Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3713-3719

  Jordão, Alessandro K ^a   Ferreira, Vitor F ^a   Lima, Emerson S ^b   de Souza, Maria C B V ^a   Carlos, Eduardo C L ^b   Castro, Helena C ^a   Geraldo, Reinaldo B ^a   Rodrigues, Carlos R ^a   Almeida, Maria C B ^a   Cunha, Anna C ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

Author keywords

Antiplatelet properties; Diazo compounds; In silico evaluation; Triazoles

Indexed keywords

1 (4 CHLOROPHENYLAMINO) N' [(FUR 2'' YL)METHYLENE] 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 1,2,3 TRIAZOLE DERIVATIVE; 5 METHYL 1 (PHENYLAMINO) N' [(PYRID 4'' YL)METHYLENE] 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; 5 METHYL N' (PHENYLMETHYLENE) 1 (PHENYLAMINO) 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CILOSTAZOL; CLOPIDOGREL; N' [(5'' BROMOTHIEN 2'' YL)METHYLENE] 5 METHYL 1 (PHENYLAMINO) 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; N' [(FUR 2'' YL)METHYLENE] 5 METHYL 1 (PHENYLAMINO) 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE; PHENYLAMINO 5 METHYL 1H 1,2,3 TRIAZOLE 4 CARBOHYDRAZIDE DERIVATIVE; TIROFIBAN; TRIFLUSAL; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; MOLECULAR WEIGHT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

HUMANS; HYDRAZINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 65349107095     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.053     Document Type: Article

References (23)

1. Yabusaki K., and Kokufuta E. Langmuir 18 (2002) 39
2. Son D.-J., Cho M.-R., Jin Y.-R., Kim S.-Y., Park Y.-H., Lee S.-H., Akiba S., Sato T., and Yun Y.-P. Prostaglandins, Leukot. Essent. Fatty Acids 71 (2004) 25
3. Schafer A.I. Am. J. Med. 101 (1996) 199
4. Hankey G.J., and Eikelboom J.W. Lancet 367 (2006) 606
5. Mousa S.A. Drug Discovery Today 4 (1999) 552
6. Born G., and Patrono C. Br. J. Pharmacol. 147 (2006) S241
7. Hata A.N., and Breyer R.M. Pharmacol. Ther. 103 (2004) 147
8. Patrono C., Bachmann F., Baigent C., Bode C., De Caterina R., Charbonnier B., Fitzgerald D., Hirsh J., Husted S., Kvasnicka J., Montalescot G., Rodríguez L.A.G., Verheugt F., Vermylen J., and Wallentin L. Eur. Heart J. 25 (2004) 166
9. Mason P.J., Jacobs A.K., and Freedman J.E. J. Am. Coll. Cardiol. 46 (2005) 986
10. Patrignani P. Thromb. Res. 110 (2003) 281
11. Zimmermann N., and Hohlfeld T. Thromb. Haemost. 100 (2008) 379
12. De La Cruz J.P., Moreno A., Ruiz-Ruiz M.I., and De La Cuesta F.S. Thromb. Res. 97 (2000) 125
13. World Health Organization (WHO) http://www.who.int/cardiovascular_diseases/en/. Accessed in 2008.
14. Cunha A.C., Figueiredo J.M., Tributino J.L.M., Miranda A.L.P., Castro H.C., Zingali R.B., Fraga C.A.M., Souza M.C.B.V., Ferreira V.F., and Barreiro E.J. Bioorg. Med. Chem. 11 (2003) 2051
15. Jordão, A.K. Msc. Thesis, Instituto de Química, UFF, Niterói, Brazil, 2007.
16. Lima L.M., Frattani F.S., Dos Santos J.L., Castro H.C., Fraga C.A.M., Zingali R.B., and Barreiro E.J. Eur. J. Med. Chem. 43 (2008) 348
17. Fraga A.G.M., Rodrigues C.R., Miranda A.L.P., Barreiro E.J., and Fraga C.A.M. Eur. J. Pharm. Sci. 11 (2000) 285
18. Barreiro E.J., Fraga C.A.M., and Miranda A.L.P. Quim. Nova 25 (2002) 129
19. Silva A.G., Zapata-Sudo G., Kummerle A.E., Fraga C.A.M., Barreiro E.J., and Sudo R.T. Bioorg. Med. Chem. 13 (2005) 3431
20. Silva G.A., Costa L.M.M., Brito F.C.F., Miranda A.L.P., Barreiro E.J., and Fraga C.A.M. Bioorg. Med. Chem. 12 (2004) 3149
21. Lipinski C.A., Lombardo F., Dominy B.W., and Feeney P..J. Adv. Drug Deliv. Rev. 46 (2001) 3
22. Born G.V.R. Nature 194 (1962) 927
23. Tekto I.V. Drug Discovery Today 22 (2005) 1497