Extensive binding of the bioflavonoid quercetin to human plasma proteins

Journal of Pharmacy and Pharmacology

Volumn 50, Issue 2, 1998, Pages 243-249

  Boulton, David W ^a,b   Walle, U Kristina ^a   Walle, Thomas ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOFLAVONOID; HUMAN SERUM ALBUMIN; OROSOMUCOID; PLASMA PROTEIN; QUERCETIN; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ERYTHROCYTE; FEMALE; HUMAN; MALE; NORMAL HUMAN; THERMODYNAMICS; ULTRACENTRIFUGATION;

EID: 0031890738     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1998.tb06183.x     Document Type: Article

References (24)

1. Ames, B. N., Swirsky Gold, L., Willett, W. C. (1995) The causes and prevention of cancer. Proc. Natl Acad. Sci. USA 92: 5258-5265
2. Cook, N. C., Samman, S. (1996) Flavonoids - chemistry, metabolism, cardioprotective effects, and dietary sources. Nutr. Biochem. 7: 66-76
3. De Azevedo, W. F., Mueller-Dieckmann, H. J., Schulze-Gahmen, U., Worland, P. J., Sausville, E., Kim, S. H. (1996) Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl Acad. Sci. USA 93: 2735-2740
4. Ferry, D. R., Smith, A., Malkhandi, J., Fyfe, D. W., deTakats, P. G., Anderson, D., Baker, J., Kerr, D. J. (1996) Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin. Cancer Res. 2: 659-668
5. Formica, J. V., Regelson, W. (1995) Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol. 33: 1061-1080
6. Fotsis, T., Pepper, M. S., Aktas, E., Breit, S., Rasku, S., Adlercreutz, H., Wähälä, K., Montesano, R., Schweigerer, L. (1997) Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res. 57: 2916-2921
7. Gugler, R., Leschik, M., Dengler, H. J. (1975) Disposition of quercetin in man after single oral and intravenous doses. Eur. J. Clin. Pharmacol. 9: 229-234
8. He, X. M., Carter, D. C. (1992) Atomic structure and chemistry of human serum albumin. Nature 358: 209-215
9. Hertog, M. G. L., Hollman, P. C. H., Katan, M. B. (1992) Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agric. Food Chem. 40: 2379-2383
10. Hertog, M. G. L., Hollman, P. C. H., van de Putte, B. (1993) Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juices. J. Agric. Food Chem. 41: 1242-1246
11. Keli, S. O., Hertog, M. G. L., Feskens, E. J. M., Kromhout, D. (1996) Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch. Intern. Med. 156: 637-642
12. Knekt, P., Järvinen, R., Reunanen, A., Maatela, J. (1996) Flavonoid intake and coronary mortality in Finland: a cohort study. Br. Med. J. 312: 478-181
13. Kremer, J. M. H., Wilting, J. A. A. P., Janssen, L. H. M. (1988) Drug binding to alpha-1-acid glycoprotein in health and disease. Pharmacol. Rev. 40: 1-47
14. Legg, B., Rowland, M. (1987) Cyclosporin: measurement of fraction unbound in plasma. J. Pharm. Pharmacol. 39: 599-603
15. 1 cell-cycle arrest by the chemopreventive agent apigenin. Mol. Carcinogen. 19: 74-82
16. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
17. Manach, C., Morand, C., Texier, O., Favier, M. L., Agullo, G., Demigné, C., Régérat, F., Rémésy, C. (1995) Quercetin metabolites in plasma of rats fed diets containing rutin and quercetin. J. Nutr. 125: 1911-1922
18. Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G., Goldberg, D. M. (1995) The red wine phenolics transresveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against heart disease. Clin. Chim. Acta. 235: 207-219
19. Smith, T. J., Yang, C. S. (1994) Effects of food phytochemicals on xenobiotic metabolism and tumorigenesis. In: Huang, M.-T., Osawa, T., Ho, C.-T., Rosen, R. T. (eds) Food Phytochemicals for Cancer Prevention I. Vol. 546, Am. Chem. Soc., Washington, DC, pp 17-48
20. Tillement, J. P., Zini, R., d'Athis, P., Vassent, G. (1974) Binding of certain acidic drugs to human albumin: theoretical and practical estimation of fundamental parameters. Eur. J. Clin. Pharmacol. 7: 307-313
21. Tsyrlov, I. B., Mikhailenko, V. M., Gelboin, H. V. (1994) Isoenzyme-and species-specific susceptibility of cDNA-expressed CYPlA P-450s to different flavonoids. Biochim. Biophys. Acta. 1205: 325-335
22. Walle, T., Eaton, E. A., Walle, U. K. (1995) Quercetin, a potent and specific inhibitor of the human P-form phenolsulfotransferase. Biochem. Pharmacol. 50: 731-734
23. Wang, Z. Y., Huang, M.-T., Lou, Y.-R., Xie, J.-G., Reuhl, K. R., Newmark, H. L., Ho, C.-T., Yang, C. S., Conney, A. H. (1994) Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice. Cancer Res. 54: 3428-3435
24. Weber, G., Shen, F., Prajda, N., Yeh, Y. A., Yang, H., Herenyiova, M., Look, K. Y. (1996) Increased signal transduction activity and down-regulation in human cancer cells. Anticancer Res. 16: 3271-3282