Thyroxine-metabolizing rat uridine diphosphate-glucuronosyltransferase 1A7 is regulated by thyroid hormone receptor

Endocrinology

Volumn 148, Issue 12, 2007, Pages 6124-6133

  Emi, Yoshikazu ^a   Ikushiro, Shin Ichi ^b   Kato, Yoshihisa ^c  

^a UNIVERSITY OF HYOGO   (Japan)

^b TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; DEATH RECEPTOR 5; GLUCURONOSYLTRANSFERASE 1A7; ISOENZYME; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR ALPHA; THYROXINE;

ARTICLE; CLEARANCE; CONTROLLED STUDY; ENZYME MECHANISM; EXPOSURE; FEEDBACK SYSTEM; GLUCURONIDATION; HOMEOSTASIS; HORMONE RESPONSE; HUMAN; HUMAN CELL; METABOLIC REGULATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FAMILY; RECEPTOR BINDING; REGULATORY MECHANISM; REPORTER GENE; TARGET CELL; THYROXINE BLOOD LEVEL; THYROXINE METABOLISM;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; GENE EXPRESSION; GLUCURONATES; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RATS; RECEPTORS, THYROID HORMONE; RETINOID X RECEPTOR ALPHA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN; THYROID HORMONES; THYROXINE; TRANSFECTION; URIDINE DIPHOSPHATE;

EID: 36349025921     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0443     Document Type: Article

References (57)

1. Oppenheimer JH, Schwartz HL, Mariash CN, Kinlaw WB, Wong NC, Freake HC 1987 Advances in our understanding of thyroid hormone action at the cellular level. Endocr Rev 8:288-308
2. Yen PM 2001 Physiological and molecular basis of thyroid hormone action. Physiol Rev 81:1097-1142
3. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89
4. Visser TJ 1990 Importance of deiodination and conjugation in the hepatic metabolism of thyroid hormone. In: Greer MA, ed. The thyroid gland. New York: Raven Press; 255-283
5. 3) glucuronidation. Toxicol Sci 55:78-84
6. 3) and its metabolites. Toxicol Sci 65:184-191
7. Saito K, Kaneko H, Sato K, Yoshitake A, Yamada H 1991 Hepatic UDP-glucuronyltransferase( s) activity toward thyroid hormones in rats: induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers. Toxicol Appl Pharmacol 111:99-106
8. Klaassen CD, Hood AM 2001 Effects of microsomal enzyme inducers on thyroid follicular cell proliferation and thyroid hormone metabolism. Toxicol Pathol 29:34-40
9. Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Roy Chowdhury J, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW 1997 The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 7:255-269
10. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS 1992 A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257-3261
11. Bosma PJ, Chowdhury NR, Goldhoorn BG, Hofker MH, Oude Elferink RP, Jansen PL, Chowdhury JR 1992 Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I. Hepatology 15:941-947
12. Emi Y, Ikushiro S, Iyanagi T 1995 Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex. J Biochem 117:392-399
13. Visser TJ, Kaptein E, van Toor H, van Raaij JAGM, van den Berg KJ, Joe CTT, van Engelen JGM, Brouwer A 1993 Glucuronidation of thyroid hormone in rat liver: effects of in vivo treatment with microsomal enzyme inducers and in vitro assay conditions. Endocrinology 133:2177-2186
14. Visser TJ, Kaptein E, Gijzel AL, de Herder WD, Ebner T, Burchell B 1993 Glucuronidation of thyroid hormone by human bilirubin and phenol UDP-glucuronyltransferase isoenzymes. FEBS Lett 324:358-360
15. 3). FEBS Lett 315:65-68
16. Jeminitz K, Veres Z, Monostory K, Vereczkey L 2000 Glucuronidation of thyroxine in primary monolayer cultures of rat hepatocytes: in vitro induction of UDP-glucuronosyltranferases by methylcholanthrene, clofibrate, and dexamethasone alone and in combination. Drug Metab Dispos 28:34-37
17. Emi Y, Ikushiro S, Iyanagi T 1996 Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. J Biol Chem 271:3952-3958
18. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T 2001 The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33:1232-1238
19. Barbier O, Villeneuve L, Bocker V, Fontaine C, Torra IP, Duhem C, Kosykh V, Fruchart JC, Guillemette C, Staels B 2003 The UDP- glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor α and γ target gene. J Biol Chem 278:13975-13983
20. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Gabrera GY, Tukey RH, Evans RM 2003 Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci USA 100:4150-4155
21. Trottier J, Verreault M, Grepper S, Monte D, Bélanger J, Caron P, Inaba T, Barbier O 2006 Human UDP-glucuronosyltransferase (UGT) 1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology 44:1158-1170
22. Magdalou J, Fournel-Gigleux S, Pritchard M, Siest G 1993 Peroxisome proliferators as inducers and substrates of UDP- glucuronosyltransferases. Biol Cell 77:13-16
23. Czernik PJ, Little JM, Barone GW, Raufman JP, Radominska-Pandya A 2000 Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa. Drug Metab Dispos 28:1210-1216
24. Bélanger A, Pelletier G, Labrie F, Barbier O, Chouinard S 2003 Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans. Trends Endocrinol Metab 14:473-479
25. Guillemette C, Bélanger A, Lépine J 2004 Metabolic interaction of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Breast Cancer Res 6:246-254
26. Harvey CB, Williams GR 2002 Mechanism of thyroid hormone action. Thyroid 12:441-446
27. Chowdhury JR, Chowdhury NR, Moscioni AD, Tukey R, Tephly T, Arias IM 1983 Differential regulation by triiodothyronine of substrate-specific uridine-diphosphoglucuronate glucuronosyltransferases in rat liver. Biochim Biophys Acta 761:58-65
28. Masmoudi T, Planells R, Mounié J, Artur Y, Magdalou, J, Goudonnet H 1996 Opposite regulation of bilirubin and 4-nitrophenol UDP-glucuronosyltransferase mRNA levels by 3,3′,5 triiodo-l-thyronine in rat liver. FEBS Lett 379:181-185
29. Masmoudi T, Hihi AK, Vázquez M, Artur Y, Desvergue B, Wahli W, Goudonnet H 1997 Transcriptional regulation by triiodothyronine of the UDP-glucuronosyltransferase family 1 gene complex in rat liver. Comparison with induction by 3-methylcholanthrene. J Biol Chem 272:17171-17175
30. Iyanagi T 1991 Molecular basis of multiple UDP- glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). J Biol Chem 266:24048-24052
31. Iyanagi T, Haniu M, Sogawa K, Fujii-Kuriyama Y, Watanabe S, Shively JE, Anan K 1986 Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. J Biol Chem 261:15607-15614
32. Ohnishi A, Emi Y 2003 Rapid proteasomal degradation of translocation-deficient UDP-glucuronosyltransferase 1A1 (UGT1A1) proteins in patients with Crigler-Najjar type II. Biochem Biophys Res Commun 310:735-741
33. Emi Y, Ohnishi A, Kajimoto T, Ikushiro S, Iyanagi T 2000 A 66-base-pair enhancer module activates the expression of a distinct isoform of UDP-glucuronosyltransferase family 1 (UGT1A2) in primary hepatocytes. Arch Biochem Biophys 378:384-392
34. Ikushiro S, Emi Y, Iyanagi T 1995 Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies. Arch Biochem Biophys 324:267-272
35. Kato Y, Haraguchi K, Yamazaki T, Miyajima S, Nemoto K, Koga N, Kimura R, Degawa M 2003 Effects of polychlorinated biphenyls, kanechlor-500, on serum thyroid hormone levels in rats and mice. Toxicol Sci 72:235-241
36. Schreiber E, Matthias P, Muller M, Schaffner W 1989 Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17:6419
37. Lamb JG, Straub P, Tukey RH 1994 Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemistry 33:10513-10520
38. Leung YK, Ho JW 2002 Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthrene in rat hepatoma cells. Biochem Pharmacol 63:767-775
39. Metz RP, Ritter JK 1998 Transcriptional activation of the UDP-glucuronosyltransferase 1A7 gene in rat liver by aryl hydrocarbon receptor ligands and oltipraz. J Biol Chem 273:5607-5614
40. Grove AD, Kessler FK, Metz RP, Ritter JK 1997 Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo( a)pyrene-7,8-dihydrodiol. J Biol Chem 272:1621-1627
41. Kobayashi T, Yokota H, Ohgiya S, Iwano H, Yuasa A 1998 UDP-glucuronosyltransferase UGT1A7 induced in rat small intestinal mucosa by oral administration of 2-naphthoflavone. Eur J Biochem 258:948-955
42. Bock KW, Raschko FT, Gschaidmeier H, Seidel A, Oesch F, Grove AD, Ritter JK 1999 Mono- and diglucuronide formation from benzopyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7. Biochem Pharmacol 57:653-656
43. Kessler FK, Kessler MR, Auyeung DJ, Ritter JK 2002 Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Drug Metab Dispos 30:324-330
44. Webb LJ, Miles KK, Auyeung DJ, Kessler FK, Ritter JK 2005 Analysis of substrate specificities and tissue expression of rat UDP- glucuronosyltransferases UGT1A7 and UGT1A8. Drug Metab Dispos 33:77-82
45. Metz RP, Auyeung DJ, Kessler FK, Ritter JK 2000 Involvement of hepatocyte nuclear factor 1 in the regulation of the UDP-glucuronosyltransferase 1A7 (UGT1A7) gene in rat hepatocytes. Mol Pharmacol 58:319-327
46. Vansell NR, Klaassen CD 2002 Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Drug Metab Dispos 30:240-246
47. Kato Y, Ikushiro S, Haraguchi K, Yamazaki T, Ito Y, Suzuki H, Kimura R, Yamada S, Inoue T, Degawa M 2004 A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Toxicol Sci 81:309-315
48. Albert A, Keating FR 1952 The role of the gastrointestinal tract, including the liver, in the metabolism of radiothyroxine. Endocrinology 51:427-443
49. Briggs FN, Taurog A, Chaikoff IL 1953 The enterohepatic circulation of thyroxine in the rat. Endocrinology 52:559-567
50. Kelly GS 2000 Peripheral metabolism of thyroid hormones: a review. Altern Med Rev 5:306-333
51. Boas M, Feldt-Rasmussen U, Shakkebæk NE, Main KM 2006 Environmental chemicals and thyroid function. Eur J Endocrinol 154:599-611
52. Nishimura N, Yonemoto J, Miyabara Y, Sato M, Tohyama C 2003 Rat thyroid hyperplasia induced by gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Endocrinology 144:2075-2083
53. Nishimura N, Yonemoto J, Miyabara Y, Fujii-Kuriyama Y, Tohyama C 2005 Altered thyroxin and retinoid metabolic response to 2,3,7,8- tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice. Arch Toxicol 79:260-267
54. Aoki Y 2001 Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans as endocrine disrupters: what we have learned from Yusho disease. Environ Res 86:2-11
55. Samuels HH, Tsai JS, Casanova J, Stanley F 1974 In vitro characterization of solubilized nuclear receptors from rat liver and cultured GH1 cells. J Clin Invest 54:853-864
56. Davis PJ, Davis FB 1996 Nongenomic actions of thyroid hormone. Thyroid 6:497-504
57. Katz RW, Subauste JS, Koenig RJ 1995 The interplay of half-site sequence and spacing on the activity of direct repeat thyroid hormone response elements. J Biol Chem 270:5238-5242