Urocanic acid suppresses induction of immunity in human skin

Photodermatology Photoimmunology and Photomedicine

Volumn 26, Issue 6, 2010, Pages 303-310

  Dahl, Mark V ^a   McEwen, Gerald N ^b   Katz, H Irving ^c  

^a MAYO CLINIC   (United States)

^b The Cosmetic Toiletry and Fragrance Association ^*  (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Immunity; Immunosuppression; Langerhans cells; Photoimmunology; Urocanic acid

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; UROCANIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHEMA; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNE FUNCTION TEST; LABORATORY TEST; LANGERHANS CELL; LYMPHOCYTE COUNT; MALE; NONHUMAN; PRIORITY JOURNAL; SKIN INDURATION; SKIN SENSITIZATION;

ADULT; DINITROCHLOROBENZENE; ERYTHEMA; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LANGERHANS CELLS; MALE; MIDDLE AGED; SKIN; STEREOISOMERISM; TIME FACTORS; ULTRAVIOLET RAYS; UROCANIC ACID;

EID: 78649495028     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2010.00550.x     Document Type: Article

References (34)

1. Tabachnick J. Urocanic acid, the major acid-soluble, ultraviolet-absorbing compound in guinea pig epidermis. Arch Biochem Biophys 1957; 70: 295-298.
2. Pasanen P, Reunala T, Jansen CT, Rasanen L, Neuvonen K, Ayras P. Urocanic acid isomers in epidermal samples and suction blister fluid of nonirradiated and UVB-irradiated human skin. Photodermatol Photoimmunol Photomed 1990; 7: 40-42.
3. Norval M, Simpson TJ, Bardshiri E, Crosby J. Quantification of urocanic acid isomers in human stratum corneum. Photodermatology 1989; 6: 142-145.
4. Harriott-Smith TG, Halliday WJ. Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid. Clin Exp Immunol 1988; 72: 174-177.
5. Fisher MS, Kripke ML. Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis. Proc Natl Acad Sci U S A 1977; 74: 1688-1692.
6. Reeve VE, Greenoak GE, Canfield PJ, Boehm-Wilcox C, Gallagher CH. Topical urocanic acid enhances UV-induced tumour yield and malignancy in the hairless mouse. Photochem Photobiol 1989; 49: 459-464.
7. Friedmann PS. The immunology of allergic contact dermatitis: the DNCB story. Adv Dermatol 1990; 5: 175-196.
8. Jessup JM, Hanna N, Palaszynski E, Kripke ML. Mechanisms of depressed reactivity to dinitrochlorobenzene and ultraviolet-induced tumors during ultraviolet carcinogenesis in BALB/c mice. Cell Immunol 1978; 38: 105-115.
9. Elmets CA, Bergstresser PR, Tigelaar RE, Wood PJ, Streilein JW. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med 1983; 158: 781-794.
10. Cooper KD, Oberhelman L, Hamilton TA, et al. UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion. Proc Natl Acad Sci U S A 1992; 89: 8497-8501.
11. Schofield O, Kist D, Lucas A, Wayner E, Carter W, Zachary C. Abnormal expression of epiligrin and alpha 6 beta 4 integrin in basal cell carcinoma. Dermatol Surg 1998; 24: 555-559.
12. Scott IR. Factors controlling the expressed activity of histidine ammonia-lyase in the epidermis and the resulting accumulation of urocanic acid. Biochem J 1981; 194: 829-838.
13. Baadsgaard O. In vivo ultraviolet irradiation of human skin results in profound perturbation of the immune system: relevance to ultraviolet-induced skin cancer. Arch Dermatol 1991; 127: 99-109. Erratum in: Arch Dermatol 1991; 127: 1368.
14. Cruz PD Jr. Ultraviolet B (UVB)-induced immunosuppression: biologic, cellular, and molecular effects. Adv Dermatol 1994; 9: 79-94.
15. Garssen J, Van Loveren H. Effects of ultraviolet exposure on the immune system. Crit Rev Immunol 2001; 21: 359-397.
16. Nghiem DX, Kazimi N, Mitchell DL, et al. Mechanisms underlying the suppression of established immune responses by ultraviolet radiation. J Invest Dermatol 2002; 119: 600-608.
17. Kim TH, Moodycliffe AM, Yarosh DB, Norval M, Kripke ML, Ullrich SE. Viability of the antigen determines whether DNA or urocanic acid act as initiator molecules for UV-induced suppression of delayed-type hypersensitivity. Photochem Photobiol 2003; 78: 228-234.
18. Mohammad T, Morrison H, HogenEsch H. Urocanic acid photochemistry and photobiology. Photchem Photobiol 1999; 69: 115-135.
19. De Fabo EC, Noonan FP. Mechanism of immune suppression by ultraviolet irradiation in vivo: I. evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med 1983; 158: 84-98.
20. De Fabo E, Noonan F, Fisher M, Burns J, Kacser H. Further evidence that the photoreceptor mediating UV-induced systemic immune suppression is urocanic acid [abstract]. J Invest Dermatol 1983; 80: 319.
21. Reilly SK, De Fabo EC. Dietary histidine increases mouse skin urocanic acid levels and enhances UVB-induced immune suppression of contact hypersensitivity. Photochem Photobiol 1991; 53: 431-438.
22. Moodycliffe AM, Bucana CD, Kripke ML, Norval M, Ullrich SE. Differential effects of a monoclonal antibody to cis-urocanic acid on the suppression of delayed and contact hypersensitivity following ultraviolet irradiation. J Immunol 1996; 157: 2891-2899.
23. Noonan FP, De Fabo EC, Morrison H. Cis-urocanic acid, a product formed by ultraviolet B irradiation of the skin, initiates an antigen presentation defect in splenic dendritic cells in vivo. J Invest Dermatol 1988; 90: 92-99.
24. Ross JA, Howie SE, Norval M, Maingay J. Systemic administration of urocanic acid generates suppression of the delayed type hypersensitivity response to herpes simplex virus in a murine model of infection. Photodermatol 1988; 5: 9-14.
25. Ross JA, Howie SE, Norval M, Maingay JP. Induction of suppression of delayed type hypersensitivity to herpes simplex virus by epidermal cells exposed to UV-irradiated urocanic acid in vivo. Viral Immunol 1987-1988; 1: 191-198.
26. Lauerma AI, Aioi A, Maibach HI. Topical cis-urocanic acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice. Acta Derm Venereol 1995; 75: 272-275.
27. Gruner S, Stoppe H, Eckert R, Sonnichsen N, Diezel W. Prolonging transplant survival time by PUVA treatment of the transplant recipient: significance of cis-urocanic acid. Dermatol Monatsschr 1990; 176: 49-54. [German].
28. Cope RB, Stang B, Valentine BA, Bermudez LE. Topical exposure to exogenous ultraviolet-irradiated urocanic acid enhances Mycobacterium ulcerans infection in a Crl:IAF(HA)-hrBR hairless guinea-pig model of Buruli ulcer disease. Photodermatol Photoimmunol Photomed 2004; 20: 14-20.
29. Kaneko K, Smetana-Just U, Matsui M, et al. cis-Urocanic acid initiates gene transcription in primary human keratinocytes. J Immunol 2008; 181: 217-224.
30. Decara JM, Aguilera J, Abdala R, Sanchez P, Figueroa FL, Herrera E. Screening of urocanic acid isomers in human basal and squamous cell carcinoma tumors compared with tumor periphery and healthy skin. Exp Dermatol 2008; 17: 806-812.
31. Norval M, El-Ghorr AA. Studies to determine the immunomodulating effects of cis-urocanic acid. Methods 2002; 28: 63-70.
32. Van Strien GA, Korstanje MJ. Treatment of contact hypersensitivity with urocanic acid. Arch Dermatol Res 1995; 287: 564-566.
33. Friedmann PS, Moss C, Shuster S, Simpson JM. Quantitative relationships between sensitizing dose of DNCB and reactivity in normal subjects. Clin Exp Immunol 1983; 53: 709-715.
34. El-Ghorr AA, Pierik F, Norval M. Comparative potency of different UV sources in reducing the density and antigen-presenting capacity of Langerhans cells in C3H mice. Photochem Photobiol 1994; 60: 256-261.