Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis

European Journal of Pharmacology

Volumn 601, Issue 1-3, 2008, Pages 186-191

  Terakawa, Maki ^a   Fujieda, Yusuke ^a   Tomimori, Yoshiaki ^a   Muto, Tsuyoshi ^a   Tanaka, Taisaku ^a   Maruoka, Hiroshi ^a   Nagahira, Kazuhiro ^a   Ogata, Atsuto ^a   Nakatsuka, Takashi ^a   Fukuda, Yoshiaki ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Atopic dermatitis; Chymase; Mast cell; Pruritus

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; 6 (5 CHLORO 2 METHOXYBENZYL) 4 ARALKYLAMINOCARBONYL 1,4 DIAZEPANE 2,5 DIONE; CHYMASE INHIBITOR; SUN 13834; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; EOSINOPHIL; FEMALE; HISTOPATHOLOGY; INFLAMMATORY CELL; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PRURITUS; SCRATCHING; SECRETORY GRANULE; SKIN INFLAMMATION; TREATMENT DURATION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ANIMALS; AZEPINES; CHYMASES; DERMATITIS, ATOPIC; DINITROFLUOROBENZENE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EOSINOPHILS; FEMALE; INFLAMMATION; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; PRURITUS; SKIN;

EID: 56949104452     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.10.040     Document Type: Article

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