Is Ankyrin a genetic risk factor for psychiatric phenotypes?

BMC Psychiatry

Volumn 11, Issue , 2011, Pages

  Gella, Alejandro ^a   Segura, Mònica ^a   Durany, Núria ^a   Pfuhlmann, Bruno ^b   Stöber, Gerald ^b   Gawlik, Micha ^b  

^a UNIVERSITAT INTERNACIONAL DE CATALUNYA   (Spain)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; ANKYRIN 3; UNCLASSIFIED DRUG; ANK3 PROTEIN, HUMAN;

ADULT; ARTICLE; BIPOLAR DEPRESSION; CASE CONTROL STUDY; DISEASE CLASSIFICATION; FEMALE; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; PHENOTYPE; PSYCHOSIS; RISK FACTOR; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; BIPOLAR DISORDER; DEPRESSION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; METHODOLOGY; STATISTICS;

ADULT; ANKYRINS; BIPOLAR DISORDER; DEPRESSIVE DISORDER; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 79959420417     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-11-103     Document Type: Article

References (26)

1. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 2008, 40:827-834. 10.1038/ng.171, 18583979.
2. Stöber G, Ben-Shachar D, Cardon M, Falkai P, Fonteh AN, Gawlik M, Glenthoj BY, Grunblatt E, Jablensky A, Kim YK, Kornhuber J, McNeil TF, Muller N, Oranje B, Saito T, Saoud M, Schmitt A, Schwartz M, Thome J, Uzbekov M, Durany N, Riederer P. Schizophrenia: From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers. World Journal of Biological Psychiatry 2009, 10:127-155. 10.1080/15622970902898980, 19396704.
3. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Réthelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA. Genetic Risk and Outcome in Psychosis (GROUP) Common variants conferring risk of schizophrenia. Nature 2009, 460:744-7. 3077530, 19571808, Genetic Risk and Outcome in Psychosis (GROUP).
4. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV, Cichon S, Nöthen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR, . Molecular Genetics of Schizophrenia Collaboration Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 2008, 40:1053-5. 10.1038/ng.201, 18677311, Molecular Genetics of Schizophrenia Collaboration.
5. Williams HJ, Craddock N, Russo G, Hamshere ML, Moskvina V, Dwyer S, Smith RL, Green E, Grozeva D, Holmans P, Owen MJ, O'Donovan MC. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Hum Mol Genet 2011, 20:387-91. 10.1093/hmg/ddq471, 21037240.
6. Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ. A genome-wide association study implicates diacylglicerol kinase (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 2008, 13:197-207. 10.1038/sj.mp.4002012, 2527618, 17486107.
7. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar V, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, McLean A, St Clair D, VanBeck M, Pereira A, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuYn P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock NJ. Wellcome Trust Case Control Consortium (WTCCC) Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008, 40:1056-1058. 10.1038/ng.209, 2703780, 18711365, Wellcome Trust Case Control Consortium (WTCCC).
8. Schulze TG, Detera-Wadleigh SD, Akula N, Gupta A, Kassem L, Steele J, Pearl J, Strohmaier J, Breuer R, Schwarz M, Propping P, Nothen MM, Cichon S, Schumacher J, Rietschel M, McMahon FJ. Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Mol Psychiatry 2009, 14:487-491. 10.1038/mp.2008.134, 2793269, 19088739.
9. Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HK, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Chen CY, Wang KH, Fann CS, Wu JY, Chen YT, Cheng AT. Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol Psychiatry 2011, 16:548-56. 10.1038/mp.2010.43, 20386566.
10. Athanasiu L, Mattingsdal M, Kähler AK, Brown A, Gustafsson O, Agartz I, Giegling I, Muglia P, Cichon S, Rietschel M, Pietiläinen OP, Peltonen L, Bramon E, Collier D, Clair DS, Sigurdsson E, Petursson H, Rujescu D, Melle I, Steen VM, Djurovic S, Andreassen OA. Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res 2010, 44:748-53. 10.1016/j.jpsychires.2010.02.002, 20185149.
11. Bennett V, Lambert S. Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels. Journal of Neurocytology 1999, 28:303-318. 10.1023/A:1007005528505, 10739573.
12. Kretschmer T, England JD, Happel LT, Liu ZP, Thouron CL, Nguyen DH, Beuerman RW, Kline DG. Ankyrin G and voltage gated sodium channels colocalize in human neurona - key proteins of membrane remodeling after axonal injury. Neuroscience Letters 1999, 323:151-155.
13. Dzhashiashvili Y, Zhang Y, Galinska J, Lam I, Grumet M, Salzer JL. Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms. J Cell Biol 2007, 177:857-70. 10.1083/jcb.200612012, 2064285, 17548513.
14. Kizhatil K, Davis JQ, Davis L, Hoffman J, Hogan BL, Bennett V. Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. J Biol Chem 2007, 282:26552-61. 10.1074/jbc.M703158200, 17620337.
15. Jenkins SM, Bennett V. Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. Proc Natl Acad Sci USA 2002, 99:2303-8. 10.1073/pnas.042601799, 122360, 11842202.
16. Jenkins SM, Bennett V. Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. J Cell Biol 2001, 155:739-46. 10.1083/jcb.200109026, 2150881, 11724816.
17. Cruz DA, Weaver CL, Lovallo EM, Melchitzky DS, Lewis DA. Selective alterations in postsynaptic markers of chandelier cell inputs to cortical pyramidal neurons in subjects with schizophrenia. Neuropsychopharmacology 2009, 34:12-24.
18. Leonhard K. Classification of endogenous psychoses and their differentiated etiology. 1999, enlarged, Wien, New York Springer, 2.
19. Franzek E, Beckmann H. Different genetic background of schizophrenia spectrum psychoses: a twin study. Am J Psychiatry 1998, 155:76-83.
20. Becker T, Knapp M. Maximum-likelihood estimation of haplotype frequencies in nuclear families. Genet Epidemiol 2004, 27:21-32. 10.1002/gepi.10323, 15185400.
21. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-5. 10.1093/bioinformatics/bth457, 15297300.
22. stastical power calculator. , http://www.dssresearch.com/toolkit/spcalc/power.asp
23. Pfuhlmann B, Jabs B, Althaus G, Schmidtke A, Bartsch A, Stöber G, Beckmann H, Franzek E. Cycloid psychoses are not part of a bipolar affective spectrum: results of a controlled family study. J Affect Disord 2004, 83:11-9. 10.1016/j.jad.2004.03.005, 15546641.
24. Stöber G, Franzek E, Lesch KP, Beckmann H. Periodic catatonia: a schizophrenic subtype with major gene effect and anticipation. Eur Arch Psychiatry Clin Neurosci 1995, 245:135-41. 10.1007/BF02193085, 7669819.
25. Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 2011, 16:2-4. 10.1038/mp.2009.107, 20351715.
26. Quinn EM, Hill M, Anney R, Gill M, Corvin AP, Morris DW. Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression. Bipolar Disord 2010, 12:440-5. 10.1111/j.1399-5618.2010.00817.x, 20636642.