메뉴 건너뛰기




Volumn 73, Issue 2, 2014, Pages 91-100

Future treatment options for atopic dermatitis - Small molecules and beyond

Author keywords

Atopic dermatitis; IgE; Pruritus; Review; Th2; Therapy

Indexed keywords

ALEFACEPT; AMG 157; AN 2728; AN 2898; ANTIHISTAMINIC AGENT; APREMILAST; BAY 169996; CD2 ANTIGEN; CHYMASE; CYCLIC AMP; DUPILUMAB; ENZYME INHIBITOR; IMMUNOGLOBULIN E; INTERLEUKIN 1BETA; INTERLEUKIN 4 RECEPTOR ALPHA; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MAPRACORAT; MONOCLONAL ANTIBODY; N (3,5 DICHLORO 4 PYRIDYL) [1 (4 FLUOROBENZYL) 5 HYDROXY 3 INDOLYL]GLYOXYLIC ACID AMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OMALIZUMAB; PHOSPHODIESTERASE IV INHIBITOR; PITRAKINRA; PLACEBO; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SUN 13350; SUN 13834; SUN C8257; UNCLASSIFIED DRUG; UNINDEXED DRUG; UROCANIC ACID; WBI 1001;

EID: 84891663624     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2013.11.009     Document Type: Review
Times cited : (29)

References (88)
  • 1
    • 84864279964 scopus 로고    scopus 로고
    • Update on systemic therapies for atopic dermatitis
    • Denby K.S., Beck L.A. Update on systemic therapies for atopic dermatitis. Curr Opin Allergy Clin Immunol 2012, 12:421-426.
    • (2012) Curr Opin Allergy Clin Immunol , vol.12 , pp. 421-426
    • Denby, K.S.1    Beck, L.A.2
  • 2
    • 37749025593 scopus 로고    scopus 로고
    • Atopic dermatitis
    • Bieber T. Atopic dermatitis. N Engl J Med 2008, 358:1483-1494.
    • (2008) N Engl J Med , vol.358 , pp. 1483-1494
    • Bieber, T.1
  • 3
    • 4544258842 scopus 로고    scopus 로고
    • Vital role of the itch-scratch response in development of spontaneous dermatitis in NC/Nga mice
    • Mihara K., Kuratani K., Matsui T., Nakamura M., Yokota K. Vital role of the itch-scratch response in development of spontaneous dermatitis in NC/Nga mice. Br J Dermatol 2004, 151:335-345.
    • (2004) Br J Dermatol , vol.151 , pp. 335-345
    • Mihara, K.1    Kuratani, K.2    Matsui, T.3    Nakamura, M.4    Yokota, K.5
  • 4
  • 5
    • 76349105505 scopus 로고    scopus 로고
    • ETFAD/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis
    • Darsow U., Wollenberg A., Simon D., Taieb A., Werfel T., Oranje A., et al. ETFAD/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis. J Eur Acad Dermatol Venereol 2010, 24:317-328.
    • (2010) J Eur Acad Dermatol Venereol , vol.24 , pp. 317-328
    • Darsow, U.1    Wollenberg, A.2    Simon, D.3    Taieb, A.4    Werfel, T.5    Oranje, A.6
  • 7
    • 84870294267 scopus 로고    scopus 로고
    • Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
    • Gittler J.K., Shemer A., Suarez-Farinas M., Fuentes-Duculan J., Gulewicz K.J., Wang C.Q., et al. Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol 2012, 130:1344-1354.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1344-1354
    • Gittler, J.K.1    Shemer, A.2    Suarez-Farinas, M.3    Fuentes-Duculan, J.4    Gulewicz, K.J.5    Wang, C.Q.6
  • 8
    • 1842422281 scopus 로고    scopus 로고
    • The genetics of psoriasis, psoriatic arthritis and atopic dermatitis
    • Bowcock A.M., Cookson W.O.C.M. The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum Mol Genet 2004, 13:R43-R55.
    • (2004) Hum Mol Genet , vol.13
    • Bowcock, A.M.1    Cookson, W.O.C.M.2
  • 9
    • 33645399288 scopus 로고    scopus 로고
    • Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
    • Palmer C.N.A., Irvine A.D., Terron-Kwiatkowski A., Zhao Y., Liao H., Lee S.P., et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006, 38:441-446.
    • (2006) Nat Genet , vol.38 , pp. 441-446
    • Palmer, C.N.A.1    Irvine, A.D.2    Terron-Kwiatkowski, A.3    Zhao, Y.4    Liao, H.5    Lee, S.P.6
  • 11
    • 34447265905 scopus 로고    scopus 로고
    • Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
    • Conti M., Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem 2007, 76:481-511.
    • (2007) Annu Rev Biochem , vol.76 , pp. 481-511
    • Conti, M.1    Beavo, J.2
  • 12
    • 84993740524 scopus 로고    scopus 로고
    • Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases
    • Schett G., Sloan V.S., Stevens R.M., Schafer P. Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases. Ther Adv Musculoskelet Dis 2010, 2:271.
    • (2010) Ther Adv Musculoskelet Dis , vol.2 , pp. 271
    • Schett, G.1    Sloan, V.S.2    Stevens, R.M.3    Schafer, P.4
  • 13
    • 0031942752 scopus 로고    scopus 로고
    • Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production
    • Eigler A., Siegmund B., Emmerich U., Baumann K.H., Hartmann G., Endres S. Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. J Leukoc Biol 1998, 63:101-107.
    • (1998) J Leukoc Biol , vol.63 , pp. 101-107
    • Eigler, A.1    Siegmund, B.2    Emmerich, U.3    Baumann, K.H.4    Hartmann, G.5    Endres, S.6
  • 14
    • 0031024418 scopus 로고    scopus 로고
    • Differential efficacy of lymphocyte-and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression
    • Essayan D.M., Huang S.K., Kagey-Sobotka A., Lichtenstein L.M. Differential efficacy of lymphocyte-and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression. J Allergy Clin Immunol 1997, 99:28-37.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 28-37
    • Essayan, D.M.1    Huang, S.K.2    Kagey-Sobotka, A.3    Lichtenstein, L.M.4
  • 15
    • 0028051721 scopus 로고
    • Modulation of antigen-and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors
    • Essayan D.M., Huang S.K., Undem B.J., Kagey-Sobotka A., Lichtenstein L.M. Modulation of antigen-and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors. J Immunol 1994, 153:3408.
    • (1994) J Immunol , vol.153 , pp. 3408
    • Essayan, D.M.1    Huang, S.K.2    Undem, B.J.3    Kagey-Sobotka, A.4    Lichtenstein, L.M.5
  • 16
    • 77249116286 scopus 로고    scopus 로고
    • Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis
    • Schafer P., Parton A., Gandhi A., Capone L., Adams M., Wu L., et al. Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. Br J Pharmacol 2010, 159:842-855.
    • (2010) Br J Pharmacol , vol.159 , pp. 842-855
    • Schafer, P.1    Parton, A.2    Gandhi, A.3    Capone, L.4    Adams, M.5    Wu, L.6
  • 17
    • 44349161096 scopus 로고    scopus 로고
    • An open-label, single-arm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-inflammatory agent, apremilast
    • Gottlieb A., Strober B., Krueger J., Rohane P., Zeldis J., Hu C., et al. An open-label, single-arm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-inflammatory agent, apremilast. Curr Med Res Opin 2008, 24:1529-1538.
    • (2008) Curr Med Res Opin , vol.24 , pp. 1529-1538
    • Gottlieb, A.1    Strober, B.2    Krueger, J.3    Rohane, P.4    Zeldis, J.5    Hu, C.6
  • 18
    • 84865675102 scopus 로고    scopus 로고
    • A pilot study of an oral phosphodiesterase inhibitor (Apremilast) for atopic dermatitis in adults
    • Samrao A., Berry T.M., Goreshi R., Simpson E.L. A pilot study of an oral phosphodiesterase inhibitor (Apremilast) for atopic dermatitis in adults. Arch Dermatol 2012, 148:890-897.
    • (2012) Arch Dermatol , vol.148 , pp. 890-897
    • Samrao, A.1    Berry, T.M.2    Goreshi, R.3    Simpson, E.L.4
  • 19
    • 84858636270 scopus 로고    scopus 로고
    • A phase 2, open-label, investigator-initiated study to evaluate the safety and efficacy of apremilast in subjects with recalcitrant allergic contact or atopic dermatitis
    • Volf E., Au S., Dumont N., Scheinman P., Gottlieb A. A phase 2, open-label, investigator-initiated study to evaluate the safety and efficacy of apremilast in subjects with recalcitrant allergic contact or atopic dermatitis. J Drugs Dermatol 2012, 11:341.
    • (2012) J Drugs Dermatol , vol.11 , pp. 341
    • Volf, E.1    Au, S.2    Dumont, N.3    Scheinman, P.4    Gottlieb, A.5
  • 20
    • 70449368604 scopus 로고    scopus 로고
    • AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis
    • Nazarian R., Weinberg J.M. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs 2009, 10:1236.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1236
    • Nazarian, R.1    Weinberg, J.M.2
  • 21
    • 0036740350 scopus 로고    scopus 로고
    • Prevention and regression of atopic dermatitis by ointment containing NF-κB decoy oligodeoxynucleotides in NC/Nga atopic mouse model
    • Nakamura H., Aoki M., Tamai K., Oishi M., Ogihara T., Kaneda Y., et al. Prevention and regression of atopic dermatitis by ointment containing NF-κB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Therapy 2002, 9:1221.
    • (2002) Gene Therapy , vol.9 , pp. 1221
    • Nakamura, H.1    Aoki, M.2    Tamai, K.3    Oishi, M.4    Ogihara, T.5    Kaneda, Y.6
  • 23
    • 70350125299 scopus 로고    scopus 로고
    • Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases
    • Schäcke H., Zollner T., Döcke W., Rehwinkel H., Jaroch S., Skuballa W., et al. Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases. Brit J Pharmacol 2009, 158:1088-1103.
    • (2009) Brit J Pharmacol , vol.158 , pp. 1088-1103
    • Schäcke, H.1    Zollner, T.2    Döcke, W.3    Rehwinkel, H.4    Jaroch, S.5    Skuballa, W.6
  • 24
    • 77956960031 scopus 로고    scopus 로고
    • Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells
    • Cavet M.E., Harrington K.L., Ward K.W., Zhang J.Z. Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells. Mol Vis 2010, 16:1791-1800.
    • (2010) Mol Vis , vol.16 , pp. 1791-1800
    • Cavet, M.E.1    Harrington, K.L.2    Ward, K.W.3    Zhang, J.Z.4
  • 25
    • 44849087684 scopus 로고    scopus 로고
    • Recent advances in urocanic acid photochemistry, photobiology and photoimmunology
    • Gibbs N.K., Tye J., Norval M. Recent advances in urocanic acid photochemistry, photobiology and photoimmunology. Photochem Photobiol Sci 2008, 7:655-667.
    • (2008) Photochem Photobiol Sci , vol.7 , pp. 655-667
    • Gibbs, N.K.1    Tye, J.2    Norval, M.3
  • 26
    • 0024351938 scopus 로고
    • Quantification of uranic acid isomers in human stratum corneum
    • Norval M., Simpson T., Bardshiri E., Crosby J. Quantification of uranic acid isomers in human stratum corneum. Photodermatology 1989, 6:142-145.
    • (1989) Photodermatology , vol.6 , pp. 142-145
    • Norval, M.1    Simpson, T.2    Bardshiri, E.3    Crosby, J.4
  • 27
    • 0345329282 scopus 로고    scopus 로고
    • Molecular mechanisms of cis-urocanic acid and permethrin-induced alterations in cutaneous immunity
    • Prater M., Blaylock B., Holladay S. Molecular mechanisms of cis-urocanic acid and permethrin-induced alterations in cutaneous immunity. Photodermatol Photoimmunol Photomed 2003, 19:287-294.
    • (2003) Photodermatol Photoimmunol Photomed , vol.19 , pp. 287-294
    • Prater, M.1    Blaylock, B.2    Holladay, S.3
  • 28
    • 0029124942 scopus 로고
    • Topical cis-urocanic acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice
    • Lauerma A., Aioi A., Maibach H. Topical cis-urocanic acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice. Acta Derm Venereol 1995, 75:272.
    • (1995) Acta Derm Venereol , vol.75 , pp. 272
    • Lauerma, A.1    Aioi, A.2    Maibach, H.3
  • 29
    • 47949119050 scopus 로고    scopus 로고
    • Cis-Urocanic acid initiates gene transcription in primary human keratinocytes
    • Kaneko K., Smetana-Just U., Matsui M., Young A.R., John S., Norval M., et al. cis-Urocanic acid initiates gene transcription in primary human keratinocytes. J Immunol 2008, 181:217.
    • (2008) J Immunol , vol.181 , pp. 217
    • Kaneko, K.1    Smetana-Just, U.2    Matsui, M.3    Young, A.R.4    John, S.5    Norval, M.6
  • 30
    • 79955993881 scopus 로고    scopus 로고
    • Cis-Urocanic acid enhances prostaglandin E2 release and apoptotic cell death via reactive oxygen species in human keratinocytes
    • Kaneko K., Walker S.L., Lai-Cheong J., Matsui M.S., Norval M., Young A.R. cis-Urocanic acid enhances prostaglandin E2 release and apoptotic cell death via reactive oxygen species in human keratinocytes. J Investig Dermatol 2011, 131:1262-1271.
    • (2011) J Investig Dermatol , vol.131 , pp. 1262-1271
    • Kaneko, K.1    Walker, S.L.2    Lai-Cheong, J.3    Matsui, M.S.4    Norval, M.5    Young, A.R.6
  • 31
    • 0032522846 scopus 로고    scopus 로고
    • A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression
    • Shreedhar V., Giese T., Sung V.W., Ullrich S.E. A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression. J Immunol 1998, 160:3783.
    • (1998) J Immunol , vol.160 , pp. 3783
    • Shreedhar, V.1    Giese, T.2    Sung, V.W.3    Ullrich, S.E.4
  • 32
    • 0023888993 scopus 로고
    • Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid
    • Harriott-Smith T.G., Halliday W. Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid. Clin Exp Immunol 1988, 72:174.
    • (1988) Clin Exp Immunol , vol.72 , pp. 174
    • Harriott-Smith, T.G.1    Halliday, W.2
  • 34
    • 0029844357 scopus 로고    scopus 로고
    • Urocanic acid suppresses the activation of human neutrophils in vitro
    • Kivistö K., Punnonen K., Toppari J., Leino L. Urocanic acid suppresses the activation of human neutrophils in vitro. Inflammation 1996, 20:451-459.
    • (1996) Inflammation , vol.20 , pp. 451-459
    • Kivistö, K.1    Punnonen, K.2    Toppari, J.3    Leino, L.4
  • 35
    • 33750582349 scopus 로고    scopus 로고
    • Effect of cis-urocanic acid on bovine neutrophil generation of reactive oxygen species
    • Rinaldi M., Moroni P., Leino L., Laihia J., Paape M., Bannerman D.D. Effect of cis-urocanic acid on bovine neutrophil generation of reactive oxygen species. J Dairy Sci 2006, 89:4188-4201.
    • (2006) J Dairy Sci , vol.89 , pp. 4188-4201
    • Rinaldi, M.1    Moroni, P.2    Leino, L.3    Laihia, J.4    Paape, M.5    Bannerman, D.D.6
  • 36
    • 0031913348 scopus 로고    scopus 로고
    • The effect of urocanic acid on graft rejection in an experimental model of orthotopic corneal transplantation in rabbits
    • Filipec M., Letko E., Hašková Z., Jeníčková D., Holler P., Jančárek A., et al. The effect of urocanic acid on graft rejection in an experimental model of orthotopic corneal transplantation in rabbits. Graefes Arch Clin Exp Ophthalmol 1998, 236:65-68.
    • (1998) Graefes Arch Clin Exp Ophthalmol , vol.236 , pp. 65-68
    • Filipec, M.1    Letko, E.2    Hašková, Z.3    Jeníčková, D.4    Holler, P.5    Jančárek, A.6
  • 38
    • 77951031588 scopus 로고    scopus 로고
    • Efficacy and safety of topical WBI-1001 in the treatment of atopic dermatitis: results from a phase 2A, randomized, placebo-controlled clinical trial
    • Bissonnette R., Chen G., Bolduc C., Maari C., Lyle M., Tang L., et al. Efficacy and safety of topical WBI-1001 in the treatment of atopic dermatitis: results from a phase 2A, randomized, placebo-controlled clinical trial. Arch Dermatol 2010, 146:446.
    • (2010) Arch Dermatol , vol.146 , pp. 446
    • Bissonnette, R.1    Chen, G.2    Bolduc, C.3    Maari, C.4    Lyle, M.5    Tang, L.6
  • 39
    • 84891663398 scopus 로고    scopus 로고
    • Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicenter, randomized, placebo-controlled double-blind trial
    • Bissonnette R., Poulin Y., Zhou Y., Tan J., Hong H., Webster J., et al. Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicenter, randomized, placebo-controlled double-blind trial. Brit J Dermatol 2011.
    • (2011) Brit J Dermatol
    • Bissonnette, R.1    Poulin, Y.2    Zhou, Y.3    Tan, J.4    Hong, H.5    Webster, J.6
  • 40
    • 0027163180 scopus 로고
    • Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses
    • Miller G.T., Hochman P.S., Meier W., Tizard R., Bixler S.A., Rosa M.D., et al. Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses. J Exp Med 1993, 178:211-222.
    • (1993) J Exp Med , vol.178 , pp. 211-222
    • Miller, G.T.1    Hochman, P.S.2    Meier, W.3    Tizard, R.4    Bixler, S.A.5    Rosa, M.D.6
  • 41
    • 0026066989 scopus 로고
    • T cell receptors: adhesion and signaling
    • Bierer't B.E., Burakoff S.J. T cell receptors: adhesion and signaling. Adv Cancer Res 1991, 56:49.
    • (1991) Adv Cancer Res , vol.56 , pp. 49
    • Bierer't, B.E.1    Burakoff, S.J.2
  • 42
    • 0025856309 scopus 로고
    • Role of lymphocyte adhesion receptors in transient interactions and cell locomotion
    • Dustin M.L., Springer T.A. Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Ann Rev Immunol 1991, 9:27-66.
    • (1991) Ann Rev Immunol , vol.9 , pp. 27-66
    • Dustin, M.L.1    Springer, T.A.2
  • 43
    • 0025947895 scopus 로고
    • CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
    • Jenkins M.K., Taylor P.S., Norton S.D., Urdahl K.B. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol 1991, 147:2461.
    • (1991) J Immunol , vol.147 , pp. 2461
    • Jenkins, M.K.1    Taylor, P.S.2    Norton, S.D.3    Urdahl, K.B.4
  • 45
    • 43249130077 scopus 로고    scopus 로고
    • Alefacept for moderate to severe atopic dermatitis: a pilot study in adults
    • Moul D.K., Routhouska S.B., Robinson M.R., Korman N.J. Alefacept for moderate to severe atopic dermatitis: a pilot study in adults. J Am Acad Dermatol 2008, 58:984-989.
    • (2008) J Am Acad Dermatol , vol.58 , pp. 984-989
    • Moul, D.K.1    Routhouska, S.B.2    Robinson, M.R.3    Korman, N.J.4
  • 46
    • 48349090587 scopus 로고    scopus 로고
    • Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema
    • Simon D., Wittwer J., Kostylina G., Buettiker U., Simon H.-U., Yawalkar N. Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema. J Allergy Clin Immunol 2008, 122:423-424.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 423-424
    • Simon, D.1    Wittwer, J.2    Kostylina, G.3    Buettiker, U.4    Simon, H.-U.5    Yawalkar, N.6
  • 48
    • 84891665019 scopus 로고    scopus 로고
    • First-in-human study of REGN668/SAR231893 (IL-4Rα mAb): safety, tolerability and biomarker results of a randomized, double-blind, placebo-controlled, single ascending dose study in healthy volunteers
    • Radin A., Ren H., Papino-Wood P., Chaudhry U., Hamilton J.D. First-in-human study of REGN668/SAR231893 (IL-4Rα mAb): safety, tolerability and biomarker results of a randomized, double-blind, placebo-controlled, single ascending dose study in healthy volunteers. J Allergy Clin Immunol 2013, 131:AB158.
    • (2013) J Allergy Clin Immunol , vol.131
    • Radin, A.1    Ren, H.2    Papino-Wood, P.3    Chaudhry, U.4    Hamilton, J.D.5
  • 49
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
    • Wenzel S., Wilbraham D., Fuller R., Getz E.B., Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007, 370:1422-1431.
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 50
    • 67649600341 scopus 로고    scopus 로고
    • Inhibition of IL-4 and IL-13 with an IL-4 mutein (Aeroderm) protects against flares in atopic eczema [abstract# 320]
    • Groves R., Wilbraham D., Fuller R., Longphre M. Inhibition of IL-4 and IL-13 with an IL-4 mutein (Aeroderm) protects against flares in atopic eczema [abstract# 320]. J Invest Dermatol 2007, 127:S54.
    • (2007) J Invest Dermatol , vol.127
    • Groves, R.1    Wilbraham, D.2    Fuller, R.3    Longphre, M.4
  • 52
  • 53
    • 78650201074 scopus 로고    scopus 로고
    • Omalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course - a randomized, placebo-controlled and double blind pilot study
    • Heil P.M., Maurer D., Klein B., Hultsch T., Stingl G. Omalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course - a randomized, placebo-controlled and double blind pilot study. J Dtsch Dermatol Ges 2010, 8:990-998.
    • (2010) J Dtsch Dermatol Ges , vol.8 , pp. 990-998
    • Heil, P.M.1    Maurer, D.2    Klein, B.3    Hultsch, T.4    Stingl, G.5
  • 54
    • 0030977229 scopus 로고    scopus 로고
    • Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase
    • Welle M. Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase. J Leukoc Biol 1997, 61:233-245.
    • (1997) J Leukoc Biol , vol.61 , pp. 233-245
    • Welle, M.1
  • 55
    • 0036282550 scopus 로고    scopus 로고
    • Chymase participates in chronic dermatitis by inducing eosinophil infiltration
    • Tomimori Y., Muto T., Fukami H., Saito K., Horikawa C., Tsuruoka N., et al. Chymase participates in chronic dermatitis by inducing eosinophil infiltration. Lab Invest 2002, 82:789-794.
    • (2002) Lab Invest , vol.82 , pp. 789-794
    • Tomimori, Y.1    Muto, T.2    Fukami, H.3    Saito, K.4    Horikawa, C.5    Tsuruoka, N.6
  • 57
    • 16044365883 scopus 로고    scopus 로고
    • Association between genetic variants of mast-cell chymase and eczema
    • Mao X.Q., Shirakawa T., Yoshikawa T., Yoshikawa K., Kawai M., Sasaki S., et al. Association between genetic variants of mast-cell chymase and eczema. Lancet 1996, 348:581-583.
    • (1996) Lancet , vol.348 , pp. 581-583
    • Mao, X.Q.1    Shirakawa, T.2    Yoshikawa, T.3    Yoshikawa, K.4    Kawai, M.5    Sasaki, S.6
  • 58
    • 0005610872 scopus 로고    scopus 로고
    • Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease
    • Tanaka K., Sugiura H., Uehara M., Sato H., Hashimoto-Tamaoki T., Furuyama J. Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease. Clin Exp Allergy 1999, 29:800-803.
    • (1999) Clin Exp Allergy , vol.29 , pp. 800-803
    • Tanaka, K.1    Sugiura, H.2    Uehara, M.3    Sato, H.4    Hashimoto-Tamaoki, T.5    Furuyama, J.6
  • 63
    • 56949104452 scopus 로고    scopus 로고
    • Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis
    • Terakawa M., Fujieda Y., Tomimori Y., Muto T., Tanaka T., Maruoka H., et al. Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis. Eur J Pharmacol 2008, 601:186-191.
    • (2008) Eur J Pharmacol , vol.601 , pp. 186-191
    • Terakawa, M.1    Fujieda, Y.2    Tomimori, Y.3    Muto, T.4    Tanaka, T.5    Maruoka, H.6
  • 64
    • 0033850005 scopus 로고    scopus 로고
    • Chymase is a potent chemoattractant for human monocytes and neutrophils
    • Tani K., Ogushi F., Kido H., Kawano T., Kunori Y., Kamimura T., et al. Chymase is a potent chemoattractant for human monocytes and neutrophils. J Leukoc Biol 2000, 67:585-589.
    • (2000) J Leukoc Biol , vol.67 , pp. 585-589
    • Tani, K.1    Ogushi, F.2    Kido, H.3    Kawano, T.4    Kunori, Y.5    Kamimura, T.6
  • 66
    • 0029123247 scopus 로고
    • Effects of naloxone infusions in patients with the pruritus of cholestasis: a double-blind, randomized, controlled trial
    • Bergasa N.V., Alling D.W., Talbot T.L., Swain M.G., Yurdaydin C., Turner M.L., et al. Effects of naloxone infusions in patients with the pruritus of cholestasis: a double-blind, randomized, controlled trial. Ann Intern Med 1995, 123:161-167.
    • (1995) Ann Intern Med , vol.123 , pp. 161-167
    • Bergasa, N.V.1    Alling, D.W.2    Talbot, T.L.3    Swain, M.G.4    Yurdaydin, C.5    Turner, M.L.6
  • 67
    • 0032860968 scopus 로고    scopus 로고
    • Efficacy and safety of naltrexone, an oral opiate receptor antagonist, in the treatment of pruritus in internal and dermatological diseases
    • Metze D., Reimann S., Beissert S., Luger T. Efficacy and safety of naltrexone, an oral opiate receptor antagonist, in the treatment of pruritus in internal and dermatological diseases. J Am Acad Dermatol 1999, 41:533-539.
    • (1999) J Am Acad Dermatol , vol.41 , pp. 533-539
    • Metze, D.1    Reimann, S.2    Beissert, S.3    Luger, T.4
  • 68
    • 0036893023 scopus 로고    scopus 로고
    • Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study
    • Terg R., Coronel E., Sordá J., Muñoz A.E., Findor J. Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study. J Hepatol 2002, 37:717-722.
    • (2002) J Hepatol , vol.37 , pp. 717-722
    • Terg, R.1    Coronel, E.2    Sordá, J.3    Muñoz, A.E.4    Findor, J.5
  • 69
    • 18244416618 scopus 로고    scopus 로고
    • Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study
    • Pauli-Magnus C., Mikus G., Alscher D.M., Kirschner T., Nagel W., Gugeler N., et al. Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. J Am Soc Nephrol 2000, 11:514-519.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 514-519
    • Pauli-Magnus, C.1    Mikus, G.2    Alscher, D.M.3    Kirschner, T.4    Nagel, W.5    Gugeler, N.6
  • 70
    • 0029821820 scopus 로고    scopus 로고
    • Randomised crossover trial of naltrexone in uraemic pruritus
    • Peer G., Kivity S., Agami O., Fireman E., Silverberg D., Blum M., et al. Randomised crossover trial of naltrexone in uraemic pruritus. Lancet 1996, 348:1552-1554.
    • (1996) Lancet , vol.348 , pp. 1552-1554
    • Peer, G.1    Kivity, S.2    Agami, O.3    Fireman, E.4    Silverberg, D.5    Blum, M.6
  • 71
    • 0035741153 scopus 로고    scopus 로고
    • Pharmacological control of opioid-induced pruritus: a quantitative systematic review of randomized trials
    • Kjellberg F., Tramer M. Pharmacological control of opioid-induced pruritus: a quantitative systematic review of randomized trials. Eur J Anaesthesiol 2001, 18:346-357.
    • (2001) Eur J Anaesthesiol , vol.18 , pp. 346-357
    • Kjellberg, F.1    Tramer, M.2
  • 72
    • 0024309482 scopus 로고
    • Efficacy and safety of nalmefene in patients with severe pruritus caused by chronic urticaria and atopic dermatitis
    • Monroe E.W. Efficacy and safety of nalmefene in patients with severe pruritus caused by chronic urticaria and atopic dermatitis. J Am Acad Dermatol 1989, 21:135.
    • (1989) J Am Acad Dermatol , vol.21 , pp. 135
    • Monroe, E.W.1
  • 74
    • 80053073997 scopus 로고    scopus 로고
    • A randomized, double-blind, vehicle-controlled crossover study to determine the anti-pruritic efficacy, safety and local dermal tolerability of a topical formulation (SRD174 cream) of the long-acting opiod antagonist nalmefene in subjects with atopic dermatitis
    • Herzog J.L., Solomon J.A., Draelos Z., Fleischer A., Stough D., Wolf D.I., et al. A randomized, double-blind, vehicle-controlled crossover study to determine the anti-pruritic efficacy, safety and local dermal tolerability of a topical formulation (SRD174 cream) of the long-acting opiod antagonist nalmefene in subjects with atopic dermatitis. J Drugs Dermatol 2011, 10:853.
    • (2011) J Drugs Dermatol , vol.10 , pp. 853
    • Herzog, J.L.1    Solomon, J.A.2    Draelos, Z.3    Fleischer, A.4    Stough, D.5    Wolf, D.I.6
  • 75
    • 8844254704 scopus 로고    scopus 로고
    • Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis
    • Arai I., Takano N., Hashimoto Y., Futaki N., Sugimoto M., Takahashi N., et al. Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. Eur J Pharmacol 2004, 505:229-235.
    • (2004) Eur J Pharmacol , vol.505 , pp. 229-235
    • Arai, I.1    Takano, N.2    Hashimoto, Y.3    Futaki, N.4    Sugimoto, M.5    Takahashi, N.6
  • 76
    • 22044452147 scopus 로고    scopus 로고
    • Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice
    • Honma Y., Arai I., Hashimoto Y., Futaki N., Sugimoto M., Tanaka M., et al. Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. Eur J Pharmacol 2005, 518:56-62.
    • (2005) Eur J Pharmacol , vol.518 , pp. 56-62
    • Honma, Y.1    Arai, I.2    Hashimoto, Y.3    Futaki, N.4    Sugimoto, M.5    Tanaka, M.6
  • 77
    • 33846089351 scopus 로고    scopus 로고
    • Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice
    • Arai I., Takaoka A., Hashimoto Y., Honma Y., Koizumi C., Futaki N., et al. Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. Eur J Pharmacol 2007, 556:207-214.
    • (2007) Eur J Pharmacol , vol.556 , pp. 207-214
    • Arai, I.1    Takaoka, A.2    Hashimoto, Y.3    Honma, Y.4    Koizumi, C.5    Futaki, N.6
  • 78
    • 34250677710 scopus 로고    scopus 로고
    • The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice
    • Sugimoto M., Arai I., Futaki N., Hashimoto Y., Sakurai T., Honma Y., et al. The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice. Eur J Pharmacol 2007, 564:196-203.
    • (2007) Eur J Pharmacol , vol.564 , pp. 196-203
    • Sugimoto, M.1    Arai, I.2    Futaki, N.3    Hashimoto, Y.4    Sakurai, T.5    Honma, Y.6
  • 79
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • Galiègue S., Mary S., Marchand J., Dussossoy D., Carrière D., Carayon P., et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 1995, 232:54-61.
    • (1995) Eur J Biochem , vol.232 , pp. 54-61
    • Galiègue, S.1    Mary, S.2    Marchand, J.3    Dussossoy, D.4    Carrière, D.5    Carayon, P.6
  • 80
    • 0028906566 scopus 로고
    • Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide
    • Facci L., Dal Toso R., Romanello S., Buriani A., Skaper S., Leon A. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc Natl Acad Sci U S A 1995, 92:3376.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3376
    • Facci, L.1    Dal Toso, R.2    Romanello, S.3    Buriani, A.4    Skaper, S.5    Leon, A.6
  • 81
    • 2442480915 scopus 로고    scopus 로고
    • Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury
    • Johanek L.M., Simone D.A. Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury. Pain 2004, 109:432-442.
    • (2004) Pain , vol.109 , pp. 432-442
    • Johanek, L.M.1    Simone, D.A.2
  • 82
    • 21644456607 scopus 로고    scopus 로고
    • Signal transduction activated by cannabinoid receptors
    • Diaz-Laviada I., Ruiz-Llorente L. Signal transduction activated by cannabinoid receptors. Mini Rev Med Chem 2005, 5:619-630.
    • (2005) Mini Rev Med Chem , vol.5 , pp. 619-630
    • Diaz-Laviada, I.1    Ruiz-Llorente, L.2
  • 83
    • 0037709373 scopus 로고    scopus 로고
    • Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin
    • Dvorak M., Watkinson A., McGlone F., Rukwied R. Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin. Inflamm Res 2003, 52:238-245.
    • (2003) Inflamm Res , vol.52 , pp. 238-245
    • Dvorak, M.1    Watkinson, A.2    McGlone, F.3    Rukwied, R.4
  • 84
    • 0344405669 scopus 로고    scopus 로고
    • Cannabinoid agonists attenuate capsaicin-induced responses in human skin
    • Rukwied R., Watkinson A., McGlone F., Dvorak M. Cannabinoid agonists attenuate capsaicin-induced responses in human skin. Pain 2003, 102:283-288.
    • (2003) Pain , vol.102 , pp. 283-288
    • Rukwied, R.1    Watkinson, A.2    McGlone, F.3    Dvorak, M.4
  • 85
    • 0035803010 scopus 로고    scopus 로고
    • Dual neurokinin NK1/NK2 antagonists: N-[(R,R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl) carbamoyl] allyl-N-methyl-3,5-bis (trifluoromethyl) benzamides and 3-[N'-3,5-bis (trifluoromethyl) benzoyl-N-arylmethyl-N'-methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl] propionamides
    • Gerspacher M., La Vecchia L., Mah R., von Sprecher A., Anderson G.P., Subramanian N., et al. Dual neurokinin NK1/NK2 antagonists: N-[(R,R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl) carbamoyl] allyl-N-methyl-3,5-bis (trifluoromethyl) benzamides and 3-[N'-3,5-bis (trifluoromethyl) benzoyl-N-arylmethyl-N'-methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl] propionamides. Bioorg Med Chem Lett 2001, 11:3081-3084.
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 3081-3084
    • Gerspacher, M.1    La Vecchia, L.2    Mah, R.3    von Sprecher, A.4    Anderson, G.P.5    Subramanian, N.6
  • 86
    • 0346505544 scopus 로고    scopus 로고
    • Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients
    • Joos G., Vincken W., Louis R., Schelfhout V., Wang J., Shaw M., et al. Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients. Eur Res J 2004, 23:76-81.
    • (2004) Eur Res J , vol.23 , pp. 76-81
    • Joos, G.1    Vincken, W.2    Louis, R.3    Schelfhout, V.4    Wang, J.5    Shaw, M.6
  • 87
    • 49249099299 scopus 로고    scopus 로고
    • Treatment following an evidence-based algorithm versus individualised symptom-oriented treatment for atopic eczema
    • Schmitt J., Meurer M., Schwanebeck U., Grählert X., Schäkel K. Treatment following an evidence-based algorithm versus individualised symptom-oriented treatment for atopic eczema. Dermatology 2008, 217:299-308.
    • (2008) Dermatology , vol.217 , pp. 299-308
    • Schmitt, J.1    Meurer, M.2    Schwanebeck, U.3    Grählert, X.4    Schäkel, K.5
  • 88
    • 80054032304 scopus 로고    scopus 로고
    • The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis
    • Jariwala S., Abrams E., Benson A., Fodeman J., Zheng T. The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis. Clin Exp Allergy 2011.
    • (2011) Clin Exp Allergy
    • Jariwala, S.1    Abrams, E.2    Benson, A.3    Fodeman, J.4    Zheng, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.