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Volumn 63, Issue 1, 2014, Pages 20-30

It's time to bring dendritic cell therapy to type 1 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; CELL FUNCTION; CELL MATURATION; CELL THERAPY; CELL TRANSPLANTATION; CLINICAL EFFECTIVENESS; DENDRITIC CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATIENT SAFETY; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TARGET CELL; THERAPY; THERAPY EFFECT;

EID: 84891762344     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0886     Document Type: Review
Times cited : (48)

References (67)
  • 1
    • 77951926420 scopus 로고    scopus 로고
    • Etiology of type 1 diabetes
    • Todd JA. Etiology of type 1 diabetes. Immunity 2010;32:457-467
    • (2010) Immunity , vol.32 , pp. 457-467
    • Todd, J.A.1
  • 3
    • 79954506102 scopus 로고    scopus 로고
    • Dendritic cell control of tolerogenic responses
    • Manicassamy S, Pulendran B. Dendritic cell control of tolerogenic responses. Immunol Rev 2011;241:206-227
    • (2011) Immunol Rev , vol.241 , pp. 206-227
    • Manicassamy, S.1    Pulendran, B.2
  • 4
    • 84878659255 scopus 로고    scopus 로고
    • Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
    • Soroosh P, Doherty TA, Duan W, et al. Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance. J Exp Med 2013;210:775-788
    • (2013) J Exp Med , vol.210 , pp. 775-788
    • Soroosh, P.1    Doherty, T.A.2    Duan, W.3
  • 5
    • 78650637508 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells prevent type 1 diabetes in murine models
    • Yin B, Ma G, Yen CY, et al. Myeloid-derived suppressor cells prevent type 1 diabetes in murine models. J Immunol 2010;185:5828-5834
    • (2010) J Immunol , vol.185 , pp. 5828-5834
    • Yin, B.1    Ma, G.2    Yen, C.Y.3
  • 6
    • 49449093723 scopus 로고    scopus 로고
    • Deletional tolerance mediated by extrathymic Aire-expressing cells
    • Gardner JM, Devoss JJ, Friedman RS, et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 2008;321:843-847
    • (2008) Science , vol.321 , pp. 843-847
    • Gardner, J.M.1    Devoss, J.J.2    Friedman, R.S.3
  • 7
    • 77951074210 scopus 로고    scopus 로고
    • Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions
    • Fletcher AL, Lukacs-Kornek V, Reynoso ED, et al. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med 2010;207:689-697
    • (2010) J Exp Med , vol.207 , pp. 689-697
    • Fletcher, A.L.1    Lukacs-Kornek, V.2    Reynoso, E.D.3
  • 8
    • 77951069509 scopus 로고    scopus 로고
    • Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation
    • Cohen JN, Guidi CJ, Tewalt EF, et al. Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation. J Exp Med 2010;207:681-688
    • (2010) J Exp Med , vol.207 , pp. 681-688
    • Cohen, J.N.1    Guidi, C.J.2    Tewalt, E.F.3
  • 9
    • 84875692817 scopus 로고    scopus 로고
    • Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3
    • Yip L, Creusot RJ, Pager CT, Sarnow P, Fathman CG. Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3. J Mol Cell Biol 2013;5:99-110
    • (2013) J Mol Cell Biol , vol.5 , pp. 99-110
    • Yip, L.1    Creusot, R.J.2    Pager, C.T.3    Sarnow, P.4    Fathman, C.G.5
  • 10
    • 84878662471 scopus 로고    scopus 로고
    • The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development
    • Cowan JE, Parnell SM, Nakamura K, et al. The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development. J Exp Med 2013;210:675-681
    • (2013) J Exp Med , vol.210 , pp. 675-681
    • Cowan, J.E.1    Parnell, S.M.2    Nakamura, K.3
  • 11
    • 84872168547 scopus 로고    scopus 로고
    • Mesenchymal stromal cells and regulatory T cells: The yin and yang of peripheral tolerance?
    • Burr SP, Dazzi F, Garden OA. Mesenchymal stromal cells and regulatory T cells: the yin and yang of peripheral tolerance? Immunol Cell Biol 2013;91: 12-18
    • (2013) Immunol Cell Biol , vol.91 , pp. 12-18
    • Burr, S.P.1    Dazzi, F.2    Garden, O.A.3
  • 12
    • 84857195764 scopus 로고    scopus 로고
    • Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet β-cells
    • Grupillo M, Gualtierotti G, He J, et al. Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet β-cells. Cell Immunol 2012;273:115-123
    • (2012) Cell Immunol , vol.273 , pp. 115-123
    • Grupillo, M.1    Gualtierotti, G.2    He, J.3
  • 13
    • 77749279470 scopus 로고    scopus 로고
    • Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells
    • Poliani PL, Kisand K, Marrella V, et al. Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells. Am J Pathol 2010;176:1104-1112
    • (2010) Am J Pathol , vol.176 , pp. 1104-1112
    • Poliani, P.L.1    Kisand, K.2    Marrella, V.3
  • 14
    • 23444442192 scopus 로고    scopus 로고
    • Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion
    • Garcia CA, Prabakar KR, Diez J, et al. Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion. J Immunol 2005;175:2111-2122
    • (2005) J Immunol , vol.175 , pp. 2111-2122
    • Garcia, C.A.1    Prabakar, K.R.2    Diez, J.3
  • 15
    • 0035089893 scopus 로고    scopus 로고
    • Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
    • Pugliese A, Brown D, Garza D, et al. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J Clin Invest 2001;107:555-564
    • (2001) J Clin Invest , vol.107 , pp. 555-564
    • Pugliese, A.1    Brown, D.2    Garza, D.3
  • 17
    • 7644229602 scopus 로고    scopus 로고
    • Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity
    • Carbone FR, Belz GT, Heath WR. Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity. Trends Immunol 2004;25:655-658
    • (2004) Trends Immunol , vol.25 , pp. 655-658
    • Carbone, F.R.1    Belz, G.T.2    Heath, W.R.3
  • 18
    • 58149376454 scopus 로고    scopus 로고
    • Dendritic cells in the thymus contribute to T-regulatory cell induction
    • Proietto AI, van Dommelen S, Zhou P, et al. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci USA 2008;105: 19869-19874
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19869-19874
    • Proietto, A.I.1    Van Dommelen, S.2    Zhou, P.3
  • 19
    • 54549096767 scopus 로고    scopus 로고
    • CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease
    • Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher EC. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol 2008;9:1253-1260
    • (2008) Nat Immunol , vol.9 , pp. 1253-1260
    • Hadeiba, H.1    Sato, T.2    Habtezion, A.3    Oderup, C.4    Pan, J.5    Butcher, E.C.6
  • 20
    • 0022578348 scopus 로고
    • Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigendependent microenvironment for T cell differentiation
    • Kyewski BA, Fathman CG, Rouse RV. Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigendependent microenvironment for T cell differentiation. J Exp Med 1986; 163:231-246
    • (1986) J Exp Med , vol.163 , pp. 231-246
    • Kyewski, B.A.1    Fathman, C.G.2    Rouse, R.V.3
  • 21
    • 84873331871 scopus 로고    scopus 로고
    • Specialized role of migratory dendritic cells in peripheral tolerance induction
    • Idoyaga J, Fiorese C, Zbytnuik L, et al. Specialized role of migratory dendritic cells in peripheral tolerance induction. J Clin Invest 2013;123: 844-854
    • (2013) J Clin Invest , vol.123 , pp. 844-854
    • Idoyaga, J.1    Fiorese, C.2    Zbytnuik, L.3
  • 22
    • 69249202402 scopus 로고    scopus 로고
    • Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells
    • Creusot RJ, Yaghoubi SS, Chang P, et al. Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells. Blood 2009;113:6638-6647
    • (2009) Blood , vol.113 , pp. 6638-6647
    • Creusot, R.J.1    Yaghoubi, S.S.2    Chang, P.3
  • 23
    • 84883711765 scopus 로고    scopus 로고
    • Regulatory multitasking of tolerogenic dendritic cells -lessons taken from vitamin d3-treated tolerogenic dendritic cells
    • Nikolic T, Roep BO. Regulatory multitasking of tolerogenic dendritic cells -lessons taken from vitamin d3-treated tolerogenic dendritic cells. Front Immunol 2013;4:113
    • (2013) Front Immunol , vol.4 , pp. 113
    • Nikolic, T.1    Roep, B.O.2
  • 24
    • 80052744510 scopus 로고    scopus 로고
    • Current state of type 1 diabetes immunotherapy: Incremental advances huge leaps or more of the same?
    • Phillips B, Trucco M, Giannoukakis N. Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same? Clin Dev Immunol 2011;2011:432016
    • (2011) Clin Dev Immunol , vol.2011 , pp. 432016
    • Phillips, B.1    Trucco, M.2    Giannoukakis, N.3
  • 25
    • 84869165311 scopus 로고    scopus 로고
    • Dendritic cell therapy for type 1 diabetes suppression
    • Giannoukakis N, Trucco M. Dendritic cell therapy for type 1 diabetes suppression. Immunotherapy 2012;4:1063-1074
    • (2012) Immunotherapy , vol.4 , pp. 1063-1074
    • Giannoukakis, N.1    Trucco, M.2
  • 26
    • 84860303882 scopus 로고    scopus 로고
    • Viral and non-viral methods to genetically modify dendritic cells
    • Humbert JM, Halary F. Viral and non-viral methods to genetically modify dendritic cells. Curr Gene Ther 2012;12:127-136
    • (2012) Curr Gene Ther , vol.12 , pp. 127-136
    • Humbert, J.M.1    Halary, F.2
  • 27
    • 77954630153 scopus 로고    scopus 로고
    • The immunotherapeutic potential of dendritic cells in type 1 diabetes
    • Mukherjee G, Dilorenzo TP. The immunotherapeutic potential of dendritic cells in type 1 diabetes. Clin Exp Immunol 2010;161:197-207
    • (2010) Clin Exp Immunol , vol.161 , pp. 197-207
    • Mukherjee, G.1    Dilorenzo, T.P.2
  • 28
    • 44649152160 scopus 로고    scopus 로고
    • A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes
    • Phillips B, Nylander K, Harnaha J, et al. A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Diabetes 2008; 57:1544-1555
    • (2008) Diabetes , vol.57 , pp. 1544-1555
    • Phillips, B.1    Nylander, K.2    Harnaha, J.3
  • 29
    • 78049438112 scopus 로고    scopus 로고
    • Multifunctional dendritic celltargeting polymeric microparticles: Engineering new vaccines for type 1 diabetes
    • Keselowsky BG, Xia CQ, Clare-Salzler M. Multifunctional dendritic celltargeting polymeric microparticles: engineering new vaccines for type 1 diabetes. Hum Vaccin 2011;7:37-44
    • (2011) Hum Vaccin , vol.7 , pp. 37-44
    • Keselowsky, B.G.1    Xia, C.Q.2    Clare-Salzler, M.3
  • 30
    • 0038792101 scopus 로고    scopus 로고
    • Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells
    • Mahnke K, Qian Y, Knop J, Enk AH. Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood 2003;101: 4862-4869
    • (2003) Blood , vol.101 , pp. 4862-4869
    • Mahnke, K.1    Qian, Y.2    Knop, J.3    Enk, A.H.4
  • 31
    • 0036659913 scopus 로고    scopus 로고
    • Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans
    • Dhodapkar MV, Steinman RM. Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans. Blood 2002;100:174-177
    • (2002) Blood , vol.100 , pp. 174-177
    • Dhodapkar, M.V.1    Steinman, R.M.2
  • 32
    • 84885094363 scopus 로고    scopus 로고
    • Retinoic acid-producing, ex-vivo-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B lymphocytes
    • Di Caro V, Phillips B, Engman C, Harnaha J, Trucco M, Giannoukakis N. Retinoic acid-producing, ex-vivo-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B lymphocytes. Clin Exp Immunol 2013;174:302-317
    • (2013) Clin Exp Immunol , vol.174 , pp. 302-317
    • Di Caro, V.1    Phillips, B.2    Engman, C.3    Harnaha, J.4    Trucco, M.5    Giannoukakis, N.6
  • 33
    • 84870798889 scopus 로고    scopus 로고
    • Autologous regulatory T cells for the treatment of type 1 diabetes
    • Thompson JA, Perry D, Brusko TM. Autologous regulatory T cells for the treatment of type 1 diabetes. Curr Diab Rep 2012;12:623-632
    • (2012) Curr Diab Rep , vol.12 , pp. 623-632
    • Thompson, J.A.1    Perry, D.2    Brusko, T.M.3
  • 34
    • 84856094049 scopus 로고    scopus 로고
    • Phase i (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients
    • Giannoukakis N, Phillips B, Finegold D, Harnaha J, Trucco M. Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care 2011;34:2026-2032
    • (2011) Diabetes Care , vol.34 , pp. 2026-2032
    • Giannoukakis, N.1    Phillips, B.2    Finegold, D.3    Harnaha, J.4    Trucco, M.5
  • 35
    • 78650912749 scopus 로고    scopus 로고
    • A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice
    • Creusot RJ, Chang P, Healey DG, Tcherepanova IY, Nicolette CA, Fathman CG. A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice. Mol Ther 2010;18:2112-2120
    • (2010) Mol Ther , vol.18 , pp. 2112-2120
    • Creusot, R.J.1    Chang, P.2    Healey, D.G.3    Tcherepanova, I.Y.4    Nicolette, C.A.5    Fathman, C.G.6
  • 36
    • 58849118836 scopus 로고    scopus 로고
    • Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage?
    • Huehn J, Polansky JK, Hamann A. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol 2009;9:83-89
    • (2009) Nat Rev Immunol , vol.9 , pp. 83-89
    • Huehn, J.1    Polansky, J.K.2    Hamann, A.3
  • 37
    • 0036318881 scopus 로고    scopus 로고
    • Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice
    • Feili-Hariri M, Falkner DH, Morel PA. Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice. Eur J Immunol 2002;32:2021-2030
    • (2002) Eur J Immunol , vol.32 , pp. 2021-2030
    • Feili-Hariri, M.1    Falkner, D.H.2    Morel, P.A.3
  • 38
    • 41549150638 scopus 로고    scopus 로고
    • Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice
    • Creusot RJ, Yaghoubi SS, Kodama K, et al. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 2008;127:176-187
    • (2008) Clin Immunol , vol.127 , pp. 176-187
    • Creusot, R.J.1    Yaghoubi, S.S.2    Kodama, K.3
  • 39
    • 0037248946 scopus 로고    scopus 로고
    • Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis
    • Feili-Hariri M, Falkner DH, Gambotto A, et al. Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis. Hum Gene Ther 2003;14:13-23
    • (2003) Hum Gene Ther , vol.14 , pp. 13-23
    • Feili-Hariri, M.1    Falkner, D.H.2    Gambotto, A.3
  • 40
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer 2012;12:265-277
    • (2012) Nat Rev Cancer , vol.12 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 41
    • 84863011757 scopus 로고    scopus 로고
    • Generation of immunogenic and tolerogenic clinical-grade dendritic cells
    • Kalantari T, Kamali-Sarvestani E, Ciric B, et al. Generation of immunogenic and tolerogenic clinical-grade dendritic cells. Immunol Res 2011;51:153-160
    • (2011) Immunol Res , vol.51 , pp. 153-160
    • Kalantari, T.1    Kamali-Sarvestani, E.2    Ciric, B.3
  • 42
    • 79957879852 scopus 로고    scopus 로고
    • PROVENGE (Sipuleucel-T) in prostate cancer: The first FDA-approved therapeutic cancer vaccine
    • Cheever MA, Higano CS: PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine. Clin Cancer Res 2011;17: 3520-3526
    • (2011) Clin Cancer Res , vol.17 , pp. 3520-3526
    • Cheever, M.A.1    Higano, C.S.2
  • 43
    • 84861787202 scopus 로고    scopus 로고
    • Dendritic cell-activating vaccine adjuvants differ in the ability to elicit antitumor immunity due to an adjuvant-specific induction of immunosuppressive cells
    • Dang Y, Wagner WM, Gad E, Rastetter L, Berger CM, Holt GE, Disis ML. Dendritic cell-activating vaccine adjuvants differ in the ability to elicit antitumor immunity due to an adjuvant-specific induction of immunosuppressive cells. Clin Cancer Res 2012;18:3122-3131
    • (2012) Clin Cancer Res , vol.18 , pp. 3122-3131
    • Dang, Y.1    Wagner, W.M.2    Gad, E.3    Rastetter, L.4    Berger, C.M.5    Holt, G.E.6    Disis, M.L.7
  • 44
    • 44349173032 scopus 로고    scopus 로고
    • Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA
    • Bonehill A, Tuyaerts S, Van Nuffel AM, et al. Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Mol Ther 2008;16: 1170-1180
    • (2008) Mol Ther , vol.16 , pp. 1170-1180
    • Bonehill, A.1    Tuyaerts, S.2    Van Nuffel, A.M.3
  • 45
    • 84876091796 scopus 로고    scopus 로고
    • Tolerogenic dendritic cell therapy for rheumatoid arthritis: Where are we now?
    • Hilkens CM, Isaacs JD. Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now? Clin Exp Immunol 2013;172:148-157
    • (2013) Clin Exp Immunol , vol.172 , pp. 148-157
    • Hilkens, C.M.1    Isaacs, J.D.2
  • 46
    • 78751562035 scopus 로고    scopus 로고
    • Shipping of therapeutic somatic cell products
    • Whiteside TL, Griffin DL, Stanson J, et al. Shipping of therapeutic somatic cell products. Cytotherapy 2011;13:201-213
    • (2011) Cytotherapy , vol.13 , pp. 201-213
    • Whiteside, T.L.1    Griffin, D.L.2    Stanson, J.3
  • 47
    • 33847629171 scopus 로고    scopus 로고
    • Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes
    • Di Lorenzo TP, Peakman M, Roep BO. Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 2007;148:1-16
    • (2007) Clin Exp Immunol , vol.148 , pp. 1-16
    • Di Lorenzo, T.P.1    Peakman, M.2    Roep, B.O.3
  • 48
    • 77953223382 scopus 로고    scopus 로고
    • Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression
    • Tree TI, Lawson J, Edwards H, et al. Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression. Diabetes 2010; 59:1451-1460
    • (2010) Diabetes , vol.59 , pp. 1451-1460
    • Tree, T.I.1    Lawson, J.2    Edwards, H.3
  • 49
    • 33845698122 scopus 로고    scopus 로고
    • Peptide-pulsed immature dendritic cells reduce response to beta cell target antigens and protect NOD recipients from type i diabetes
    • Lo J, Peng RH, Barker T, Xia CQ, Clare-Salzler MJ. Peptide-pulsed immature dendritic cells reduce response to beta cell target antigens and protect NOD recipients from type I diabetes. Ann N Y Acad Sci 2006;1079:153-156
    • (2006) Ann N y Acad Sci , vol.1079 , pp. 153-156
    • Lo, J.1    Peng, R.H.2    Barker, T.3    Xia, C.Q.4    Clare-Salzler, M.J.5
  • 51
    • 4644297765 scopus 로고    scopus 로고
    • Antisense oligonucleotides down-regulating costimulation confer diabetespreventive properties to nonobese diabetic mouse dendritic cells
    • Machen J, Harnaha J, Lakomy R, Styche A, Trucco M, Giannoukakis N. Antisense oligonucleotides down-regulating costimulation confer diabetespreventive properties to nonobese diabetic mouse dendritic cells. J Immunol 2004;173:4331-4341
    • (2004) J Immunol , vol.173 , pp. 4331-4341
    • Machen, J.1    Harnaha, J.2    Lakomy, R.3    Styche, A.4    Trucco, M.5    Giannoukakis, N.6
  • 52
    • 28844506094 scopus 로고    scopus 로고
    • Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo
    • Haase C, Ejrnaes M, Juedes AE, Wolfe T, Markholst H, von Herrath MG. Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo. Blood 2005;106:4225-4233
    • (2005) Blood , vol.106 , pp. 4225-4233
    • Haase, C.1    Ejrnaes, M.2    Juedes, A.E.3    Wolfe, T.4    Markholst, H.5    Von Herrath, M.G.6
  • 53
    • 69049109653 scopus 로고    scopus 로고
    • Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes
    • Yip L, Su L, Sheng D, et al. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol 2009;10:1026-1033
    • (2009) Nat Immunol , vol.10 , pp. 1026-1033
    • Yip, L.1    Su, L.2    Sheng, D.3
  • 54
    • 63449133991 scopus 로고    scopus 로고
    • Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus
    • Li J, Park J, Foss D, Goldschneider I. Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J Exp Med 2009;206:607-622
    • (2009) J Exp Med , vol.206 , pp. 607-622
    • Li, J.1    Park, J.2    Foss, D.3    Goldschneider, I.4
  • 55
    • 84874038489 scopus 로고    scopus 로고
    • Therapeutic potential of semi-mature dendritic cells for tolerance induction
    • Lutz MB. Therapeutic potential of semi-mature dendritic cells for tolerance induction. Front Immunol 2012;3:123
    • (2012) Front Immunol , vol.3 , pp. 123
    • Lutz, M.B.1
  • 56
    • 22644445634 scopus 로고    scopus 로고
    • Dexamethasone induces IL-10-producing monocyte-derived dendritic cells with durable immaturity
    • Xia CQ, Peng R, Beato F, Clare-Salzler MJ. Dexamethasone induces IL-10-producing monocyte-derived dendritic cells with durable immaturity. Scand J Immunol 2005;62:45-54
    • (2005) Scand J Immunol , vol.62 , pp. 45-54
    • Xia, C.Q.1    Peng, R.2    Beato, F.3    Clare-Salzler, M.J.4
  • 57
    • 84984763849 scopus 로고    scopus 로고
    • Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides
    • Giannoukakis N, Bonham CA, Qian S, et al. Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides. Mol Ther 2000;1:430-437
    • (2000) Mol Ther , vol.1 , pp. 430-437
    • Giannoukakis, N.1    Bonham, C.A.2    Qian, S.3
  • 58
    • 0042767606 scopus 로고    scopus 로고
    • Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factorkappaB activity
    • Ma L, Qian S, Liang X, et al. Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factorkappaB activity. Diabetes 2003;52:1976-1985
    • (2003) Diabetes , vol.52 , pp. 1976-1985
    • Ma, L.1    Qian, S.2    Liang, X.3
  • 59
    • 35748936133 scopus 로고    scopus 로고
    • Activation and route of administration both determine the ability of bone marrowderived dendritic cells to accumulate in secondary lymphoid organs and prime CD8+ T cells against tumors
    • Huck SP, Tang SC, Andrew KA, Yang J, Harper JL, Ronchese F. Activation and route of administration both determine the ability of bone marrowderived dendritic cells to accumulate in secondary lymphoid organs and prime CD8+ T cells against tumors. Cancer Immunol Immunother 2008; 57:63-71
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 63-71
    • Huck, S.P.1    Tang, S.C.2    Andrew, K.A.3    Yang, J.4    Harper, J.L.5    Ronchese, F.6
  • 60
    • 77955610171 scopus 로고    scopus 로고
    • Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice
    • Ruffner MA, Robbins PD. Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS ONE 2010;5:e11848
    • (2010) PLoS ONE , vol.5
    • Ruffner, M.A.1    Robbins, P.D.2
  • 61
    • 84872018209 scopus 로고    scopus 로고
    • Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials
    • Staeva TP, Chatenoud L, Insel R, Atkinson MA. Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes 2013;62:9-17
    • (2013) Diabetes , vol.62 , pp. 9-17
    • Staeva, T.P.1    Chatenoud, L.2    Insel, R.3    Atkinson, M.A.4
  • 62
    • 77951891703 scopus 로고    scopus 로고
    • Prediction and pathogenesis in type 1 diabetes
    • Ziegler AG, Nepom GT. Prediction and pathogenesis in type 1 diabetes. Immunity 2010;32:468-478
    • (2010) Immunity , vol.32 , pp. 468-478
    • Ziegler, A.G.1    Nepom, G.T.2
  • 63
    • 82755197361 scopus 로고    scopus 로고
    • Detection of β cell death in diabetes using differentially methylated circulating DNA
    • Akirav EM, Lebastchi J, Galvan EM, et al. Detection of β cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci USA 2011;108:19018-19023
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 19018-19023
    • Akirav, E.M.1    Lebastchi, J.2    Galvan, E.M.3
  • 65
    • 77950356610 scopus 로고    scopus 로고
    • Progression to diabetes in relatives of type 1 diabetic patients: Mechanisms and mode of onset
    • DPT-1 Study Group
    • Ferrannini E, Mari A, Nofrate V, Sosenko JM, Skyler JS; DPT-1 Study Group. Progression to diabetes in relatives of type 1 diabetic patients: mechanisms and mode of onset. Diabetes 2010;59:679-685
    • (2010) Diabetes , vol.59 , pp. 679-685
    • Ferrannini, E.1    Mari, A.2    Nofrate, V.3    Sosenko, J.M.4    Skyler, J.S.5
  • 66
    • 0035862333 scopus 로고    scopus 로고
    • Antigenspecific inhibition of effector T cell function in humans after injection of immature dendritic cells
    • Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N. Antigenspecific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001;193:233-238
    • (2001) J Exp Med , vol.193 , pp. 233-238
    • Dhodapkar, M.V.1    Steinman, R.M.2    Krasovsky, J.3    Munz, C.4    Bhardwaj, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.