Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes

International Journal of Biochemistry and Cell Biology

Volumn 47, Issue 1, 2014, Pages 83-92

  Lin, Wei Shiang ^a   Lu, Guan Yu ^a,b   Huang, Shih Ming ^c   Liu, Shu Ting ^a,c   Liu, Pei Yao ^c   Chou, Wei Yuan ^c  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b KUANG TIEN GENERAL HOSPITAL   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Alternative splicing; Caffeine; p53; Splicing factor; SRSF3

Indexed keywords

CAFFEINE; PROTEIN P53; SERINE ARGININE RICH PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ADHESION; CELL CYCLE ARREST; CELL HYPOXIA; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; MTT ASSAY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; TRANSLATION INITIATION; TUMOR GENE; WESTERN BLOTTING;

ACTN; ALPHA ACTININ; ALTERNATIVE SPLICING; CAFFEINE; COX-2; CYCLOOXYGENASE-2; EGFR; EMT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPITHELIAL-MESENCHYMAL-TRANSITION; FASN; FATTY ACID SYNTHASE; GLUCOSE TRANSPORTER 1; GLUT1; HIF-1Α; HYPOXIA INDUCIBLE FACTOR 1Α; KLF6; KRÜPPEL-LIKE FACTOR 6; L-OHP; L-OXALIPLATIN; P53; SERINE/ARGININE-RICH; SPLICING FACTOR; SR; SREBP1C; SRSF3; STEROL REGULATORY ELEMENT-BINDING PROTEIN 1C; VASCULAR ENDOTHELIAL GROWTH FACTOR; VEGF;

ALTERNATIVE SPLICING; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAFFEINE; CELL LINE, TUMOR; DOWN-REGULATION; DRUG SYNERGISM; HELA CELLS; HUMANS; NEOPLASMS; ORGANOPLATINUM COMPOUNDS; PROTEIN ISOFORMS; RATS; RNA-BINDING PROTEINS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84891512320     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.12.004     Document Type: Article

References (35)

1. E.S. Anderson, C.H. Lin, X. Xiao, P. Stoilov, C.B. Burge, and D.L. Black The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B RNA 18 2012 1041 1049
2. M.L. Anko, M. Muller-McNicoll, H. Brandl, T. Curk, C. Gorup, and I. Henry et al. The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes Genome Biol 13 2012 R17
3. A.M. Bode, and Z. Dong The enigmatic effects of caffeine in cell cycle and cancer Cancer Lett 247 2007 26 39 (Pubitemid 44959418)
4. S.K. Bohn, N.C. Ward, J.M. Hodgson, and K.D. Croft Effects of tea and coffee on cardiovascular disease risk Food Funct 3 2012 575 591
5. J.C. Bourdon, K. Fernandes, F. Murray-Zmijewski, G. Liu, A. Diot, and D.P. Xirodimas et al. p53 isoforms can regulate p53 transcriptional activity Genes Dev 19 2005 2122 2137 (Pubitemid 41330315)
6. A. Busch, and K.J. Hertel Evolution of SR protein and hnRNP splicing regulatory factors Wiley Interdiscip Rev RNA 3 2012 1 12
7. Y.L. Chang, H.J. Lee, S.T. Liu, Y.S. Lin, T.C. Chen, and T.Y. Hsieh et al. Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin Int J Biochem Cell Biol 43 2011 1720 1728
8. H.R. Christofk, M.G. Vander Heiden, M.H. Harris, A. Ramanathan, R.E. Gerszten, and R. Wei et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth Nature 452 2008 230 233 (Pubitemid 351380249)
9. M. de la Mata, and A.R. Kornblihtt RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20 Nat Struct Mol Biol 13 2006 973 980 (Pubitemid 44684848)
10. A. Di Castelnuovo, R. di Giuseppe, L. Iacoviello, and G. de Gaetano Consumption of cocoa, tea and coffee and risk of cardiovascular disease Eur J Intern Med 23 2012 15 25
11. S. Erkelenz, W.F. Mueller, M.S. Evans, A. Busch, K. Schoneweis, and K.J. Hertel et al. Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms RNA 19 2013 96 102
12. F. Essmann, I.H. Engels, G. Totzke, K. Schulze-Osthoff, and R.U. Janicke Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event Cancer Res 64 2004 7065 7072 (Pubitemid 39331018)
13. S. Ferre An update on the mechanisms of the psychostimulant effects of caffeine J Neurochem 105 2008 1067 1079 (Pubitemid 351590775)
14. S. Ferre, F. Ciruela, J. Borycz, M. Solinas, D. Quarta, and K. Antoniou et al. Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain Front Biosci 13 2008 2391 2399 (Pubitemid 351589262)
15. K. Fujita, A.M. Mondal, I. Horikawa, G.H. Nguyen, K. Kumamoto, and J.J. Sohn et al. p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence Nat Cell Biol 11 2009 1135 1142
16. B.R. Graveley Sorting out the complexity of SR protein functions RNA 6 2000 1197 1211
17. X. He, A.D. Arslan, M.D. Pool, T.T. Ho, K.M. Darcy, and J.S. Coon et al. Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer Oncogene 30 2011 356 365
18. K. Ito, T. Nakazato, Y. Miyakawa, K. Yamato, Y. Ikeda, and M. Kizaki Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells J Cell Physiol 196 2003 276 283 (Pubitemid 36775874)
19. R. Jia, C. Li, J.P. McCoy, C.X. Deng, and Z.M. Zheng SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance Int J Biol Sci 6 2010 806 826
20. H. Jumaa, and P.J. Nielsen The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation EMBO J 16 1997 5077 5085 (Pubitemid 27348416)
21. H. Jumaa, G. Wei, and P.J. Nielsen Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20 Curr Biol 9 1999 899 902 (Pubitemid 29456007)
22. Y.M. Lee, J.H. Lim, H. Yoon, Y.S. Chun, and J.W. Park Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1alpha pre-mRNA in mice and in vitro Hepatology 53 2011 171 180
23. H. Lou, K.M. Neugebauer, R.F. Gagel, and S.M. Berget Regulation of alternative polyadenylation by U1 snRNPs and SRp20 Mol Cell Biol 18 1998 4977 4985 (Pubitemid 28388080)
24. V. Marcel, M.L. Dichtel-Danjoy, C. Sagne, H. Hafsi, D. Ma, and S. Ortiz-Cuaran et al. Biological functions of p53 isoforms through evolution: lessons from animal and cellular models Cell Death Differ 18 2011 1815 1824
25. E. Mostofsky, M.S. Rice, E.B. Levitan, and M.A. Mittleman Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis Circ Heart Fail 5 2012 401 405
26. K.M. Ng, Y.K. Lee, Y.C. Chan, W.H. Lai, M.L. Fung, and R.A. Li et al. Exogenous expression of HIF-1 alpha promotes cardiac differentiation of embryonic stem cells J Mol Cell Cardiol 48 2010 1129 1137
27. N. Pabla, S. Huang, Q.S. Mi, R. Daniel, and Z. Dong ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis J Biol Chem 283 2008 6572 6583
28. E.B. Rankin, J. Rha, M.A. Selak, T.L. Unger, B. Keith, and Q. Liu et al. Hypoxia-inducible factor 2 regulates hepatic lipid metabolism Mol Cell Biol 29 2009 4527 4538
29. S. Sen, H. Jumaa, and N.J. Webster Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function Nat Commun 4 2013 1336
30. J. Shi, Z. Hu, K. Pabon, and K.W. Scotto Caffeine regulates alternative splicing in a subset of cancer-associated genes: a role for SC35 Mol Cell Biol 28 2008 883 895
31. N. Tang, Y. Wu, J. Ma, B. Wang, and R. Yu Coffee consumption and risk of lung cancer: a meta-analysis Lung Cancer 67 2010 17 22
32. Y. Tang, I. Horikawa, M. Ajiro, A.I. Robles, K. Fujita, and A.M. Mondal et al. Downregulation of splicing factor SRSF3 induces p53beta, an alternatively spliced isoform of p53 that promotes cellular senescence Oncogene 32 22 2013 2792 2798
33. C. Valacca, S. Bonomi, E. Buratti, S. Pedrotti, F.E. Baralle, and C. Sette et al. Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene J Cell Biol 191 2010 87 99
34. M.T. Valenzuela, S. Mateos, J.M. Ruiz de Almodovar, and T.J. McMillan Variation in sensitizing effect of caffeine in human tumour cell lines after gamma-irradiation Radiother Oncol 54 2000 261 271 (Pubitemid 30157837)
35. V. Zuckerman, K. Wolyniec, R.V. Sionov, S. Haupt, and Y. Haupt Tumour suppression by p53: the importance of apoptosis and cellular senescence J Pathol 219 2009 3 15