Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity

Diabetes

Volumn 62, Issue 11, 2013, Pages 3697-3708

  Carobbio, Stefania ^a   Hagen, Rachel M ^a   Lelliott, Christopher J ^b   Slawik, Marc ^a,c   Medina Gomez, Gema ^a,d   Tan, Chong Yew ^a   Sicard, Audrey ^e   Atherton, Helen J ^a   Barbarroja, Nuria ^a,f   Bjursell, Mikael ^b   Bohlooly Y, Mohammad ^b   Virtue, Sam ^a   Tuthill, Antoinette ^a   Lefai, Etienne ^g   Laville, Martine ^g   Wu, Tingting ^b   Considine, Robert V ^h   Vidal, Hubert ^g   Langin, Dominique ^e,i   Oresic, Matej ^j   Tinahones, Francisco J ^f   Fernandez Real, Jose Manuel ^k   Griffin, Julian L ^a   Sethi, Jaswinder K ^a   López, Miguel ^a,l   Vidal Puig, Antonio ^a,m   more..

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSIDAD REY JUAN CARLOS   (Spain)

^e University Hospital of Toulouse   (France)

^f HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^g UNIVERSITÉ LYON 1   (France)

^h INDIANA UNIVERSITY   (United States)

ⁱ Departments of Clinical Biochemistry   (France)

^j HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^k Instituto de Salud Carlos III   (Spain)

^l UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^m WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; INSULIN; INSULIN INDUCED GENE 1 PROTEIN; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; ACYL COENZYME A DESATURASE; INSIG1 PROTEIN, MOUSE; MEMBRANE PROTEIN; SCD1 PROTEIN, MOUSE; SREBF1 PROTEIN, MOUSE;

ADAPTATION; ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIET; DISEASE ASSOCIATION; DOWN REGULATION; ESTERIFICATION; FATTY ACID DESATURATION; FEEDBACK SYSTEM; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RESISTANCE; LIPID STORAGE; LIPOGENESIS; MALE; MOUSE; NONHUMAN; OBESITY; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; ANIMAL; BIOSYNTHESIS; CELL STRAIN 3T3; KNOCKOUT MOUSE; LIPID METABOLISM; METABOLISM; MORBID OBESITY; PATHOPHYSIOLOGY; WHITE ADIPOSE TISSUE; 3T3 CELL LINE;

3T3-L1 CELLS; ADAPTATION, PHYSIOLOGICAL; ADIPOSE TISSUE, WHITE; ANIMALS; DOWN-REGULATION; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; OBESITY; OBESITY, MORBID; RNA, MESSENGER; STEAROYL-COA DESATURASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84891714343     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1748     Document Type: Article

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