The use of the Integrated Discrete Multiple Organ Co-culture (IdMOC®) system for the evaluation of multiple organ toxicity

Alternatives to Laboratory Animals

Volumn 37, Issue 4, 2009, Pages 377-385

  Li, Albert P ^a  

^a In Vitro ADMET Laboratories Inc ^*  (United States)

Author keywords

Alternative methods; Cytotoxicity screening; Drug development; Human drug toxicity; IdMOC; In vitro toxicity; Precision cut slices; Primary cultures; Tissue slices

Indexed keywords

NICOTINE; TAMOXIFEN;

BREAST CANCER; CELL TYPE; COCULTURE; CONFERENCE PAPER; CULTURE MEDIUM; CYTOTOXICITY; HEART; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; METABOLISM; MULTIPLE ORGAN TOXICITY; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC CIRCULATION; TISSUE SLICE; TOXICITY;

EID: 70449574700     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290903700408     Document Type: Conference Paper

References (28)

1. Olinga, P., Meijer, K.F., Slooff, M.J.H. & Groothuis, G.M.M. (1998). Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue. Toxicology in Vitro 12, 77-100. (Pubitemid 28057328)
2. Vickers, A.E.M. (2009). Tissue slices for the evaluation of metabolism-based toxicity with the example of diclofenac. Chemico-Biological Interactions 179, 9-16.
3. Li, A.P. & Myers, C.A. (1988). In vitro evaluation of the cytotoxic potential of a novel man-made fiber, calcium sodium metaphosphate fiber (phosphate fiber). Fundamental & Applied Toxicology 11, 21-28.
4. Li, A.P., Lu, C., Brent, J.A., Pham, C., Fackett, A., Ruegg, C.E. & Silber, P.M. (1999). Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chemico-Biological Interactions 121, 17-35. (Pubitemid 29240667)
5. Deldar, A. & Stevens, C.E. (1993). Development and application of in vitro models of hematopoiesis to drug development. Toxicologic Pathology 21, 231-240. (Pubitemid 23241717)
6. Dietrich, D.R., O'Brien, E., Stack, M.E. & Heussner, A.H. (2001). Species- and sex-specific renal cytotoxicity of ochratoxin A and B in vitro. Experimental & Toxicologic Pathology 53, 215-225. (Pubitemid 32625766)
7. Guizzetti, M., Pathak, S., Giordano, G. & Costa, L.G. (2005). Effect of organophosphorous insecticides and their metabolites on astroglial cell proliferation. Toxicology 215, 182-190. (Pubitemid 41446320)
8. Hasinoff, B.B., Patel, D. & Wu, X. (2007). The cytotoxicity of celecoxib towards cardiac myocytes is cyclooxygenase-2 independent. Cardiovascular Toxicology 7, 19-27. (Pubitemid 47338488)
9. Han, S.G., Castranova, V. & Vallyathan, V. (2007). Comparative cytotoxicity of cadmium and mercury in a human bronchial epithelial cell line (BEAS-2B) and its role in oxidative stress and induction of heat shock protein 70. Journal of Toxicology & Environmental Health. Part A 70, 852-860. (Pubitemid 46633966)
10. Guillouzo, A., Corlu, A., Aninat, C., Glaise, D., Morel, F. & Guguen-Guillouzo, C. (2007). The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chemico-Biological Interactions 168, 66-73. (Pubitemid 46659919)
11. Castell, J.V., Jover, R., Martizez-Jimenez, C.P. & Gomez-Lechon, M.J. (2006). Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opinion on Drug Metabolism & Toxicology 2, 183-212. (Pubitemid 46372364)
12. Clemedson, C., Dierickx, P.J. & Sjöström, M. (2003). The prediction of human acute systemic toxicity by the EDIT/MEIC in vitro test battery: the importance of protein binding and of partitioning into lipids. ATLA 31, 245-256. (Pubitemid 36950596)
13. Gerets, H.H.J., Cornet, H.M., Depelchin, D.O., Canning, M. & Atienzar, F.A. (2009). Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: a preliminary study using a multiplexing approach. Toxicology in Vitro 23, 319-332.
14. Dambach, D.M., Andrews, B.A. & Moulin, F. (2005). New technologies and screening strategies for hepatotoxicity: use of in vitro models. Toxicologic Pathology 33, 17-26.
15. Li, A.P. (2001). Screening for human ADME/Tox drug properties in drug discovery. Drug Discovery Today 6, 357-366. (Pubitemid 32208650)
16. Li, A.P. (2004). In vitro approaches to evaluate ADMET drug properties. Current Topics in Medicinal Chemistry 4, 701-706.
17. Li, A.P. (2005). Cell culture tool and method. US Patent 20050101010.
18. Li, A.P., Bode, C. & Sakai, Y. (2004). A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells. Chemico-Biological Interactions 150, 129-136. (Pubitemid 39441299)
19. Li, A.P. (2008). In vitro evaluation of human xenobiotic toxicity: scientific concepts and the novel integrated discrete multiple cell co-culture (IdMOC) technology. ALTEX 25, 43-49.
20. Li, A.P. (2002). A review of the common properties of drugs with idiosyncratic hepatotoxicity and the "multiple determinant hypothesis" for the manifestation of idiosyncratic drug toxicity. Chemico-Biological Interactions 142, 7-23.
21. Li, A.P. (2004). An integrated, multidisciplinary approach for drug safety assessment. Drug Discovery Today 9, 687-693. (Pubitemid 39070278)
22. Li, A.P. (2007). Human-based in vitro experimental systems for the evaluation of human drug safety. Current Drug Safety 2, 193-199.
23. Li, A.P. (2004). A comprehensive approach for drug safety assessment. Chemico-Biological Interactions 150, 27-33.
24. Li, A.P. (2009). Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: Proof-of-concept study with aflatoxin B1. Chemico-Biological Interactions 179, 4-8.
25. Liu, C.L., Huang, J.K., Cheng, S.P., Chang, Y.C., Lee, J.J. & Liu, T.P. (2006). Fatty liver and transaminase changes with adjuvant tamoxifen therapy. Anticancer Drugs 17, 709-713.
26. McClay, E.F., McClay, M.T., Monroe, L., Jones, J.A. & Winski, P.J. (2001). A phase II study of high dose tamoxifen and weekly cisplatin in patients with metastatic melanoma. Melanoma Research 11, 309-313. (Pubitemid 32578819)
27. Li, A.P. (2009). Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. Drug Metabolism & Disposition 37, 1598-1603.
28. Benowitz, N.L. (2009). Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annual Review of Pharmacology & Toxicology 49, 57-71.