Neuroprotective effects of quercetin, rutin and okra (Abelmoschus esculentus Linn.) in dexamethasone-treated mice

Neurochemistry International

Volumn 59, Issue 5, 2011, Pages 677-685

  Tongjaroenbuangam, Walaiporn ^a   Ruksee, Nootchanart ^b   Chantiratikul, Piyanete ^a   Pakdeenarong, Noppakun ^a   Kongbuntad, Watee ^a   Govitrapong, Piyarat ^b  

^a MAHASARAKHAM UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Cell proliferation; Dexamethasone; Hippocampus; Memory; Neuroprotective; NMDA receptor; Okra; Quercetin; Rutin; Stress

Indexed keywords

DEXAMETHASONE; HIBISCUS ESCULENTUS EXTRACT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PLANT EXTRACT; QUERCETIN; RUTOSIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; DRUG SCREENING; ESCAPE BEHAVIOR; HIPPOCAMPAL CA3 REGION; LATENT PERIOD; MALE; MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; OKRA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL;

ABELMOSCHUS; ANIMALS; ANTIMETABOLITES; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BODY WEIGHT; BROMODEOXYURIDINE; CA3 REGION, HIPPOCAMPAL; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOHISTOCHEMISTRY; MALE; MAZE LEARNING; MICE; MICE, INBRED ICR; NEUROPROTECTIVE AGENTS; PLANT EXTRACTS; QUERCETIN; RECEPTORS, N-METHYL-D-ASPARTATE; RUTIN;

ABELMOSCHUS; ABELMOSCHUS ESCULENTUS; MUS;

EID: 80052947979     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.06.014     Document Type: Article

References (42)

1. 2+ concentration in gerbil hippocampus J. Cereb. Blood Flow Metab. 18 1998 274 280 (Pubitemid 28103634)
2. A. Amsel Hippocampal function in the rat: cognitive mapping or vicarious trial and error? Hippocampus 3 1993 251 256 (Pubitemid 23231461)
3. I. Arbel, T. Kadar, M. Silbermann, and A. Levy The effects of long-term corticosterone administration on hippocampal morphology and cognitive performance of middle-aged rats Brain Res. 657 1994 227 235 (Pubitemid 24281269)
4. C. Behl, F. Lezoualc'h, T. Trapp, M. Widmann, T. Skutella, and F. Holsboer Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro Endocrinology 138 1997 101 106 (Pubitemid 27009411)
5. J. Chen, N. Adachi, S. Tsubota, T. Nagaro, and T. Arai Dexamethasone augments ischemia-induced extracellular accumulation of glutamate in gerbil hippocampus Eur. J. Pharmacol. 347 1998 67 70 (Pubitemid 28238087)
6. J.Y. Cho, I.S. Kim, Y.H. Jang, A.R. Kim, and S.R. Lee Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia Neurosci. Lett. 404 2006 330 335
7. S.H. Choi, M.T. Woodlee, J.J. Hong, and T. Schallert A simple modification of the water maze test to enhance daily detection of spatial memory in rats and mice J. Neurosci. Methods 156 2006 182 193 (Pubitemid 44233679)
8. C.D. Conrad, K.J. McLaughlin, J.S. Harman, C. Foltz, L. Wieczorek, E. Lightner, and R.L. Wright Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory J. Neurosci. 27 2007 8278 8285 (Pubitemid 47219614)
9. Z. Danilczuk, J. Sekita-Krzak, T. Lupina, M. Danilczuk, and K. Czerny Influence of dizocilpine (MK-801) on neurotoxic effect of dexamethasone: behavioral and histological studies Acta Neurobiol Exp (Wars) 66 2006 215 226 (Pubitemid 44747561)
10. L. Fan, L.Y. Dong, Q. Jiang, D.Y. Cen, Z.W. Chen, and C.G. Ma Anti-inflammatory and antipyretic effects of TFA Acta Univ. Med. Anhui 38 2003 25 27
11. L.E. Haynes, M.R. Griffiths, R.E. Hyde, D.J. Barber, and I.J. Mitchell Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disorders Neuroscience 104 2001 57 69 (Pubitemid 32322613)
12. H. Huang, C. Gazzola, G.G. Pegg, and M.N. Sillence Differential effects of dexamethasone and clenbuterol on rat growth and on beta2-adrenoceptors in lung and skeletal muscle J. Anim. Sci. 78 2000 604 608
13. P.J. Kamphuis, F. Gardoni, A. Kamal, G. Croiset, J.M. Bakker, F. Cattabeni, W.H. Gispen, F. van Bel, M. Di Luca, and V.M. Wiegant Long-lasting effects of neonatal dexamethasone treatment on spatial learning and hippocampal synaptic plasticity: involvement of the NMDA receptor complex FASEB J. 17 2003 911 913
14. G. Kempermann Why new neurons? Possible functions for adult hippocampal neurogenesis J. Neurosci. 22 2002 635 638 (Pubitemid 34141743)
15. P. Khomsug, W. Tongjaroenbuangam, N. Pakdeenarong, M. Suttajit, and P. Chantiratikul Antioxidative activities and phenolic content of extracts from okra (Abelmoschus esculentus L.) Res. J. Biol. Sci. 5 2010 310 313
16. J.B. Kim, J.Y. Ju, J.H. Kim, T.Y. Kim, B.H. Yang, Y.S. Lee, and H. Son Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro Brain Res. 1027 2004 1 10 (Pubitemid 39370989)
17. Q.L. Li, Z.W. Chen, and C.G. Ma Protective effects and mechanism of total flavone of the flowers of Abelmoschl on the injury of myocardial ischemia Chin. Pharmacol. Bull. 17 2001 466 468
18. J. Lu, Y.L. Zheng, L. Luo, D.M. Wu, D.X. Sun, and Y.J. Feng Quercetin reverses D-galactose induced neurotoxicity in mouse brain Behav. Brain Res. 171 2006 251 260 (Pubitemid 43946498)
19. S.J. Lupien, and B.S. McEwen The acute effects of corticosteroids on cognition: integration of animal and human model studies Brain Res. Brain Res. Rev. 24 1997 1 27 (Pubitemid 27293806)
20. N. Majlessi, and N. Naghdi Impaired spatial learning in the Morris water maze induced by serotonin reuptake inhibitors in rats Behav. Pharmacol. 13 2002 237 242 (Pubitemid 34816469)
21. C. Manach, and J.L. Donovan Pharmacokinetics and metabolism of dietary flavonoids in humans Free Radic. Res. 38 2004 771 785 (Pubitemid 39077365)
22. M.P. Mattson Glutamate and neurotrophic factors in neuronal plasticity and disease Ann. NY Acad. Sci. 1144 2008 97 112
23. B.S. McEwen Physiology and neurobiology of stress and adaptation: central role of the brain Physiol. Rev. 87 2007 873 904 (Pubitemid 47086281)
24. I.A. Mendez, K.S. Montgomery, C.L. LaSarge, N.W. Simon, J.L. Bizon, and B. Setlow Long-term effects of prior cocaine exposure on Morris water maze performance Neurobiol. Learn Mem. 89 2008 185 191 (Pubitemid 350235970)
25. C. Mirescu, and E. Gould Stress and adult neurogenesis Hippocampus 16 2006 233 238
26. K. Morita, K. Ishimura, Y. Tsuruo, and D.L. Wong Dexamethasone enhances serum deprivation-induced necrotic death of rat C6 glioma cells through activation of glucocorticoid receptors Brain Res. 816 1999 309 316 (Pubitemid 29225377)
27. R. Morris Developments of a water-maze procedure for studying spatial learning in the rat J. Neurosci. Methods 11 1984 47 60 (Pubitemid 14088970)
28. G. Paxinos, and K.B.J. Franklin The Mouse Brain in Stereotaxic Coordinates 2001 Elsevier Academic San Diego
29. F. Pu, K. Mishima, K. Irie, K. Motohashi, Y. Tanaka, K. Orito, T. Egawa, Y. Kitamura, N. Egashira, K. Iwasaki, and M. Fujiwara Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats J. Pharmacol. Sci. 104 2007 329 334 (Pubitemid 47378420)
30. B. Roozendaal, S. Okuda, D.J. de Quervain, and J.L. McGaugh Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions Neuroscience 138 2006 901 910
31. M. Roy, and R.M. Sapolsky The exacerbation of hippocampal excitotoxicity by glucocorticoids is not mediated by apoptosis Neuroendocrinology 77 2003 24 31 (Pubitemid 36302419)
32. D. Saucier, E.L. Hargreaves, F. Boon, C.H. Vanderwolf, and D.P. Cain Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: nonspatial pretraining eliminates spatial learning deficits Behav. Neurosci. 110 1996 103 116 (Pubitemid 26068799)
33. J. Sekita-Krzak, I. Zebrowska-Lupina, K. Czerny, M. Stepniewska, and A. Wrobel Neuroprotective effect of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: morphological, immunocytochemical and ultrastructural studies Acta Neurobiol. Exp. (Wars) 63 2003 1 8 (Pubitemid 36383282)
34. K. Shimoi, K. Yoshizumi, T. Kido, Y. Usui, and T. Yumoto Absorption and urinary excretion of quercetin, rutin, and alphaG-rutin, a water soluble flavonoid, in rats J. Agric. Food Chem. 51 2003 2785 2789
35. G. Shui, and L.L. Peng An improved method for the analysis of major antioxidants of Hibiscus esculentus Linn. J. Chromatogr. A 1048 2004 17 24 (Pubitemid 39158815)
36. M.N. Sillence, and T.D. Etherton Cortisone arrests growth but enhances the inductive effect of porcine growth hormone on plasma IGF-I concentrations in female rats J. Anim. Sci. 69 1991 2815 2821
37. J.E. Slemmer, J.J. Shacka, M.I. Sweeney, and J.T. Weber Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging Curr. Med. Chem. 15 2008 404 414 (Pubitemid 351266946)
38. N.D. Turner, L.A. Braby, J. Ford, and J.R. Lupton Opportunities for nutritional amelioration of radiation-induced cellular damage Nutrition 18 2002 904 912 (Pubitemid 35292264)
39. A.A. Vafaei, A. Rashidy-Pour, and A.A. Taherian Peripheral injection of dexamethasone modulates anxiety related behaviors in mice: an interaction with opioidergic neurons Pak. J. Pharm. Sci. 21 2008 285 289
40. X.R. Wang, Z.H. Zhou, A.Q. Du, and Z.M. Huang Studies on the flavonol constituents of Abelmoschus manihot L. Med. Chin. J. Nat. Med. 2 2004 91 93
41. C.S. Woolley, E. Gould, and B.S. McEwen Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons Brain Res. 531 1990 225 231 (Pubitemid 20348626)
42. Y.Y. Yao, D.M. Liu, D.F. Xu, and W.P. Li Memory and learning impairment induced by dexamethasone in senescent but not young mice Eur. J. Pharmacol. 574 2007 20 28