Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 50, Issue , 2014, Pages 110-115

  Zhang, Chen ^a,b   Cai, Jun ^a   Zhang, Jiangtao ^c   Li, Zezhi ^d   Guo, Zhongwei ^c   Zhang, Xu ^e   Lu, Weihong ^a   Zhang, Yi ^a   Yuan, Aihua ^a   Yu, Shunying ^a   Fang, Yiru ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b KUNMING INSTITUTE OF ZOOLOGY   (China)

^c TONGDE HOSPITAL OF ZHEJIANG PROVINCE   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

^e TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

ANK3; First episode schizophrenia; SNP; Working memory

Indexed keywords

ACCURACY; ADULT; ANKYRIN 3 GENE; ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GENE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; REACTION TIME; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; WORKING MEMORY DEFICIT; CASE CONTROL STUDY; COMPLICATION; ENDOPHENOTYPE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SHORT TERM MEMORY; YOUNG ADULT;

ANK3 PROTEIN, HUMAN; ANKYRIN;

ADULT; ANKYRINS; CASE-CONTROL STUDIES; ENDOPHENOTYPES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; YOUNG ADULT;

EID: 84891600402     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.12.010     Document Type: Article

References (50)

1. Ackerman P.L., Beier M.E., Boyle M.O. Working memory and intelligence: the same or different constructs?. Psychol Bull 2005, 131:30-60.
2. American Psychiatric Association Handbook of psychiatric measures 2000, American Psychiatric Association, Washington.
3. Bi C., Wu J., Jiang T., Liu Q., Cai W., Yu P., et al. Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility. Hum Mutat 2012, 33:1635-1638.
4. Cunninghame Graham D.S. Genome-wide association studies in systemic lupus erythematosus: a perspective. Arthritis Res Ther 2009, 11:119.
5. Deserno L., Sterzer P., Wustenberg T., Heinz A., Schlagenhauf F. Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia. J Neurosci 2012, 32:12-20.
6. Elvevag B., Goldberg T.E. Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiol 2000, 14:1-21.
7. Ettinger U., Williams S.C., Fannon D., Premkumar P., Kuipers E., Moller H.J., et al. Functional magnetic resonance imaging of a parametric working memory task in schizophrenia: relationship with performance and effects of antipsychotic treatment. Psychopharmacology (Berl) 2011, 216:17-27.
8. Fatemi S.H., Folsom T.D. The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull 2009, 35:528-548.
9. Gella A., Segura M., Durany N., Pfuhlmann B., Stober G., Gawlik M. Is Ankyrin a genetic risk factor for psychiatric phenotypes?. BMC Psychiatry 2011, 11:103.
10. Glahn D.C., Therman S., Manninen M., Huttunen M., Kaprio J., Lonnqvist J., et al. Spatial working memory as an endophenotype for schizophrenia. Biol Psychiatry 2003, 53:624-626.
11. Goldman A.L., Pezawas L., Mattay V.S., Fischl B., Verchinski B.A., Zoltick B., et al. Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study. Biol Psychiatry 2008, 63:475-483.
12. Green E.K., Hamshere M., Forty L., Gordon-Smith K., Fraser C., Russell E., et al. Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. Mol Psychiatry 2013, 18:1302-1307.
13. Greenwood T.A., Braff D.L., Light G.A., Cadenhead K.S., Calkins M.E., Dobie D.J., et al. Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Arch Gen Psychiatry 2007, 64:1242-1250.
14. Gunduz-Bruce H., Oliver S., Gueorguieva R., Forselius-Bielen K., D'Souza D.C., Zimolo Z., et al. Efficacy of pimozide augmentation for clozapine partial responders with schizophrenia. Schizophr Res 2013, 143:344-347.
15. Hansell N.K., Medland S.E., Ferreira M.A., Geffen G.M., Zhu G., Montgomery G.W., et al. Linkage analyses of event-related potential slow wave phenotypes recorded in a working memory task. Behav Genet 2006, 36:29-44.
16. Hatzimanolis A., Smyrnis N., Avramopoulos D., Stefanis C.N., Evdokimidis I., Stefanis N.C. Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population. Psychiatr Genet 2012, 22:210-213.
17. Hui L., Zhang X., Yu Y.Q., Han M., Huang X.F., Chen D.C., et al. Association between DBH 19bp insertion/deletion polymorphism and cognition in first-episode schizophrenic patients. Schizophr Res 2013, 147:236-240.
18. Iqbal Z., Vandeweyer G., van der Voet M., Waryah A.M., Zahoor M.Y., Besseling J.A., et al. Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders. Hum Mol Genet 2013, 22:1960-1970.
19. Jaeggi S.M., Buschkuehl M., Perrig W.J., Meier B. The concurrent validity of the N-back task as a working memory measure. Memory 2010, 18:394-412.
20. Johnson M.K., McMahon R.P., Robinson B.M., Harvey A.N., Hahn B., Leonard C.J., et al. The relationship between working memory capacity and broad measures of cognitive ability in healthy adults and people with schizophrenia. Neuropsychology 2013, 27:220-229.
21. Kosaka T., Komada M., Kosaka K. Sodium channel cluster, betaIV-spectrin and ankyrinG positive "hot spots" on dendritic segments of parvalbumin-containing neurons and some other neurons in the mouse and rat main olfactory bulbs. Neurosci Res 2008, 62:176-186.
22. Kuperberg G., Heckers S. Schizophrenia and cognitive function. Curr Opin Neurobiol 2000, 10:205-210.
23. LaBar K.S., Gitelman D.R., Parrish T.B., Mesulam M. Neuroanatomic overlap of working memory and spatial attention networks: a functional MRI comparison within subjects. Neuroimage 1999, 10:695-704.
24. Lee J., Park S. Working memory impairments in schizophrenia: a meta-analysis. J Abnorm Psychol 2005, 114:599-611.
25. Lee J., Folley B.S., Gore J., Park S. Origins of spatial working memory deficits in schizophrenia: an event-related fMRI and near-infrared spectroscopy study. PloS One 2008, 3:e1760.
26. Leussis M.P., Madison J.M., Petryshen T.L. Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology. Biol Mood Anxiety Disord 2012, 2:18.
27. Leussis M.P., Berry-Scott E.M., Saito M., Jhuang H., de Haan G., Alkan O., et al. The ANK3 bipolar disorder gene regulates psychiatric-related behaviors that are modulated by lithium and stress. Biol Psychiatry 2013, 73:683-690.
28. Linke J., Witt S.H., King A.V., Nieratschker V., Poupon C., Gass A., et al. Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain. Neuroimage 2012, 59:3288-3296.
29. Lu W.H., Zhang C., Yi Z.H., Li Z.Z., Wu Z.G., Fang Y.R. Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naive patients with schizophrenia. J Mol Neurosci 2012, 47:505-510.
30. Myles-Worsley M., Park S. Spatial working memory deficits in schizophrenia patients and their first degree relatives from Palau, micronesia. Am J Med Genet 2002, 114:609-615.
31. Nagai T., Takuma K., Dohniwa M., Ibi D., Mizoguchi H., Kamei H., et al. Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol. Psychopharmacology (Berl) 2007, 194:21-32.
32. Quinn E.M., Hill M., Anney R., Gill M., Corvin A.P., Morris D.W. Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression. Bipolar Disord 2010, 12:440-445.
33. Reilly J.L., Harris M.S., Khine T.T., Keshavan M.S., Sweeney J.A. Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia. Biol Psychiatry 2007, 62:818-821.
34. Roussos P., Katsel P., Davis K.L., Bitsios P., Giakoumaki S.G., Jogia J., et al. Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia. Arch Gen Psychiatry 2012, 69:7-15.
35. Ruberto G., Vassos E., Lewis C.M., Tatarelli R., Girardi P., Collier D., et al. The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention. PloS One 2011, 6:e16671.
36. Rueckert E.H., Barker D., Ruderfer D., Bergen S.E., O'Dushlaine C., Luce C.J., et al. Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder. Mol Psychiatry 2013, 18:922-929.
37. Sanches M., Keshavan M.S., Brambilla P., Soares J.C. Neurodevelopmental basis of bipolar disorder: a critical appraisal. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:1617-1627.
38. Schlagenhauf F., Dinges M., Beck A., Wustenberg T., Friedel E., Dembler T., et al. Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activation. Schizophr Res 2010, 118:189-200.
39. Schmidt-Hansen M., Honey R.C. Working memory and multidimensional schizotypy: dissociable influences of the different dimensions. Cogn Neuropsychol 2009, 26:655-670.
40. Shi Y.Y., He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 2005, 15:97-98.
41. Silver H., Feldman P., Bilker W., Gur R.C. Working memory deficit as a core neuropsychological dysfunction in schizophrenia. Am J Psychiatry 2003, 160:1809-1816.
42. Talkowski M.E., Rosenfeld J.A., Blumenthal I., Pillalamarri V., Chiang C., Heilbut A., et al. Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. Cell 2012, 149:525-537.
43. Tesli M., Koefoed P., Athanasiu L., Mattingsdal M., Gustafsson O., Agartz I., et al. Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. Am J Med Genet B Neuropsychiatr Genet 2011, 156B:969-974.
44. Tsuang M.T., Stone W.S., Faraone S.V. Genes, environment and schizophrenia. Br J Psychiatry 2001, 40:s18-s24.
45. Turetsky B.I., Calkins M.E., Light G.A., Olincy A., Radant A.D., Swerdlow N.R. Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophr Bull 2007, 33:69-94.
46. Wang Z., Li Z., Chen J., Huang J., Yuan C., Hong W., et al. Association of BDNF gene polymorphism with bipolar disorders in Han Chinese population. Genes Brain Behav 2012, 11:524-528.
47. Wang Z., Fan J., Gao K., Li Z., Yi Z., Wang L., et al. Neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene associated with treatment response to mood stabilizers in patients with bipolar I disorder. J Mol Neurosci 2013, 50:305-310.
48. Yuan A.H., Yi Z.H., Wang Q., Sun J.H., Li Z.Q., Du Y.S., et al. ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis. Am J Med Genet B Neuropsychiatr Genet 2012, 159B:997-1005.
49. Zhang Y., Bertolino A., Fazio L., Blasi G., Rampino A., Romano R., et al. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci U S A 2007, 104:20552-20557.
50. Zhang C., Fang Y., Xie B., Cheng W., Du Y., Wang D., et al. DNA methyltransferase 3B gene increases risk of early onset schizophrenia. Neurosci Lett 2009, 462:308-311.