-
1
-
-
6344233216
-
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling
-
Abrahamsen, H., Baillie, G., Ngai, J., Vang, T., Nika, K., Ruppelt, A. et al. (2004) TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling. J Immunol 173: 4847-4858.
-
(2004)
J Immunol
, vol.173
, pp. 4847-4858
-
-
Abrahamsen, H.1
Baillie, G.2
Ngai, J.3
Vang, T.4
Nika, K.5
Ruppelt, A.6
-
2
-
-
0030593745
-
Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro
-
Alves, A.C., Pires, A.L., Cruz, H.N., Serra, M.F., Diaz, B.L., Cordeiro, R.S. et al. (1996) Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro. Eur J Pharmacol 312: 89-96.
-
(1996)
Eur J Pharmacol
, vol.312
, pp. 89-96
-
-
Alves, A.C.1
Pires, A.L.2
Cruz, H.N.3
Serra, M.F.4
Diaz, B.L.5
Cordeiro, R.S.6
-
3
-
-
77649192790
-
Novel mechanism of signaling by CD28
-
Bjørgo, E. and Taskén, K. (2010) Novel mechanism of signaling by CD28. Immunol Lett 129: 1-6.
-
(2010)
Immunol Lett
, vol.129
, pp. 1-6
-
-
Bjørgo, E.1
Taskén, K.2
-
4
-
-
0041856176
-
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2
-
Bolger, G.B., Peden, A.H., Steele, M.R., MacKenzie, C., McEwan, D.G., Wallace, D.A. et al. (2003) Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. J Biol Chem 278: 33351-33363.
-
(2003)
J Biol Chem
, vol.278
, pp. 33351-33363
-
-
Bolger, G.B.1
Peden, A.H.2
Steele, M.R.3
MacKenzie, C.4
McEwan, D.G.5
Wallace, D.A.6
-
5
-
-
36448943590
-
Immunologic changes in TNF-α, sE-selectin, sP-selectin, sICAM-1, and IL-8 in pediatric patients treated for psoriasis with the Goeckerman regimen
-
Borska, L., Fiala, Z., Krejsek, J., Andrys, C., Vokurkova, D., Hamakova, K. et al. (2007) Immunologic changes in TNF-α, sE-selectin, sP-selectin, sICAM-1, and IL-8 in pediatric patients treated for psoriasis with the Goeckerman regimen. Pediatr Dermatol 24: 607-612.
-
(2007)
Pediatr Dermatol
, vol.24
, pp. 607-612
-
-
Borska, L.1
Fiala, Z.2
Krejsek, J.3
Andrys, C.4
Vokurkova, D.5
Hamakova, K.6
-
6
-
-
21644455704
-
Psoriasis: dysregulation of innate immunity
-
Bos, J.D., de Rie, M.A., Teunissen, M.B. and Piskin, G. ( 2005) Psoriasis: dysregulation of innate immunity. Br J Dermatol 152: 1098-1107.
-
(2005)
Br J Dermatol
, vol.152
, pp. 1098-1107
-
-
Bos, J.D.1
de Rie, M.A.2
Teunissen, M.B.3
Piskin, G.4
-
7
-
-
34447265905
-
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
-
Conti, M. and Beavo, J. ( 2007) Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem 76: 481-511.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 481-511
-
-
Conti, M.1
Beavo, J.2
-
8
-
-
0031942752
-
Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production
-
Eigler, A., Siegmund, B., Emmerich, U., Baumann, K.H., Hartmann, G. and Endres, S. ( 1998) Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. J Leukoc Biol 63: 101-107.
-
(1998)
J Leukoc Biol
, vol.63
, pp. 101-107
-
-
Eigler, A.1
Siegmund, B.2
Emmerich, U.3
Baumann, K.H.4
Hartmann, G.5
Endres, S.6
-
9
-
-
0031024418
-
Differential efficacy of lymphocyte- and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression
-
Essayan, D.M., Huang, S.K., Kagey-Sobotka, A. and Lichtenstein, L.M. ( 1997) Differential efficacy of lymphocyte- and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression. J Allergy Clin Immunol 99: 28-37.
-
(1997)
J Allergy Clin Immunol
, vol.99
, pp. 28-37
-
-
Essayan, D.M.1
Huang, S.K.2
Kagey-Sobotka, A.3
Lichtenstein, L.M.4
-
10
-
-
0028051721
-
Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors
-
Essayan, D.M., Huang, S.K., Undem, B.J., Kagey-Sobotka, A. and Lichtenstein, L.M. ( 1994) Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors. J Immunol 153: 3408-3416.
-
(1994)
J Immunol
, vol.153
, pp. 3408-3416
-
-
Essayan, D.M.1
Huang, S.K.2
Undem, B.J.3
Kagey-Sobotka, A.4
Lichtenstein, L.M.5
-
11
-
-
0034942625
-
Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease
-
Giembycz, M.A. ( 2001) Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease. Expert Opin Investig Drugs 2001 10: 1361-1379.
-
(2001)
Expert Opin Investig Drugs
, vol.10
, pp. 1361-1379
-
-
Giembycz, M.A.1
-
12
-
-
57349120536
-
Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease
-
Gobejishvili, L., Barve, S., Joshi-Barve, S. and McClain, C. ( 2008) Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 295: G718-G724.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.295
, pp. G718-G724
-
-
Gobejishvili, L.1
Barve, S.2
Joshi-Barve, S.3
McClain, C.4
-
13
-
-
67651119981
-
CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-alpha and MMP-3 production in patients with inflammatory bowel disease
-
Gordon, J.N., Prothero, J.D., Thornton, C.A., Pickard, K.M., Di Sabatino, A., Goggin, P.M. et al. (2009) CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-alpha and MMP-3 production in patients with inflammatory bowel disease. J Crohn's Colitis 3: 175-182.
-
(2009)
J Crohn's Colitis
, vol.3
, pp. 175-182
-
-
Gordon, J.N.1
Prothero, J.D.2
Thornton, C.A.3
Pickard, K.M.4
Di Sabatino, A.5
Goggin, P.M.6
-
14
-
-
44349161096
-
An open-label, single-arm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-inflammatory agent, apremilast
-
Gottlieb, A.B., Strober, B., Krueger, J.G., Rohane, P., Zeldis, J.B., Hu, C.C. et al. (2008) An open-label, single-arm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-inflammatory agent, apremilast. Curr Med Res Opin 24: 1529-1538.
-
(2008)
Curr Med Res Opin
, vol.24
, pp. 1529-1538
-
-
Gottlieb, A.B.1
Strober, B.2
Krueger, J.G.3
Rohane, P.4
Zeldis, J.B.5
Hu, C.C.6
-
15
-
-
0037443097
-
PDE 4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
-
Houslay, M.D. and Adams, D.R. ( 2003) PDE 4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem J 370: 1-18.
-
(2003)
Biochem J
, vol.370
, pp. 1-18
-
-
Houslay, M.D.1
Adams, D.R.2
-
16
-
-
34247105883
-
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling
-
Houslay, M.D., Baillie, G.S. and Maurice, D.H. ( 2007) cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ Res 100: 950-966.
-
(2007)
Circ Res
, vol.100
, pp. 950-966
-
-
Houslay, M.D.1
Baillie, G.S.2
Maurice, D.H.3
-
17
-
-
27344449614
-
Keynote review: phosphodiesterase-4 as a therapeutic target
-
Houslay, M.D., Schafer, P. and Zhang, K.Y. ( 2005) Keynote review: phosphodiesterase-4 as a therapeutic target. Drug Discov Today 10: 1503-1519.
-
(2005)
Drug Discov Today
, vol.10
, pp. 1503-1519
-
-
Houslay, M.D.1
Schafer, P.2
Zhang, K.Y.3
-
18
-
-
0034763008
-
Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-κB and nuclear factor of activated T cells activation
-
Jimenez, J.L., Punzon, C., Navarro, J., Munoz-Fernandez, M.A. and Fresno, M. ( 2001) Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-κB and nuclear factor of activated T cells activation. J Pharmacol Exp Ther 299: 753-759.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 753-759
-
-
Jimenez, J.L.1
Punzon, C.2
Navarro, J.3
Munoz-Fernandez, M.A.4
Fresno, M.5
-
19
-
-
11844249945
-
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro
-
Jones, N.A., Boswell-Smith, V., Lever, R. and Page, C.P. ( 2005) The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro. Pulm Pharmacol Ther 18: 93-101.
-
(2005)
Pulm Pharmacol Ther
, vol.18
, pp. 93-101
-
-
Jones, N.A.1
Boswell-Smith, V.2
Lever, R.3
Page, C.P.4
-
20
-
-
27744595123
-
Roflumilast inhibits lipopolysaccharide-induced inflammatory mediators via suppression of nuclear factor-κB, p 38 mitogen-activated protein kinase, and c-Jun NH2-terminal kinase activation
-
Kwak, H.J., Song, J.S., Heo, J.Y., Yang, S.D., Nam, J.-Y. and Cheon, H.G. ( 2005) Roflumilast inhibits lipopolysaccharide-induced inflammatory mediators via suppression of nuclear factor-κB, p 38 mitogen-activated protein kinase, and c-Jun NH2-terminal kinase activation. J Pharm Exp Ther 315: 1188-1195.
-
(2005)
J Pharm Exp Ther
, vol.315
, pp. 1188-1195
-
-
Kwak, H.J.1
Song, J.S.2
Heo, J.Y.3
Yang, S.D.4
Nam, J.-Y.5
Cheon, H.G.6
-
21
-
-
0033806006
-
Calcitonin gene-related peptide inhibits lipopolysaccharide-induced interleukin-12 release from mouse peritoneal macrophages, mediated by the cAMP pathway
-
Liu, J., Chen, M. and Wang, X. ( 2000) Calcitonin gene-related peptide inhibits lipopolysaccharide-induced interleukin-12 release from mouse peritoneal macrophages, mediated by the cAMP pathway. Immunology 101: 61-67.
-
(2000)
Immunology
, vol.101
, pp. 61-67
-
-
Liu, J.1
Chen, M.2
Wang, X.3
-
22
-
-
64349119966
-
Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methane-sulfonylethyl]-1,3-dioxo-2,3-dihy dro-1 H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor
-
Man, H.W., Schafer, P., Wong, L.M., Patterson, R.T., Corral, L.G., Raymon, H. et al. (2009) Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methane-sulfonylethyl]-1,3-dioxo-2,3-dihy dro-1 H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor. J Med Chem 52: 1522-1524.
-
(2009)
J Med Chem
, vol.52
, pp. 1522-1524
-
-
Man, H.W.1
Schafer, P.2
Wong, L.M.3
Patterson, R.T.4
Corral, L.G.5
Raymon, H.6
-
23
-
-
78649804751
-
Apremilast, a novel PDE 4 inhibitor, inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
-
McCann, F.E., Palfreeman, A.C., Andrews, M., Perocheau, D.P., Inglis, J.J., Schafer, P. et al. (2010) Apremilast, a novel PDE 4 inhibitor, inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Arthritis Res Ther 12: R107.
-
(2010)
Arthritis Res Ther
, vol.12
, pp. R107
-
-
McCann, F.E.1
Palfreeman, A.C.2
Andrews, M.3
Perocheau, D.P.4
Inglis, J.J.5
Schafer, P.6
-
24
-
-
0029833716
-
Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells
-
Ollivier, V., Parry, G.C.N., Cobb, R.R., de Prost, D. and Mackman, N. (1996) Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells. J Biol Chem 271: 20828-20835.
-
(1996)
J Biol Chem
, vol.271
, pp. 20828-20835
-
-
Ollivier, V.1
Parry, G.C.N.2
Cobb, R.R.3
de Prost, D.4
Mackman, N.5
-
25
-
-
84860193460
-
A phase 2 study demonstrating the efficacy and safety of the oral therapy CC-1004 in subjects with moderate to severe psoriasis [abstract P2614]
-
Papp, K., Zeldis, J.B., Rohane, P. and Thaci, D. ( 2008) A phase 2 study demonstrating the efficacy and safety of the oral therapy CC-1004 in subjects with moderate to severe psoriasis [abstract P2614]. J Am Acad Dermatol 58: AB3.
-
(2008)
J Am Acad Dermatol
, vol.58
, pp. AB3
-
-
Papp, K.1
Zeldis, J.B.2
Rohane, P.3
Thaci, D.4
-
26
-
-
0032858430
-
Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells
-
Platzer, C., Fritsch, E., Elsner, T., Lehmann, M.H., Volk, H.D. and Prosch, S. ( 1999) Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells. Eur J Immunol 29: 3098-3104.
-
(1999)
Eur J Immunol
, vol.29
, pp. 3098-3104
-
-
Platzer, C.1
Fritsch, E.2
Elsner, T.3
Lehmann, M.H.4
Volk, H.D.5
Prosch, S.6
-
27
-
-
3142776354
-
The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases
-
Richter, W. and Conti, M. ( 2004) The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases. J Biol Chem 279: 30338-30348.
-
(2004)
J Biol Chem
, vol.279
, pp. 30338-30348
-
-
Richter, W.1
Conti, M.2
-
28
-
-
0036790480
-
Deletion of phosphodiesterase 4D in mice shortens alpha (2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
-
Robichaud, A., Stamatiou, P.B., Jin, S.L., Lachance, N., MacDonald, D., Laliberté, F. et al. (2002) Deletion of phosphodiesterase 4D in mice shortens alpha (2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest 110: 1045-1052.
-
(2002)
J Clin Invest
, vol.110
, pp. 1045-1052
-
-
Robichaud, A.1
Stamatiou, P.B.2
Jin, S.L.3
Lachance, N.4
MacDonald, D.5
Laliberté, F.6
-
29
-
-
84993770938
-
Maximizing efficacy of phosphodiesterase 4 inhibitors for COPD and asthma: therapeutic index of CC-10004
-
SMi Asthma and COPD Conference SMi Group Ltd: London, UK: 28 April
-
Schafer, P.H. ( 2005) Maximizing efficacy of phosphodiesterase 4 inhibitors for COPD and asthma: therapeutic index of CC-10004. SMi Asthma and COPD Conference, SMi Group Ltd: London, UK, 28 April 2005.
-
(2005)
-
-
Schafer, P.H.1
-
30
-
-
77249116286
-
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis
-
Schafer, P., Parton, A., Gandhi, A., Capone, L., Adams, M., Wu, L. et al. (2010) Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. Br J Pharmacol 159: 842-855.
-
(2010)
Br J Pharmacol
, vol.159
, pp. 842-855
-
-
Schafer, P.1
Parton, A.2
Gandhi, A.3
Capone, L.4
Adams, M.5
Wu, L.6
-
31
-
-
84863105096
-
Apremilast is active in the treatment of psoriatic arthritis (PsA)
-
Schett, G., Wollenhaupt, J., Papp, K., Joos, R., de Vlam, K.L., Rodrigues, J. et al. (2009) Apremilast is active in the treatment of psoriatic arthritis (PsA). Arthritis Rheum 60(Suppl. 10): 1258.
-
(2009)
Arthritis Rheum
, vol.60
, Issue.Suppl.
, pp. 1258
-
-
Schett, G.1
Wollenhaupt, J.2
Papp, K.3
Joos, R.4
de Vlam, K.L.5
Rodrigues, J.6
-
32
-
-
0028822281
-
Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase
-
Seldon, P.M., Barnes, P.J., Meja, K. and Giembycz, M.A. ( 1995) Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase. Mol Pharmacol 48: 747-757.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 747-757
-
-
Seldon, P.M.1
Barnes, P.J.2
Meja, K.3
Giembycz, M.A.4
-
33
-
-
0031616317
-
Interleukin-10 does not mediate the inhibitory effect of PDE-4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes
-
Seldon, P.M., Barnes, P.J. and Giembycz, M.A. ( 1998) Interleukin-10 does not mediate the inhibitory effect of PDE-4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes. Cell Biochem Biophys 29: 179-201.
-
(1998)
Cell Biochem Biophys
, vol.29
, pp. 179-201
-
-
Seldon, P.M.1
Barnes, P.J.2
Giembycz, M.A.3
-
34
-
-
2942552151
-
Remodelling of the PDE 4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U 937 cells
-
Shepherd, M.C., Baillie, G.S., Stirling, D.I. and Houslay, M.D. ( 2004) Remodelling of the PDE 4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U 937 cells. Br J Pharmacol 142: 339-351.
-
(2004)
Br J Pharmacol
, vol.142
, pp. 339-351
-
-
Shepherd, M.C.1
Baillie, G.S.2
Stirling, D.I.3
Houslay, M.D.4
-
35
-
-
0347359224
-
Localized effects of cAMP mediated by distinct routes of protein kinase A
-
Tasken, K. and Aandahl, E.M. ( 2004) Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev 84: 137-167.
-
(2004)
Physiol Rev
, vol.84
, pp. 137-167
-
-
Tasken, K.1
Aandahl, E.M.2
-
36
-
-
0033591233
-
The RACK 1 signaling scaffold protein selectively interacts with the cAMPspecific phosphodiesterase PDE4D5 isoform
-
Yarwood, S.J., Steele, M.R., Scotland, G., Houslay, M.D. and Bolger, G.B. ( 1999) The RACK 1 signaling scaffold protein selectively interacts with the cAMPspecific phosphodiesterase PDE4D5 isoform. J Biol Chem 274: 14909-14917.
-
(1999)
J Biol Chem
, vol.274
, pp. 14909-14917
-
-
Yarwood, S.J.1
Steele, M.R.2
Scotland, G.3
Houslay, M.D.4
Bolger, G.B.5
|