Overexpression of human wildtype torsinA and human ΔGAG torsinA in a transgenic mouse model causes phenotypic abnormalities

Neurobiology of Disease

Volumn 27, Issue 2, 2007, Pages 190-206

  Grundmann, K ^a   Reischmann, B ^a   Vanhoutte, G ^b   Hubener J ^a   Teismann, P ^c   Hauser, T K ^a   Bonin, M ^a   Wilbertz, J ^d   Horn, S ^e   Nguyen, H P ^a   Kuhn, M ^a   Chanarat, S ^a   Wolburg, H ^f   Van der Linden, A ^b   Riess, O ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF TÜBINGEN   (Germany)

^f UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

DTI MRI; DYT1; Nuclear envelope; Primary torsion dystonia; TorsinA; Transgenic mouse model

Indexed keywords

ADENINE; GENE PRODUCT; GUANINE; PRION PROTEIN; TORSIN A; TRINUCLEOTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; BEHAVIOR DISORDER; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; DISEASE MODEL; DYT1 GENE; GENE; GENE DELETION; MOUSE; NEUROCHEMISTRY; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PENETRANCE; PHENOTYPIC VARIATION; PRIMARY TORSION DYSTONIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TORSION DYSTONIA; TRANSGENIC MOUSE;

ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; DYSTONIA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR CHAPERONES; MOTOR ACTIVITY; NEURONS; NEUROTRANSMITTER AGENTS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34447641630     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2007.04.015     Document Type: Article

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