Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin

International Journal of Biochemistry and Cell Biology

Volumn 43, Issue 12, 2011, Pages 1720-1728

  Chang, Yung Lung ^a   Lee, Hwei Jen ^a   Liu, Shu Ting ^a   Lin, Yu Sheng ^a   Chen, Tsung Chih ^a   Hsieh, Tsai Yuan ^b   Huang, Hsu Shan ^a   Huang, Shih Ming ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Autophagy; DNA damage; Doxorubicin; Senescence

Indexed keywords

2 ETHYL 1(3H) ANTHRA[1,2 D]IMIDAZOLE 6,11 DIONE; ALPHA ACTININ; ANTHRA[2,1 C][1,2,5]THIADIAZOLE 6,11 DIONE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DIMETHYL SULFOXIDE; DNA; DOXORUBICIN; MOXIFLOXACIN; NAPHTHO[2,3 F]QUINOXALINE 7,12 DIONE; NSC 745795; NSC 745885; NSC 745887; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL CYCLE REGULATION; CONTROLLED STUDY; DNA DAMAGE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NATIONAL CANCER INSTITUTE 60; NATIONAL HEALTH ORGANIZATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SENESCENCE;

AGING; ANTHRAQUINONES; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DOXORUBICIN; HELA CELLS; HUMANS; MODELS, MOLECULAR; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80255122756     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.08.006     Document Type: Article

References (30)

1. T. Abbas, and A. Dutta p21 in cancer: intricate networks and multiple activities Nat Rev Cancer 9 2009 400 414
2. B.D. Bax, P.F. Chan, D.S. Eggleston, A. Fosberry, D.R. Gentry, and F. Gorrec Type IIA topoisomerase inhibition by a new class of antibacterial agents Nature 466 2010 935 940
3. B.D. Chang, M.E. Swift, M. Shen, J. Fang, E.V. Broude, and I.B. Roninson Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent Proc Natl Acad Sci USA 99 2002 389 394 (Pubitemid 34060371)
4. T. Eisenberg, H. Knauer, A. Schauer, S. Buttner, C. Ruckenstuhl, and D. Carmona-Gutierrez Induction of autophagy by spermidine promotes longevity Nat Cell Biol 11 2009 1305 1314
5. W.S. el-Deiry, T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons, and J.M. Trent WAF1, a potential mediator of p53 tumor suppression Cell 75 1993 817 825 (Pubitemid 23346378)
6. K.H. Ho, H.E. Chang, and W.P. Huang Mutation at the cargo-receptor binding site of Atg8 also affects its general autophagy regulation function Autophagy 5 2009 461 471
7. H.S. Huang, I.B. Chen, K.F. Huang, W.C. Lu, F.Y. Shieh, and Y.Y. Huang Synthesis and human telomerase inhibition of a series of regioisomeric disubstituted amidoanthraquinones Chem Pharm Bull (Tokyo) 55 2007 284 292
8. H.S. Huang, T.C. Chen, R.H. Chen, K.F. Huang, F.C. Huang, and J.R. Jhan Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues Bioorg Med Chem 17 2009 7418 7428
9. H.S. Huang, H.F. Chiu, C.W. Tao, and I.B. Chen Synthesis and antitumor evaluation of symmetrical 1,5-diamidoanthraquinone derivatives as compared to their disubstituted homologues Chem Pharm Bull (Tokyo) 54 2006 458 464
10. H.S. Huang, K.F. Huang, C.L. Li, Y.Y. Huang, Y.H. Chiang, and F.C. Huang Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives Bioorg Med Chem 16 2008 6976 6986
11. S.M. Huang, A.H. Schonthal, and M.R. Stallcup Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1 Oncogene 20 2001 2134 2143 (Pubitemid 32424007)
12. S.M. Huang, and M.R. Stallcup Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors Mol Cell Biol 20 2000 1855 1867 (Pubitemid 30100202)
13. Y. Kouroku, E. Fujita, I. Tanida, T. Ueno, A. Isoai, and H. Kumagai ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation Cell Death Differ 14 2007 230 239 (Pubitemid 46092226)
14. A.K. Larsen, A.E. Escargueil, and A. Skladanowski Catalytic topoisomerase II inhibitors in cancer therapy Pharmacol Ther 99 2003 167 181 (Pubitemid 36897748)
15. B.Y. Lee, J.A. Han, J.S. Im, A. Morrone, K. Johung, and E.C. Goodwin Senescence-associated beta-galactosidase is lysosomal beta-galactosidase Aging Cell 5 2006 187 195
16. T.K. Li, and L.F. Liu Tumor cell death induced by topoisomerase-targeting drugs Annu Rev Pharmacol Toxicol 41 2001 53 77 (Pubitemid 32385882)
17. P. May, and E. May Twenty years of p53 research: structural and functional aspects of the p53 protein Oncogene 18 1999 7621 7636 (Pubitemid 30052689)
18. A.K. McClendon, and N. Osheroff DNA topoisomerase II, genotoxicity, and cancer Mutat Res 623 2007 83 97 (Pubitemid 47368578)
19. T. Morimoto, M. Fujita, T. Kawamura, Y. Sunagawa, T. Takaya, and H. Wada Myocardial regulation of p300 and p53 by doxorubicin involves ubiquitin pathways Circ J 72 2008 1506 1511
20. P.J. Perry, S.M. Gowan, A.P. Reszka, P. Polucci, T.C. Jenkins, and L.R. Kelland 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase J Med Chem 41 1998 3253 3260 (Pubitemid 28376531)
21. P.J. Perry, M.A. Read, R.T. Davies, S.M. Gowan, A.P. Reszka, and A.A. Wood 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase J Med Chem 42 1999 2679 2684 (Pubitemid 29344308)
22. A. Rebbaa, X. Zheng, P.M. Chou, and B.L. Mirkin Caspase inhibition switches doxorubicin-induced apoptosis to senescence Oncogene 22 2003 2805 2811 (Pubitemid 36609594)
23. W.P. Roos, and B. Kaina DNA damage-induced cell death by apoptosis Trends Mol Med 12 2006 440 450 (Pubitemid 44291571)
24. M. Schuler, and D.R. Green Transcription, apoptosis and p53: catch-22 Trends Genet 21 2005 182 187 (Pubitemid 40269857)
25. T. Simunek, M. Sterba, O. Popelova, M. Adamcova, R. Hrdina, and V. Gersl Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron Pharmacol Rep 61 2009 154 171
26. Z. Talloczy, W. Jiang, H.W. Virgin, t. Leib, D.A. Scheuner, and D.R.J. Kaufman Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway Proc Natl Acad Sci USA 99 2002 190 195 (Pubitemid 34060339)
27. S. Venitt, C. Crofton-Sleigh, M. Agbandje, T.C. Jenkins, and S. Neidle Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity J Med Chem 41 1998 3748 3752 (Pubitemid 28449357)
28. M.H. Wu, J.Y. Chan, P.Y. Liu, S.T. Liu, and S.M. Huang Human papillomavirus E2 protein associates with nuclear receptors to stimulate nuclear receptor- and E2-dependent transcriptional activations in human cervical carcinoma cells Int J Biochem Cell Biol 39 2007 413 425 (Pubitemid 44855660)
29. Y. Zhang, Y. Gao, G. Zhang, S. Huang, Z. Dong, and C. Kong DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells Int J Cancer 128 2011 551 561
30. Y.W. Zhang, J. Shi, Y.J. Li, and L. Wei Cardiomyocyte death in doxorubicin-induced cardiotoxicity Arch Immunol Ther Exp (Warsz) 57 2009 435 445