The cognitive impact of the ANK3 risk variant for bipolar disorder: Initial evidence of selectivity to signal detection during sustained attention

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Ruberto, Gaia ^a,c   Vassos, Evangelos ^a   Lewis, Cathryn M ^a,b   Tatarelli, Roberto ^c   Girardi, Paolo ^c   Collier, David ^a   Frangou, Sophia ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; ANKYRIN 3; UNCLASSIFIED DRUG; ANK3 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; ATTENTION; BIPOLAR DISORDER; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DECISION MAKING; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTELLIGENCE; INTERVIEW; NEUROLOGIC EXAMINATION; POPULATION GENETICS; PSYCHOPHYSIOLOGY; RESPONSE INHIBITION; SIGNAL DETECTION; SUSTAINED ATTENTION; CASE CONTROL STUDY; CAUCASIAN; COGNITIVE DEFECT; GENETIC PREDISPOSITION; GENETICS; RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

ANKYRINS; ATTENTION; BIPOLAR DISORDER; CASE-CONTROL STUDIES; COGNITION DISORDERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 79551617320     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016671     Document Type: Article

References (45)

1. Cardno AG, Marshall EJ, Coid B, Macdonald AM, Ribchester TR, et al. (1999) Heritability estimates for psychotic disorders: the Maudsley twin psychosis series. Arch Gen Psychiatry 56: 162-168.
2. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, et al. (2008) Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 40: 1056-1058.
3. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
4. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, et al. (2008) Whole-genome association study of bipolar disorder. Mol Psychiatry 3: 558-569.
5. Lambert S, Davis JQ, Bennett V (1997) Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. J Neurosci 17: 7025-7036.
6. Zhou D, Lambert S, Malen PL, Carpenter S, Boland LM, et al. (1998) AnkyrinG is required for clustering of voltage-gated Na channels at the axon hillock and normal action potential firing. J Cell Biol 143: 1295-1304.
7. Schimpf R, Veltmann C, Wolpert C, Borggrefe M (2009) Channelopathies: Brugada syndrome, long QT syndrome, short QT syndrome, and CPVT. Herz 34: 281-288.
8. Meola G, Hanna MG, Fontaine B (2009) Diagnosis and new treatment in muscle channelopathies. J Neurol Neurosurg Psychiatry 80: 360-365.
9. Catterall WA, Dib-Hajj S, Meisler MH, Pietrobon D (2008) Inherited neuronal ion channelopathies: new windows on complex neurological diseases. J Neurosci 28: 11768-11777.
10. Yanagita T, Maruta T, Uezono Y, Satoh S, Yoshikawa N, et al. (2007) Lithium inhibits function of voltage-dependent sodium channels and catecholamine secretion independent of glycogen synthase kinase-3 in adrenal chromaffin cells. Neuropharmacology 53: 881-889.
11. Huang X, Lei Z, El-Mallakh RS (2007) Lithium normalizes elevated intracellular sodium. Bipolar Disord 9: 298-300.
12. White HS, Smith MD, Wilcox KS (2007) Mechanisms of action of antiepileptic drugs. Int Rev Neurobiol 81: 85-110.
13. DeGeus EJC, Boomsma DI (2001) A genetic neuroscience approach to human cognition. Eur Psychol 6: 241-245.
14. Glahn DC, Almasy L, Barguil M, Hare E, Peralta JM, et al. (2010) Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch Gen Psychiatry 67: 168-177.
15. Bora E, Yucel M, Pantelis C (2009) Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord 113: 1-20.
16. Arts B, Jabben N, Krabbendam L, van Os J (2008) Meta-analyses of cognitive functioning in euthymic bipolar patients and their first degree relatives. Psychol Med 38: 771-785.
17. Fohlmeister JF, Miller RF (1997) The impulse encoding mechanisms of ganglion cells in the tiger salamander retina. J Neurophysiol 78: 1935-1947.
18. Dhingra NK, Freed MA, Smith RG (2005) Voltage-Gated Sodium Channels Improve Contrast Sensitivity of a Retinal Ganglion Cell. J Neurosci 25: 8097-8103.
19. Naundorf B, Geisel T, Wolf F (2005) Action potential onset dynamics and the response speed of neuronal populations. J Comput Neurosci 18: 297-309.
20. Naundorf B, Wolf F, Volgushev M (2006) Unique features of action potential initiation in cortical neurons. Nature 440: 1060-1063.
21. Gregoriou GG, Gotts SJ, Zhou H, Desimone R (2009) High-Frequency, longrange coupling between prefrontal and visual cortex during attention. Science 324: 1207-1210.
22. Cunningham MO, Whittington MA, Bibbig A, Roopun A, LeBeau FE, et al. (2004) A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro. Proc Natl Acad Sci U S A 101: 7152-7157.
23. Nuechterlein KH, Asarnow RF (1992) Manual and Computer Program for the UCLA Continuous Performance Test: Version 4 Unpublished manual and program.
24. Nuechterlein KH, Parasuraman R, Jiang Q (1983) Visual sustained attention: image degradation produces rapid sensitivity decrements over time. Science 220: 327-329.
25. Frangou S (2009) Risk and resilience in bipolar disorder: rationale and design of the Vulnerability to Bipolar Disorders Study (VIBES). Biochem Soc Trans 37: 1085-1089.
26. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th Edition). American Psychiatric Association, Washington D.C.
27. First MB, Spitzer RL, Gibbon M, Williams JBW (2002) Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient Edition. (SCID-I/NP). New York: Biometrics Research, New York State Psychiatric Institute.
28. First MB, Spitzer RL, Gibbon M, Williams JBW (2001) Structured Clinical Interview for DSM-IV-TR Axis 1 Disorders - Research Version, Patient Edition (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute.
29. Maxwell E (1992) The Family Interview for Genetic Studies Manual. Washington, DC: National Institute of Mental Health, Intramural Research Program, Clinical Neurogenetics Branch.
30. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62.
31. Young R, Biggs J, Zieglar V, Meyer D (1978) A rating scale for mania: reliability, validity sensitivity. Br J Psychiatry 133: 429-435.
32. Overall JE, Gorham DR (1962) The Brief Psychiatric Rating Scale. Psychological Report 10: 799-812.
33. Wechsler D Wechsler Adult Intelligence Scale - Revised (WAIS-R) Manual, Psychological Corporation, New York.
34. Trenerry MR, Crosson B, DeBoe J, Leber WR Stroop Neuropsychological Screening Test, Psychological Assessment Resources, Lutz, Florida.
35. Heaton RK Wisconsin Card Sorting Test Manual, Psychological Assessment Resources, Odessa, Florida.
36. Wechsler D Wechsler Memory Scale -3rd Edition (WMS-III) Manual, Psychological Corporation, New York.
37. Bechara A, Damasio AR, Damasio H, Anderson SW (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7-15.
38. Freeman B, Smith N, Curtis C, Huckett L, Mill J, et al. (2003) DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behav Genet 33: 67-72.
39. Cohen J (1988) Statistical power analysis for the behavioral sciences (2nd ed.). Lawrence Earlbaum Associates Hillsdale, NJ.
40. Shiffrin RM, Schneider W (1984) Automatic and controlled processing revisited. Psychol Rev 91: 269-276.
41. Swann AC, Pazzaglia P, Nicholls A, Dougherty DM, Moeller FG (2003) Impulsivity and phase of illness in bipolar disorder. J Affect Disord 73: 105-111.
42. Lewis M, Scott J, Frangou S (2009) Impulsivity, personality and bipolar disorder. Eur Psychiatry 24: 464-9.
43. Ress D, Backus BT, Heeger DJ (2000) Activity in primary visual cortex predicts performance in a visual detection task. Nature Neurosci 3: 940-945.
44. Kumar CTS, Christodoulou T, Kyriakopoulos M, Corrigall R, Reichenberg A, et al. (2010) Deficits in visual sustained attention differentiate genetic liability and disease expression for Schizophrenia from Bipolar Disorder. Schizophr Res. doi:10.1016/j.schres.2010.07.006.
45. Athanasiu L, Mattingsdal M, Kähler AK, Brown A, Gustafsson O, et al. (2010) Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res 44: 748-753.