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Volumn 92, Issue 1, 2014, Pages 57-63

Follicular helper T-cell memory: Establishing new frontiers during antibody response

Author keywords

Antibody; Memory; Plasticity; Tfh

Indexed keywords

ADAPTIVE IMMUNITY; ANTIBODY RESPONSE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL HETEROGENEITY; FOLLICULAR HELPER T CELL; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; INFECTION; LYMPHOCYTE DIFFERENTIATION; REVIEW; VACCINATION;

EID: 84891819896     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2013.68     Document Type: Review
Times cited : (63)

References (73)
  • 3
    • 41549131849 scopus 로고    scopus 로고
    • T follicular helper (TFH) cells in normal and dysregulated immune responses
    • King C, Tangye SG, Mackay CR. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol 2008; 26: 741-766.
    • (2008) Annu Rev Immunol , vol.26 , pp. 741-766
    • King, C.1    Tangye, S.G.2    Mackay, C.R.3
  • 5
    • 77957256910 scopus 로고    scopus 로고
    • The elusive identity of T follicular helper cells
    • Yu D, Vinuesa CG. The elusive identity of T follicular helper cells. Trends Immunol 2010; 31: 377-383.
    • (2010) Trends Immunol , vol.31 , pp. 377-383
    • Yu, D.1    Vinuesa, C.G.2
  • 6
    • 70449490395 scopus 로고    scopus 로고
    • Lineage specification and heterogeneity of T follicular helper cells
    • Yu D, Batten M, Mackay CR, King C. Lineage specification and heterogeneity of T follicular helper cells. Curr Opin Immunol 2009; 21: 619-625.
    • (2009) Curr Opin Immunol , vol.21 , pp. 619-625
    • Yu, D.1    Batten, M.2    Mackay, C.R.3    King, C.4
  • 7
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011; 29: 621-663.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 8
    • 0025370195 scopus 로고
    • Persistence of memory B cells in mice deprived of T cell help
    • Vieira P, Rajewsky K. Persistence of memory B cells in mice deprived of T cell help. Int Immunol 1990; 2: 487-494.
    • (1990) Int Immunol , vol.2 , pp. 487-494
    • Vieira, P.1    Rajewsky, K.2
  • 9
    • 33749987324 scopus 로고    scopus 로고
    • Naive T-cell receptor transgenic T cells help memory B cells produce antibody
    • Duffy D, Yang CP, Heath A, Garside P, Bell EB. Naive T-cell receptor transgenic T cells help memory B cells produce antibody. Immunology 2006; 119: 376-384.
    • (2006) Immunology , vol.119 , pp. 376-384
    • Duffy, D.1    Yang, C.P.2    Heath, A.3    Garside, P.4    Bell, E.B.5
  • 10
    • 0029147310 scopus 로고
    • Stimulation of a memory B cell response does not require primed helper T cells
    • Leclerc C, Sedlik C, Lo-Man R, Charlot B, Rojas M, Deriaud E. Stimulation of a memory B cell response does not require primed helper T cells. Eur J Immunol 1995; 25: 2533-2538.
    • (1995) Eur J Immunol , vol.25 , pp. 2533-2538
    • Leclerc, C.1    Sedlik, C.2    Lo-Man, R.3    Charlot, B.4    Rojas, M.5    Deriaud, E.6
  • 11
  • 13
    • 79952282195 scopus 로고    scopus 로고
    • Different B cell populations mediate early and late memory during an endogenous immune response
    • Pape KA, Taylor JJ, Maul RW, Gearhart PJ, Jenkins MK. Different B cell populations mediate early and late memory during an endogenous immune response. Science 2011; 331: 1203-1207.
    • (2011) Science , vol.331 , pp. 1203-1207
    • Pape, K.A.1    Taylor, J.J.2    Maul, R.W.3    Gearhart, P.J.4    Jenkins, M.K.5
  • 15
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • Bernasconi NL, Traggiai E, Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002; 298: 2199-2202.
    • (2002) Science , vol.298 , pp. 2199-2202
    • Bernasconi, N.L.1    Traggiai, E.2    Lanzavecchia, A.3
  • 16
    • 0038142387 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi NL, Onai N, Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003; 101: 4500-4504.
    • (2003) Blood , vol.101 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 17
    • 29144519767 scopus 로고    scopus 로고
    • IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    • Ettinger R, Sims GP, Fairhurst AM, Robbins R, da Silva YS, Spolski R et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 2005; 175: 7867-7879.
    • (2005) J Immunol , vol.175 , pp. 7867-7879
    • Ettinger, R.1    Sims, G.P.2    Fairhurst, A.M.3    Robbins, R.4    Da Silva, Y.S.5    Spolski, R.6
  • 18
    • 0033975857 scopus 로고    scopus 로고
    • Functional responses and costimulator dependence of memory CD4+ T cells
    • London CA, Lodge MP, Abbas AK. Functional responses and costimulator dependence of memory CD4+ T cells. J Immunol 2000; 164: 265-272.
    • (2000) J Immunol , vol.164 , pp. 265-272
    • London, C.A.1    Lodge, M.P.2    Abbas, A.K.3
  • 19
    • 0034162511 scopus 로고    scopus 로고
    • Qualitative changes accompany memory T cell generation: Faster, more effective responses at lower doses of antigen
    • Rogers PR, Dubey C, Swain SL. Qualitative changes accompany memory T cell generation: faster, more effective responses at lower doses of antigen. J Immunol 2000; 164: 2338-2346.
    • (2000) J Immunol , vol.164 , pp. 2338-2346
    • Rogers, P.R.1    Dubey, C.2    Swain, S.L.3
  • 20
    • 0032701695 scopus 로고    scopus 로고
    • In vivoactivated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
    • Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG. In vivoactivated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med 1999; 190: 1123-1134.
    • (1999) J Exp Med , vol.190 , pp. 1123-1134
    • Ansel, K.M.1    McHeyzer-Williams, L.J.2    Ngo, V.N.3    McHeyzer-Williams, M.G.4    Cyster, J.G.5
  • 21
    • 80755172184 scopus 로고    scopus 로고
    • Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    • Pepper M, Pagan AJ, Igyarto BZ, Taylor JJ, Jenkins MK. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 2011; 35: 583-595.
    • (2011) Immunity , vol.35 , pp. 583-595
    • Pepper, M.1    Pagan, A.J.2    Igyarto, B.Z.3    Taylor, J.J.4    Jenkins, M.K.5
  • 23
    • 0034880029 scopus 로고    scopus 로고
    • The perifollicular and marginal zones of the human splenic white pulp: Do fibroblasts guide lymphocyte immigration?
    • Steiniger B, Barth P, Hellinger A. The perifollicular and marginal zones of the human splenic white pulp: do fibroblasts guide lymphocyte immigration? Am J Pathol 2001; 159: 501-512.
    • (2001) Am J Pathol , vol.159 , pp. 501-512
    • Steiniger, B.1    Barth, P.2    Hellinger, A.3
  • 25
    • 0026451165 scopus 로고
    • B cells turn off virgin but not memory T cells
    • Fuchs EJ, Matzinger P. B cells turn off virgin but not memory T cells. Science 1992; 258: 1156-1159.
    • (1992) Science , vol.258 , pp. 1156-1159
    • Fuchs, E.J.1    Matzinger, P.2
  • 28
    • 79956125257 scopus 로고    scopus 로고
    • Origins of CD4(+) effector and central memory T cells
    • Pepper M, Jenkins MK. Origins of CD4(+) effector and central memory T cells. Nat Immunol 2011; 12: 467-471.
    • (2011) Nat Immunol , vol.12 , pp. 467-471
    • Pepper, M.1    Jenkins, M.K.2
  • 29
    • 38749121326 scopus 로고    scopus 로고
    • Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors
    • Lohning M, Hegazy AN, Pinschewer DD, Busse D, Lang KS, Hofer T et al. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J Exp Med 2008; 205: 53-61.
    • (2008) J Exp Med , vol.205 , pp. 53-61
    • Lohning, M.1    Hegazy, A.N.2    Pinschewer, D.D.3    Busse, D.4    Lang, K.S.5    Hofer, T.6
  • 31
    • 33745293693 scopus 로고    scopus 로고
    • Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth
    • Zaph C, Rook KA, Goldschmidt M, Mohrs M, Scott P, Artis D. Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth. J Immunol 2006; 177: 511-518.
    • (2006) J Immunol , vol.177 , pp. 511-518
    • Zaph, C.1    Rook, K.A.2    Goldschmidt, M.3    Mohrs, M.4    Scott, P.5    Artis, D.6
  • 32
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009; 325: 1006-1010.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1    Poholek, A.C.2    Ditoro, D.3    Yusuf, I.4    Eto, D.5    Barnett, B.6
  • 34
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, Rao S, Tsai LM, Lee SK, He Y, Sutcliffe EL et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009; 31: 457-468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1    Rao, S.2    Tsai, L.M.3    Lee, S.K.4    He, Y.5    Sutcliffe, E.L.6
  • 35
    • 79959343565 scopus 로고    scopus 로고
    • Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    • Kitano M, Moriyama S, Ando Y, Hikida M, Mori Y, Kurosaki T et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 2011; 34: 961-972.
    • (2011) Immunity , vol.34 , pp. 961-972
    • Kitano, M.1    Moriyama, S.2    Ando, Y.3    Hikida, M.4    Mori, Y.5    Kurosaki, T.6
  • 36
    • 77955924180 scopus 로고    scopus 로고
    • Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling
    • Deenick EK, Chan A, Ma CS, Gatto D, Schwartzberg PL, Brink R et al. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 2010; 33: 241-253.
    • (2010) Immunity , vol.33 , pp. 241-253
    • Deenick, E.K.1    Chan, A.2    Ma, C.S.3    Gatto, D.4    Schwartzberg, P.L.5    Brink, R.6
  • 37
    • 84875549975 scopus 로고    scopus 로고
    • Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype
    • Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A et al. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity 2013; 38: 596-605.
    • (2013) Immunity , vol.38 , pp. 596-605
    • Baumjohann, D.1    Preite, S.2    Reboldi, A.3    Ronchi, F.4    Ansel, K.M.5    Lanzavecchia, A.6
  • 39
    • 84859897308 scopus 로고    scopus 로고
    • The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
    • Luthje K, Kallies A, Shimohakamada Y, GT TB, Light A, Tarlinton DM et al. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol 2012; 13: 491-498.
    • (2012) Nat Immunol , vol.13 , pp. 491-498
    • Luthje, K.1    Kallies, A.2    Shimohakamada, Y.3    Light, A.4    Tarlinton, D.M.5
  • 40
    • 84864742274 scopus 로고    scopus 로고
    • T-follicular helper cells survive as long-term memory cells
    • Weber JP, Fuhrmann F, Hutloff A. T-follicular helper cells survive as long-term memory cells. Eur J Immunol 2012; 42: 1981-1988.
    • (2012) Eur J Immunol , vol.42 , pp. 1981-1988
    • Weber, J.P.1    Fuhrmann, F.2    Hutloff, A.3
  • 42
    • 80755163540 scopus 로고    scopus 로고
    • Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection
    • Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA et al. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity 2011; 35: 633-646.
    • (2011) Immunity , vol.35 , pp. 633-646
    • Marshall, H.D.1    Chandele, A.2    Jung, Y.W.3    Meng, H.4    Poholek, A.C.5    Parish, I.A.6
  • 43
    • 80052649061 scopus 로고    scopus 로고
    • Cutting edge: Distinct waves of BCL6 expression during T follicular helper cell development
    • Baumjohann D, Okada T, Ansel KM. Cutting edge: distinct waves of BCL6 expression during T follicular helper cell development. J Immunol 2011; 187: 2089-2092.
    • (2011) J Immunol , vol.187 , pp. 2089-2092
    • Baumjohann, D.1    Okada, T.2    Ansel, K.M.3
  • 44
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 2011; 34: 932-946.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3    Escobar, T.C.4    Johnston, R.J.5    Monticelli, L.6
  • 45
    • 80051618656 scopus 로고    scopus 로고
    • Cutting edge: Dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation
    • Goenka R, Barnett LG, Silver JS, O'Neill PJ, Hunter CA, Cancro MP et al. Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation. J Immunol 2011; 187: 1091-1095.
    • (2011) J Immunol , vol.187 , pp. 1091-1095
    • Goenka, R.1    Barnett, L.G.2    Silver, J.S.3    O'neill, P.J.4    Hunter, C.A.5    Cancro, M.P.6
  • 46
    • 79959342619 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
    • Kerfoot SM, Yaari G, Patel JR, Johnson KL, Gonzalez DG, Kleinstein SH et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 2011; 34: 947-960.
    • (2011) Immunity , vol.34 , pp. 947-960
    • Kerfoot, S.M.1    Yaari, G.2    Patel, J.R.3    Johnson, K.L.4    Gonzalez, D.G.5    Kleinstein, S.H.6
  • 47
    • 84875444198 scopus 로고    scopus 로고
    • Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory
    • Choi YS, Yang JA, Yusuf I, Johnston RJ, Greenbaum J, Peters B et al. Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol 2013; 190: 4014-4026.
    • (2013) J Immunol , vol.190 , pp. 4014-4026
    • Choi, Y.S.1    Yang, J.A.2    Yusuf, I.3    Johnston, R.J.4    Greenbaum, J.5    Peters, B.6
  • 48
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
    • Fazilleau N, McHeyzer-Williams LJ, Rosen H, McHeyzer-Williams MG. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat Immunol 2009; 10: 375-384.
    • (2009) Nat Immunol , vol.10 , pp. 375-384
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 50
    • 84877710866 scopus 로고    scopus 로고
    • Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection
    • Tubo NJ, Pagan AJ, Taylor JJ, Nelson RW, Linehan JL, Ertelt JM et al. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell 2013; 153: 785-796.
    • (2013) Cell , vol.153 , pp. 785-796
    • Tubo, N.J.1    Pagan, A.J.2    Taylor, J.J.3    Nelson, R.W.4    Linehan, J.L.5    Ertelt, J.M.6
  • 51
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000; 192: 1545-1552.
    • (2000) J Exp Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6
  • 52
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000; 192: 1553-1562.
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 53
    • 0035908122 scopus 로고    scopus 로고
    • Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells
    • Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J Exp Med 2001; 193: 1373-1381.
    • (2001) J Exp Med , vol.193 , pp. 1373-1381
    • Kim, C.H.1    Rott, L.S.2    Clark-Lewis, I.3    Campbell, D.J.4    Wu, L.5    Butcher, E.C.6
  • 54
    • 79956196930 scopus 로고    scopus 로고
    • CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses
    • Chevalier N, Jarrossay D, Ho E, Avery DT, Ma CS, Yu D et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol 2011; 186: 5556-5568.
    • (2011) J Immunol , vol.186 , pp. 5556-5568
    • Chevalier, N.1    Jarrossay, D.2    Ho, E.3    Avery, D.T.4    Ma, C.S.5    Yu, D.6
  • 55
    • 33749151018 scopus 로고    scopus 로고
    • ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells
    • Bossaller L, Burger J, Draeger R, Grimbacher B, Knoth R, Plebani A et al. ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J Immunol 2006; 177: 4927-4932.
    • (2006) J Immunol , vol.177 , pp. 4927-4932
    • Bossaller, L.1    Burger, J.2    Draeger, R.3    Grimbacher, B.4    Knoth, R.5    Plebani, A.6
  • 56
    • 84885741984 scopus 로고    scopus 로고
    • Circulating precursor CCR7loPD-1hi CXCR5+ CD4+ T cells indicate follicular helper T cell activity and promote antibody responses upon antigen re-exposure
    • He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N et al. Circulating precursor CCR7loPD-1hi CXCR5+ CD4+ T cells indicate follicular helper T cell activity and promote antibody responses upon antigen re-exposure. Immunity 2013; 39: 770-781.
    • (2013) Immunity , vol.39 , pp. 770-781
    • He, J.1    Tsai, L.M.2    Leong, Y.A.3    Hu, X.4    Ma, C.S.5    Chevalier, N.6
  • 57
    • 53649107278 scopus 로고    scopus 로고
    • SAP-controlled T-B cell interactions underlie germinal centre formation
    • Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 2008; 455: 764-769.
    • (2008) Nature , vol.455 , pp. 764-769
    • Qi, H.1    Cannons, J.L.2    Klauschen, F.3    Schwartzberg, P.L.4    Germain, R.N.5
  • 59
    • 84867896903 scopus 로고    scopus 로고
    • Transcriptional control of effector and memory CD8+ T cell differentiation
    • Kaech SM, Cui W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol 2012; 12: 749-761.
    • (2012) Nat Rev Immunol , vol.12 , pp. 749-761
    • Kaech, S.M.1    Cui, W.2
  • 60
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: Function, generation, and maintenance
    • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004; 22: 745-763.
    • (2004) Annu Rev Immunol , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 61
    • 84875129611 scopus 로고    scopus 로고
    • Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination
    • Bentebibel SE, Lopez S, Obermoser G, Schmitt N, Mueller C, Harrod C et al. Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination. Sci Transl Med 2013; 5: 176ra32.
    • (2013) Sci Transl Med , vol.5
    • Bentebibel, S.E.1    Lopez, S.2    Obermoser, G.3    Schmitt, N.4    Mueller, C.5    Harrod, C.6
  • 62
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008; 29: 138-149.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3    Yang, X.O.4    Kang, H.S.5    Ma, L.6
  • 63
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008; 29: 127-137.
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    Mackay, C.R.5    King, C.6
  • 64
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman MA, Beaton L, Yu D, Ramiscal RR, Srivastava M, Hogan JJ et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 2010; 207: 353-363.
    • (2010) J Exp Med , vol.207 , pp. 353-363
    • Linterman, M.A.1    Beaton, L.2    Yu, D.3    Ramiscal, R.R.4    Srivastava, M.5    Hogan, J.J.6
  • 65
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos D, Coquet JM, Zhang Y, Light A, D'Costa K, Kallies A et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 2010; 207: 365-378.
    • (2010) J Exp Med , vol.207 , pp. 365-378
    • Zotos, D.1    Coquet, J.M.2    Zhang, Y.3    Light, A.4    D'costa, K.5    Kallies, A.6
  • 66
    • 70249100293 scopus 로고    scopus 로고
    • Heterogeneity of CD4+ memory T cells: Functional modules for tailored immunity
    • Sallusto F, Lanzavecchia A. Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity. Eur J Immunol 2009; 39: 2076-2082.
    • (2009) Eur J Immunol , vol.39 , pp. 2076-2082
    • Sallusto, F.1    Lanzavecchia, A.2
  • 67
    • 79251521021 scopus 로고    scopus 로고
    • Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • Morita R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011; 34: 108-121.
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1    Schmitt, N.2    Bentebibel, S.E.3    Ranganathan, R.4    Bourdery, L.5    Zurawski, G.6
  • 68
    • 36048946330 scopus 로고    scopus 로고
    • Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
    • Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG et al. Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 2007; 450: 299-303.
    • (2007) Nature , vol.450 , pp. 299-303
    • Yu, D.1    Tan, A.H.2    Hu, X.3    Athanasopoulos, V.4    Simpson, N.5    Silva, D.G.6
  • 69
    • 84872685720 scopus 로고    scopus 로고
    • The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
    • Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol 2013; 14: 152-161.
    • (2013) Nat Immunol , vol.14 , pp. 152-161
    • Sage, P.T.1    Francisco, L.M.2    Carman, C.V.3    Sharpe, A.H.4
  • 70
    • 84876780521 scopus 로고    scopus 로고
    • Distinct memory CD4+ T cells with commitment to T follicular helper-and T helper 1-cell lineages are generated after acute viral infection
    • Hale JS, Youngblood B, Latner DR, Mohammed AU, Ye L, Akondy RS et al. Distinct memory CD4+ T cells with commitment to T follicular helper-and T helper 1-cell lineages are generated after acute viral infection. Immunity 2013; 38: 805-817.
    • (2013) Immunity , vol.38 , pp. 805-817
    • Hale, J.S.1    Youngblood, B.2    Latner, D.R.3    Mohammed, A.U.4    Ye, L.5    Akondy, R.S.6
  • 71
    • 84870285173 scopus 로고    scopus 로고
    • Bcl6 expression specifies the T follicular helper cell program in vivo
    • Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med 2012; 209: 1841-1852.
    • (2012) J Exp Med , vol.209 , pp. 1841-1852
    • Liu, X.1    Yan, X.2    Zhong, B.3    Nurieva, R.I.4    Wang, A.5    Wang, X.6
  • 72
    • 80755136623 scopus 로고    scopus 로고
    • Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitrogenerated and in vivo-derived follicular T helper cells
    • Lu KT, Kanno Y, Cannons JL, Handon R, Bible P, Elkahloun AG et al. Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitrogenerated and in vivo-derived follicular T helper cells. Immunity 2011; 35: 622-632.
    • (2011) Immunity , vol.35 , pp. 622-632
    • Lu, K.T.1    Kanno, Y.2    Cannons, J.L.3    Handon, R.4    Bible, P.5    Elkahloun, A.G.6
  • 73
    • 84877140255 scopus 로고    scopus 로고
    • T follicular helper cell diversity and plasticity
    • Cannons JL, Lu KT, Schwartzberg PL. T follicular helper cell diversity and plasticity. Trends Immunol 2013; 34: 200-207.
    • (2013) Trends Immunol , vol.34 , pp. 200-207
    • Cannons, J.L.1    Lu, K.T.2    Schwartzberg, P.L.3


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