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Volumn 14, Issue 4, 2013, Pages 383-394

Quercetin reverses hypobaric hypoxia-induced hippocampal neurodegeneration and improves memory function in the rat

Author keywords

hippocampus; memory impairment; Morris Water Maze; neuroprotection; oxidative stress; quercetin

Indexed keywords

ANTIOXIDANT; CASPASE 3; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIPID; QUERCETIN; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE DISMUTASE;

EID: 84891609803     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2013.1014     Document Type: Article
Times cited : (56)

References (62)
  • 1
    • 61749103704 scopus 로고    scopus 로고
    • Protective effect of quercetin in primary neurons against Ab (1-42): Relevance to Alzheimer's disease
    • Ansari MA, Abdul HM, Joshi G, Opii Wycliffe O, and Butterfield DA. (2009). Protective effect of quercetin in primary neurons against Ab (1-42): Relevance to Alzheimer's disease. J Nutri Biochem 20:269-275.
    • (2009) J Nutri Biochem , vol.20 , pp. 269-275
    • Ansari, M.A.1    Abdul, H.M.2    Joshi, G.3    Opii Wycliffe, O.4    Butterfield, D.A.5
  • 2
    • 77955097118 scopus 로고    scopus 로고
    • After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult
    • Arredondo F, Echeverry C, Abin-Carriquiry JA, et al. (2010). After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radic Biol Med 49:738-747.
    • (2010) Free Radic Biol Med , vol.49 , pp. 738-747
    • Arredondo, F.1    Echeverry, C.2    Abin-Carriquiry, J.A.3
  • 3
    • 83655169827 scopus 로고    scopus 로고
    • Corticosterone synthesis inhibitor metyrapone ameliorates chronic hypobaric hypoxia induced memory impairment in rat
    • Baitharu I, Deep SN, Jain V., et al. (2012). Corticosterone synthesis inhibitor metyrapone ameliorates chronic hypobaric hypoxia induced memory impairment in rat. Behav Brain Res 228:53-65.
    • (2012) Behav Brain Res , vol.228 , pp. 53-65
    • Baitharu, I.1    Deep, S.N.2    Jain, V.3
  • 4
    • 84871009507 scopus 로고    scopus 로고
    • Inhibition of glucocorticoid receptors ameliorates hypobaric hypoxia induced memory impairment in rat
    • Baitharu I, Deep SN, Jain V, Prasad D, and Ilavazhagan G. (2013). Inhibition of glucocorticoid receptors ameliorates hypobaric hypoxia induced memory impairment in rat. Behav Brain Res 240:76-86.
    • (2013) Behav Brain Res , vol.240 , pp. 76-86
    • Baitharu, I.1    Deep, S.N.2    Jain, V.3    Prasad, D.4    Ilavazhagan, G.5
  • 5
    • 64549090002 scopus 로고    scopus 로고
    • Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory impairment: Complementary roles of L-type calcium channel and NMDA receptors
    • Barhwal K, Hota SK, Baitharu I, Prasad D, Singh SB, and Ilavazhagan G. (2009). Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory impairment: Complementary roles of L-type calcium channel and NMDA receptors. Neurobiol Dis 34:230-244.
    • (2009) Neurobiol Dis , vol.34 , pp. 230-244
    • Barhwal, K.1    Hota, S.K.2    Baitharu, I.3    Prasad, D.4    Singh, S.B.5    Ilavazhagan, G.6
  • 6
    • 0027236287 scopus 로고
    • Effect of altitude on mood, behavior and cognitive functioning
    • Bharke M, and Hale SB. (1993). Effect of altitude on mood, behavior and cognitive functioning. Sports Med 16:97-125.
    • (1993) Sports Med , vol.16 , pp. 97-125
    • Bharke, M.1    Hale, S.B.2
  • 8
    • 0021947045 scopus 로고
    • Inhibitory action of quercetin on xanthine oxidase and xanthine dehydrogenase activity
    • Bindoli A, Valente M, and Cavallini L. (1985). Inhibitory action of quercetin on xanthine oxidase and xanthine dehydrogenase activity. Pharmacol Res Commun 17:831-839.
    • (1985) Pharmacol Res Commun , vol.17 , pp. 831-839
    • Bindoli, A.1    Valente, M.2    Cavallini, L.3
  • 9
    • 27744529413 scopus 로고    scopus 로고
    • The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity
    • Boots AW, Balk JM, Bast A, and Haenen GRMM. (2005). The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity. Biochem Biophys Res Commun 338:923-929.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 923-929
    • Boots, A.W.1    Balk, J.M.2    Bast, A.3    Haenen, G.R.M.M.4
  • 10
    • 0043166966 scopus 로고    scopus 로고
    • Oxidized quercetin reacts with thiols rather than with ascorbate: Implication for quercetin supplementation
    • Boots AW, Kubben N, Haenen GRMM, and Bast A. (2003). Oxidized quercetin reacts with thiols rather than with ascorbate: Implication for quercetin supplementation. Biochem Biophys Res Commun 308:560-565.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 560-565
    • Boots, A.W.1    Kubben, N.2    Haenen, G.R.M.M.3    Bast, A.4
  • 11
    • 0031890738 scopus 로고    scopus 로고
    • Extensive binding of the bioflavonoid quercetin to human plasma proteins
    • Boulton DW, Walle UK, andWalle T. (1998). Extensive binding of the bioflavonoid quercetin to human plasma proteins. J Pharm Pharmacol 50:243-249.
    • (1998) J Pharm Pharmacol , vol.50 , pp. 243-249
    • Boulton, D.W.1    Walle, U.K.2    Walle, T.3
  • 12
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
    • Bradford M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Ann Biochem 72:248-254.
    • (1976) Ann Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 13
    • 29744458225 scopus 로고    scopus 로고
    • Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide
    • Burai G, Sairam M, Sharma SK, Ilavazaghan G, and Banerjee PK. (2006). Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide. Fr Rad Res 40:95-102.
    • (2006) Fr Rad Res , vol.40 , pp. 95-102
    • Burai, G.1    Sairam, M.2    Sharma, S.K.3    Ilavazaghan, G.4    Banerjee, P.K.5
  • 14
    • 15244352965 scopus 로고    scopus 로고
    • Long-term combined administration of quercetin and daidzein inhibits quercetin-induced suppression of glutathione antioxidant defenses
    • Choi EJ, Lee BH, Lee K, and Chee KM. (2005). Long-term combined administration of quercetin and daidzein inhibits quercetin-induced suppression of glutathione antioxidant defenses. Food Chem Toxicol 43:793-798.
    • (2005) Food Chem Toxicol , vol.43 , pp. 793-798
    • Choi, E.J.1    Lee, B.H.2    Lee, K.3    Chee, K.M.4
  • 15
    • 84875325881 scopus 로고    scopus 로고
    • Neuroprotective actions of flavones and flavonols: Mechanisms and relationship to flavonoid structural features
    • Dajas F, Andrés AC, Florencia A, Carolina E, and Felicia RM. (2013). Neuroprotective actions of flavones and flavonols: Mechanisms and relationship to flavonoid structural features.Cent Nerv Syst Agents Med Chem 13:30-35.
    • (2013) Cent Nerv Syst Agents Med Chem , vol.13 , pp. 30-35
    • Dajas, F.1    Andrés, A.C.2    Florencia, A.3    Carolina, E.4    Felicia, R.M.5
  • 16
    • 84860897896 scopus 로고    scopus 로고
    • Antioxidants and cancer III: Quercetin
    • Davis WL and Matthew SB. (2000). Antioxidants and cancer III: Quercetin. Altern Med Rev 5:196-208.
    • (2000) Altern Med Rev , vol.5 , pp. 196-208
    • Davis, W.L.1    Matthew, S.B.2
  • 18
    • 0016811010 scopus 로고
    • Disposition of quercetin in man after single oral and intravenous doses
    • Gugler R, Leschik M, Dengler HJ. (1975). Disposition of quercetin in man after single oral and intravenous doses. Eur J Clin Pharmacol 9:229-234.
    • (1975) Eur J Clin Pharmacol , vol.9 , pp. 229-234
    • Gugler, R.1    Leschik, M.2    Dengler, H.J.3
  • 19
    • 10644277049 scopus 로고    scopus 로고
    • Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration
    • Heo HJ, and Lee CY. (2004). Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem 52:7514-7517.
    • (2004) J Agric Food Chem , vol.52 , pp. 7514-7517
    • Heo, H.J.1    Lee, C.Y.2
  • 20
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidized and reduced glutathione in tissues
    • Hissin PJ, and Hilf R. (1976). A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214-226.
    • (1976) Anal Biochem , vol.74 , pp. 214-226
    • Hissin, P.J.1    Hilf, R.2
  • 21
    • 62149137729 scopus 로고    scopus 로고
    • Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment
    • Hota SK, Barhwal K, Baitharu I, Prasad D, Singh SB, and Ilavazhagan G. (2009). Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment. Neurobiol Dis 34:23-39.
    • (2009) Neurobiol Dis , vol.34 , pp. 23-39
    • Hota, S.K.1    Barhwal, K.2    Baitharu, I.3    Prasad, D.4    Singh, S.B.5    Ilavazhagan, G.6
  • 22
    • 84865840222 scopus 로고    scopus 로고
    • Effects of quercetin on the learning and memory ability of neonatal rats with hypoxic-ischemic brain damage
    • Huang JJ, Liu X, Wang XQ, Yang LH, Qi DS, and Yao RQ. (2012). Effects of quercetin on the learning and memory ability of neonatal rats with hypoxic-ischemic brain damage. Zhongguo Dang Dai Er Ke Za Zhi. 14:454-457.
    • (2012) Zhongguo Dang Dai Er Ke Za Zhi. , vol.14 , pp. 454-457
    • Huang, J.J.1    Liu, X.2    Wang, X.Q.3    Yang, L.H.4    Qi, D.S.5    Yao, R.Q.6
  • 23
    • 80052269348 scopus 로고    scopus 로고
    • Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
    • Ishisaka A, Ichikawa S, Sakakibara H, et al. (2011). Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic Biol Med 51:1329-1336.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1329-1336
    • Ishisaka, A.1    Ichikawa, S.2    Sakakibara, H.3
  • 24
    • 20144375857 scopus 로고    scopus 로고
    • Neuroprotective effect of N-acetyl cysteine on hypoxia induced oxidative stress in primary hippocampal culture
    • Jayalakshmi K, Sairam M, Singh SB, Sharma SK, Ilavazhagan G, and Banerjee PK. (2005). Neuroprotective effect of N-acetyl cysteine on hypoxia induced oxidative stress in primary hippocampal culture. Brain Res 1046:97-104.
    • (2005) Brain Res , vol.1046 , pp. 97-104
    • Jayalakshmi, K.1    Sairam, M.2    Singh, S.B.3    Sharma, S.K.4    Ilavazhagan, G.5    Banerjee, P.K.6
  • 25
    • 77953963280 scopus 로고    scopus 로고
    • Quercetin impairs learning and memory in normal mice via suppression of hippocampal phosphorylated cyclic AMP response element-binding protein expression
    • Jung WY, Park SJ, Park DH, Kim JM, Kim DH, and Ryu JH. (2010).Quercetin impairs learning and memory in normal mice via suppression of hippocampal phosphorylated cyclic AMP response element-binding protein expression. Toxicol Lett 197:97-105.
    • (2010) Toxicol Lett , vol.197 , pp. 97-105
    • Jung, W.Y.1    Park, S.J.2    Park, D.H.3    Kim, J.M.4    Kim, D.H.5    Ryu, J.H.6
  • 26
    • 84874547093 scopus 로고    scopus 로고
    • Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats
    • Karuppagounder SS, Madathil SK, Pandey M, Haobam R, Rajamma U, andMohanakumar KP. (2013). Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats. J Neurosci 236:136-148.
    • (2013) J Neurosci , vol.236 , pp. 136-148
    • Karuppagounder, S.S.1    Madathil, S.K.2    Pandey, M.3    Haobam, R.4    Rajamma, U.5    Mohanakumar, K.P.6
  • 27
    • 34248159351 scopus 로고    scopus 로고
    • Role of a2 receptors in quercetin-induced behavioral despair in mice
    • Kaur R, Chopra K, and Singh D. (2007). Role of a2 receptors in quercetin-induced behavioral despair in mice. J Med Food 10:165-168.
    • (2007) J Med Food , vol.10 , pp. 165-168
    • Kaur, R.1    Chopra, K.2    Singh, D.3
  • 28
    • 84871185529 scopus 로고    scopus 로고
    • Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury
    • Keddy PG, Dunlop K, Warford J, et al. (2012). Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury. PLoS One 7:e51324.
    • (2012) PLoS One , vol.7
    • Keddy, P.G.1    Dunlop, K.2    Warford, J.3
  • 29
    • 57549084304 scopus 로고    scopus 로고
    • Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats
    • Kumar A, Sehgal N, Kumar P, Padi SS, and Naidu PS. (2008). Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. Phytother Res 22:1563-1569.
    • (2008) Phytother Res , vol.22 , pp. 1563-1569
    • Kumar, A.1    Sehgal, N.2    Kumar, P.3    Padi, S.S.4    Naidu, P.S.5
  • 30
    • 0025313038 scopus 로고
    • Organometalinduced increases in oxygen reactive species: The potential of 2', 7'-dichlorofluorescin diacetate as an index of neurotoxic damage
    • LeBel CP, Ali SF, McKee M, and Bondy SC. (1990). Organometalinduced increases in oxygen reactive species: The potential of 2', 7'-dichlorofluorescin diacetate as an index of neurotoxic damage. Toxicol Appl Pharmacol 104:17-24.
    • (1990) Toxicol Appl Pharmacol , vol.104 , pp. 17-24
    • Lebel, C.P.1    Ali, S.F.2    McKee, M.3    Bondy, S.C.4
  • 32
    • 84873380843 scopus 로고    scopus 로고
    • Quercetin protects against the Ab(25-35)-induced amnesic injury: Involvement of inactivation of rage-mediated pathway and conservation of the NVU
    • Liu R, Zhang TT, Zhou D, et al. (2013). Quercetin protects against the Ab(25-35)-induced amnesic injury: Involvement of inactivation of rage-mediated pathway and conservation of the NVU. Neuropharmacol 67:419-431.
    • (2013) Neuropharmacol , vol.67 , pp. 419-431
    • Liu, R.1    Zhang, T.T.2    Zhou, D.3
  • 34
    • 56549118754 scopus 로고    scopus 로고
    • High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum
    • Maiti P, Singh SB, Mallick B, Muthuraju S, and Ilavazhagan G. (2008). High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum. J Chem Neuroanat 36:227-238.
    • (2008) J Chem Neuroanat , vol.36 , pp. 227-238
    • Maiti, P.1    Singh, S.B.2    Mallick, B.3    Muthuraju, S.4    Ilavazhagan, G.5
  • 35
    • 0036827673 scopus 로고    scopus 로고
    • Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity
    • Mira L, Fernandez MT, Santos M, Rocha R, Florencio MH, and Jennings KR. (2002). Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity. Free Radic Res 36:1199-1208.
    • (2002) Free Radic Res , vol.36 , pp. 1199-1208
    • Mira, L.1    Fernandez, M.T.2    Santos, M.3    Rocha, R.4    Florencio, M.H.5    Jennings, K.R.6
  • 36
    • 0027492737 scopus 로고
    • Antioxidant and iron chelating activities of the flavonoids catechin, quercetin and iomertin on iron loaded rat hepatocyte
    • Morel I, Lescoat G, Cogrel P, et al. (1993).Antioxidant and iron chelating activities of the flavonoids catechin, quercetin and iomertin on iron loaded rat hepatocyte. Biochem Pharmacol 45:13-19.
    • (1993) Biochem Pharmacol , vol.45 , pp. 13-19
    • Morel, I.1    Lescoat, G.2    Cogrel, P.3
  • 37
    • 0021173996 scopus 로고
    • Development of a water maze procedure for studying spatial learning the rat
    • Morris RGM. (1984). Development of a water maze procedure for studying spatial learning the rat. J Neurosci Meth 11:47-60.
    • (1984) J Neurosci Meth , vol.11 , pp. 47-60
    • Morris, R.G.M.1
  • 39
    • 0034137882 scopus 로고    scopus 로고
    • A study of mood changes and personality during a 31-day period of chronic hypoxia in a hypobaric chamber (Everest-Comex 97)
    • Nicolas M, Thullier-Lestienne F, Bouquet C, Gardette B, Gortan C, Richalet JP, and Abraini JH. (2000). A study of mood changes and personality during a 31-day period of chronic hypoxia in a hypobaric chamber (Everest-Comex 97). Psychol Rep 86: 119-26.
    • (2000) Psychol Rep , vol.86 , pp. 119-126
    • Nicolas, M.1    Thullier-Lestienne, F.2    Bouquet, C.3    Gardette, B.4    Gortan, C.5    Richalet, J.P.6    Abraini, J.H.7
  • 40
    • 0030638249 scopus 로고    scopus 로고
    • Neuronal necrosis and apoptosis: Two distinct events induced by exposure to glutamate or oxidative stress
    • Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, and Lipton SA. (1997). Neuronal necrosis and apoptosis: Two distinct events induced by exposure to glutamate or oxidative stress. Adv Neurol 72:95-101.
    • (1997) Adv Neurol , vol.72 , pp. 95-101
    • Nicotera, P.1    Ankarcrona, M.2    Bonfoco, E.3    Orrenius, S.4    Lipton, S.A.5
  • 41
    • 84862877169 scopus 로고    scopus 로고
    • Quercetin in hypoxia-induced oxidative stress: Novel target for neuroprotection
    • Pandey AK, Patnaik R, Muresanu DF, Sharma A, and Sharma HS. (2012). Quercetin in hypoxia-induced oxidative stress: Novel target for neuroprotection. Int Rev Neurobiol 102:107-146.
    • (2012) Int Rev Neurobiol , vol.102 , pp. 107-146
    • Pandey, A.K.1    Patnaik, R.2    Muresanu, D.F.3    Sharma, A.4    Sharma, H.S.5
  • 43
    • 0014478046 scopus 로고
    • The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates
    • Pinto RE, and Bartley W. (1969). The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates. Biochem J 112:109-115.
    • (1969) Biochem J , vol.112 , pp. 109-115
    • Pinto, R.E.1    Bartley, W.2
  • 44
    • 34548471990 scopus 로고    scopus 로고
    • Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats
    • Pu F, Mishima K, Irie K, et al. (2007). Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J Pharmacol Sci 104:329-334.
    • (2007) J Pharmacol Sci , vol.104 , pp. 329-334
    • Pu, F.1    Mishima, K.2    Irie, K.3
  • 45
    • 78149273255 scopus 로고    scopus 로고
    • Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish
    • Richetti SK, Blank M, Capiotti KM, et al. (2011). Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish. Behav Brain Res 217:10-15.
    • (2011) Behav Brain Res , vol.217 , pp. 10-15
    • Richetti, S.K.1    Blank, M.2    Capiotti, K.M.3
  • 46
    • 34247872831 scopus 로고    scopus 로고
    • Quercetin inhibits TNF-induced NF-jB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells
    • Ruiz PA, Braune A, Holzlwimmer G, Quintanilla-Fend L, and Haller D. (2007).Quercetin inhibits TNF-induced NF-jB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr 137: 1208-1215.
    • (2007) J Nutr , vol.137 , pp. 1208-1215
    • Ruiz, P.A.1    Braune, A.2    Holzlwimmer, G.3    Quintanilla-Fend, L.4    Haller, D.5
  • 47
    • 0034714392 scopus 로고    scopus 로고
    • Fluoro-jade B: A high affinity fluorescent marker for the localization of neural degeneration
    • Schmued LC, and Hopkins KJ. (2000). Fluoro-jade B: A high affinity fluorescent marker for the localization of neural degeneration. Brain Res 874:123-130.
    • (2000) Brain Res , vol.874 , pp. 123-130
    • Schmued, L.C.1    Hopkins, K.J.2
  • 48
    • 67649946192 scopus 로고    scopus 로고
    • Quercetin inhibits human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/b-catenin signaling pathway
    • Shan BE, Wang MX, and Li RQ. (2009). Quercetin inhibits human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/b-catenin signaling pathway. Cancer Invest 27:604-612.
    • (2009) Cancer Invest , vol.27 , pp. 604-612
    • Shan, B.E.1    Wang, M.X.2    Li, R.Q.3
  • 49
    • 84876297040 scopus 로고    scopus 로고
    • Quercetin protects against chronic aluminum-induced oxidative stress and ensuing biochemical, cholinergic, and neurobehavioral impairments in rats
    • Sharma DR, Wani WY, Sunkaria A, et al. (2013). Quercetin protects against chronic aluminum-induced oxidative stress and ensuing biochemical, cholinergic, and neurobehavioral impairments in rats. Neurotox Res 23:336-357.
    • (2013) Neurotox Res , vol.23 , pp. 336-357
    • Sharma, D.R.1    Wani, W.Y.2    Sunkaria, A.3
  • 50
    • 0033252747 scopus 로고    scopus 로고
    • Quercetin in men with category III chronic prostatitis: A preliminary prospective, double blind, placebo-controlled trial
    • Shoskes DA, Zeitlin SI, Shahed A, and Rajfer J. (1999). Quercetin in men with category III chronic prostatitis: A preliminary prospective, double blind, placebo-controlled trial. Urology 54:960-963.
    • (1999) Urology , vol.54 , pp. 960-963
    • Shoskes, D.A.1    Zeitlin, S.I.2    Shahed, A.3    Rajfer, J.4
  • 52
    • 74949110261 scopus 로고    scopus 로고
    • Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
    • Tchantchou F, Lacor PN, Cao Z, et al. (2009). Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons. J Alzheimers Dis 18:787-798.
    • (2009) J Alzheimers Dis , vol.18 , pp. 787-798
    • Tchantchou, F.1    Lacor, P.N.2    Cao, Z.3
  • 53
    • 79959853124 scopus 로고    scopus 로고
    • Nasal administration of quercetin liposomes improves memory impairment and neurodegeneration in animal model of Alzheimer's disease
    • Terdthai T, Supaporn M, Jintanaporn W, and Wathita P. (2010). Nasal administration of quercetin liposomes improves memory impairment and neurodegeneration in animal model of Alzheimer's disease. Am J Ag Biol Sc 5:286-293.
    • (2010) Am J Ag Biol Sc , vol.5 , pp. 286-293
    • Terdthai, T.1    Supaporn, M.2    Jintanaporn, W.3    Wathita, P.4
  • 55
    • 65549150307 scopus 로고    scopus 로고
    • Potential of flavonoids as anti-inflammatory agents: Modulation of pro-inflammatory gene expression and signal transduction pathways
    • Tunon MJ, Garcia-Mediavilla MV, Sanchez-Campos S, and Gonzalez-Gallego J. (2009). Potential of flavonoids as anti-inflammatory agents: Modulation of pro-inflammatory gene expression and signal transduction pathways. Curr Drug Metab 10:256-271.
    • (2009) Curr Drug Metab , vol.10 , pp. 256-271
    • Tunon, M.J.1    Garcia-Mediavilla, M.V.2    Sanchez-Campos, S.3    Gonzalez-Gallego, J.4
  • 56
    • 24844459981 scopus 로고
    • Effect of sulfhydryl reagents on peroxidation of microsomes
    • Utley HG, Bergheim F, and Hochstein P. (1967). Effect of sulfhydryl reagents on peroxidation of microsomes. Arch Biochem Biophys 118:29-32.
    • (1967) Arch Biochem Biophys , vol.118 , pp. 29-32
    • Utley, H.G.1    Bergheim, F.2    Hochstein, P.3
  • 57
    • 80053237664 scopus 로고    scopus 로고
    • Quercetin protects oligodendrocyte precursor cells from oxygen/glucose deprivation injury in vitro via the activation of the PI3K/Akt signaling pathway
    • Wang XQ, Yao RQ, Liu X, Huang JJ, Qi DS, and Yang LH. (2011). Quercetin protects oligodendrocyte precursor cells from oxygen/glucose deprivation injury in vitro via the activation of the PI3K/Akt signaling pathway. Brain Res Bull 86:277-284.
    • (2011) Brain Res Bull , vol.86 , pp. 277-284
    • Wang, X.Q.1    Yao, R.Q.2    Liu, X.3    Huang, J.J.4    Qi, D.S.5    Yang, L.H.6
  • 59
    • 77955249910 scopus 로고    scopus 로고
    • Quercetin targets cysteine string protein (CSPa) and impairs synaptic transmission
    • Xu F, Proft J, Gibbs S, Winkfein B, and Johnson JN. (2010). Quercetin targets cysteine string protein (CSPa) and impairs synaptic transmission. PLoS ONE 5:e11045.
    • (2010) PLoS ONE , vol.5
    • Xu, F.1    Proft, J.2    Gibbs, S.3    Winkfein, B.4    Johnson, J.N.5
  • 60
    • 28044467747 scopus 로고    scopus 로고
    • Bioavailability and metabolic pharmacokinetics of rutin and quercetin in rats
    • Yang CY, Hsiu S, Wen K, Shiuan-Pey Lin, Tsai S, Hou Y, and Chao E. (2005). Bioavailability and metabolic pharmacokinetics of rutin and quercetin in rats. J Food Drug Anal 13:244-250.
    • (2005) J Food Drug Anal , vol.13 , pp. 244-250
    • Yang, C.Y.1    Hsiu, S.2    Wen, K.3    Lin, S.4    Tsai, S.5    Hou, Y.6    Chao, E.7
  • 61
    • 74249099539 scopus 로고    scopus 로고
    • Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons
    • Yao Y, Han DD, Zhang T, and Yang Z. (2010). Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons. Phytother Res 24:136-140.
    • (2010) Phytother Res , vol.24 , pp. 136-140
    • Yao, Y.1    Han, D.D.2    Zhang, T.3    Yang, Z.4
  • 62
    • 84855526073 scopus 로고    scopus 로고
    • Modulatory effects of quercetin on hypobaric hypoxic rats
    • Zhou J, Zhou S, Gao Y, and Zeng S. (2012). Modulatory effects of quercetin on hypobaric hypoxic rats. Eur J Pharmacol 674:450-454.
    • (2012) Eur J Pharmacol , vol.674 , pp. 450-454
    • Zhou, J.1    Zhou, S.2    Gao, Y.3    Zeng, S.4


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