Design, synthesis and molecular modeling of novel N-acylhydrazone derivatives as pyruvate dehydrogenase complex E1 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 89-94

  He, Jun Bo ^a   Feng, Ling Ling ^a   Li, Jing ^a   Tao, Rui Juan ^a   Ren, Yan Liang ^a   Wan, Jian ^a   He, Hong Wu ^a  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

Author keywords

Molecular modeling; N Acylhydrazone derivatives; PDHc E1 inhibitors; Synthesis

Indexed keywords

1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL) 5 METHYL] N' (3 METHYLBENZYLIDENE) 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL) 5 METHYL] N' (4 METHYLBENZYLIDENE) 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL) 5 METHYL] N' (4 NITROBENZYLIDENE) 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL) 5 METHYL] N' [4 (TRIFLUOROMETHYL)BENZYLIDENE] 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL) 5 METHYL] N'(PYRIDIN 2 YLMETHYLENE) 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] 5 METHYL N' (SUBSTITUENT)BENZYLIDENE 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (2 BROMOENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (2 HYDROXYBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (2,3 DICHLOROBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (2,4 DICHLOROBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (3 HYDROXYBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (3,4 DICHLOROBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (4 BROMOBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (4 CHLORO 3 NITROBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (4 CHLOROBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (4 FLUOROBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (BENZO[D][1,3]DIOXOL 5 YLMETHYLENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' BENZYLIDENE 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] N' (4 CHLOROBENZYLIDENE) 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING SITE; BIOASSAY; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ESCHERICHIA COLI;

MOLECULAR MODELING; N-ACYLHYDRAZONE DERIVATIVES; PDHC-E1 INHIBITORS; SYNTHESIS;

HYDRAZONES; MODELS, MOLECULAR; PYRUVATE DEHYDROGENASE (LIPOAMIDE); PYRUVATE DEHYDROGENASE COMPLEX;

EID: 84891487156     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.051     Document Type: Article

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