Mov Disord 1997, 12:443-447.
71. Kuoppamaki M., Giunti P., Quinn N., Wood N.W., Bhatia K.P. Slowly progressive cerebellar ataxia and cervical dystonia: clinical presentation of a new form of spinocerebellar ataxia?. Mov Disord 2003, 18:200-206.
72. Lange N., Hamann M., Shashidharan P., Richter A. Behavioural and pharmacological examinations in a transgenic mouse model of early-onset torsion dystonia. Pharmacol Biochem Behav 2011, 97:647-655.
73. Le Ber I., Clot F., Vercueil L., Camzuat A., Viemont M., Benamar N., De Liege P., Ouvrard-Hernandez A.M., Pollak P., Stevanin G., Brice A., Durr A. Predominant dystonia with marked cerebellar atrophy: a rare phenotype in familial dystonia. Neurology 2006, 67:1769-1773.
74. LeDoux M.S. The genetics of dystonias. Adv Genet 2012, 79:35-85.
75. LeDoux M.S., Brady K.A. Secondary cervical dystonia associated with structural lesions of the central nervous system. Mov Disord 2003, 18:60-69.
76. LeDoux M.S., Lorden J.F. Abnormal cerebellar output in the genetically dystonic rat. Dystonia 3 1998, Vol. 78:63-78. Lippincott-Raven Publishers, Philadelphia.
77. LeDoux M.S., Lorden J.F., Ervin J.M. Cerebellectomy eliminates the motor syndrome of the genetically dystonic rat. Exp Neurol 1993, 120:302-310.
78. LeDoux M.S., Lorden J.F., Meinzen-Derr J. Selective elimination of cerebellar output in the genetically dystonic rat. Brain Res 1995, 697:91-103.
79. LeDoux M.S., Hurst D.C., Lorden J.F. Single-unit activity of cerebellar nuclear cells in the awake genetically dystonic rat. Neurosci 1998, 86:533-545.
80. LeDoux MS, Dauer WT, Warner T (2013) Emerging molecular pathways for dystonia. Mov Disord [this issue].
81. Lehericy S., Tijssen M.A., Vidailhet M., Kaji R., Meunier S. The anatomical basis of dystonia: Current view using neuroimaging. Mov Disord 2013, 28:944-957.
82. Lohmann K., Klein C. Genetics of dystonia: what's known? What's new? What's next?. Mov Disord 2013, 28:899-905.
83. Ma K., Babij R., Cortes E., Vonsattel J.P., Louis E.D. Cerebellar pathology of a dual clinical diagnosis: patients with essential tremor and dystonia. Tremor Other Hyperkinet Mov 2012, 2:1-6.
84. Magoun H.W., Hare W.K., Ranson S.W. Electrical stimulation of the interior of the cerebellum in the monkey. Am J Physiol 1935, 112:329-339.
85. Manni E., Petrosini L. A century of cerebellar somatotopy: a debated representation. Nat Rev Neurosci 2004, 5:241-249.
86. Marsden C.D., Obeso J.A., Zarranz J.J. The anatomical basis of symptomatic dystonia. Brain 1985, 108:463-483.
87. Martella G., Tassone A., Sciamanna G., Platania P., Cuomo D., Viscomi M.T., Bonsi P., Cacci E., Biagioni S., Usiello A., Bernardi G., Sharma N., Standaert D.G., Pisani A. Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. Brain 2009, 132:2336-2349.
88. McGeer E.G., McGeer P.L. The dystonias. Can J Neurol Sci 1988, 15:447-483.
89. McGeer E.G., McGeer P.L. Pathology of dystonias. Handbook of dystonia 1995, 77-102. Marcel Dekker, New York. J.K.C. Tsui, D.B. Calne (Eds.).
90. Morishita T., Foote K.D., Haq I.U., Zeilman P., Jacobson C.E., Okun M.S. Should we consider Vim thalamic deep brain stimulation for select cases of severe refractory dystonic tremor. Stereotact Funct Neurosurg 2010, 88:98-104.
91. Moro E., Gross R.E., Krauss J.K. What's new in surgical treatments for dystonia?. Mov Disord 2013, 28:1013-1020.
92. Mottolese C., Richard N., Harquel S., Szathmari A., Sirigu A., Desmurget M. Mapping motor representations in the human cerebellum. Brain 2012, 136:330-342.
93. Neychev V., Fan X., Mitev V.I., Hess E.J., Jinnah H.A. The basal ganglia and cerebellum interact in the expression of dystonic movement. Brain 2008, 131:2499-2509.
94. Neychev V.K., Gross R., Lehericy S., Hess E.J., Jinnah H.A. The functional neuroanatomy of dystonia. Neurobiol Dis 2011, 42:185-201.
95. Niethammer M., Carbon-Correll M., Argyelan M., Eidelberg D. Hereditary dystonia as a neurodevelopmental circuit disorder: evidence from neuroimaging. Neurobiol Dis 2010, 42:202-209.
96. Obeso J.A., Gimenez-Roldan S. Clinicopathologic correlation in symptomatic dystonia. Adv Neurol 1988, 50:113-122.
97. Odergren T., Stone-Elander S., Ingvar M. Cerebral and cerebellar activation in correlation to the action-induced dystonia in writer's cramp. Mov Disord 1998, 13:497-508.
98. Oleas J., Yokoi F., Deandrade M.P., Pisani A., Li Y. Engineering animal models for dystonia: what have we learned?. Mov Disord 2013, 28:990-1000.
99. Page M.E., Bao L., Andre P., Pelta-Heller J., Sluzas E., Gonzalez-Alegre P., Bogush A., Khan L.E., Iacovitti L., Rice M.E., Ehrlich M.E. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice. Neurobiol Dis 2010, 39:318-326.
100. Palfi S., Leventhal L., Goetz C.G., Hantraye T., Roitberg B.Z., Sramek J., Emborg M., Kordower J.H. Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys. Mov Disord 2000, 15:524-530.
101. Perlmutter J.S., Mink J.W. Dysfunction of dopaminergic pathways in dystonia. Adv Neurol 2004, 94:163-170.
102. Peterson D.A., Sejnowski T.J., Poizner H. Convergent evidence for abnormal striatal synaptic plasticity in dystonia. Neurobiol Dis 2010, 37:558-573.
103. Pettigrew L.C., Jankovic J. Hemidystonia: a report of 22 patients and a review of the literature. J Neurol Neurosurg Psychiatry 1985, 48:650-657.
104. Pisani A., Martella G., Tscherter A., Bonsi P., Sharma N., Bernadi G., Standaert D.G. Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia. Neurobiol Dis 2006, 24:318-325.
105. Pisani A., Bernardi G., Ding J., Surmeier D.J. Re-emergence of striatal cholinergic interneurons in movement disorders. Trends Neurosci 2007, 30:545-553.
106. Pita Lobo P., Quattrocchi G., Jutras M.F., Sangla S., Apartis E., Vidailhet M., Grabli D. Primary writing tremor and writer's cramp: two faces of a same coin?. Mov Disord 2013, 28:1306-1307.
107. Pizoli C.E., Jinnah H.A., Billingsley M.L., Hess E.J. Abnormal cerebellar signaling induces dystonia in mice. J Neurosci 2002, 22:7825-7833.
108. Prudente C.N., Pardo C.A., Xiao J., Hanfelt J., Hess E.J., LeDoux M.S., Jinnah H.A. Neuropathology of cervical dystonia. Exp Neurol 2012, 241:95-104.
109. Quartarone A., Hallett M. Emerging concepts in the physiological basis of dystonia. Mov Disord 2013, 28:958-967.
110. Quinn N.P., Schneider S.A., Schwingenschuh P., Bhatia K.P. Tremor - some controversial aspects. Mov Disord 2011, 26:18-23.
111. Raethjen J., Deuschl G. The oscillating central network of essential tremor. Clin Neurophysiol 2012, 123:61-64.
112. Raike R.S., Pizoli C.E., Weisz C., van den Maagdenberg A.M., Jinnah H.A., Hess E.J. Limited regional cerebellar dysfunction induces focal dystonia in mice. Neurobiol Dis 2012, 49:200-210.
113. Sadnicka A., Hoffland B.S., Bhatia K.P., van de Warrenburg B.P., Edwards M.J. The cerebellum in dystonia - help or hindrance?. Clin Neurophysiol 2012, 123:65-70.
114. Sadnicka A., Teo J., Kojovic M., Kassavetis P., Saifee T., Isabel P., Schwingenschuh P., Rothwell J., Bhatia K., Edwards M. Genotype specific cerebellar involvement in dyt1 and dyt6 dystonia?. J Neurol Neurosurg Psychiatry 2013, 84:e2.
115. Saint Hilaire M.H., Burke R.E., Bressman S.B., Brin M.F., Fahn S. Delayed-onset dystonia due to perinatal or early childhood asphyxia. Neurology 1991, 41:216-222.
116. Schicatano E.J., Basso M.A., Evinger C. Animal model explains the origins of the cranial dystonia benign essential blepharospasm. J Neurophysiol 1997, 77:2842-2846.
117. Schiebler S., Schmidt A., Zittel S., Baumer T., Gerloff C., Klein C., Munchau A. Arm tremor in cervical dystonia - is it a manifestation of dystonia or essential tremor?. Mov Disord 2011, 26:1789-1792.
118. Sciamanna G., Hollis R., Ball C., Martella G., Tassone A., Marshall A., Parsons D., Li X., Yokoi F., Zhang L., Li Y., Pisani A., Standaert D.G. Cholinergic dysregulation produced by selective inactivation of the dystonia-associated protein torsinA. Neurobiol Dis 2012, 47:416-427.
119. Sciamanna G., Tassone A., Mandolesi G., Puglisi F., Ponterio G., Martella G., Madeo G., Bernardi G., Standaert D.G., Bonsi P., Pisani A. Cholinergic dysfunction alters synaptic integration between thalamostriatal and corticostriatal inputs in DYT1 dystonia. J Neurosci 2012, 32:11991-12004.
120. Scott B.L., Jankovic J. Delayed-onset progressive movement disorders after static brain lesions. Neurology 1996, 46:68-74.
121. Song C.H., Fan X., Exeter C.J., Hess E.J., Jinnah H.A. Functional analysis of dopaminergic systems in a DYT1 knock-in mouse model of dystonia. Neurobiol Dis 2012, 48:66-78.
122. Song C.H., Bernhard D., Bolarinwa C., Hess E.J., Smith Y., Jinnah H.A. Subtle microstructural changes of the striatum in a DYT1 knock-in mouse model of dystonia. Neurobiol Dis 2013, 54:362-371.
123. Tanabe L.M., Kim C.E., Alagem N., Dauer W.T. Primary dystonia: molecules and mechanisms. Nat Rev Neurol 2009, 5:598-609.
124. Teo J.T., van de Warrenburg B.P., Schneider S.A., Rothwell J.C., Bhatia K.P. Neurophysiological evidence for cerebellar dysfunction in primary focal dystonia. J Neurol Neurosurg Psychiatry 2009, 80:80-83.
125. Thobois S., Ballanger B., Xie-Brustolin J., Damier P., Durif F., Azulay J.P., Derost P., Witjas T., Raoul S., Le Bars D., Broussolle E. Globus pallidus stimulation reduces frontal hyperactivity in tardive dystonia. J Cereb Blood Flow Metab 2008, 28:1127-1138.
126. Thompson R.F., Steinmetz J.E. The role of the cerebellum in classical conditioning of discrete behavioral responses. Neuroscience 2009, 162:732-755.
127. Vidailhet M., Jutras M.F., Grabli D., Roze E. Deep brain stimulation for dystonia. J Neurol Neurosurg Psychiatry 2012, 84:1029-1040.
128. Wilson B., Hess E.J. Animal models for dystonia. Mov Disord 2013, 28:982-989.
129. Xiao J., Ledoux M.S. Caytaxin deficiency causes generalized dystonia in rats. Brain Res Mol Brain Res 2005, 141:181-192.
130. Zhao Y., DeCuypere M., LeDoux M.S. Abnormal motor function and dopamine neurotransmission in DYT1 DeltaGAG transgenic mice. Exp Neurol 2008, 210:719-730.
131. Zoons E., Tijssen M.A.J. Pathological changes in the brain in cervical dystonia pre- and post-mortem: a commentary with a special focus on the cerebellum. Exp Neurol 2013, 247:130-133.
132. Zoons E., Booij J., Nederveen A.J., Dijk J.M., Tijssen M.A. Structural, functional and molecular imaging of the brain in primary focal dystonia - a review. Neuroimage 2011, 56:1011-1020.