Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 8, 2011, Pages 969-974

  Tesli, Martin ^a,b   Koefoed, Pernille ^c,d   Athanasiu, Lavinia ^a,b   Mattingsdal, Morten ^b   Gustafsson, Omar ^b,e   Agartz, Ingrid ^a,f,g   Rimol, Lars M ^g   Brown, Andrew ^a   Wirgenes, Katrine V ^a,b   Smorr, Lisa Lena ^a,b   Kähler, Anna K ^b,f,h   Werge, Thomas ⁱ   Mors, Ole ^j   Mellerup, Erling ^c,d   Jönsson, Erik G ^f   Melle, Ingrid ^a,b   Morken, Gunnar ^k,l   Djurovic, Srdjan ^a,b   Andreassen, Ole A ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Rigshospitalet   (Denmark)

^e DECODE GENETICS   (Iceland)

^f KAROLINSKA INSTITUTE   (Sweden)

^g DIAKONHJEMMET HOSPITAL   (Norway)

^h UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

ⁱ Mental Health Services CPH   (Denmark)

^j AARHUS UNIVERSITY HOSPITAL   (Denmark)

^k TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^l NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

more..

Author keywords

ANK3; Bipolar disorder; Genetic association; Schizophrenia

Indexed keywords

ANKYRIN; ANKYRIN 3; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; CASE CONTROL STUDY; CONTROLLED STUDY; DENMARK; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; ICELAND; MAJOR CLINICAL STUDY; MALE; NORWAY; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCHIZOPHRENIFORM DISORDER; SCHIZOTYPAL PERSONALITY DISORDER; SINGLE NUCLEOTIDE POLYMORPHISM; SWEDEN;

ANKYRINS; BIPOLAR DISORDER; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; ICELAND; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SCANDINAVIA; SCHIZOPHRENIA;

EID: 80054856206     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31244     Document Type: Article

References (33)

1. Askland K, Read C, Moore J. 2009. Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission. Hum Genet 125(1): 63-79.
2. Athanasiu L, Mattingsdal M, Kahler AK, Brown A, Gustafsson O, Agartz I, Giegling I, Muglia P, Cichon S, Rietschel M, Pietilainen OP, Peltonen L, Bramon E, Collier D, Clair DS, Sigurdsson E, Petursson H, Rujescu D, Melle I, Steen VM, Djurovic S, Andreassen OA. 2010. Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res 44(12): 748-753.
3. Craddock N, Khodel V, Van EP, Reich T. 1995. Mathematical limits of multilocus models: The genetic transmission of bipolar disorder. Am J Hum Genet 57(3): 690-702.
4. Craddock N, O'Donovan MC, Owen MJ. 2009. Psychosis genetics: Modeling the relationship between schizophrenia, bipolar disorder, and mixed (or "schizoaffective") psychoses. Schizophr Bull 35(3): 482-490.
5. Djurovic S, Gustafsson O, Mattingsdal M, Athanasiu L, Bjella T, Tesli M, Agartz I, Lorentzen S, Melle I, Morken G, Andreassen OA. 2010. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. J Affect Disord 126(1-2): 312-316.
6. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, Maclean AW, St CD, Robinson M, Van BM, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N. 2008. Collaborative genomewide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 40(9): 1056-1058.
7. Kordeli E, Lambert S, Bennett V. 1995. AnkyrinG. A new ankyrin gene with neuralspecific isoforms localized at the axonal initial segment and node of Ranvier. J Biol Chem 270(5): 2352-2359.
8. Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HK, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Chen CY, Wang KH, Fann CS, Wu JY, Chen YT, Cheng AT. 2011. Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol Psychiatry 16(5): 548-556.
9. Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM. 2009. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study. Lancet 373(9659): 234-239.
10. Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF. Wellcome Trust Case-Control Consortium. 2011. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 16(1): 2-4.
11. McGuffin P, Farmer A, Harvey I. 1991. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 48(8): 764-770.
12. McQuillin A, Rizig M, Gurling HM. 2007. A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder. Pharmacogenet Genomics 17(8): 605-617.
13. Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E, Owen MJ, O'Donovan MC. 2009. Gene-wide analyses of genome-wide association data sets: Evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol Psychiatry 14(3): 252-260.
14. Nothen MM, Nieratschker V, Cichon S, Rietschel M. 2010. New findings in the genetics of major psychoses. Dialogues Clin Neurosci 12(1): 85-93.
15. Owen MJ, Williams HJ, O'Donovan MC. 2009. Schizophrenia genetics: Advancing on two fronts. Curr Opin Genet Dev 19(3): 266-270.
16. Pan Z, Kao T, Horvath Z, Lemos J, Sul JY, Cranstoun SD, Bennett V, Scherer SS, Cooper EC. 2006. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci 26(10): 2599-2613.
17. Peters L, Andrews G. 1995. Procedural validity of the computerized version of the Composite International Diagnostic Interview (CIDI-Auto) in the anxiety disorders. Psychol Med 25(6): 1269-1280.
18. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. 2007. PLINK: A tool set for wholegenome association and population-based linkage analyses. Am J Hum Genet 81(3): 559-575.
19. Quinn EM, Hill M, Anney R, Gill M, Corvin AP, Morris DW. 2010. Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression. Bipolar Disord 12(4): 440-445.
20. Schulze TG, tera-Wadleigh SD, Akula N, Gupta A, Kassem L, Steele J, Pearl J, Strohmaier J, Breuer R, Schwarz M, Propping P, Nothen MM, Cichon S, Schumacher J, Rietschel M, McMahon FJ. 2009. Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Mol Psychiatry 14(5): 487-491.
21. Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M. 2009. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci USA 106(18): 7501-7506.
22. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM. 2008. Whole-genome association study of bipolar disorder. Mol Psychiatry 13(6): 558-569.
23. Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg HJ, Eskin E, Foroud T, Gershon E, Greenwood TA, Hipolito M, Koller DL, Lawson WB, Liu C, Lohoff F, McInnis MG, McMahon FJ, Mirel DB, Murray SS, Nievergelt C, Nurnberger J, Nwulia EA, Paschall J, Potash JB, Rice J, Schulze TG, Scheftner W, Panganiban C, Zaitlen N, Zandi PP, Zollner S, Schork NJ, Kelsoe JR. 2009. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry 14(8): 755-763.
24. Smoller JW, Finn CT. 2003. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet Part C 123C(1): 48-58.
25. Sobotzik JM, Sie JM, Politi C, Del TD, Bennett V, Deller T, Schultz C. 2009. AnkyrinG is required to maintain axo-dendritic polarity in vivo. Proc Natl Acad Sci USA 106(41): 17564-17569.
26. Spitzer REJ. 1977. The schedule for affective disorders and schizophrenia, lifetime version. New York: New York State Psychiatric Institute.
27. Spitzer RL, Endicott J, Robins E. 1978. Research diagnostic criteria: Rationale and reliability. Arch Gen Psychiatry 35(6): 773-782.
28. Spitzer RL, Williams JB, Gibbon M, First MB. 1992. The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description. Arch Gen Psychiatry 49(8): 624-629.
29. Sullivan PF. 2005. The genetics of schizophrenia. PLoS Med 2(7): 0614-0618.
30. Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, He Q, Heath AC, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, MacIntyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery GW, Muir WJ, Nolen WA, Nothen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW, Tzeng JY, van DR, Verhage M, Zitman FG, Martin NG, Wray NR, Boomsma DI, Penninx BW. 2009. Genome-wide association for major depressive disorder: A possible role for the presynaptic protein piccolo. Mol Psychiatry 14(4): 359-375.
31. Thorgeirsson TE, Oskarsson H, Desnica N, Kostic JP, Stefansson JG, Kolbeinsson H, Lindal E, Gagunashvili N, Frigge ML, Kong A, Stefansson K, Gulcher JR. 2003. Anxiety with panic disorder linked to chromosome 9q in Iceland. Am J Hum Genet 72(5): 1221-1230.
32. Wittchen HU, Zhao S, Abelson JM, Abelson JL, Kessler RC. 1996. Reliability and procedural validity of UM-CIDI DSM-III-R phobic disorders. Psychol Med 26(6): 1169-1177.
33. Zhou D, Lambert S, Malen PL, Carpenter S, Boland LM, Bennett V. 1998. AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J Cell Biol 143(5): 1295-1304.